Lycopene alleviates oxidative stress via the PI3K/Akt/Nrf2pathway in a cell model of Alzheimer’s disease

Therapeutic Approaches to Alzheimer’s Disease Through Modulation of NRF2

(2019) Gahee Bahn et al.   NEUROMOLECULAR MEDICINE

Presenilins and γ-Secretase in Membrane Proteostasis

(2019) Naoto Oikawa et al.   Cells

Sulforaphane Attenuates H₂O₂-induced Oxidant Stress in Human Trabecular Meshwork Cells (HTMCs) via the Phosphatidylinositol 3-Kinase (PI3K)/Serine/Threonine Kinase (Akt)-Mediated Factor-E2-Related Factor 2 (Nrf2) Signaling Activation

(2019) Yuzhen Liu et al.   MEDICAL SCIENCE MONITOR

Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer's disease

(2019) Elizabeta Zaplatic et al.   LIFE SCIENCES

Lycopene protects against t-BHP-induced neuronal oxidative damage and apoptosis via activation of the PI3K/Akt pathway

(2019) Cuiqin Huang et al.   MOLECULAR BIOLOGY REPORTS

Lycopene Inhibits Reactive Oxygen Species-Mediated NF-κB Signaling and Induces Apoptosis in Pancreatic Cancer Cells

(2019) Yoonseon Jeong et al.   Nutrients

Nrf2 Pathway in Age-Related Neurological Disorders: Insights into MicroRNAs

(2018) Simona Paladino et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The Underlying Role of Oxidative Stress in Neurodegeneration: A Mechanistic Review

(2018) Habib Yaribeygi et al.   CNS & Neurological Disorders-Drug Targets

Supplementation of lycopene attenuates lipopolysaccharide-induced amyloidogenesis and cognitive impairments via mediating neuroinflammation and oxidative stress

(2018) Jia Wang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

β-Ecdysterone protects SH-SY5Y cells against β-amyloid-induced apoptosis via c-Jun N-terminal kinase- and Akt-associated complementary pathways

(2018) Tianjiao Xu et al.   LABORATORY INVESTIGATION

Pigment Epithelium-Derived Factor Plays a Role in Alzheimer’s Disease by Negatively Regulating Aβ42

(2018) Mao Huang et al.   Neurotherapeutics

Mangiferin and Morin Attenuate Oxidative Stress, Mitochondrial Dysfunction, and Neurocytotoxicity, Induced by Amyloid Beta Oligomers

(2018) Elena Alberdi et al.   Oxidative Medicine and Cellular Longevity

Klotho protein inhibits H2O2-induced oxidative injury in endothelial Cells via regulation of PI3K/Akt/Nrf2/HO-1 Pathways.

(2018) wei cui et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Lycopene attenuates western-diet-induced cognitive deficits via improving glycolipid metabolism dysfunction and inflammatory responses in gut–liver–brain axis

(2018) Jia Wang et al.   INTERNATIONAL JOURNAL OF OBESITY

Lycopene Triggers Nrf2–AMPK Cross Talk to Alleviate Atrazine-Induced Nephrotoxicity in Mice

(2018) Jia Lin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

(2017) Eric Tönnies et al.   JOURNAL OF ALZHEIMERS DISEASE

Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer’s Disease

(2017) Tahir Ali et al.   MOLECULAR NEUROBIOLOGY

Inhibitory Effect of Lycopene on Amyloid-β-Induced Apoptosis in Neuronal Cells

(2017) et al.   Nutrients

Modifications and Trafficking of APP in the Pathogenesis of Alzheimer’s Disease

(2017) Xin Wang et al.   Frontiers in Molecular Neuroscience

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

(2017) Ana I. Rojo et al.   Redox Biology

Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function

(2016) Noemí Esteras et al.   BIOLOGICAL CHEMISTRY

Lycopene Prevents Amyloid [Beta]-Induced Mitochondrial Oxidative Stress and Dysfunctions in Cultured Rat Cortical Neurons

(2016) Mingyue Qu et al.   NEUROCHEMICAL RESEARCH

Nrf2–ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases

(2016) Izaskun Buendia et al.   PHARMACOLOGY & THERAPEUTICS

The complexity of the Nrf2 pathway: beyond the antioxidant response

(2015) Ying Huang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Lycopene and Risk of Prostate Cancer

(2015) Ping Chen et al.   MEDICINE

Hydrogen Sulfide Selectively Inhibits γ-Secretase Activity and Decreases Mitochondrial Aβ Production in Neurons from APP/PS1 Transgenic Mice

(2015) Feng-li Zhao et al.   NEUROCHEMICAL RESEARCH

Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases

(2015) Eleonore Beurel et al.   PHARMACOLOGY & THERAPEUTICS

Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease

(2013) Susan A. Farr et al.   FREE RADICAL BIOLOGY AND MEDICINE

Edaravone Protects HT22 Neurons from H2O2-induced Apoptosis by Inhibiting the MAPK Signaling Pathway

(2012) Zhong-Yan Zhao et al.   CNS Neuroscience & Therapeutics

Lycopene: Chemistry, Biology, and Implications for Human Health and Disease

(2010) Steven K. Clinton   NUTRITION REVIEWS

Effect of lycopene and epigallocatechin-3-gallate against 3-nitropropionic acid induced cognitive dysfunction and glutathione depletion in rat: A novel nitric oxide mechanism

(2009) Puneet Kumar et al.   FOOD AND CHEMICAL TOXICOLOGY

Intramembrane Proteolysis by γ-Secretase

(2008) Harald Steiner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GSK-3β down-regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress

(2008) Ana I. Rojo et al.   JOURNAL OF NEUROCHEMISTRY

Lycopene inhibits growth of human colon cancer cellsvia suppression of the Akt signaling pathway

(2008) Feng-Yao Tang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Ginsenoside Rg1 attenuates β-amyloid-induced apoptosis in mutant PS1 M146L cells

(2008) Cuibai Wei et al.   NEUROSCIENCE LETTERS