Targeting the latent cytomegalovirus reservoir with an antiviral fusion toxin protein

The future of antiviral immunotoxins

(2016) Katja Spiess et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Transient activation of human cytomegalovirus lytic gene expression during latency allows cytotoxic T cell killing of latently infected cells

(2016) B. A. Krishna et al.   Scientific Reports

The Expression of Human Cytomegalovirus MicroRNA MiR-UL148D during Latent Infection in Primary Myeloid Cells Inhibits Activin A-triggered Secretion of IL-6

(2016) Betty Lau et al.   Scientific Reports

Cytomegalovirus Reactivation after Allogeneic Hematopoietic Stem Cell Transplantation is Associated with a Reduced Risk of Relapse in Patients with Acute Myeloid Leukemia Who Survived to Day 100 after Transplantation: The Japan Society for Hematopoietic Cell Transplantation Transplantation-related Complication Working Group

(2015) Katsuto Takenaka et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Human Cytomegalovirus US28 Is Important for Latent Infection of Hematopoietic Progenitor Cells

(2015) Monica S. Humby et al.   JOURNAL OF VIROLOGY

Sleepless latency of human cytomegalovirus

(2015) Emma Poole et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo

(2015) Katja Spiess et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor

(2015) J. S. Burg et al.   SCIENCE

Alveolar Macrophages Isolated Directly From Human Cytomegalovirus (HCMV)–Seropositive Individuals Are Sites of HCMV Reactivation In Vivo

(2015) Emma Poole et al.   JOURNAL OF INFECTIOUS DISEASES

Immunotoxins for leukemia

(2014) A. S. Wayne et al.   BLOOD

Maintenance and Replication of the Human Cytomegalovirus Genome during Latency

(2014) Margaret Tarrant-Elorza et al.   Cell Host & Microbe

The immunology of human cytomegalovirus latency: could latent infection be cleared by novel immunotherapeutic strategies?

(2014) Mark R Wills et al.   Cellular & Molecular Immunology

Latency-Associated Viral Interleukin-10 (IL-10) Encoded by Human Cytomegalovirus Modulates Cellular IL-10 and CCL8 Secretion during Latent Infection through Changes in the Cellular MicroRNA hsa-miR-92a

(2014) E. Poole et al.   JOURNAL OF VIROLOGY

Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?

(2014) Henry F. Vischer et al.   NATURE REVIEWS DRUG DISCOVERY

Biased and Constitutive Signaling in the CC-chemokine Receptor CCR5 by Manipulating the Interface between Transmembrane Helices 6 and 7

(2013) Anne Steen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Myeloid Transcription Factor GATA-2 Regulates the Viral UL144 Gene during Human Cytomegalovirus Latency in an Isolate-Specific Manner

(2013) E. Poole et al.   JOURNAL OF VIROLOGY

Latency-Associated Degradation of the MRP1 Drug Transporter During Latent Human Cytomegalovirus Infection

(2013) M. P. Weekes et al.   SCIENCE

Regulation of Human Cytomegalovirus Transcription in Latency: Beyond the Major Immediate-Early Promoter

(2013) Matthew Reeves et al.   Viruses-Basel

Human Cytomegalovirus Manipulation of Latently Infected Cells

(2013) John Sinclair et al.   Viruses-Basel

Cis and Trans Acting Factors Involved in Human Cytomegalovirus Experimental and Natural Latent Infection of CD14 (+) Monocytes and CD34 (+) Cells

(2013) Cyprian C. Rossetto et al.   PLoS Pathogens

A Myeloid Progenitor Cell Line Capable of Supporting Human Cytomegalovirus Latency and Reactivation, Resulting in Infectious Progeny

(2012) Christine M. O'Connor et al.   JOURNAL OF VIROLOGY

HCMV Protein LUNA Is Required for Viral Reactivation from Latently Infected Primary CD14+ Cells

(2012) Lisa R. Keyes et al.   PLoS One

Human cytomegalovirus latency alters the cellular secretome, inducing cluster of differentiation (CD)4+ T-cell migration and suppression of effector function

(2012) G. M. Mason et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heteromerization of human cytomegalovirus encoded chemokine receptors

(2011) Pia Tschische et al.   BIOCHEMICAL PHARMACOLOGY

Therapeutic potential of anticancer immunotoxins

(2011) Swati Choudhary et al.   DRUG DISCOVERY TODAY

Virally induced changes in cellular microRNAs maintain latency of human cytomegalovirus in CD34+ progenitors

(2011) E. Poole et al.   JOURNAL OF GENERAL VIROLOGY

Viral Interleukin-10 Expressed by Human Cytomegalovirus during the Latent Phase of Infection Modulates Latently Infected Myeloid Cell Differentiation

(2011) S. Avdic et al.   JOURNAL OF VIROLOGY

Human cytomegalovirus latent infection and associated viral gene expression

(2010) Barry Slobedman et al.   Future Microbiology

Cytomegalovirus in Hematopoietic Stem Cell Transplant Recipients

(2010) Per Ljungman et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Experimental human cytomegalovirus latency in CD14+ monocytes

(2010) D. Hargett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How we treat cytomegalovirus in hematopoietic cell transplant recipients

(2009) M. Boeckh et al.   BLOOD

Congenital cytomegalovirus (CMV) epidemiology and awareness

(2009) Michael J. Cannon   JOURNAL OF CLINICAL VIROLOGY

Analysis of latent viral gene expression in natural and experimental latency models of human cytomegalovirus and its correlation with histone modifications at a latent promoter

(2009) M. B. Reeves et al.   JOURNAL OF GENERAL VIROLOGY

Identification of TRIM23 as a Cofactor Involved in the Regulation of NF- B by Human Cytomegalovirus

(2009) E. Poole et al.   JOURNAL OF VIROLOGY

Characterization of a Novel Golgi Apparatus-Localized Latency Determinant Encoded by Human Cytomegalovirus

(2009) A. Petrucelli et al.   JOURNAL OF VIROLOGY

Management of CMV, HHV-6, HHV-7 and Kaposi-sarcoma herpesvirus (HHV-8) infections in patients with hematological malignancies and after SCT

(2008) P Ljungman et al.   BONE MARROW TRANSPLANTATION