Article
Oncology
Jamal Elhasnaoui, Giulio Ferrero, Valentina Miano, Santina Cutrupi, Michele De Bortoli
Summary: This study reveals a novel mechanism of gene regulation mediated by estrogen receptor alpha in breast cancer cells, involving the control of RNA-binding protein expression and effects on isoform usage and alternative splicing. These regulatory mechanisms play a significant role in cell proliferation and epithelial-to-mesenchymal transition in breast cancer.
Review
Biochemistry & Molecular Biology
Misung Park, Dohee Kim, Sunghyub Ko, Ayoung Kim, Kyumin Mo, Hyunho Yoon
Summary: Breast cancer is the most common malignancy in women worldwide, and metastasis is the leading cause of high mortality. Currently, breast cancer is often discovered or diagnosed after metastasis has occurred, resulting in poor prognosis. Understanding the mechanisms and nature of breast cancer metastasis can facilitate the development of targeted therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Xiaoyong Fu, Carmine De Angelis, Rachel Schiff
Summary: Cancer immunology is a rapidly expanding field in cancer research, and the immune system plays an important role in the development of breast cancer. IFN signaling is critical in determining therapy response and outcome of breast cancer patients, depending on the subtype. The role of tumor cell-inherent IFN signaling in the breast cancer microenvironment could influence therapy response with protumor activities.
Article
Biochemistry & Molecular Biology
Lorenz Isert, Aditi Mehta, Gabriele Loiudice, Altea Oliva, Andreas Roidl, Olivia M. Merkel
Summary: During the progression from ductal carcinoma in situ (DCIS) to invasive breast cancer (IBC), cells undergo epithelial-to-mesenchymal transition (EMT) to acquire invasive features. In this study, the interplay between the tumor microenvironment and EMT phenotype was investigated in vitro. The combination of collagen with the growth factor TGF-beta 1 induced prominent phenotypic changes, independent of collagen type and cell line. The results highlight the potential of the EMT-phenotyping model to predict the efficacy of EMT-targeting drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Yusheng Guo, Guohui Wu, Junrong Yi, Qin Yang, Wengong Jiang, Shaoqiang Lin, Xiaorong Yang, Xiangsheng Cai, Liufeng Mao
Summary: The estrogen signaling pathway has been postulated to have a protective effect on the occurrence and development of hepatocellular carcinoma (HCC), with multiple studies supporting its anti-HCC effects. Strategies targeting the estrogen signaling pathway have been investigated for potential therapeutic effects in HCC treatment, highlighting potential targets and current obstacles.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Erina Iwabuchi, Yasuhiro Miki, Takashi Suzuki, Hisashi Hirakawa, Takanori Ishida, Hironobu Sasano
Summary: The study investigated the biological functions of hnRNPK in the ER-mediated signaling pathway in breast cancer, finding that hnRNPK interacts with ER alpha and is involved in this pathway. Additionally, hnRNPK expression could potentially be a target for endocrine therapy in ER alpha-positive breast cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Dahae Lee, Young-Mi Kim, Young-Won Chin, Ki Sung Kang
Summary: This study demonstrated that schisandrol A has estrogen-like effects by inducing the expression of ER alpha through the PI3K/AKT and ERK signaling pathways, promoting the proliferation of MCF-7 cells. The effects of schisandrol A were more significant compared to E2 and could be mitigated by the ER antagonist ICI.
Review
Oncology
Tiecheng Wang, Jiakang Jin, Chao Qian, Jianan Lou, Jinti Lin, Ankai Xu, Kaishun Xia, Libin Jin, Bing Liu, Huimin Tao, Zhengming Yang, Wei Yu
Summary: Estrogen and its receptor play crucial roles in regulating autoimmune diseases and anti-tumor immunity. The mechanisms of estrogen-induced immunity, including canonical and non-canonical signal pathways, are important for understanding tumor immunity and providing potential targets for cancer immunotherapy.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Yang Zhou, Jiang Xu, Haichang Luo, Xiangjing Meng, Ming Chen, Di Zhu
Summary: Abnormal activation of the Wnt/beta-catenin signaling pathway is closely related to tumorigenesis and immune surveillance, leading to increased resistance to immunotherapy.
Review
Endocrinology & Metabolism
Binita Chakraborty, Jovita Byemerwa, Taylor Krebs, Felicia Lim, Ching-Yi Chang, Donald P. McDonnell
Summary: This review explores the impact of estrogen on immune function and its role in the pathobiology of autoimmune diseases and cancers. Estrogen can influence the activity of various immune cells and dysregulation of estrogen signaling may contribute to disease development. Understanding the effects of ER modulators on the immune system can provide insights into the mechanistic basis of sex-biased responses.
Article
Oncology
Christos A. Aggelopoulos, Anna-Maria Christodoulou, Myrsini Tachliabouri, Stauros Meropoulis, Maria-Elpida Christopoulou, Theodoros T. Karalis, Athanasios Chatzopoulos, Spyros S. Skandalis
Summary: This study investigated the effects of cold atmospheric plasma (CAP) treatment on breast cancer cells of different phenotypes and estrogen receptor (ER) status. CAP treatment induced phenotypic changes and apoptosis in breast cancer cells, and significantly reduced CD44 protein expression. CAP could be an efficient therapeutic approach for distinct breast cancer subtypes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Plant Sciences
Xia Liu, Xianli Liu, Weiye Mao, Yingxue Guo, Ningning Bai, Lu Jin, Qiyang Shou, Huiying Fu
Summary: This study investigated the antitumor effect and mechanism of Tetrastigma Hemsleyanum Diels et Gilg (SYQ) on breast cancer. It was found that SYQ inhibited breast cancer through PPAR γ activation and β-catenin-mediated M2 macrophage polarization. These results elucidate the antitumor effect and mechanism of SYQ and provide a basis for the potential use of SYQ as an adjuvant drug in macrophage tumor immunotherapy for breast cancer.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Oncology
Byung-Hee Kang, Bum-Sup Jang, In Ah Kim
Summary: This study evaluates the association between radiosensitivity and the tumor microenvironment (TME) in breast cancer patients. The results suggest that tumor radiosensitivity is associated with activation of antitumor immunity and has a better prognosis, especially in ER-negative breast cancer.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Jennifer R. Bourn, Sasha J. Ruiz-Torres, Brian G. Hunt, Nancy M. Benight, Susan E. Waltz
Summary: This study provides evidence for the novel role of RON signaling in regulating breast cancer initiation, progression, and metastasis by modulating tumor cell intrinsic processes and the tumor microenvironment. Activation of RON signaling promotes tumor cell intrinsic growth and immune evasion, supporting breast cancer progression, and targeting RON signaling may be a potential therapeutic strategy against breast cancer.
Review
Biochemistry & Molecular Biology
Daniela Miricescu, Alexandra Totan, Iulia-Ioana Stanescu-Spinu, Silviu Constantin Badoiu, Constantin Stefani, Maria Greabu
Summary: Breast cancer is a complex disease with various factors contributing to its pathogenesis. Current research is focused on the PI3K/AKT/mTOR signaling pathway and related cancer mutations. Clinical trials are also evaluating the efficacy of inhibitors targeting these signaling pathways in breast cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Fabrizio Ceraudo, Giovanna Caparello, Angelo Galluccio, Ennio Avolio, Giuseppina Augimeri, Daniela De Rose, Adele Vivacqua, Catia Morelli, Ines Barone, Stefania Catalano, Cinzia Giordano, Diego Sisci, Daniela Bonofiglio
Summary: The study evaluated the impact of Mediterranean food choices on lipid and glycemic metabolic profile in adolescents. The results indicated that adopting a Mediterranean diet could significantly reduce glucose and lipid profile in healthy adolescents.
Review
Nutrition & Dietetics
Elisa Mattavelli, Elena Olmastroni, Daniela Bonofiglio, Alberico L. Catapano, Andrea Baragetti, Paolo Magni
Summary: The Mediterranean diet is a comprehensive lifestyle that promotes health and reduces the prevalence of chronic diseases. Its implementation is influenced by sociocultural and geographical factors, as well as personal food preferences and nutrition habits.
Editorial Material
Nutrition & Dietetics
Daniela Bonofiglio
Article
Food Science & Technology
Serena Carpentieri, Giuseppina Augimeri, Jessica Ceramella, Adele Vivacqua, Maria Stefania Sinicropi, Gianpiero Pataro, Daniela Bonofiglio, Giovanna Ferrari
Summary: The study utilized pulsed electric field pretreatment to enhance the extractability of valuable compounds from artichoke by-products, demonstrating the antioxidant and anti-inflammatory properties of the extracts. Biological effects on THP-1 macrophages were investigated.
Article
Biochemistry & Molecular Biology
Luca Gelsomino, Ines Barone, Amanda Caruso, Francesca Giordano, Matteo Brindisi, Giovanna Morello, Felice Maria Accattatis, Salvatore Panza, Anna Rita Cappello, Daniela Bonofiglio, Sebastiano Ando, Stefania Catalano, Cinzia Giordano
Summary: Tumor extracellular vesicles (EVs) play a crucial role in cell-to-cell communication in breast cancer by transporting nucleic acids, proteins, and metabolites. Leptin induces the release of EVs from breast cancer cells, and these vesicles have a specific proteomic signature related to mitochondrial processes and activity. Lep-EVs increase ATP levels and modulate the oxidative metabolism of breast cancer cells. Furthermore, Lep-EVs sustain the polarization of macrophages in the tumor microenvironment (TME) towards a tumor-promoting phenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Michele Pellegrino, Elena Ricci, Rosangela Ceraldi, Alessandra Nigro, Daniela Bonofiglio, Marilena Lanzino, Catia Morelli
Summary: This review highlights the anti-tumor activity of several antiepileptic drugs in breast, prostate, and other cancers. It focuses on their ability to block ion channels and inhibit histone deacetylases, which are well-established tumor markers and molecular targets. The repurposing of already approved drugs as adjuvants in cancer treatment is advantageous due to reduced toxicity and faster clinical approval. The review also discusses the attempt to administer antiepileptic drugs through drug delivery systems to improve their effectiveness and reduce toxicity.
Article
Oncology
Giuseppina Augimeri, Marco Fiorillo, Catia Morelli, Salvatore Panza, Cinzia Giordano, Ines Barone, Stefania Catalano, Diego Sisci, Sebastiano Ando, Daniela Bonofiglio
Summary: Triple-negative breast cancer (TNBC), lacking effective targeted therapies, can be attenuated by DHEA through reducing cell migration, invasion, and metabolic activity. In addition, DHEA suppresses macrophage recruitment by reducing CCL5 secretion from TNBC cells, providing a potential treatment option against TNBC.
Review
Biochemistry & Molecular Biology
Giuseppina Augimeri, Daniela Bonofiglio
Summary: Unhealthy dietary habits increase the risk of cancer, and adopting a healthy eating pattern, such as the Mediterranean diet high in omega-3 polyunsaturated fatty acids (N-3 PUFAs), is recommended to prevent various types of cancers, including breast cancer. The consumption of N-3 PUFAs, particularly EPA and DHA, reduces the risk and progression of breast cancer, and also helps counteract side effects of chemotherapy. DHA, in particular, has shown significant antitumoral effects in breast cancer cells and its derivative DHEA has potential therapeutic benefits.
Article
Chemistry, Multidisciplinary
Giovanna Caparello, Angelo Galluccio, Fabrizio Ceraudo, Claudio Pecorella, Fabio Buzzanca, Francesco Cuccomarino, Daniela Bonofiglio, Ennio Avolio
Summary: An optimal body composition in volleyball players can be achieved by monitoring training plans and nutritional habits, and the Mediterranean Diet (MD) is a good choice to meet the nutritional needs of athletes. This study used bioelectrical impedance vector analysis (BIVA) to monitor body composition changes in volleyball players following MD recommendations. The results showed that athletes maintained an optimal MD adherence and experienced significant changes in BIVA parameters, indicating improved body cell mass and skeletal muscle mass. These findings support the use of BIVA as a tool to monitor athlete's body adaptations and highlight the importance of the MD in sports settings.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Cinzia Giordano, Felice Maria Accattatis, Luca Gelsomino, Piercarlo Del Console, Balazs Gyorffy, Mario Giuliano, Bianca Maria Veneziani, Grazia Arpino, Carmine De Angelis, Pietro De Placido, Erica Pietroluongo, Francesco Zinno, Daniela Bonofiglio, Sebastiano Ando, Ines Barone, Stefania Catalano
Summary: This study identified novel miRNA signatures, miRNA-27a and miRNA-128, in breast cancer by analyzing the expression profiles of EV-derived miRNAs in the blood circulation. These miRNAs showed diagnostic accuracy in distinguishing breast cancer patients from non-cancer controls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Giuseppina Augimeri, Marco Fiorillo, Giovanna Caparello, Fabrizio Ceraudo, Ennio Avolio, Catia Morelli, Ines Barone, Stefania Catalano, Sebastiano Ando, Cinzia Giordano, Diego Sisci, Adele Vivacqua, Daniela Bonofiglio
Summary: This study found that the COVID-19 lockdown had a negative impact on the metabolic and inflammatory profile of adolescents, despite no significant differences in anthropometric measurements and adherence to the Mediterranean diet. Post-lockdown adolescents had higher levels of fasting glucose, triglycerides, total cholesterol, LDL, tumor necrosis factor (TNF)-alpha, interleukin-1 beta, and ferritin, along with lower levels of high-density lipoprotein (HDL). The study also identified several serum markers as predictors for metabolic and inflammatory profiling after the lockdown period.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Simona De Angelis, Emanuela Medda, Daniela Rotondi, Maria Masocco, Valentina Minardi, Benedetta Contoli, Valentina Possenti, Angela Sorbo, Marilena D'Amato, Anna Chiara Turco, Alberto Augusto Pastorelli, Paolo Stacchini, Roberto Da Cas, Marcello Bagnasco, Daniela Bonofiglio, Maurizio Gasperi, Domenico Meringolo, Caterina Mian, Mariacarla Moleti, Francesco Vermiglio, Efisio Puxeddu, Augusto Taccaliti, Massimo Tonacchera, Salvatore Ulisse, Antonio Dimida, Teresa Rago, Elena Nazzari, Mara Schiavo, Irene Bossert, Giacomo Sturniolo, Carlo Corbetta, Cristina Cereda, Laura Cappelletti, Marta Camilot, Francesca Teofoli, Renzo Ciatti, Elisabetta Tarsi, Nicola Perrotti, Onorina Marasco, Giovanna Scozzafava, Francesca Righetti, Sebastiano Ando, Stefania Catalano, Mariarosaria Cristofaro, Giovanni Sorrenti, Simona Censi, Silvia Morelli, Enke Baldini, Giuseppe Plutino, Roberto Copparoni, Elena Alonzo, Claudia Giacomozzi, Marco Silano, Antonella Olivieri
Summary: This study evaluated the efficiency and adverse effects of the iodine prophylaxis program in Italy. The results showed that Italy has achieved iodine sufficiency through the program, but there are still concerns about iodine nutritional status during pregnancy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)