A 3D Cell Culture Model Identifies Wnt/ β ‐Catenin Mediated Inhibition of p53 as a Critical Step during Human Hepatocyte Regeneration

Understanding the marvels behind liver regeneration

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The multiple mechanisms that regulate p53 activity and cell fate

(2019) Antonina Hafner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

F-actin dynamics regulates mammalian organ growth and cell fate maintenance

(2019) Arianna Pocaterra et al.   JOURNAL OF HEPATOLOGY

3D Primary Hepatocyte Culture Systems for Analyses of Liver Diseases, Drug Metabolism, and Toxicity: Emerging Culture Paradigms and Applications

(2019) Volker M. Lauschke et al.   Biotechnology Journal

WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs

(2019) Yuxing Liao et al.   NUCLEIC ACIDS RESEARCH

Pleiotropic Role of p53 in Injury and Liver Regeneration after Acetaminophen Overdose

(2018) Prachi Borude et al.   AMERICAN JOURNAL OF PATHOLOGY

Gene expression profiling of human hepatocytes grown on differing substrate stiffness

(2018) Tingting Xia et al.   BIOTECHNOLOGY LETTERS

Distinct role of nuclear receptor corepressor 1 regulated de novo fatty acids synthesis in liver regeneration and hepatocarcinogenesis in mice

(2018) Qing Ou-Yang et al.   HEPATOLOGY

Hepatocyte transplantation and advancements in alternative cell sources for liver-based regenerative medicine

(2018) Charlotte A Lee et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Alternative splicing rewires Hippo signaling pathway in hepatocytes to promote liver regeneration

(2018) Sushant Bangru et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cycles of gene expression and genome response during mammalian tissue regeneration

(2018) Leonor Rib et al.   Epigenetics & Chromatin

Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids

(2018) Huili Hu et al.   CELL

Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture

(2018) Weng Chuan Peng et al.   CELL

In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity

(2018) Kun Zhang et al.   Cell Stem Cell

Metabolic Remodeling during Liver Regeneration

(2018) Matias J. Caldez et al.   DEVELOPMENTAL CELL

Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long-term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics

(2017) Sabine U. Vorrink et al.   FASEB JOURNAL

Regulatory signatures of liver regeneration distilled by integrative analysis of mRNA, histone methylation, and proteomics

(2017) Yoshihiro Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 on the crossroad between regeneration and cancer

(2016) Meital Charni et al.   CELL DEATH AND DIFFERENTIATION

Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates

(2016) Volker M. Lauschke et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha

(2016) Seema S. Desai et al.   HEPATOLOGY

Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation

(2016) Volker M. Lauschke et al.   HEPATOLOGY

The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size

(2016) Lara Planas-Paz et al.   NATURE CELL BIOLOGY

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

(2016) Catherine C. Bell et al.   Scientific Reports

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

(2015) Meritxell Huch et al.   CELL

β-Catenin Signaling and Roles in Liver Homeostasis, Injury, and Tumorigenesis

(2015) Satdarshan Pal Monga   GASTROENTEROLOGY

Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver

(2015) Bruce Wang et al.   NATURE

Hepatic progenitor cells of biliary origin with liver repopulation capacity

(2015) Wei-Yu Lu et al.   NATURE CELL BIOLOGY

ISMARA: automated modeling of genomic signals as a democracy of regulatory motifs

(2014) P. J. Balwierz et al.   GENOME RESEARCH

Beta-catenin signaling in murine liver zonation and regeneration: A Wnt-Wnt situation!

(2014) Jing Yang et al.   HEPATOLOGY

rMATS: Robust and flexible detection of differential alternative splicing from replicate RNA-Seq data

(2014) Shihao Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of p53 is critical for vertebrate limb regeneration

(2013) M. H. Yun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypertrophy and Unconventional Cell Division of Hepatocytes Underlie Liver Regeneration

(2012) Yuichiro Miyaoka et al.   CURRENT BIOLOGY

Secreted and Transmembrane Wnt Inhibitors and Activators

(2012) C.-M. Cruciat et al.   Cold Spring Harbor Perspectives in Biology

Liver Regeneration after Partial Hepatectomy

(2009) George K. Michalopoulos   AMERICAN JOURNAL OF PATHOLOGY

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

Proteomic analysis reveals a major role for contact inhibition in the terminal differentiation of hepatocytes

(2009) Carmine Mancone et al.   JOURNAL OF HEPATOLOGY