The Natural Compound Homoharringtonine Presents Broad Antiviral Activity In Vitro and In Vivo

Acyclovir in the Treatment of Herpes Viruses – a Review

(2018) Katarzyna Klysik et al.   CURRENT MEDICINAL CHEMISTRY

Synthesis, biological evaluation and molecular modeling of novel azaspiro dihydrotriazines as influenza virus inhibitors targeting the host factor dihydrofolate reductase (DHFR)

(2018) Valeria Francesconi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Herpes Simplex Virus Shedding Rate: Surrogate Outcome for Genital Herpes Recurrence Frequency and Lesion Rates, and Phase 2 Clinical Trials End Point for Evaluating Efficacy of Antivirals

(2018) Elfriede Agyemang et al.   JOURNAL OF INFECTIOUS DISEASES

Targeting of phospho-eIF4E by homoharringtonine eradicates a distinct subset of human acute myeloid leukemia

(2018) Hong Zhou et al.   LEUKEMIA & LYMPHOMA

Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus

(2017) Michele Tonelli et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The androgen receptor is a negative regulator of eIF4E phosphorylation at S209: implications for the use of mTOR inhibitors in advanced prostate cancer

(2017) L S D'Abronzo et al.   ONCOGENE

Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses

(2017) Hanna Roth et al.   mBio

Lactimidomycin is a broad-spectrum inhibitor of dengue and other RNA viruses

(2016) Margot Carocci et al.   ANTIVIRAL RESEARCH

Merestinib blocks Mnk kinase activity in acute myeloid leukemia progenitors and exhibits antileukemic effects in vitro and in vivo

(2016) E. M. Kosciuczuk et al.   BLOOD

Fight Against H1N1 Influenza A Virus: Recent Insights Towards the Development of Druggable Compounds

(2016) Michele Tonelli et al.   CURRENT MEDICINAL CHEMISTRY

Non-thermal plasma for inactivated-vaccine preparation

(2016) Guomin Wang et al.   VACCINE

The nucleolar protein GLTSCR2 is required for efficient viral replication

(2016) Peng Wang et al.   Scientific Reports

A screen of the NIH Clinical Collection small molecule library identifies potential anti-coronavirus drugs

(2015) Jianzhong Cao et al.   ANTIVIRAL RESEARCH

Requirement of the eukaryotic translation initiation factor 4F complex in hepatitis E virus replication

(2015) Xinying Zhou et al.   ANTIVIRAL RESEARCH

Synthesis and Biological Evaluation of Lactimidomycin and Its Analogues

(2015) Brian J. Larsen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Murine Norovirus 1 (MNV1) Replication Induces Translational Control of the Host by Regulating eIF4E Activity during Infection

(2015) Elizabeth Royall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of protein expression changes of the Vero E6 cells infected with classic PEDV strain CV777 by using quantitative proteomic technique

(2015) Dongbo Sun et al.   JOURNAL OF VIROLOGICAL METHODS

Targeting the translation machinery in cancer

(2015) Mamatha Bhat et al.   NATURE REVIEWS DRUG DISCOVERY

eIF4E as a Control Target for Viruses

(2015) Hilda Montero et al.   Viruses-Basel

Small-molecule induction of phospho-eIF4E sumoylation and degradation via targeting its phosphorylated serine 209 residue

(2015) Ying Gu et al.   Oncotarget

Broad-spectrum antiviral agents

(2015) Jun-Da Zhu et al.   Frontiers in Microbiology

A unique phosphorylation-dependent eIF4E assembly on 40S ribosomes co-ordinated by hepatitis C virus protein NS5A that activates internal ribosome entry site translation

(2014) Swarupa Panda et al.   BIOCHEMICAL JOURNAL

Rocaglamide, silvestrol and structurally related bioactive compounds from Aglaia species

(2014) Li Pan et al.   NATURAL PRODUCT REPORTS

Development of a reverse genetics system based on RNA polymerase II for Newcastle disease virus genotype VII

(2014) Jianzhong Wang et al.   VIRUS GENES

Origin, Evolution, and Genotyping of Emergent Porcine Epidemic Diarrhea Virus Strains in the United States

(2013) Y.-W. Huang et al.   mBio

Inhibition of Chikungunya Virus Replication by Harringtonine, a Novel Antiviral That Suppresses Viral Protein Expression

(2012) Parveen Kaur et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E

(2012) Barbara Herdy et al.   NATURE IMMUNOLOGY

Genetic and biological characterizations of a Newcastle disease virus from swine in china

(2012) Xiaoyuan Yuan et al.   Virology Journal

Porcine epidemic diarrhoea virus: a comprehensive review of molecular epidemiology, diagnosis, and vaccines

(2012) Daesub Song et al.   VIRUS GENES

Tinkering with Translation: Protein Synthesis in Virus-Infected Cells

(2012) D. Walsh et al.   Cold Spring Harbor Perspectives in Biology

Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma

(2011) Jonathan H. Schatz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Omacetaxine may have a role in chronic myeloid leukaemia eradication through downregulation of Mcl-1 and induction of apoptosis in stem/progenitor cells

(2011) E K Allan et al.   LEUKEMIA

US3 protein kinase of HSV-1 cycles between the cytoplasm and nucleus and interacts with programmed cell death protein 4 (PDCD4) to block apoptosis

(2011) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Type Mediated Resistance of Vesicular Stomatitis Virus and Sendai Virus to Ribavirin

(2010) Nirav R. Shah et al.   PLoS One

eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression

(2010) L. Furic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mnk earmarks eIF4E for cancer therapy

(2010) N. Hay   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibitory effects of omacetaxine on leukemic stem cells and BCR-ABL-induced chronic myeloid leukemia and acute lymphoblastic leukemia in mice

(2009) Y Chen et al.   LEUKEMIA

Antiviral activity of quercetin 7-rhamnoside against porcine epidemic diarrhea virus

(2008) Hwa-Jung Choi et al.   ANTIVIRAL RESEARCH

Ribavirin targets eIF4E dependent Akt survival signaling

(2008) Keith Tan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting the Eukaryotic Translation Initiation Factor 4E for Cancer Therapy

(2008) J. R. Graff et al.   CANCER RESEARCH

Preparation of Monoclonal Antibodies Against Pseudorabies Virus Glycoprotein gC by Adenovirus Immunization Alone or as a Boost Following DNA Priming

(2008) Zhenhai Chen et al.   HYBRIDOMA

Short hairpin RNA targeting NP mRNA inhibiting Newcastle disease virus production and other viral structural mRNA transcription

(2008) Hua Yue et al.   VIRUS GENES