Knockdown of Leptin Receptor Affects Macrophage Phenotype in the Tumor Microenvironment Inhibiting Breast Cancer Growth and Progression

Modulating Tumor-Associated Macrophage Polarization by Synthetic and Natural PPARγ Ligands as a Potential Target in Breast Cancer

(2020) Giulia Gionfriddo et al.   Cells

Leptin Signaling Contributes to Aromatase Inhibitor Resistant Breast Cancer Cell Growth and Activation of Macrophages

(2020) Luca Gelsomino et al.   Biomolecules

Leptin Receptor as a Potential Target to Inhibit Human Testicular Seminoma Growth

(2019) Salvatore Panza et al.   AMERICAN JOURNAL OF PATHOLOGY

Obesity, Leptin and Breast Cancer: Epidemiological Evidence and Proposed Mechanisms

(2019) Sebastiano Andò et al.   Cancers

The weight of obesity in breast cancer progression and metastasis: Clinical and molecular perspectives

(2019) Ines Barone et al.   SEMINARS IN CANCER BIOLOGY

PD‑L1 expression levels on tumor cells affect their immunosuppressive activity

(2019) Yang Zheng et al.   Oncology Letters

STAT3 Activity Promotes Programmed-Death Ligand 1 Expression and Suppresses Immune Responses in Breast Cancer

(2019) Zerdes et al.   Cancers

Upregulation of PD-L1 expression in breast cancer cells through the formation of 3D multicellular cancer aggregates under different chemical and mechanical conditions

(2019) Shohreh Azadi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Harnessing tumor-associated macrophages as aids for cancer immunotherapy

(2019) Xiaolei Li et al.   Molecular Cancer

The chemokine MCP-1 (CCL2) in the host interaction with cancer: a foe or ally?

(2018) Teizo Yoshimura   Cellular & Molecular Immunology

Uncoupling effects of estrogen receptor α on LKB1/AMPK interaction upon adiponectin exposure in breast cancer

(2018) Loredana Mauro et al.   FASEB JOURNAL

Tumor-associated macrophages: implications in cancer immunotherapy

(2017) Amy J Petty et al.   Immunotherapy

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

(2017) Sydney R. Gordon et al.   NATURE

Conditional expression of Ki-RasG12V in the mammary epithelium of transgenic mice induces estrogen receptor alpha (ERα)-positive adenocarcinoma

(2017) S Andò et al.   ONCOGENE

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

(2017) W. K. Eddie Ip et al.   SCIENCE

T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition

(2017) Enfu Hui et al.   SCIENCE

The Leptin Receptor Complex: Heavier Than Expected?

(2017) Joris Wauman et al.   Frontiers in Endocrinology

Glucocorticoid Receptor as a Potential Target to Decrease Aromatase Expression and Inhibit Leydig Tumor Growth

(2016) Salvatore Panza et al.   AMERICAN JOURNAL OF PATHOLOGY

Tissue-resident versus monocyte-derived macrophages in the tumor microenvironment

(2016) Qods Lahmar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Leptin, obesity and breast cancer: progress to understanding the molecular connections

(2016) Ines Barone et al.   CURRENT OPINION IN PHARMACOLOGY

Leptin promotes breast cancer cell migration and invasion via IL-18 expression and secretion

(2016) KUANGFA LI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants

(2016)   LANCET

Leptin Regulation of Immune Responses

(2016) Caitlin Naylor et al.   TRENDS IN MOLECULAR MEDICINE

Attenuation of the programmed cell death-1 pathway increases the M1 polarization of macrophages induced by zymosan

(2016) W Chen et al.   Cell Death & Disease

Leptin promotes migration and invasion of breast cancer cells by stimulating IL-8 production in M2 macrophages

(2016) Hong Cao et al.   Oncotarget

Activated FXR Inhibits Leptin Signaling and Counteracts Tumor-promoting Activities of Cancer-Associated Fibroblasts in Breast Malignancy

(2016) Cinzia Giordano et al.   Scientific Reports

Expression and Function of Phosphodiesterase Type 5 in Human Breast Cancer Cell Lines and Tissues: Implications for Targeted Therapy

(2015) S. Catalano et al.   CLINICAL CANCER RESEARCH

A novel leptin antagonist peptide inhibits breast cancer growthin vitroandin vivo

(2015) Stefania Catalano et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Leptin as a mediator of tumor-stromal interactions promotes breast cancer stem cell activity

(2015) Cinzia Giordano et al.   Oncotarget

PD-1 expression on dendritic cells suppresses CD8+ T cell function and antitumor immunity

(2015) Tong Seng Lim et al.   OncoImmunology

Overweight, Obesity, and Postmenopausal Invasive Breast Cancer Risk

(2015) Marian L. Neuhouser et al.   JAMA Oncology

Paracrine Interactions between Adipocytes and Tumor Cells Recruit and Modify Macrophages to the Mammary Tumor Microenvironment: The Role of Obesity and Inflammation in Breast Adipose Tissue

(2015) Ana Santander et al.   Cancers

Macrophage IL-10 Blocks CD8+ T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells

(2014) Brian Ruffell et al.   CANCER CELL

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2014) Marie Ng et al.   LANCET

Macrophages associated with tumors as potential targets and therapeutic intermediates

(2014) Serguei Vinogradov et al.   Nanomedicine

High infiltration of tumor-associated macrophages in triple-negative breast cancer is associated with a higher risk of distant metastasis

(2014) Zhong-Yu Yuan et al.   OncoTargets and Therapy

The Multifaceted Mechanism of Leptin Signaling within Tumor Microenvironment in Driving Breast Cancer Growth and Progression

(2014) Sebastiano Andò et al.   Frontiers in Oncology

Leptin–cytokine crosstalk in breast cancer

(2013) Gale Newman et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Oncogenic role and therapeutic target of leptin signaling in breast cancer and cancer stem cells

(2012) Shanchun Guo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Stromal cells in tumor microenvironment and breast cancer

(2012) Yan Mao et al.   CANCER AND METASTASIS REVIEWS

Leptin Mediates Tumor-Stromal Interactions That Promote the Invasive Growth of Breast Cancer Cells

(2012) I. Barone et al.   CANCER RESEARCH

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Selective Effects of PD-1 on Akt and Ras Pathways Regulate Molecular Components of the Cell Cycle and Inhibit T Cell Proliferation

(2012) N. Patsoukis et al.   Science Signaling

TGF /TNF -Mediated Epithelial-Mesenchymal Transition Generates Breast Cancer Stem Cells with a Claudin-Low Phenotype

(2011) M. K. Asiedu et al.   CANCER RESEARCH

The multifactorial role of leptin in driving the breast cancer microenvironment

(2011) Sebastiano Andò et al.   Nature Reviews Endocrinology

Notch, IL-1 and Leptin Crosstalk Outcome (NILCO) Is Critical for Leptin-Induced Proliferation, Migration and VEGF/VEGFR-2 Expression in Breast Cancer

(2011) Shanchun Guo et al.   PLoS One

Leptin upregulates tissue factor expression in human breast cancer MCF-7 cells

(2011) Emanuela Napoleone et al.   THROMBOSIS RESEARCH

Role of Notch and its oncogenic signaling crosstalk in breast cancer

(2010) Shanchun Guo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Leptin upregulates VEGF in breast cancer via canonic and non-canonical signalling pathways and NFκB/HIF-1α activation

(2010) Ruben R. Gonzalez-Perez et al.   CELLULAR SIGNALLING

Combined Low Doses of PPARγ and RXR Ligands Trigger an Intrinsic Apoptotic Pathway in Human Breast Cancer Cells

(2009) Daniela Bonofiglio et al.   AMERICAN JOURNAL OF PATHOLOGY

PD-1 signaling in primary T cells

(2009) James L. Riley   IMMUNOLOGICAL REVIEWS

Stromal MCP-1 in mammary tumors induces tumor-associated macrophage infiltration and contributes to tumor progression

(2009) Hiroshi Fujimoto et al.   INTERNATIONAL JOURNAL OF CANCER

The canonical NF-κB pathway is required for formation of luminal mammary neoplasias and is activated in the mammary progenitor population

(2009) M A C Pratt et al.   ONCOGENE

PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis

(2009) X. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pre-diagnosis body mass index, post-diagnosis weight change, and prognosis among women with early stage breast cancer

(2008) Bette J. Caan et al.   CANCER CAUSES & CONTROL

The inflammatory chemokines CCL2 and CCL5 in breast cancer

(2008) Gali Soria et al.   CANCER LETTERS