Controlling TIME: How MNK Kinases Function to Shape Tumor Immunity

Translation control of the immune checkpoint in cancer and its therapeutic targeting

(2019) Yichen Xu et al.   NATURE MEDICINE

Computer-Aided Discovery of Small Molecules Targeting the RNA Splicing Activity of hnRNP A1 in Castration-Resistant Prostate Cancer

(2019) Lavinia Carabet et al.   MOLECULES

Targeting Tumor-Associated Macrophages in Cancer

(2019) Paulina Pathria et al.   TRENDS IN IMMUNOLOGY

Quercetin Enhances the Anti-Tumor Effects of BET Inhibitors by Suppressing hnRNPA1

(2019) Thao N.D. Pham et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structure-based Design of Pyridone–Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition

(2018) Siegfried H. Reich et al.   JOURNAL OF MEDICINAL CHEMISTRY

Myeloid-derived suppressor cells coming of age

(2018) Filippo Veglia et al.   NATURE IMMUNOLOGY

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

Translational control in the tumor microenvironment promotes lung metastasis: Phosphorylation of eIF4E in neutrophils

(2018) Nathaniel Robichaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage polarization and allergic asthma

(2018) Arjun Saradna et al.   Translational Research

Targeting Myeloid-Derived Suppressor Cells to Bypass Tumor-Induced Immunosuppression

(2018) Viktor Fleming et al.   Frontiers in Immunology

Lack of Sprouty 1 and 2 enhances survival of effector CD8+ T cells and yields more protective memory cells

(2018) Hesham M. Shehata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Translational Machinery of Human CD4+ T Cells Is Poised for Activation and Controls the Switch from Quiescence to Metabolic Remodeling

(2018) Sara Ricciardi et al.   Cell Metabolism

Osteopontin mediates glioblastoma-associated macrophage infiltration and is a potential therapeutic target

(2018) Jun Wei et al.   JOURNAL OF CLINICAL INVESTIGATION

Induction of MNK Kinase–dependent eIF4E Phosphorylation by Inhibitors Targeting BET Proteins Limits Efficacy of BET Inhibitors

(2018) Thao N.D. Pham et al.   MOLECULAR CANCER THERAPEUTICS

Quercetin Targets hnRNPA1 to Overcome Enzalutamide Resistance in Prostate Cancer Cells

(2017) Ramakumar Tummala et al.   MOLECULAR CANCER THERAPEUTICS

Emerging roles of hnRNPA1 in modulating malignant transformation

(2017) Rajat Roy et al.   Wiley Interdisciplinary Reviews-RNA

Tumor-Infiltrating Plasma Cells Are Associated with Tertiary Lymphoid Structures, Cytolytic T-Cell Responses, and Superior Prognosis in Ovarian Cancer

(2016) D. R. Kroeger et al.   CLINICAL CANCER RESEARCH

Type I IFN Inhibits Alternative Macrophage Activation duringMycobacterium tuberculosisInfection and Leads to Enhanced Protection in the Absence of IFN-γ Signaling

(2016) Lúcia Moreira-Teixeira et al.   JOURNAL OF IMMUNOLOGY

Biological role of granulocyte macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) on cells of the myeloid lineage

(2016) Irina Ushach et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CGP57380 enhances efficacy of RAD001 in non-small cell lung cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway

(2016) Qiuyuan Wen et al.   Oncotarget

Signalling to eIF4E in cancer

(2015) N. Siddiqui et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mnks, eIF4E phosphorylation and cancer

(2015) Christopher G. Proud   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Regulation of myelopoiesis by the transcription factor IRF8

(2015) Tomohiko Tamura et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

The Adapter Protein Sprouty 2 (Spry 2) Differentially Regulates Lymphoid and Myeloid Cell Function and Is Important for Allergic Asthma

(2015) Balachandra K. Gorentla et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Peritumoural neutrophils negatively regulate adaptive immunity via the PD-L1/PD-1 signalling pathway in hepatocellular carcinoma

(2015) Gaixia He et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The burgeoning family of unconventional T cells

(2015) Dale I Godfrey et al.   NATURE IMMUNOLOGY

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

eIF4E as a Control Target for Viruses

(2015) Hilda Montero et al.   Viruses-Basel

Spatial distribution of B cells predicts prognosis in human pancreatic adenocarcinoma

(2015) Giovanni Francesco Castino et al.   OncoImmunology

Targeting Mnks for Cancer Therapy

(2015) Jinqiang Hou et al.   Oncotarget

Tumor suppression by small molecule inhibitors of translation initiation

(2015) Limo Chen et al.   Oncotarget

The eIF4E/eIF4G Interaction Inhibitor 4EGI-1 Augments TRAIL-Mediated Apoptosis through c-FLIP Down-regulation and DR5 Induction Independent of Inhibition of Cap-Dependent Protein Translation

(2015) Songqing Fan et al.   NEOPLASIA

Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8K108E mutation

(2014) S. Salem et al.   BLOOD

Tumor-Derived Osteopontin Suppresses Antitumor Immunity by Promoting Extramedullary Myelopoiesis

(2014) E.-K. Kim et al.   CANCER RESEARCH

Osteopontin Shapes Immunosuppression in the Metastatic Niche

(2014) Sabina Sangaletti et al.   CANCER RESEARCH

CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T-cell Checkpoint Immunotherapy in Pancreatic Cancer Models

(2014) Y. Zhu et al.   CANCER RESEARCH

Chemical Proteomics Identifies Heterogeneous Nuclear Ribonucleoprotein (hnRNP) A1 as the Molecular Target of Quercetin in Its Anti-cancer Effects in PC-3 Cells

(2014) Chia-Chen Ko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inducible costimulator facilitates T-dependent B cell activation by augmenting IL-4 translation

(2014) Mathieu Gigoux et al.   MOLECULAR IMMUNOLOGY

Translational control of immune responses: from transcripts to translatomes

(2014) Ciriaco A Piccirillo et al.   NATURE IMMUNOLOGY

Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3

(2014) N Robichaud et al.   ONCOGENE

Translational Regulation of Specific mRNAs Controls Feedback Inhibition and Survival during Macrophage Activation

(2014) Johanna Schott et al.   PLoS Genetics

Myeloid Colony-Stimulating Factors as Regulators of Macrophage Polarization

(2014) Thomas A. Hamilton et al.   Frontiers in Immunology

Tumor-associated neutrophils (TAN) develop pro-tumorigenic properties during tumor progression

(2013) Inbal Mishalian et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer

(2013) Gabriela Bindea et al.   IMMUNITY

hnRNP A1: The Swiss Army Knife of Gene Expression

(2013) Jacques Jean-Philippe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Myeloid-derived suppressor cell development is regulated by a STAT/IRF-8 axis

(2013) Jeremy D. Waight et al.   JOURNAL OF CLINICAL INVESTIGATION

Sprouty-2 regulates HIV-specific T cell polyfunctionality

(2013) Yen-Ling Chiu et al.   JOURNAL OF CLINICAL INVESTIGATION

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Distinct Translational Control in CD4+ T Cell Subsets

(2013) Eva Bjur et al.   PLoS Genetics

The cap-translation inhibitor 4EGI-1 induces apoptosis in multiple myeloma through Noxa induction

(2012) G Descamps et al.   BRITISH JOURNAL OF CANCER

Immunotype and Immunohistologic Characteristics of Tumor-Infiltrating Immune Cells Are Associated with Clinical Outcome in Metastatic Melanoma

(2012) G. Erdag et al.   CANCER RESEARCH

CD4+T Cells: Differentiation and Functions

(2012) Rishi Vishal Luckheeram et al.   Clinical & Developmental Immunology

Sprouty Proteins Are Negative Regulators of Interferon (IFN) Signaling and IFN-inducible Biological Responses

(2012) Bhumika Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mnk1 and 2 Are Dispensable for T Cell Development and Activation but Important for the Pathogenesis of Experimental Autoimmune Encephalomyelitis

(2012) B. K. Gorentla et al.   JOURNAL OF IMMUNOLOGY

Notch–RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization

(2012) Haixia Xu et al.   NATURE IMMUNOLOGY

Gemcitabine triggers a pro-survival response in pancreatic cancer cells through activation of the MNK2/eIF4E pathway

(2012) L Adesso et al.   ONCOGENE

MKNK1 is a YB-1 target gene responsible for imparting trastuzumab resistance and can be blocked by RSK inhibition

(2012) A Astanehe et al.   ONCOGENE

Regulation of CD4+ and CD8+ Effector Responses by Sprouty-1

(2012) Sam Collins et al.   PLoS One

A Role for the Chemokine RANTES in Regulating CD8 T Cell Responses during Chronic Viral Infection

(2011) Alison Crawford et al.   PLoS Pathogens

Akt isoforms differentially regulate neutrophil functions

(2010) J. Chen et al.   BLOOD

Genetic Dissection of the Oncogenic mTOR Pathway Reveals Druggable Addiction to Translational Control via 4EBP-eIF4E

(2010) Andrew C. Hsieh et al.   CANCER CELL

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Osteopontin: An Effector and an Effect of Tumor Metastasis

(2010) L. Shevde et al.   CURRENT MOLECULAR MEDICINE

Osteopontin is up-regulated and associated with neutrophil and macrophage infiltration in glioblastoma

(2010) Nadia A. Atai et al.   IMMUNOLOGY

TCR-Dependent Translational Control of GATA-3 Enhances Th2 Differentiation

(2010) K. D. Cook et al.   JOURNAL OF IMMUNOLOGY

Sprouty Proteins Inhibit Receptor-mediated Activation of Phosphatidylinositol-specific Phospholipase C

(2010) Simge Akbulut et al.   MOLECULAR BIOLOGY OF THE CELL

Negative Regulatory Effects of Mnk Kinases in the Generation of Chemotherapy-Induced Antileukemic Responses

(2010) J. K. Altman et al.   MOLECULAR PHARMACOLOGY

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

MHC molecules and microbial antigen processing in phagosomes

(2009) Lakshmi Ramachandra et al.   CURRENT OPINION IN IMMUNOLOGY

Interleukin-1 Receptor-associated Kinase 2 Is Critical for Lipopolysaccharide-mediated Post-transcriptional Control

(2009) Youzhong Wan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recruitment of Sprouty1 to Immune Synapse Regulates T Cell Receptor Signaling

(2009) J. S. Lee et al.   JOURNAL OF IMMUNOLOGY

Targeting the Eukaryotic Translation Initiation Factor 4E for Cancer Therapy

(2008) J. R. Graff et al.   CANCER RESEARCH

MNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages

(2007) Robert M. Rowlett et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY