Protein Glycoengineering: An Approach for Improving Protein Properties

A Brief Reminder of Systems of Production and Chromatography-Based Recovery of Recombinant Protein Biopharmaceuticals

(2019) B. Owczarek et al.   Biomed Research International

Automated Glycan Assembly: A Perspective

(2019) Mónica Guberman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Glycoengineering of Antibodies for Modulating Functions

(2019) Lai-Xi Wang et al.   Annual Review of Biochemistry

Recombinant Proteins for Industrial versus Pharmaceutical Purposes: A Review of Process and Pricing

(2019) John Puetz et al.   Processes

Emerging structural insights into glycosyltransferase-mediated synthesis of glycans

(2019) Kelley W. Moremen et al.   Nature Chemical Biology

Exploiting metabolic glycoengineering to advance healthcare

(2019) Christian Agatemor et al.   Nature Reviews Chemistry

Awakening dormant glycosyltransferases in CHO cells with CRISPRa

(2019) Karen Julie la Cour Karottki et al.   BIOTECHNOLOGY AND BIOENGINEERING

A cell-free biosynthesis platform for modular construction of protein glycosylation pathways

(2019) Weston Kightlinger et al.   Nature Communications

Toward universal donor blood: Enzymatic conversion of A and B to O type

(2019) Peter Rahfeld et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Industrial Enzymology: The Next Chapter

(2019) Michael V. Arbige et al.   TRENDS IN BIOTECHNOLOGY

Using Chemical Synthesis To Study and Apply Protein Glycosylation

(2018) Patrick K. Chaffey et al.   BIOCHEMISTRY

Antibody glycoengineering strategies in mammalian cells

(2018) Qiong Wang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Sequential Multivariate Cell Culture Modeling at Multiple Scales Supports Systematic Shaping of a Monoclonal Antibody Toward a Quality Target

(2018) Michael Sokolov et al.   Biotechnology Journal

Glycoengineering in CHO Cells: Advances in Systems Biology

(2018) Vijay Tejwani et al.   Biotechnology Journal

Toward Automated Enzymatic Synthesis of Oligosaccharides

(2018) Liuqing Wen et al.   CHEMICAL REVIEWS

CRISPR/Cas9-mediated knockout of six glycosyltransferase genes in Nicotiana benthamiana for the production of recombinant proteins lacking β-1,2-xylose and core α-1,3-fucose

(2018) Julia Jansing et al.   PLANT BIOTECHNOLOGY JOURNAL

Sequential Multivariate Cell Culture Modeling at Multiple Scales Supports Systematic Shaping of a Monoclonal Antibody Toward a Quality Target

(2018) Michael Sokolov et al.   Biotechnology Journal

Glycoengineering in CHO Cells: Advances in Systems Biology

(2018) Vijay Tejwani et al.   Biotechnology Journal

Polysaccharides as vaccine adjuvants

(2018) Beini Sun et al.   VACCINE

Author Correction: Single-pot glycoprotein biosynthesis using a cell-free transcription-translation system enriched with glycosylation machinery

(2018) Thapakorn Jaroentomeechai et al.   Nature Communications

Impact of cell culture media additives on IgG glycosylation produced in CHO cells

(2018) Janike Ehret et al.   BIOTECHNOLOGY AND BIOENGINEERING

Current trends in protein engineering: updates and progress

(2018) Rajeshwari Sinha et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Site-selective chemoenzymatic glycoengineering of Fab and Fc glycans of a therapeutic antibody

(2018) John P. Giddens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improving Immunotherapy Through Glycodesign

(2018) Matthew J. Buettner et al.   Frontiers in Immunology

Model-based analysis of N-glycosylation in Chinese hamster ovary cells

(2017) Frederick J. Krambeck et al.   PLoS One

CRISPR-Cas9 vectors for genome editing and host engineering in the baculovirus–insect cell system

(2017) Hideaki Mabashi-Asazuma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy

(2017) Yusuke Mimura et al.   Protein & Cell

Integrated Genome and Protein Editing Swaps α -2,6 Sialylation for α -2,3 Sialic Acid on Recombinant Antibodies from CHO

(2017) Cheng-yu Chung et al.   Biotechnology Journal

Understanding the Chemistry and Biology of Glycosylation with Glycan Synthesis

(2016) Larissa Krasnova et al.   Annual Review of Biochemistry

Predictive glycoengineering of biosimilars using a Markov chain glycosylation model

(2016) Philipp N. Spahn et al.   Biotechnology Journal

Challenges of glycosylation analysis and control: an integrated approach to producing optimal and consistent therapeutic drugs

(2016) Peiqing Zhang et al.   DRUG DISCOVERY TODAY

N-glycosylation heterogeneity and the influence on structure, function and pharmacokinetics of monoclonal antibodies and Fc fusion proteins

(2016) Fabian Higel et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Biological roles of glycans

(2016) Ajit Varki   GLYCOBIOLOGY

A Markov chain model for N-linked protein glycosylation – towards a low-parameter tool for model-driven glycoengineering

(2016) Philipp N. Spahn et al.   METABOLIC ENGINEERING

Influenza A surface glycosylation and vaccine design

(2016) Chung-Yi Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycoengineering of plants yields glycoproteins with polysialylation and other defined N-glycoforms

(2016) Qiang Chen   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-Glycosylation Design and Control of Therapeutic Monoclonal Antibodies

(2016) Sha Sha et al.   TRENDS IN BIOTECHNOLOGY

Hybrid mass spectrometry approaches in glycoprotein analysis and their usage in scoring biosimilarity

(2016) Yang Yang et al.   Nature Communications

Predictive glycoengineering of biosimilars using a Markov chain glycosylation model

(2016) Philipp N. Spahn et al.   Biotechnology Journal

Inactivation of GDP-fucose transporter gene (Slc35c1) in CHO cells by ZFNs, TALENs and CRISPR-Cas9 for production of fucose-free antibodies

(2015) Kah Fai Chan et al.   Biotechnology Journal

Using glyco-engineering to produce therapeutic proteins

(2015) Martina Dicker et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Fc glycans of therapeutic antibodies as critical quality attributes

(2015) Dietmar Reusch et al.   GLYCOBIOLOGY

Production of α2,6-sialylated IgG1 in CHO cells

(2015) Céline Raymond et al.   mAbs

Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity

(2015) Nathaniel Washburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A common glycan structure on immunoglobulin G for enhancement of effector functions

(2015) Chin-Wei Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inactivation of GDP-fucose transporter gene (Slc35c1) in CHO cells by ZFNs, TALENs and CRISPR-Cas9 for production of fucose-free antibodies

(2015) Kah Fai Chan et al.   Biotechnology Journal

Toolboxes for a standardised and systematic study of glycans

(2014) Matthew P Campbell et al.   BMC BIOINFORMATICS

The Making of a Sweet Modification: Structure and Function ofO-GlcNAc Transferase

(2014) John Janetzko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycans-by-design: Engineering bacteria for the biosynthesis of complex glycans and glycoconjugates

(2013) Judith H. Merritt et al.   BIOTECHNOLOGY AND BIOENGINEERING

CHO cell line specific prediction and control of recombinant monoclonal antibodyN-glycosylation

(2013) Rhian K. Grainger et al.   BIOTECHNOLOGY AND BIOENGINEERING

Structure-function relationships of membrane-associated GT-B glycosyltransferases

(2013) D. Albesa-Jove et al.   GLYCOBIOLOGY

Adaptive immune activation: glycosylation does matter

(2013) Margreet A Wolfert et al.   Nature Chemical Biology

Erythropoietin Derived by Chemical Synthesis

(2013) P. Wang et al.   SCIENCE

Expanding the glycoengineering toolbox: the rise of bacterial N-linked protein glycosylation

(2013) Jenny L. Baker et al.   TRENDS IN BIOTECHNOLOGY

N-glycosylation of enhanced aromatic sequons to increase glycoprotein stability

(2012) Joshua L. Price et al.   BIOPOLYMERS

Marketing approval of mogamulizumab

(2012) Alain Beck et al.   mAbs

Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose

(2011) Michael J. Gramer et al.   BIOTECHNOLOGY AND BIOENGINEERING

Harnessing glycosylation to improve cellulase activity

(2011) Gregg T Beckham et al.   CURRENT OPINION IN BIOTECHNOLOGY

Control of mucin-type O-glycosylation: A classification of the polypeptide GalNAc-transferase gene family

(2011) E. P. Bennett et al.   GLYCOBIOLOGY

Glycosylation of the enhanced aromatic sequon is similarly stabilizing in three distinct reverse turn contexts

(2011) J. L. Price et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Probing the role of N-linked glycans in the stability and activity of fungal cellobiohydrolases by mutational analysis

(2009) William S. Adney et al.   CELLULOSE

Emerging methods for the production of homogeneous human glycoproteins

(2009) Jamie R Rich et al.   Nature Chemical Biology

Glycoengineering of Human IgG1-Fc through Combined Yeast Expression andin VitroChemoenzymatic Glycosylation†§

(2008) Yadong Wei et al.   BIOCHEMISTRY

Glycoprotein Synthesis: An Update

(2008) David P. Gamblin et al.   CHEMICAL REVIEWS

Mass Spectrometry and the Emerging Field of Glycomics

(2008) Joseph Zaia   CHEMISTRY & BIOLOGY

Trends in Glycosylation, Glycoanalysis and Glycoengineering of Therapeutic Antibodies and Fc-Fusion Proteins

(2008) Alain Beck et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Recombinant human lactoferrin expressed in glycoengineered Pichia pastoris: effect of terminal N-acetylneuraminic acid on in vitro secondary humoral immune response

(2008) Byung-Kwon Choi et al.   GLYCOCONJUGATE JOURNAL

Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc

(2008) R. M. Anthony et al.   SCIENCE

Glycosyltransferases: Structures, Functions, and Mechanisms

(2007) L.L. Lairson et al.   Annual Review of Biochemistry