CFTR Modulator Therapy Enhances Peripheral Blood Monocyte Contributions to Immune Responses in People With Cystic Fibrosis

Airway macrophages as the guardians of tissue repair in the lung

(2019) Franz Puttur et al.   IMMUNOLOGY AND CELL BIOLOGY

Cystic Fibrosis Plasma Blunts the Immune Response to Bacterial Infection

(2019) Xi Zhang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A Flow Cytometric Method for Isolating Cystic Fibrosis Airway Macrophages from Expectorated Sputum

(2019) Katherine B. Hisert et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Cystic Fibrosis Inflammation: Hyper-inflammatory, Hypo-inflammatory, or Both?

(2019) Sean V Murphy et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Transcriptomic responses to Ivacaftor and prediction of Ivacaftor clinical responsiveness

(2019) Tao Sun et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Transcriptional consequences of impaired immune cell responses induced by cystic fibrosis plasma characterized via dual RNA sequencing

(2019) Justin E. Ideozu et al.   BMC Medical Genomics

WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs

(2019) Yuxing Liao et al.   NUCLEIC ACIDS RESEARCH

Whole-blood transcriptomic responses to lumacaftor/ivacaftor therapy in cystic fibrosis

(2019) Benjamin T. Kopp et al.   Journal of Cystic Fibrosis

Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases

(2019) Theodore S. Kapellos et al.   Frontiers in Immunology

New therapeutic strategies for IPF: Based on the “phagocytosis-secretion-immunization” network regulation mechanism of pulmonary macrophages

(2019) Guoxiu Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Strong toll-like receptor responses in cystic fibrosis patients are associated with higher lung function

(2019) Susanna Kosamo et al.   Journal of Cystic Fibrosis

Utilizing centralized biorepository samples for biomarkers of cystic fibrosis lung disease severity

(2019) Scott D. Sagel et al.   Journal of Cystic Fibrosis

Lumacaftor (VX-809) restores the ability of CF macrophages to phagocytose and kill Pseudomonas aeruginosa

(2018) Roxanna Barnaby et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Infection Is Not Required for Mucoinflammatory Lung Disease in CFTR-Knockout Ferrets

(2018) Bradley H. Rosen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

CORK Study in Cystic Fibrosis

(2018) Nicola J. Ronan et al.   CHEST

Macrophage Polarization as a Therapeutic Target in Myocardial Infarction

(2018) Yuanyuan Cheng et al.   CURRENT DRUG TARGETS

Mutations of deubiquitinase OTUD1 are associated with autoimmune disorders

(2018) Dan Lu et al.   JOURNAL OF AUTOIMMUNITY

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Cystic fibrosis transmembrane conductance regulator (CFTR) modulators have differential effects on cystic fibrosis macrophage function

(2018) Shuzhong Zhang et al.   Scientific Reports

Inflammation: A Double-Edged Sword in the Response to Pseudomonas aeruginosa Infection

(2017) Christina K. Lin et al.   Journal of Innate Immunity

mixOmics: An R package for ‘omics feature selection and multiple data integration

(2017) Florian Rohart et al.   PLoS Computational Biology

Clinical utility of C-reactive protein to predict treatment response during cystic fibrosis pulmonary exacerbations

(2017) Ashutosh Sharma et al.   PLoS One

Characterisation of lung macrophage subpopulations in COPD patients and controls

(2017) Jennifer A. Dewhurst et al.   Scientific Reports

Mutations of Cystic Fibrosis Transmembrane Conductance Regulator Gene Cause a Monocyte-Selective Adhesion Deficiency

(2016) Claudio Sorio et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Ivacaftor-Induced Proteomic Changes Suggest Monocyte Defects May Contribute to the Pathogenesis of Cystic Fibrosis

(2016) Katherine B. Hisert et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Long-term computed tomographic changes in cystic fibrosis patients treated with ivacaftor

(2016) Guillaume Chassagnon et al.   EUROPEAN RESPIRATORY JOURNAL

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

Alterations in blood leukocytes of G551D-bearing cystic fibrosis patients undergoing treatment with ivacaftor

(2016) Preston E. Bratcher et al.   Journal of Cystic Fibrosis

Cystic Fibrosis Lung Immunity: The Role of the Macrophage

(2016) Emanuela M. Bruscia et al.   Journal of Innate Immunity

Factors associated with response to treatment of pulmonary exacerbations in cystic fibrosis patients

(2015) Valerie J. Waters et al.   Journal of Cystic Fibrosis

Inflammation in cystic fibrosis lung disease: Pathogenesis and therapy

(2015) André M. Cantin et al.   Journal of Cystic Fibrosis

ATF3 Is a Key Regulator of Macrophage IFN Responses

(2015) Larisa I. Labzin et al.   JOURNAL OF IMMUNOLOGY

Free DNA in Cystic Fibrosis Airway Fluids Correlates with Airflow Obstruction

(2015) Veronica Marcos et al.   MEDIATORS OF INFLAMMATION

The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation

(2015) Dan Lu et al.   NATURE IMMUNOLOGY

Clinical Mechanism of the Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Ivacaftor in G551D-mediated Cystic Fibrosis

(2014) Steven M. Rowe et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Pseudomonas aeruginosa in Cystic Fibrosis Patients With G551D-CFTR Treated With Ivacaftor

(2014) Sonya L. Heltshe et al.   CLINICAL INFECTIOUS DISEASES

A randomized double blind, placebo controlled phase 2 trial of BIIL 284 BS (an LTB4 receptor antagonist) for the treatment of lung disease in children and adults with cystic fibrosis

(2014) M.W. Konstan et al.   Journal of Cystic Fibrosis

Cystic Fibrosis Pulmonary Guidelines

(2013) Peter J. Mogayzel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation

(2013) K. De Filippo et al.   BLOOD

BIIL 284 reduces neutrophil numbers but increases P. aeruginosa bacteremia and inflammation in mouse lungs

(2013) Gerd Döring et al.   Journal of Cystic Fibrosis

Blood mRNA biomarkers for detection of treatment response in acute pulmonary exacerbations of cystic fibrosis

(2013) J A Nick et al.   THORAX

Changes in physiological, functional and structural markers of cystic fibrosis lung disease with treatment of a pulmonary exacerbation

(2013) Alex R Horsley et al.   THORAX

Pulmonary Macrophage Subpopulations in the Induction and Resolution of Acute Lung Injury

(2012) Laura K. Johnston et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Absence of the cystic fibrosis transmembrane regulator (Cftr ) from myeloid-derived cells slows resolution of inflammation and infection

(2012) T. L. Bonfield et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Alternatively Activated Macrophages and Airway Disease

(2011) Derek E. Byers et al.   CHEST

Small macrophages are present in early childhood respiratory disease

(2011) Luke W. Garratt et al.   Journal of Cystic Fibrosis

A CFTR Potentiator in Patients with Cystic Fibrosis and theG551DMutation

(2011) Bonnie W. Ramsey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Translocated LPS Might Cause Endotoxin Tolerance in Circulating Monocytes of Cystic Fibrosis Patients

(2011) Rosa del Campo et al.   PLoS One

Soluble CD163

(2011) Holger J. Møller   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Sputum and serum calprotectin are useful biomarkers during CF exacerbation

(2010) R.D. Gray et al.   Journal of Cystic Fibrosis

Alveolar macrophages and CC chemokines are increased in children with cystic fibrosis

(2009) S. Brennan et al.   EUROPEAN RESPIRATORY JOURNAL

Pivotal Advance: Expansion of small sputum macrophages in CF: failure to express MARCO and mannose receptors

(2009) Adam K. A. Wright et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Circulating RNA Transcripts Identify Therapeutic Response in Cystic Fibrosis Lung Disease

(2008) Milene T. Saavedra et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Macrophages Directly Contribute to the Exaggerated Inflammatory Response in Cystic Fibrosis Transmembrane Conductance Regulator−/−Mice

(2008) Emanuela M. Bruscia et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Monocyte chemoattractant chemokines in cystic fibrosis

(2008) Satish Rao et al.   Journal of Cystic Fibrosis

Monocytes from Cystic Fibrosis Patients Are Locked in an LPS Tolerance State: Down-Regulation of TREM-1 as Putative Underlying Mechanism

(2008) Carlos del Fresno et al.   PLoS One

ATF3 regulates MCMV infection in mice by modulating IFN-  expression in natural killer cells

(2008) C. M. Rosenberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA