Review
Immunology
Paul Chaintreuil, Emeline Kerreneur, Maxence Bourgoin, Coline Savy, Cecile Favreau, Guillaume Robert, Arnaud Jacquel, Patrick Auberger
Summary: Macrophages can adopt various phenotypes and play important roles in immune response, inflammation, and tissue repair. In human tissues, there are three main subpopulations of macrophages: naive macrophages, pro-inflammatory macrophages, and anti-inflammatory macrophages. Naive macrophages display phagocytic functions and can polarize into pro or anti-inflammatory macrophages. Pro-inflammatory macrophages are involved in the inflammatory response, while anti-inflammatory macrophages aid in the resolution of inflammation and tissue repair. Understanding the molecular mechanisms of macrophage generation, activation, and polarization is crucial for developing new therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Weiyang Li, Yuanru Yang, Lin Yang, Na Chang, Liying Li
Summary: This study reveals that bone marrow monocyte-derived Kupffer cells (MoKCs) dominate in injured livers. MoKCs exhibit enhanced proliferative and anti-apoptotic properties compared to embryonic KCs (EmKCs), promoting repair and attenuating fibrosis while reducing functional damage, necrosis, and fibrosis.
Article
Multidisciplinary Sciences
Jake W. Rhodes, Rachel A. Botting, Kirstie M. Bertram, Erica E. Vine, Hafsa Rana, Heeva Baharlou, Peter Vegh, Thomas R. O'Neil, Anneliese S. Ashhurst, James Fletcher, Grant P. Parnell, J. Dinny Graham, Najla Nasr, Jake J. K. Lim, Laith Barnouti, Peter Haertsch, Martijn P. Gosselink, Angelina Di Re, Faizur Reza, Grahame Ctercteko, Gregory J. Jenkins, Andrew J. Brooks, Ellis Patrick, Scott N. Byrne, Eric Hunter, Muzlifah A. Haniffa, Anthony L. Cunningham, Andrew N. Harman
Summary: The study examines the interaction of HIV with sub-epithelial MNPs in anogenital tissues and identifies two subsets, CD14(+)CD1c(+) monocyte-derived dendritic cells and langerin-expressing conventional dendritic cells 2, that preferentially take up and transmit the virus to CD4 T cells.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Feifei Yang, Zhaoxian Wu, Dan Yang, Xiuqun Zhang, Xuezhong Zhang, Yanli Xu
Summary: This study investigated the characteristics and phenotypic evolution of macrophages from patients with MDS, revealing that MDS macrophages exhibit more M2-related characteristics and that ferric chloride can polarize them to display more M1-related characteristics, which can be partially reversed by iron chelation with DFO.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Immunology
Audrey Paoletti, Bineta Ly, Samuel Bitoun, Gaetane Nocturne, Elodie Riviere, Jessica J. Manson, Andrea Matucci, Marc Pallardy, Niek De Vries, Xavier Mariette
Summary: This longitudinal study demonstrates that ADA but not ETA is able to restore the M2-like polarization of monocytes that is defective in RA.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Francesco Fracassi, Giampaolo Niccoli, Nicola Cosentino, Sonia Eligini, Susanna Fiorelli, Franco Fabbiocchi, Vincenzo Vetrugno, Hesham Refaat, Rocco Antonio Montone, Giancarlo Marenzi, Elena Tremoli, Filippo Crea
Summary: The study revealed morpho-phenotypic heterogeneity of monocyte-derived macrophages (MDMs) in acute coronary syndrome (ACS) patients, with a prevalence of pro-thrombotic and pro-oxidative properties in case of plaque rupture and systemic inflammation.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Immunology
Steven P. Cass, Olivia Mekhael, Danya Thayaparan, Joshua J. C. McGrath, Spencer D. Revill, Matthew F. Fantauzzi, Peiyao Wang, Amir Reihani, Aaron Hayat, Christopher S. Stevenson, Anna Dvorkin-Gheva, Fernando M. Botelho, Martin R. Stampfli, Kjetil Ask
Summary: Cigarette smoke exposure altered the composition of pulmonary macrophages by expanding CD11b(+) subpopulations. These compositional changes were associated with attenuated fibrogenesis, as well as predominant M1 polarization and decreased fibrotic activity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Jennillee Wallace, Hemil Gonzalez, Reshma Rajan, Srinivas D. Narasipura, Amber K. Virdi, Arnold Z. Olali, Ankur Naqib, Zarema Arbieva, Mark Maienschein-Cline, Lena Al-Harthi
Summary: Combination antiretroviral therapy (cART) has significantly improved the treatment of HIV/AIDS, but it may also affect cell dysregulation and increase susceptibility to comorbidities in persons living with HIV (PLWH).
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Immunology
Rinal Sahputra, Krittee Dejyong, Adrian S. Woolf, Matthias Mack, Judith E. Allen, Dominik Ruckerl, Sarah E. Herrick
Summary: Peritoneal adhesions commonly occur after abdominal or pelvic surgery and there are currently no effective treatments available. Peritoneal macrophages have complex and nuanced responses after surgery, and differences in response among specific macrophage subpopulations partially explain the risk of developing peritoneal scars. In a mouse experiment, it was found that monocyte-derived macrophages play an important protective role in reducing adhesion formation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Paul Chaintreuil, Lucie Laplane, Florian Esnault, Victoria Ghesquier, Coline Savy, Nathan Furstoss, Marie-Laure Arcangeli, Thomas Cluzeau, Guillaume Robert, Nathalie Droin, Eric Solary, Patrick Auberger, Arnaud Jacquel
Summary: Macrophages are innate immune cells that play crucial roles in various physiological and pathological processes. Caspases, previously known for their involvement in programmed cell death, are found to have non-apoptotic functions in macrophage differentiation and inflammation. Emricasan, a pan-caspase inhibitor, has shown potential in reprogramming monocyte-derived macrophages and could be an alternative therapy for diseases driven by these macrophages.
Article
Nutrition & Dietetics
Nuha A. Alkhattabi, Sowsan A. Hussein, Nesrin I. Tarbiah, Reem Y. Alzahri, Reham Khalifa
Summary: This study found that thymoquinone can enhance the immunological properties of macrophages by activating phagocytosis ability and increasing the expression of HLA-DR and the secretion of IFN-gamma. This may enhance the antigen-presentation capabilities of macrophages.
Article
Clinical Neurology
Nayana Gaur, Elena Huss, Tino Prell, Robert Steinbach, Joel Guerra, Akash Srivastava, Otto W. Witte, Julian Grosskreutz
Summary: The study found that immune cells in ALS patients have an inherently increased potential for chitinase production, which may contribute to chronic neuroinflammation, and that age influences the levels of CHI3L1.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rajkishor Nishad, Dhanunjay Mukhi, Srinivas Kethavath, Sumathi Raviraj, Atreya S. V. Paturi, Manga Motrapu, Sreenivasulu Kurukuti, Anil Kumar Pasupulati
Summary: This study finds that podocytes in diabetic kidney disease (DKD) may contribute to renal inflammation by secreting TNF-alpha and promoting macrophage migration. Inhibiting the action of GH or TNF-alpha in podocytes could be a novel therapeutic approach for treating DKD.
Article
Immunology
Giulia Franzoni, Samanta Mecocci, Chiara Grazia De Ciucis, Lorena Mura, Filippo Dell'Anno, Susanna Zinellu, Floriana Fruscione, Livia De Paolis, Tania Carta, Antonio G. Anfossi, Silvia Dei Guidici, Elisabetta Chiaradia, Luisa Pascucci, Annalisa Oggiano, Katia Cappelli, Elisabetta Razzuoli
Summary: This study investigated the immunomodulatory effects of goat milk extracellular vesicles (EVs) on untreated and classically activated porcine monocyte-derived macrophages. The results showed that these particles were efficiently internalized by macrophages and high doses upregulated MHC I and MHC II DR on untreated macrophages, while low doses enhanced the gene expression of IL10, EBI3, and IFNB. High doses also upregulated several pro-inflammatory cytokines. Overall, these findings support the clinical application of these molecules in polarizing macrophages towards an M1-like phenotype.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Hana Stepanova, Lenka Kavanova, Lenka Leva, Monika Vicenova, Kamil Stastny, Martin Faldyna
Summary: The aim of this study was to provide an improved in vitro model of porcine monocyte-derived macrophages (MDMs) based on reduced-serum culture. The study assessed the impact of different culture conditions on the morphology, surface marker expression, and functional activities of MDMs, as well as the induction of cytokine gene expression. The results showed that reduced-serum culture conditions had a significant impact on the characteristics and function of MDMs. Furthermore, the study found that the choice of fetal bovine serum (FBS) supplier also influenced the phenotype and gene expression profile of MDMs.
Letter
Hematology
Huijuan Jiang, Huiqin Zhang, Yihao Wang, Weiwei Qi, Qiuying Cao, Limin Xing, Rong Fu, Zonghong Shao, Huaquan Wang
BRITISH JOURNAL OF HAEMATOLOGY
(2019)
Article
Cell Biology
Chunyan Liu, Mengying Zheng, Ting Wang, Huijuan Jiang, Rong Fu, Huaquan Wang, Kai Ding, Qiufan Zhou, Zonghong Shao
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2018)
Article
Cell Biology
Huijuan Jiang, Liyan Yang, Lifang Guo, Ningbo Cui, Gaochao Zhang, Chunyan Liu, Limin Xing, Zonghong Shao, Huaquan Wang
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2018)
Article
Cell Biology
Mengying Zheng, Bingnan Liu, Yuanyuan Shao, Luogang Hua, Rong Fu, Huaquan Wang, Ting Wang, Weiwei Qi, Zonghong Shao, Chunyan Liu
MEDIATORS OF INFLAMMATION
(2020)
Review
Pharmacology & Pharmacy
Qi Lv, Zhang Huiqin, Xiao Na, Liu Chunyan, Shao Zonghong, Wang Huaquan
CURRENT PHARMACEUTICAL DESIGN
(2020)
Article
Hematology
Jiaxi Liu, Haiyue Niu, Lanzhu Yue, Qi Lv, Liyan Yang, Chunyan Liu, Huijuan Jiang, Limin Xing, Zonghong Shao, Huaquan Wang
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2020)
Article
Oncology
Xifeng Dong, Yu Han, Yumei Liu, Liyan Yang, Haiyue Niu, Li Yan, Chunyan Liu, Zonghong Shao, Limin Xing, Huaquan Wang
Summary: Results indicate that high expression of CD47 on CD34(+)CD38(-) cells in high-risk MDS patients is associated with poor clinical prognosis. The PI3K/AKT/mTOR signaling pathway is active in CD34(+)CD38(-)CD47(+) cells of MDS patients, affecting phagocytosis of macrophages. Overexpression of CD47 may lead to anti-phagocytosis and decreased survival time in leukemia stem cell-transplanted mice.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Cell Biology
Gaochao Zhang, Liyan Yang, Yu Han, Haiyue Niu, Li Yan, Zonghong Shao, Limin Xing, Huaquan Wang
Summary: This study identified abnormal macrophage subsets in bone marrow of MDS patients, suggesting they may play a role in altering the bone marrow microenvironment.
MEDIATORS OF INFLAMMATION
(2021)
Review
Oncology
Yating Yu, Xifeng Dong, Meifeng Tu, Huaquan Wang
Summary: PMBCL is an aggressive large B cell lymphoma mainly expressing B cell surface molecules, with diagnosis relying on pathological features, imaging examination, and clinical features. The commonly used therapeutic regimens include R-CHOP and R-EPOCH, with radiotherapy being beneficial in some patients but potentially leading to long-term toxicity. Research on novel therapies, such as CAR-T cell therapy and anti-PD-1 drugs, is ongoing, with the need for larger randomized controlled trials. PET-CT is mainly used to assess treatment response and guide subsequent treatment strategies.
Article
Immunology
Na Xiao, Xin He, Haiyue Niu, Hong Yu, Ningbo Cui, Hongzhao Li, Li Yan, Zonghong Shao, Limin Xing, Huaquan Wang
Summary: In patients with MDS, the proportion of those with AI was 19.6%, with an overall response rate of 81% for first-line treatment. There were no differences in leukemia progression and survival rates between those with and without AI, but CD4(+)CXCR5(+) cells and IgG4 levels increased in patients with AI.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Hematology
Haiyue Niu, Li Yan, Liping Yang, Mengying Zhang, Mengyuan Liu, Jie Ren, Zonghong Shao, Rong Fu, Limin Xing, Huaquan Wang
Summary: TOX expression is increased in PRCA patients, leading to CD8(+) T cell overactivation and decrease in regulatory T cells, which play a critical role in the immune pathogenesis of PRCA.
ANNALS OF HEMATOLOGY
(2023)
Review
Hematology
Pu Tang, Huaquan Wang
Summary: Erythropoiesis is a complex process involving the transfer of cells from the yolk sac to the fetal hepar and then to the bone marrow. Erythroid progenitor cells in the bone marrow undergo stages of development to produce reticulocytes that enter the bloodstream. Various factors, including erythropoietin and hepcidin, regulate erythropoiesis. Disruptions in these factors can lead to abnormal red blood cell production and function. Understanding erythropoiesis is important for diagnosing and treating hematological disorders.
Article
Hematology
Manjun Zhao, Yang Zhang, Jin Yang, Lei Chen, Ziying Zhang, Huaquan Wang, Zonghong Shao, Limin Xing
Summary: The DNA methylation pattern of B cells in patients with autoimmune hemolytic anemia (AIHA) differs from that of healthy controls, with a higher proportion of hypo-methylation regions. Genes related to differentially methylated regions (DMRs) are mainly involved in specific signaling pathways.
Article
Hematology
Hui Liu, Kai Ding, Wei Zhang, Limin Xing, Yihao Wang, Huaquan Wang, Jia Song, Lijuan Li, Rong Fu
Summary: Currently, there is no effective treatment for refractory/relapsed autoimmune haemolytic anaemia. A clinical trial on orelabrutinib treatment showed positive results for some patients, suggesting it may become a new second-line treatment.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Hematology
Huaquan Wang, Haiyue Niu, Tian Zhang, Limin Xing, Zonghong Shao, Rong Fu
Summary: The study identified 6 cases of low- and intermediate-risk MDS patients with PRCA, showing difficult treatment but a good prognosis.