The Michael J. Fox Foundation’s Strategies for Accelerating Translation of LRRK2 into Therapies for Parkinson Disease

The In situ Structure of Parkinson's Disease-Linked LRRK2

(2020) Reika Watanabe et al.   BIOPHYSICAL JOURNAL

An Assessment of LRRK2 Serine 935 Phosphorylation in Human Peripheral Blood Mononuclear Cells in Idiopathic Parkinson’s Disease and G2019S LRRK2 Cohorts

(2020) Shalini Padmanabhan et al.   Journal of Parkinsons Disease

The effect of LRRK2 loss-of-function variants in humans

(2020) Nicola Whiffin et al.   NATURE MEDICINE

LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits

(2020) Marco A. S. Baptista et al.   Science Translational Medicine

Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation

(2020) Ying Fan et al.   Jove-Journal of Visualized Experiments

Crystal structure of the WD40 domain dimer of LRRK2

(2019) Pengfei Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The G2019S variant of leucine-rich repeat kinase 2 (LRRK2) alters endolysosomal trafficking by impairing the function of the GTPase RAB8A

(2019) Pilar Rivero-Ríos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Higher urate in LRRK2 mutation carriers resistant to Parkinson disease

(2019) Rachit Bakshi et al.   ANNALS OF NEUROLOGY

The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGψ motif in the kinase domain

(2019) Sven H. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Higher Urine bis(Monoacylglycerol)Phosphate Levels in LRRK2 G2019S Mutation Carriers: Implications for Therapeutic Development

(2019) Roy N. Alcalay et al.   MOVEMENT DISORDERS

Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner

(2019) Bojan Shutinoski et al.   Science Translational Medicine

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

(2019) Kerryn Berndsen et al.   eLife

The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human

(2018) Rafeeq Mir et al.   BIOCHEMICAL JOURNAL

Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration

(2018) Ga Ram Jeong et al.   Molecular Neurodegeneration

LRRK2 kinase in Parkinson's disease

(2018) Dario R. Alessi et al.   SCIENCE

Functional variants in the LRRK2 gene confer shared effects on risk for Crohn’s disease and Parkinson’s disease

(2018) Ken Y. Hui et al.   Science Translational Medicine

LRRK2 activation in idiopathic Parkinson’s disease

(2018) Roberto Di Maio et al.   Science Translational Medicine

A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

(2018) Herschel S Dhekne et al.   eLife

Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016)

(2017) Paul Galatsis   EXPERT OPINION ON THERAPEUTIC PATENTS

LRRK2 G2019S-induced mitochondrial DNA damage is LRRK2 kinase dependent and inhibition restores mtDNA integrity in Parkinson’s disease

(2017) Evan H Howlett et al.   HUMAN MOLECULAR GENETICS

A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci

(2017) Diana Chang et al.   NATURE GENETICS

A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants

(2017) Katie J. Ryan et al.   Science Translational Medicine

A homologue of the Parkinson’s disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover

(2017) Egon Deyaert et al.   Nature Communications

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis

(2017) Martin Steger et al.   eLife

LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model

(2017) Hien Tran Zhao et al.   Molecular Therapy-Nucleic Acids

First model of dimeric LRRK2: the challenge of unrevealing the structure of a multidomain Parkinson's-associated protein

(2016) G. Guaitoli et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Effect of selective LRRK2 kinase inhibition on nonhuman primate lung

(2015) Reina N. Fuji et al.   Science Translational Medicine

Leucine-Rich Repeat Kinase 2 Binds to Neuronal Vesicles through Protein Interactions Mediated by Its C-Terminal WD40 Domain

(2014) G. Piccoli et al.   MOLECULAR AND CELLULAR BIOLOGY

Leucine-Rich Repeat Kinase 2 (LRRK2)-Deficient Rats Exhibit Renal Tubule Injury and Perturbations in Metabolic and Immunological Homeostasis

(2013) Daniel Ness et al.   PLoS One

Loss of Leucine-Rich Repeat Kinase 2 (LRRK2) in Rats Leads to Progressive Abnormal Phenotypes in Peripheral Organs

(2013) Marco A. S. Baptista et al.   PLoS One

Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway

(2012) Youren Tong et al.   Molecular Neurodegeneration

LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

(2011) Martin C. Herzig et al.   HUMAN MOLECULAR GENETICS

MultipleLRRK2variants modulate risk of Parkinson disease: a Chinese multicenter study

(2010) Eng-King Tan et al.   HUMAN MUTATION

LRRK2 G2019S mutation: frequency and haplotype data in South African Parkinson’s disease patients

(2010) Soraya Bardien et al.   JOURNAL OF NEURAL TRANSMISSION

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

(2010) Mark R. Cookson   NATURE REVIEWS NEUROSCIENCE