Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A

Phase I Trial of Anti-CD22 Recombinant Immunotoxin Moxetumomab Pasudotox (CAT-8015 or HA22) in Patients With Hairy Cell Leukemia

(2012) Robert J. Kreitman et al.   JOURNAL OF CLINICAL ONCOLOGY

Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes

(2012) W. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treatment of Hematologic Malignancies with Immunotoxins and Antibody-Drug Conjugates

(2011) D. J. FitzGerald et al.   CANCER RESEARCH

Effect of HLA DR epitope de-immunization of Factor VIII in vitro and in vivo

(2011) Leonard Moise et al.   CLINICAL IMMUNOLOGY

Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift

(2011) J. R. Cantor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity

(2011) W. Liu et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Dealing with immunogenicity of biologicals: assessment and clinical relevance

(2010) Gerrit J Wolbink et al.   CURRENT OPINION IN RHEUMATOLOGY

Molecular Determinants of T Cell Epitope Recognition to the Common Timothy Grass Allergen

(2010) C. Oseroff et al.   JOURNAL OF IMMUNOLOGY

A Recombinant Immunotoxin Targeting CD22 With Low Immunogenicity, Low Nonspecific Toxicity, and High Antitumor Activity in Mice

(2010) Johanna K. Hansen et al.   JOURNAL OF IMMUNOTHERAPY

Immunogenicity of biologic therapies—we need tolerance

(2010) Charlotte L. M. Krieckaert et al.   Nature Reviews Rheumatology

Allele frequency net: a database and online repository for immune gene frequencies in worldwide populations

(2010) F. F. Gonzalez-Galarza et al.   NUCLEIC ACIDS RESEARCH

Removal of B cell epitopes as a practical approach for reducing the immunogenicity of foreign protein-based therapeutics☆

(2009) Satoshi Nagata et al.   ADVANCED DRUG DELIVERY REVIEWS

Phase I Trial of Continuous Infusion Anti-Mesothelin Recombinant Immunotoxin SS1P

(2009) R. J. Kreitman et al.   CLINICAL CANCER RESEARCH

Immunoproteomic Identification of Human T Cell Antigens ofMycobacterium tuberculosisThat Differentiate Healthy Contacts from Tuberculosis Patients

(2009) Anbarasu Deenadayalan et al.   MOLECULAR & CELLULAR PROTEOMICS

A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity

(2008) J. E. Weldon et al.   BLOOD