Hallmarks of frailty and osteosarcopenia in prematurely aged PolgA (D257A/D257A) mice

A toolbox for the longitudinal assessment of healthspan in aging mice

(2020) I. Bellantuono et al.   Nature Protocols

Resistance Exercise-Induced Hypertrophy

(2019) Riki Ogasawara et al.   EXERCISE AND SPORT SCIENCES REVIEWS

mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism

(2019) Huibin Tang et al.   AGING CELL

Rodent models of frailty and their application in preclinical research

(2019) Shubham Banga et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Novel application and validation of in vivo micro‐CT to study bone modelling in 3D

(2019) Ulas Oz et al.   Orthodontics & Craniofacial Research

Myonuclear accretion is a determinant of exercise-induced remodeling in skeletal muscle

(2019) Qingnian Goh et al.   eLife

Rapamycin rescues age-related changes in muscle-derived stem/progenitor cells from progeroid mice

(2019) Yohei Kawakami et al.   Molecular Therapy-Methods & Clinical Development

Geroprotectors: A role in the treatment of frailty

(2019) A.U. Trendelenburg et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Partial inhibition of mTORC1 in aged rats counteracts the decline in muscle mass and reverses molecular signaling associated with sarcopenia

(2019) Giselle A. Joseph et al.   MOLECULAR AND CELLULAR BIOLOGY

Voluntary exercise normalizes the proteomic landscape in muscle and brain and improves the phenotype of progeroid mice

(2019) Jaime M. Ross et al.   AGING CELL

Ethical guidelines for publishing in the Journal of Cachexia, Sarcopenia and Muscle : update 2019

(2019) Stephan Haehling et al.   Journal of Cachexia Sarcopenia and Muscle

Voluntary Resistance Running as a Model to Induce mTOR Activation in Mouse Skeletal Muscle

(2019) Gommaar D’Hulst et al.   Frontiers in Physiology

Find drugs that delay many diseases of old age

(2018) Ilaria Bellantuono   NATURE

Uncoupling protein 1 expression in adipocytes derived from skeletal muscle fibro/adipogenic progenitors is under genetic and hormonal control

(2018) Tatiane Gorski et al.   Journal of Cachexia Sarcopenia and Muscle

MuscleJ: a high-content analysis method to study skeletal muscle with a new Fiji tool

(2018) Alicia Mayeuf-Louchart et al.   Skeletal Muscle

Leisure-Time Physical Activity and Risk of Fracture: A Cohort Study of 66,940 Men and Women

(2017) Karl Stattin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Development of a Rat Clinical Frailty Index

(2017) Amy Yorke et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Osteosarcopenia: where bone, muscle, and fat collide

(2017) H. P. Hirschfeld et al.   OSTEOPOROSIS INTERNATIONAL

Severity classification of repeated isoflurane anesthesia in C57BL/6JRj mice—Assessing the degree of distress

(2017) Katharina Hohlbaum et al.   PLoS One

mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass

(2017) Mee-Sup Yoon   Frontiers in Physiology

A Frailty Index Based On Deficit Accumulation Quantifies Mortality Risk in Humans and in Mice

(2017) K. Rockwood et al.   Scientific Reports

Inactivation of Regulatory-associated Protein of mTOR (Raptor)/Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in Osteoclasts Increases Bone Mass by Inhibiting Osteoclast Differentiation in Mice

(2016) Qinggang Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging

(2016) Koji Takayama et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Aging Reduces the Activation of the mTORC1 Pathway after Resistance Exercise and Protein Intake in Human Skeletal Muscle: Potential Role of REDD1 and Impaired Anabolic Sensitivity

(2016) Marc Francaux et al.   Nutrients

Skeletal muscle satellite cells are located at a closer proximity to capillaries in healthy young compared with older men

(2016) Joshua P Nederveen et al.   Journal of Cachexia Sarcopenia and Muscle

Aging related ER stress is not responsible for anabolic resistance in mouse skeletal muscle

(2015) Sreeda Chalil et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bone adaptation to cyclic loading in murine caudal vertebrae is maintained with age and directly correlated to the local micromechanical environment

(2015) Floor M. Lambers et al.   JOURNAL OF BIOMECHANICS

Impact of Longevity Interventions on a Validated Mouse Clinical Frailty Index

(2015) Alice E. Kane et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Physical Resilience in Older Adults: Systematic Review and Development of an Emerging Construct

(2015) Heather E. Whitson et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The altered fate of aging satellite cells is determined by signaling and epigenetic changes

(2015) Maura H. Parker   Frontiers in Genetics

Musculoskeletal health, frailty and functional decline

(2014) R. Milte et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Aging diminishes lamellar and woven bone formation induced by tibial compression in adult C57BL/6

(2014) Nilsson Holguin et al.   BONE

Mineralizing surface is the main target of mechanical stimulation independent of age: 3D dynamic in vivo morphometry

(2014) Annette I. Birkhold et al.   BONE

Defects in mitochondrial DNA replication and oxidative damage in muscle of mtDNA mutator mice

(2014) Jill E. Kolesar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Comprehensive nutritional status in sarco-osteoporotic older fallers

(2014) Y. R. Huo et al.   Journal of Nutrition Health & Aging

Incremental Predictive Value of Sarcopenia for Incident Fracture in an Elderly Chinese Cohort: Results From the Osteoporotic Fractures in Men (MrOs) Study

(2014) Ruby Yu et al.   Journal of the American Medical Directors Association

WNT7B Promotes Bone Formation in part through mTORC1

(2014) Jianquan Chen et al.   PLoS Genetics

Effect of acute environmental hypoxia on protein metabolism in human skeletal muscle

(2013) G. D'Hulst et al.   Acta Physiologica

Age-dependent alteration in muscle regeneration: the critical role of tissue niche

(2013) Laura Barberi et al.   BIOGERONTOLOGY

Diminished response to in vivo mechanical loading in trabecular and not cortical bone in adulthood of female C57Bl/6 mice coincides with a reduction in deformation to load

(2013) Bettina M. Willie et al.   BONE

Mechanisms regulating skeletal muscle growth and atrophy

(2013) Stefano Schiaffino et al.   FEBS Journal

Anesthesia and Other Considerations for in Vivo Imaging of Small Animals

(2013) I. J. Hildebrandt et al.   ILAR JOURNAL

High-frequency electrical stimulation reveals a p38-mTOR signaling module correlated with force-time integral

(2013) J. A. Rahnert et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Eccentric contractions increase the phosphorylation of tuberous sclerosis complex-2 (TSC2) and alter the targeting of TSC2 and the mechanistic target of rapamycin to the lysosome

(2013) Brittany L. Jacobs et al.   JOURNAL OF PHYSIOLOGY-LONDON

A Clinical Frailty Index in Aging Mice: Comparisons With Frailty Index Data in Humans

(2013) Jocelyne C. Whitehead et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Behavioral and metabolic characterization of heterozygous and homozygous POLG mutator mice

(2013) Ying Dai et al.   MITOCHONDRION

Satellite Cells and the Muscle Stem Cell Niche

(2013) Hang Yin et al.   PHYSIOLOGICAL REVIEWS

Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression

(2013) J. Julie Wu et al.   Cell Reports

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Searching for an Operational Definition of Frailty: A Delphi Method Based Consensus Statement. The Frailty Operative Definition-Consensus Conference Project

(2012) Leocadio Rodríguez-Mañas et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

(2012) Lingling Xian et al.   NATURE MEDICINE

Tibial Loading Increases Osteogenic Gene Expression and Cortical Bone Volume in Mature and Middle-Aged Mice

(2012) Matthew J. Silva et al.   PLoS One

Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C-Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival

(2012) F. J. Ramos et al.   Science Translational Medicine

Mouse tail vertebrae adapt to cyclic mechanical loading by increasing bone formation rate and decreasing bone resorption rate as shown by time-lapsed in vivo imaging of dynamic bone morphometry

(2011) Floor M. Lambers et al.   BONE

Development of micro-CT protocols for in vivo follow-up of mouse bone architecture without major radiation side effects

(2011) K. Laperre et al.   BONE

Tibial compression is anabolic in the adult mouse skeleton despite reduced responsiveness with aging

(2011) Maureen E. Lynch et al.   BONE

A Procedure for Creating a Frailty Index Based on Deficit Accumulation in Aging Mice

(2011) Randi J. Parks et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Skeletal muscle protein metabolism in the elderly: Interventions to counteract the 'anabolic resistance' of ageing

(2011) Leigh Breen et al.   Nutrition & Metabolism

Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice

(2011) A. Safdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging technologies for preclinical models of bone and joint disorders

(2011) Jordi L Tremoleda et al.   EJNMMI Research

Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis

(2011) Christopher S Fry et al.   Skeletal Muscle

Severe osteopenia and osteoporosis, sarcopenia, and frailty status in community-dwelling older women: Results from the Women's Health and Aging Study (WHAS) II

(2010) Alberto Frisoli et al.   BONE

In vivo micro-computed tomography allows direct three-dimensional quantification of both bone formation and bone resorption parameters using time-lapsed imaging

(2010) Friederike A. Schulte et al.   BONE

Age-Related Changes in Bone Structure and Strength in Female and Male BALB/c Mice

(2010) Mark D. Willinghamm et al.   CALCIFIED TISSUE INTERNATIONAL

Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee

(2010) A. Michael Parfitt et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Guidelines for assessment of bone microstructure in rodents using micro-computed tomography

(2010) Mary L Bouxsein et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Solubilities of amino acids in water at various pH values under 298.15K

(2009) Hsieng-Cheng Tseng et al.   FLUID PHASE EQUILIBRIA

The role of phosphoinositide 3-kinase and phosphatidic acid in the regulation of mammalian target of rapamycin following eccentric contractions

(2009) T. K. O’Neil et al.   JOURNAL OF PHYSIOLOGY-LONDON

A novelin vivomouse model for mechanically stimulated bone adaptation – a combined experimental and computational validation study

(2008) Duncan J. Webster et al.   COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING

Leucine-enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesis

(2008) Micah J Drummond et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Postpubertal Architectural Developmental Patterns Differ Between the L3Vertebra and Proximal Tibia in Three Inbred Strains of Mice*

(2008) Helen R Buie et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Radiation effects on bone architecture in mice and rats resulting from in vivo micro-computed tomography scanning

(2008) R. Josh Klinck et al.   MEDICAL ENGINEERING & PHYSICS

Rapamycin inhibits osteoblast proliferation and differentiation in MC3T3-E1 cells and primary mouse bone marrow stromal cells

(2007) Ujjal K. Singha et al.   JOURNAL OF CELLULAR BIOCHEMISTRY