Journal
EXERCISE AND SPORT SCIENCES REVIEWS
Volume 47, Issue 3, Pages 188-194Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/JES.0000000000000189
Keywords
exercise; hypertrophy; protein synthesis; mTOR; mTORC1; mTORC2; rapamycin
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Funding
- National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health (NIH) [AR057347]
- Novo Nordisk Foundation Excellence project [15182]
- JSPS KAKENHI [26702028, 17KK0192]
- Grants-in-Aid for Scientific Research [17KK0192, 26702028] Funding Source: KAKEN
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The mechanistic target of rapamycin (mTOR) exerts both rapamycin-sensitive and rapamycin-insensitive signaling events, and the rapamycin-sensitive components of mTOR signaling have been widely implicated in the pathway through which resistance exercise induces skeletal muscle hypertrophy. This review explores the hypothesis that rapamycin-insensitive components of mTOR signaling also contribute to this highly important process.
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