The Making of a Sweet Modification: Structure and Function ofO-GlcNAc Transferase

Differential Regulation of the Ten-Eleven Translocation (TET) Family of Dioxygenases byO-Linked β-N-Acetylglucosamine Transferase (OGT)

(2014) Qiao Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nutrient-driven O-GlcNAc cycling - think globally but act locally

(2014) K. R. Harwood et al.   JOURNAL OF CELL SCIENCE

Microarray Discovery of New OGT Substrates: The Medulloblastoma Oncogene OTX2 Is O-GlcNAcylated

(2014) Rodrigo F. Ortiz-Meoz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Global identification ofO-GlcNAc transferase (OGT) interactors by a human proteome microarray and the construction of an OGT interactome

(2014) Rui-Ping Deng et al.   PROTEOMICS

Bisubstrate UDP–peptide conjugates as human O-GlcNAc transferase inhibitors

(2013) Vladimir S. Borodkin et al.   BIOCHEMICAL JOURNAL

HCFC1 is a common component of active human CpG-island promoters and coincides with ZNF143, THAP11, YY1, and GABP transcription factor occupancy

(2013) J. Michaud et al.   GENOME RESEARCH

Mixed Lineage Leukemia 5 (MLL5) Protein Regulates Cell Cycle Progression and E2F1-responsive Gene Expression via Association with Host Cell Factor-1 (HCF-1)

(2013) Peipei Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The carbohydrate-active enzymes database (CAZy) in 2013

(2013) Vincent Lombard et al.   NUCLEIC ACIDS RESEARCH

Crystal Structure of the Pseudomonas aeruginosa MurG: UDP-GlcNAc Substrate Complex

(2013) Kieron Brown et al.   PROTEIN AND PEPTIDE LETTERS

HCF-1 Is Cleaved in the Active Site of O-GlcNAc Transferase

(2013) M. B. Lazarus et al.   SCIENCE

O-GlcNAcylation of kinases

(2012) Wagner B. Dias et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

O-GlcNAc Transferase/Host Cell Factor C1 Complex Regulates Gluconeogenesis by Modulating PGC-1α Stability

(2012) Hai-Bin Ruan et al.   Cell Metabolism

O-GlcNAc processing enzymes: catalytic mechanisms, substrate specificity, and enzyme regulation

(2012) David J Vocadlo   CURRENT OPINION IN CHEMICAL BIOLOGY

Insights intoO-LinkedN-Acetylglucosamine ([0-9]O-GlcNAc) Processing and Dynamics through Kinetic Analysis ofO-GlcNAc Transferase andO-GlcNAcase Activity on Protein Substrates

(2012) David L. Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate-Assisted Catalytic Mechanism of O-GlcNAc Transferase Discovered by Quantum Mechanics/Molecular Mechanics Investigation

(2012) Igor Tvaroška et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

TET2 promotes histone O-GlcNAcylation during gene transcription

(2012) Qiang Chen et al.   NATURE

Structural snapshots of the reaction coordinate for O-GlcNAc transferase

(2012) Michael B Lazarus et al.   Nature Chemical Biology

O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis

(2012) Marianne Schimpl et al.   Nature Chemical Biology

Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1

(2012) M. Kebede et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HCF-1 self-association via an interdigitated Fn3 structure facilitates transcriptional regulatory complex formation

(2012) J. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross Talk Between O-GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription, and Chronic Disease

(2011) Gerald W. Hart et al.   Annual Review of Biochemistry

O-GlcNAc Transferase Catalyzes Site-Specific Proteolysis of HCF-1

(2011) Francesca Capotosti et al.   CELL

Structure of human O-GlcNAc transferase and its complex with a peptide substrate

(2011) Michael B. Lazarus et al.   NATURE

A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase

(2011) Jiaoyang Jiang et al.   Nature Chemical Biology

Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells

(2011) Tracey M Gloster et al.   Nature Chemical Biology

Crosstalk between O-GlcNAcylation and proteolytic cleavage regulates the host cell factor-1 maturation pathway

(2011) S. Daou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate and product analogues as human O-GlcNAc transferase inhibitors

(2010) Helge C. Dorfmueller et al.   AMINO ACIDS

Elevated O-GlcNAc-dependent signaling through inducible mOGT expression selectively triggers apoptosis

(2010) Sang-Hoon Shin et al.   AMINO ACIDS

Versatile TPR domains accommodate different modes of target protein recognition and function

(2010) Rudi Kenneth Allan et al.   CELL STRESS & CHAPERONES

Mechanism, Structure, and Inhibition of O-GlcNAc Processing Enzymes

(2010) Tracey Gloster et al.   Current Signal Transduction Therapy

The THAP-Zinc Finger Protein THAP1 Associates with Coactivator HCF-1 andO-GlcNAc Transferase

(2010) Raoul Mazars et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

O-Linked β-N-acetylglucosamine (O-GlcNAc) Regulates Stress-induced Heat Shock Protein Expression in a GSK-3β-dependent Manner

(2010) Zahra Kazemi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the HCF-1 Basic Region in Sustaining Cell Proliferation

(2010) Marco Mangone et al.   PLoS One

Structural analyses of enzymes involved in the O-GlcNAc modification

(2009) Carlos Martinez-Fleites et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

O-linked β-N-acetylglucosamine (O-GlcNAc): Extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stress

(2009) Chutikarn Butkinaree et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Sp1 modulates ncOGT activity to alter target recognition and enhanced thermotolerance in E. coli

(2008) In-Hyun Riu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular mechanisms of O-GlcNAcylation

(2008) Ramon Hurtado-Guerrero et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural insights into mechanism and specificity of O-GlcNAc transferase

(2008) Andrew J Clarke et al.   EMBO JOURNAL

O-Linked β-N-Acetylglucosaminyltransferase Substrate Specificity Is Regulated by Myosin Phosphatase Targeting and Other Interacting Proteins

(2008) Win D. Cheung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance

(2008) Xiaoyong Yang et al.   NATURE

Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation

(2008) Carlos Martinez-Fleites et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Glycosyltransferases: Structures, Functions, and Mechanisms

(2007) L.L. Lairson et al.   Annual Review of Biochemistry