MKNK1 is a YB-1 target gene responsible for imparting trastuzumab resistance and can be blocked by RSK inhibition

Targeting RSK: An Overview of Small Molecule Inhibitors

(2012) Tam Nguyen   Anti-Cancer Agents in Medicinal Chemistry

MAP Kinase-Interacting Kinase 1 Regulates SMAD2-Dependent TGF-  Signaling Pathway in Human Glioblastoma

(2011) M. Grzmil et al.   CANCER RESEARCH

Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways

(2011) Siyuan Zhang et al.   NATURE MEDICINE

YB-1 evokes susceptibility to cancer through cytokinesis failure, mitotic dysfunction and HER2 amplification

(2011) A H Davies et al.   ONCOGENE

Y-Box Binding Protein-1 Induces the Expression ofCD44andCD49fLeading to Enhanced Self-Renewal, Mammosphere Growth, and Drug Resistance

(2010) Karen To et al.   CANCER RESEARCH

The expression of activated Y-box binding protein-1 serine 102 mediates trastuzumab resistance in breast cancer cells by increasing CD44+ cells

(2010) J Dhillon et al.   ONCOGENE

Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development

(2010) T. Ueda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941

(2009) Teemu T. Junttila et al.   CANCER CELL

Elevation of Receptor Tyrosine Kinase EphA2 Mediates Resistance to Trastuzumab Therapy

(2009) G. Zhuang et al.   CANCER RESEARCH

Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice

(2009) Adam D. Judge et al.   JOURNAL OF CLINICAL INVESTIGATION

Candidate genes for sensitivity and resistance of human glioblastoma multiforme cell lines to erlotinib

(2009) Marc-Eric Halatsch et al.   JOURNAL OF NEUROSURGERY

The transcriptional induction of PIK3CA in tumor cells is dependent on the oncoprotein Y-box binding protein-1

(2009) A Astanehe et al.   ONCOGENE

Profiling YB-1 target genes uncovers a new mechanism for MET receptor regulation in normal and malignant human mammary cells

(2009) M R Finkbeiner et al.   ONCOGENE

Met Receptor Contributes to Trastuzumab Resistance of Her2-Overexpressing Breast Cancer Cells

(2008) D. L. Shattuck et al.   CANCER RESEARCH

Phosphorylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells

(2008) Andrea Bianchini et al.   CARCINOGENESIS

Lapatinib Resistance in HCT116 Cells Is Mediated by Elevated MCL-1 Expression and Decreased BAK Activation and Not by ERBB Receptor Kinase Mutation

(2008) A. P. Martin et al.   MOLECULAR PHARMACOLOGY