Article
Engineering, Biomedical
Michaela Petaroudi, Aleixandre Rodrigo-Navarro, Oana Dobre, Matthew J. Dalby, Manuel Salmeron-Sanchez
Summary: Living biointerfaces are a new type of biomaterials that combine living cells and polymeric matrices to act as instructive materials for surrounding cells. In this study, living biomaterials based on Lactococcus lactis expressing specific genes were used to control hematopoietic stem cells in both 2D and 3D environments. The results showed that these living biomaterials can direct the interaction between stem cells and bacteria, and can significantly expand the population of specific stem cells in 3D hydrogels. The findings suggest the potential of using genetically engineered bacteria-based living materials for ex-vivo expansion of stem cells and clinical applications in hematological disorders.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Jie Zhang, Chengxinyue Ye, Yufan Zhu, Jun Wang, Jin Liu
Summary: Src homology-2 containing protein tyrosine phosphatase (SHP2), encoded by PTPN11, plays a complex role in bone remodeling and homeostasis maintenance. It affects the differentiation and maturation of bone cells and can also impact the immune system, vasculature, and nervous system, influencing bone development and remodeling. SHP2 regulates signaling pathways involved in the proliferation, differentiation, and migration of bone cells. This review summarizes recent advances in understanding the role of SHP2 in bone-related diseases and discusses potential therapeutic applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Chengyun Pan, Tianzhen Hu, Ping Liu, Dan Ma, Shuyun Cao, Qin Shang, Luxin Zhang, Qingzhen Chen, Qin Fang, Jishi Wang
Summary: The tumor microenvironment plays a crucial role in promoting tumor growth, and bone marrow mesenchymal stem cells (BM-MSCs), as important stromal cells in the tumor microenvironment, have been found to promote the malignant progression of tumors. However, the changes induced by leukemia cells in BM-MSCs within the microenvironment of adult B-cell acute lymphoblastic leukemia (B-ALL) are still uncertain.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Immunology
Florent Artru, Mark J. W. McPhail, Evangelos Triantafyllou, Francesca Maria Trovato
Summary: Lipids are organic compounds with various functions. They are not only efficient energy sources, but also play key roles as inflammatory and anti-inflammatory molecules. The liver has a unique role in immune tolerance, which is disrupted in liver failure syndromes. Active lipid mediators have been found to play a pivotal role in immune dysfunction observed in liver failure syndromes.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Sarah Rashid, Dezhi Song, Jinbo Yuan, Benjamin H. Mullin, Jiake Xu
Summary: Siglec-15, a type-1 transmembrane protein mainly expressed in human macrophages and dendritic cells, plays important roles in osteoclast physiology and tumor microenvironment through regulating signaling pathways. It shows potential immune-regulatory role in cancer immunology and may serve as an alternative target for cancers not responsive to anti-PD-L1/PD-1 immunotherapy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Genetics & Heredity
Marco Varrone, Daniele Tavernari, Albert Santamaria-Martinez, Logan A. Walsh, Giovanni Ciriello
Summary: CellCharter is an algorithmic framework that identifies, characterizes, and compares cellular niches in spatially resolved datasets. It outperforms existing approaches and has been successfully applied to different technologies and datasets, uncovering important cellular niches associated with cancer progression and patient prognosis in lung cancer.
Article
Multidisciplinary Sciences
Kazumasa Kanemaru, James Cranley, Daniele Muraro, Antonio M. A. Miranda, Siew Yen Ho, Anna Wilbrey-Clark, Jan Patrick Pett, Krzysztof Polanski, Laura Richardson, Monika Litvinukova, Natsuhiko Kumasaka, Yue Qin, Zuzanna Jablonska, Claudia I. Semprich, Lukas Mach, Monika Dabrowska, Nathan Richoz, Liam Bolt, Lira Mamanova, Rakeshlal Kapuge, Sam N. Barnett, Shani Perera, Carlos Talavera-Lopez, Ilaria Mulas, Krishnaa T. Mahbubani, Liz Tuck, Lu Wang, Margaret M. Huang, Martin Prete, Sophie Pritchard, John Dark, Kourosh Saeb-Parsy, Minal Patel, Menna R. Clatworthy, Norbert Hubner, Rasheda A. Chowdhury, Michela Noseda, Sarah A. Teichmann
Summary: In this study, single-cell and spatial transcriptomics data were used to explore cellular niches in eight regions of the human heart. Specific ion channels, G-protein-coupled receptors, and regulatory networks were identified in different cell types, highlighting the importance of FOXP2 in pacemaker cells. The sinoatrial node was found to be compartmentalized, with glial cells and fibroblasts supporting glutamatergic signaling. The study also introduced a drug target prediction tool, drug2cell, and revealed the presence of immune niches in the epicardium.
Article
Biochemistry & Molecular Biology
Alireza Saraji, Kang Duan, Christian Watermann, Katharina Hempel, Marie C. Roesch, Rosemarie Krupar, Janine Stegmann-Frehse, Danny Jonigk, Mark Philipp Kuehnel, Wolfram Klapper, Axel S. Merseburger, Jutta Kirfel, Sven Perner, Anne Offermann, Verena Sailer
Summary: Bone metastatic prostate cancer is a highly lethal form with limited therapeutic options. This study identified 116 differentially expressed genes in bone metastases compared to primary tumors, with functions related to extracellular matrix, cell motility, and signaling pathways. Data integration and gene annotation were used to build a manually annotated and curated Nanostring-data platform for further investigations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Syed A. Mian, Dominique Bonnet
Summary: Myelodysplastic syndromes (MDS) are a group of bone marrow disorders driven by genetic mutations in stem cells, primarily affecting the elderly but also younger individuals. Current treatments have limited success, with allogeneic HSC transplantation being the only potential cure for <5% of patients. The role of the bone marrow microenvironment in MDS development is still not fully understood, but is increasingly recognized as critical in disease progression.
Article
Oncology
Hanwen Wang, Huilin Ma, Richard J. Sove, Leisha A. Emens, Aleksander S. Popel
Summary: This study introduces a modular quantitative systems pharmacology (QSP) platform for predicting immunotherapy efficacy and identifying predictive biomarkers. Virtual clinical trials were conducted using a virtual patient cohort generated by the model, with retrospective analysis and model validation based on clinical trial data.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Cell Biology
Ting Qiao, Wanli Yang, Xiangchuan He, Ping Song, Xiao Chen, Ruijie Liu, Jian Xiao, Xiaoli Yang, Mingqi Li, Yudan Gao, Guoan Chen, Yi Lu, Jian Zhang, Jing Leng, Huan Ren
Summary: Tumor-associated macrophages (TAMs) are heterogeneous and play a crucial role in tumor progression, particularly in colorectal liver metastasis (CRLM). In this study, using a mouse model, researchers found that the critical period for tumor neovascularization was 7-9 days post-injection and TAMs were involved in this process. The transformation of TAMs and their proximity to neovascularization and tumor vessels suggests their important role in CRLM.
CELL DEATH & DISEASE
(2023)
Review
Immunology
Weinan Wang, Rui Zou, Ye Qiu, Jishuang Liu, Yu Xin, Tianzhu He, Zhidong Qiu
Summary: Granzyme B, primarily used by CTLs and NK cells against abnormal cells during immunosurveillance, has been established as a prognostic marker in tumor microenvironment. Recent findings have shown immunosuppressive effects of Granzyme B, sparking interest in further characterizing its role in immune responses. Research on the regulatory effects of Granzyme B and its interactions within the tumor microenvironment may provide insight for developing therapeutic strategies and diagnostic tools against cancer.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Stephane J. C. Mancini, Karl Balabanian, Isabelle Corre, Julie Gavard, Gwendal Lazennec, Marie-Caroline Le Bousse-Kerdiles, Fawzia Louache, Veronique Maguer-Satta, Nathalie M. Mazure, Fatima Mechta-Grigoriou, Jean-Francois Peyron, Valerie Trichet, Olivier Herault
Summary: Recent advances in understanding the hematopoietic niche have been made through in vitro analysis and animal models. Insights from the study of solid tumor niches can provide valuable information for understanding the hematopoietic niche.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Chao Yang, Haoqiang Zhan, Yiqing Zhao, Yasong Wu, Lisha Li, Heping Wang
Summary: Through studying the role of MEX3A in glioma, this research found that it may promote glioma development by regulating cell proliferation, apoptosis, cycle, and migration, with CCL2 being a potential downstream target. These findings reveal a new therapeutic target for treating glioma.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Yunfei He, Wenqian Luo, Yingjie Liu, Yuan Wang, Chengxin Ma, Qiuyao Wu, Pu Tian, Dasa He, Zhenchang Jia, Xianzhe Lv, Yu-Shui Ma, Haitang Yang, Ke Xu, Xue Zhang, Yansen Xiao, Peiyuan Zhang, Yajun Liang, Da Fu, Feng Yao, Guohong Hu
Summary: This study revealed the role of IL-20RB in promoting bone metastasis of lung cancer. IL-20RB facilitated the growth of lung cancer cells in the bone by activating JAK1/STAT3 signaling. Blocking IL-20RB significantly suppressed the bone metastasis of lung cancer.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Hematology
Allison J. Li, Laura M. Calvi
EXPERIMENTAL HEMATOLOGY
(2017)
Article
Immunology
D. Oleksyn, J. Zhao, A. Vosoughi, J. C. Zhao, R. Misra, A. P. Pentland, D. Ryan, J. Anolik, C. Ritchlin, J. Looney, A. P. Anandarajah, G. Schwartz, L. M. Calvi, M. Georger, C. Mohan, I. Sanz, L. Chen
IMMUNOLOGY LETTERS
(2017)
Article
Endocrinology & Metabolism
Rialnat A. Lawal, Xichao Zhou, Kaylind Batey, Corey M. Hoffman, Mary A. Georger, Freddy Radtke, Matthew J. Hilton, Lianping Xing, Benjamin J. Frisch, Laura M. Calvi
JOURNAL OF BONE AND MINERAL RESEARCH
(2017)
Article
Hematology
Sarah E. Latchney, Laura M. Calvi
SEMINARS IN HEMATOLOGY
(2017)
Review
Endocrinology & Metabolism
Corey M. Hoffman, Jimin Han, Laura M. Calvi
Article
Multidisciplinary Sciences
Rhonda J. Staversky, Daniel K. Byun, Mary A. Georger, Brandon J. Zaffuto, Alexandra Goodman, Michael W. Becker, Laura M. Calvi, Benjamin J. Frisch
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Edward Ayoub, Michael P. Wilson, Kathleen E. McGrath, Allison J. Li, Benjamin J. Frisch, James Palis, Laura M. Calvi, Yi Zhang, Archibald S. Perkins
NATURE COMMUNICATIONS
(2018)
Review
Hematology
Titas Banerjee, Laura M. Calvi, Michael W. Becker, Jane L. Liesveld
Editorial Material
Endocrinology & Metabolism
Laura M. Calvi, Lorenz C. Hofbauer
JOURNAL OF BONE AND MINERAL RESEARCH
(2019)
Article
Biology
Laura M. Calvi, Benjamin J. Frisch, Paul D. Kingsley, Anne D. Koniski, Tanzy M. Love, Jacqueline P. Williams, James Palis
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2019)
Article
Oncology
Mitra Azadniv, Jason R. Myers, Helene R. McMurray, Naxin Guo, Phil Rock, Myra L. Coppage, John Ashton, Michael W. Becker, Laura M. Calvi, Jane L. Liesveld
Editorial Material
Endocrinology & Metabolism
Laura M. Calvi
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Editorial Material
Hematology
Laura M. Calvi
Summary: This study highlights the novel role of FGF-23 in G-CSF-stimulated mobilization of HSPCs, shedding light on the connection between phosphate metabolism and hematopoietic stem cells.
Article
Oncology
Allison N. Seyfried, Amanda McCabe, Julianne N. P. Smith, Laura M. Calvi, Katherine C. MacNamara
Summary: Our research has identified CCR5 signaling as a key axis promoting the development of IFN gamma-dependent bone marrow failure, particularly relevant in aging where Ccr5 expression is elevated.
Article
Medicine, Research & Experimental
Benjamin J. Frisch, Corey M. Hoffman, Sarah E. Latchney, Mark W. LaMere, Jason Myers, John Ashton, Allison J. Li, Jerry Saunders, James Palis, Archibald S. Perkins, Amanda McCabe, Julianne N. P. Smith, Kathleen E. McGrath, Fatima Rivera-Escalera, Andrew McDavid, Jane L. Liesveld, Vyacheslav A. Korshunov, Michael R. Elliott, Katherine C. MacNamara, Michael W. Becker, Laura M. Calvi