Implications of Hereditary Origin on the Immune Phenotype of Mismatch Repair-Deficient Cancers: Systematic Literature Review

Distinct Immunological Landscapes Characterize Inherited and Sporadic Mismatch Repair Deficient Endometrial Cancer

(2020) Neal C. Ramchander et al.   Frontiers in Immunology

Combined prognostic value of CD274 (PD-L1)/PDCDI (PD-1) expression and immune cell infiltration in colorectal cancer as per mismatch repair status

(2019) Maarit Ahtiainen et al.   MODERN PATHOLOGY

Characterization of Lynch syndrome (LS) associated cancers in patients with immune dysfunction.

(2019) Shahla Bari et al.   JOURNAL OF CLINICAL ONCOLOGY

High endothelial venules are associated with microsatellite instability, hereditary background and immune evasion in colorectal cancer

(2019) Pauline L. Pfuderer et al.   BRITISH JOURNAL OF CANCER

Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

(2019) Mev Dominguez-Valentin et al.   GENETICS IN MEDICINE

Colorectal carcinoma with double somatic mismatch repair gene inactivation: clinical and pathological characteristics and response to immune checkpoint blockade

(2019) Tao Wang et al.   MODERN PATHOLOGY

Microsatellite instability screening in colorectal adenomas to detect Lynch syndrome patients? A systematic review and meta-analysis

(2019) Parag D. Dabir et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Microsatellite instability and survival after adjuvant chemotherapy among stage II and III colon cancer patients: results from a population‐based study

(2019) Elizabeth Alwers et al.   Molecular Oncology

Three molecular pathways model colorectal carcinogenesis in Lynch syndrome

(2018) Aysel Ahadova et al.   INTERNATIONAL JOURNAL OF CANCER

Durable Clinical Benefit With Nivolumab Plus Ipilimumab in DNA Mismatch Repair–Deficient/Microsatellite Instability–High Metastatic Colorectal Cancer

(2018) Michael J. Overman et al.   JOURNAL OF CLINICAL ONCOLOGY

DNA mismatch repair protein deficient non-neoplastic colonic crypts: a novel indicator of Lynch syndrome

(2018) Rish K. Pai et al.   MODERN PATHOLOGY

Differences in gene mutations according to gender among patients with colorectal cancer

(2018) Yi-Jian Tsai et al.   World Journal of Surgical Oncology

Complex pattern of immune evasion in MSI colorectal cancer

(2018) Mine Ozcan et al.   OncoImmunology

Immune Profiling of Premalignant Lesions in Patients With Lynch Syndrome

(2018) Kyle Chang et al.   JAMA Oncology

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

(2018) Peng Jiang et al.   NATURE MEDICINE

How the BRAF V600E Mutation Defines a Distinct Subgroup of Colorectal Cancer: Molecular and Clinical Implications

(2018) Catherine E. Bond et al.   Gastroenterology Research and Practice

PD-1/ PD-L1 blockade as a novel treatment for colorectal cancer

(2018) Neda Yaghoubi et al.   BIOMEDICINE & PHARMACOTHERAPY

Somatic mutations of the coding microsatellites within the beta-2-microglobulin gene in mismatch repair-deficient colorectal cancers and adenomas

(2017) Mark Clendenning et al.   Familial Cancer

Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome

(2017) Hans Binder et al.   JOURNAL OF PATHOLOGY

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

(2017) Dung T. Le et al.   SCIENCE

Novel Implications in Molecular Diagnosis of Lynch Syndrome

(2017) Raffaella Liccardo et al.   Gastroenterology Research and Practice

High numbers of PDCD1 (PD-1)-positive T cells and B2M mutations in microsatellite-unstable colorectal cancer

(2017) Jonas Janikovits et al.   OncoImmunology

HLA class II antigen-processing pathway in tumors: Molecular defects and clinical relevance

(2017) Barbara Seliger et al.   OncoImmunology

Classification and characterization of microsatellite instability across 18 cancer types

(2016) Ronald J Hause et al.   NATURE MEDICINE

Early changes of endometrial neoplasia revealed by loss of mismatch repair gene protein expression in a patient diagnosed with Lynch syndrome

(2016) Ross McKenzie et al.   PATHOLOGY

Lynch Syndrome Caused by Germline PMS2 Mutations: Delineating the Cancer Risk

(2015) Sanne W. ten Broeke et al.   JOURNAL OF CLINICAL ONCOLOGY

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

Low density of FOXP3-positive T cells in normal colonic mucosa is related to the presence of beta2-microglobulin mutations in Lynch syndrome-associated colorectal cancer

(2015) Fabian Echterdiek et al.   OncoImmunology

Mismatch Repair-Deficient Crypt Foci in Lynch Syndrome – Molecular Alterations and Association with Clinical Parameters

(2015) Laura Staffa et al.   PLoS One

Association of high CD4-positive T cell infiltration with mutations in HLA class II-regulatory genes in microsatellite-unstable colorectal cancer

(2014) Eva-Maria Surmann et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Guidelines on Genetic Evaluation and Management of Lynch Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer

(2014) Francis M. Giardiello et al.   GASTROENTEROLOGY

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Expression of HLA Class I Antigen, Aspirin Use, and Survival After a Diagnosis of Colon Cancer

(2014) Marlies S. Reimers et al.   JAMA Internal Medicine

Lynch syndrome-associated neoplasms: a discussion on histopathology and immunohistochemistry

(2013) Jinru Shia et al.   Familial Cancer

Cancer risk in Lynch Syndrome

(2013) Emma Barrow et al.   Familial Cancer

Colorectal cancer

(2013) Hermann Brenner et al.   LANCET

Clinical significance of microsatellite instability in colorectal cancer

(2013) Matthias Kloor et al.   LANGENBECKS ARCHIVES OF SURGERY

Regulatory T Lymphocytes Are Associated with Less Aggressive Histologic Features in Microsatellite-Unstable Colorectal Cancers

(2013) David Tougeron et al.   PLoS One

Microsatellite instability and Beta2-Microglobulin mutations as prognostic markers in colon cancer: results of the FOGT-4 trial

(2012) A Tikidzhieva et al.   BRITISH JOURNAL OF CANCER

BRAF Mutation Status and Survival after Colorectal Cancer Diagnosis According to Patient and Tumor Characteristics

(2012) A. I. Phipps et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Immune aging and autoimmunity

(2012) Jörg J. Goronzy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The serrated pathway to colorectal carcinoma: current concepts and challenges

(2012) Mark Bettington et al.   HISTOPATHOLOGY

Correlation of tumour BRAF mutations andMLH1methylation with germline mismatch repair (MMR) gene mutation status: a literature review assessing utility of tumour features for MMR variant classification

(2012) Michael T Parsons et al.   JOURNAL OF MEDICAL GENETICS

Prevalence of mismatch repair-deficient crypt foci in Lynch syndrome: a pathological study

(2012) Matthias Kloor et al.   LANCET ONCOLOGY

The Role of DNA Methylation in Aging, Rejuvenation, and Age-Related Disease

(2012) Adiv A. Johnson et al.   REJUVENATION RESEARCH

Comparison of 17,641 Patients With Right- and Left-Sided Colon Cancer: Differences in Epidemiology, Perioperative Course, Histology, and Survival

(2011) Frank Benedix et al.   DISEASES OF THE COLON & RECTUM

DNA Mismatch Repair Status and Colon Cancer Recurrence and Survival in Clinical Trials of 5-Fluorouracil-Based Adjuvant Therapy

(2011) F. A. Sinicrope et al.   JNCI-Journal of the National Cancer Institute

Hereditary and Familial Colon Cancer

(2010) Kory W. Jasperson et al.   GASTROENTEROLOGY

Microsatellite Instability in Colorectal Cancer

(2010) C. Richard Boland et al.   GASTROENTEROLOGY

Immune evasion of microsatellite unstable colorectal cancers

(2010) Matthias Kloor et al.   INTERNATIONAL JOURNAL OF CANCER

Defective Mismatch Repair As a Predictive Marker for Lack of Efficacy of Fluorouracil-Based Adjuvant Therapy in Colon Cancer

(2010) Daniel J. Sargent et al.   JOURNAL OF CLINICAL ONCOLOGY

Microsatellite instability in colorectal cancer—the stable evidence

(2010) Eduardo Vilar et al.   Nature Reviews Clinical Oncology

Clinical implications of microsatellite instability in sporadic colon cancers

(2009) Frank A Sinicrope et al.   CURRENT OPINION IN ONCOLOGY

In Lynch syndrome adenomas, loss of mismatch repair proteins is related to an enhanced lymphocytic response

(2009) Tineke W H Meijer et al.   HISTOPATHOLOGY

SelTarbase, a database of human mononucleotide-microsatellite mutations and their potential impact to tumorigenesis and immunology

(2009) Stefan M. Woerner et al.   NUCLEIC ACIDS RESEARCH

Fas Ligand Expression in Lynch Syndrome-Associated Colorectal Tumours

(2009) Jan J. Koornstra et al.   PATHOLOGY & ONCOLOGY RESEARCH

Immune Response Against Frameshift-Induced Neopeptides in HNPCC Patients and Healthy HNPCC Mutation Carriers

(2008) Yvette Schwitalle et al.   GASTROENTEROLOGY