Turning the Tide: Natural Products and Natural-Product-Inspired Chemicals as Potential Counters to SARS-CoV-2 Infection

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak

(2020) Hussin A. Rothan et al.   JOURNAL OF AUTOIMMUNITY

A novel coronavirus outbreak of global health concern

(2020) Chen Wang et al.   LANCET

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Therapeutic options for the 2019 novel coronavirus (2019-nCoV)

(2020) Guangdi Li et al.   NATURE REVIEWS DRUG DISCOVERY

First Case of 2019 Novel Coronavirus in the United States

(2020) Michelle L. Holshue et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

On the origin and continuing evolution of SARS-CoV-2

(2020) Xiaolu Tang et al.   National Science Review

Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods

(2020) Canrong Wu et al.   Acta Pharmaceutica Sinica B

Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs

(2020) Sangeun Jeon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

(2020) Xueting Yao et al.   CLINICAL INFECTIOUS DISEASES

Chloroquine for SARS-CoV-2: Implications of Its Unique Pharmacokinetic and Safety Properties

(2020) Cornelis Smit et al.   CLINICAL PHARMACOKINETICS

The Approved Dose of Ivermectin Alone is not the Ideal Dose for the Treatment of COVID‐19

(2020) Virginia D. Schmith et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Treating COVID-19—Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics

(2020) Andre C. Kalil   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

(2020) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Regulators split on antimalarials for COVID-19

(2020) Susan Jaffe   LANCET

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

(2020) Zhenming Jin et al.   NATURE

Remdesivir for the Treatment of Covid-19 — Preliminary Report

(2020) John H. Beigel et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

(2020) Bin Cao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Compassionate Use of Remdesivir for Patients with Severe Covid-19

(2020) Jonathan Grein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system

(2020) Shuofeng Yuan et al.   PHARMACOLOGICAL RESEARCH

Race to find COVID-19 treatments accelerates

(2020) Kai Kupferschmidt et al.   SCIENCE

Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2

(2020) Jianzhong Shi et al.   SCIENCE

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

(2020) Timothy P. Sheahan et al.   Science Translational Medicine

Remdesivir in covid-19

(2020) Robin E Ferner et al.   BMJ-British Medical Journal

Hydroxychloroquine in the management of critically ill patients with COVID-19: the need for an evidence base

(2020) Fabio S Taccone et al.   Lancet Respiratory Medicine

Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro

(2020) Jia Liu et al.   Cell Discovery

The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

(2020) Leon Caly et al.   ANTIVIRAL RESEARCH

Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro

(2020) Ka-Tim Choy et al.   ANTIVIRAL RESEARCH

The FDA-approved gold drug auranofin inhibits novel coronavirus (SARS-COV-2) replication and attenuates inflammation in human cells

(2020) Hussin A. Rothan et al.   VIROLOGY

High-throughput Screening and Identification of Potent Broad-spectrum Inhibitors of Coronaviruses

(2019) Liang Shen et al.   JOURNAL OF VIROLOGY

Total Synthesis of (-)-Cephalotaxine and (-)-Homoharringtonine via Furan Oxidation-Transannular Mannich Cyclization

(2019) Xuan Ju et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inhibitory effects of homoharringtonine on foot and mouth disease virus in vitro

(2019) Mei‐jiao Gong et al.   JOURNAL OF MEDICAL VIROLOGY

Multiple-dose versus single-dose ivermectin for Strongyloides stercoralis infection (Strong Treat 1 to 4): a multicentre, open-label, phase 3, randomised controlled superiority trial

(2019) Dora Buonfrate et al.   LANCET INFECTIOUS DISEASES

Cepharanthine: An update of its mode of action, pharmacological properties and medical applications

(2019) Christian Bailly   PHYTOMEDICINE

Small-Molecule Antiviral β-D-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

(2019) Maria L. Agostini et al.   JOURNAL OF VIROLOGY

Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia

(2019) Mart Toots et al.   Science Translational Medicine

Novel Antiviral Activities of Obatoclax, Emetine, Niclosamide, Brequinar, and Homoharringtonine

(2019) Andersen et al.   Viruses-Basel

Natural Bis-Benzylisoquinoline Alkaloids-Tetrandrine, Fangchinoline, and Cepharanthine, Inhibit Human Coronavirus OC43 Infection of MRC-5 Human Lung Cells

(2019) Kim et al.   Biomolecules

Quantitative efficacy paradigms of the influenza clinical drug candidate EIDD-2801 in the ferret model

(2019) Mart Toots et al.   Translational Research

Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry

(2018) Shu Yang et al.   Cell Discovery

The Natural Compound Homoharringtonine Presents Broad Antiviral Activity In Vitro and In Vivo

(2018) Hui-Jun Dong et al.   Viruses-Basel

First Newborn Baby to Receive Experimental Therapies Survives Ebola Virus Disease

(2017) Jenny Dörnemann et al.   JOURNAL OF INFECTIOUS DISEASES

Safety and efficacy of ebselen for the prevention of noise-induced hearing loss: a randomised, double-blind, placebo-controlled, phase 2 trial

(2017) Jonathan Kil et al.   LANCET

Stereoselective Total Synthesis of Carolacton

(2017) Tapan Kumar Kuilya et al.   ORGANIC LETTERS

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

(2017) Timothy P. Sheahan et al.   Science Translational Medicine

The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD

(2017) Chengzhang Fu et al.   Nature Communications

Ivermectin: A Reflection on Simplicity (Nobel Lecture)

(2016) William C. Campbell   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Late Ebola virus relapse causing meningoencephalitis: a case report

(2016) Michael Jacobs et al.   LANCET

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

(2016) Travis K. Warren et al.   NATURE

A screen of the NIH Clinical Collection small molecule library identifies potential anti-coronavirus drugs

(2015) Jianzhong Cao et al.   ANTIVIRAL RESEARCH

A New Golden Age of Natural Products Drug Discovery

(2015) Ben Shen   CELL

Repurposing of Clinically Developed Drugs for Treatment of Middle East Respiratory Syndrome Coronavirus Infection

(2014) Julie Dyall et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Concise Synthesis of Carolacton

(2014) Michal S. Hallside et al.   ORGANIC LETTERS

Inhibition of Signal Transducer and Activator of Transcription 3 and Cyclooxygenase-2 Is Involved in Radiosensitization of Cepharanthine in HeLa Cells

(2013) Zhen-hao Fang et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

2012 FDA drug approvals

(2013) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Synthesis and antiviral activity of a series of 1′-substituted 4-aza-7,9-dideazaadenosine C-nucleosides

(2012) Aesop Cho et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, Synthesis, and Evaluation of pH-Dependent Hydrolyzable Emetine Analogues as Treatment for Prostate Cancer

(2012) Emmanuel S. Akinboye et al.   JOURNAL OF MEDICINAL CHEMISTRY

Topical 0.5% Ivermectin Lotion for Treatment of Head Lice

(2012) David M. Pariser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Total Synthesis of Carolacton, a Highly Potent Biofilm Inhibitor

(2011) Thomas Schmidt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biochemistry of uridine in plasma

(2011) Tetsuya Yamamoto et al.   CLINICA CHIMICA ACTA

Carolacton - A Macrolide Ketocarbonic Acid that Reduces Biofilm Formation by the Caries- and Endocarditis-Associated BacteriumStreptococcus mutans

(2010) Rolf Jansen et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of AntiproliferativeCephalotaxus Esters and Their Evaluation against Several Human Hematopoietic and Solid Tumor Cell Lines: Uncovering Differential Susceptibilities to Multidrug Resistance

(2008) Joseph D. Eckelbarger et al.   CHEMISTRY-A EUROPEAN JOURNAL