Regulation of Apoptosis by Enteroviruses

The relation between PI3K/AKT signalling pathway and cancer

(2019) Saeed Noorolyai et al.   GENE

microRNA‐34a aggravates coxsackievirus B3‐induced apoptosis of cardiomyocytes through the SIRT1‐p53 pathway

(2019) Dehua Jiang et al.   JOURNAL OF MEDICAL VIROLOGY

Seneca Valley Virus 2C and 3Cpro Induce Apoptosis via Mitochondrion-Mediated Intrinsic Pathway

(2019) Tingting Liu et al.   Frontiers in Microbiology

EV71 3C protease induces apoptosis by cleavage of hnRNP A1 to promote apaf-1 translation

(2019) Mei-Ling Li et al.   PLoS One

Apoptosis and Autophagy in Picornavirus Infection

(2019) Di Sun et al.   Frontiers in Microbiology

Poliovirus induces autophagic signaling independent of the ULK1 complex

(2018) Angel Corona Velazquez et al.   Autophagy

Autophagy activation is required for influenza A virus-induced apoptosis and replication

(2018) B. Yeganeh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Paeoniflorin induces G2/M cell cycle arrest and caspase-dependent apoptosis through the upregulation of Bcl-2 X-associated protein and downregulation of B-cell lymphoma 2 in human osteosarcoma cells

(2018) Li‑Bin Jin et al.   Molecular Medicine Reports

Caspase-3 Inhibition Attenuates the Cytopathic Effects of EV71 Infection

(2018) Fengmei Song et al.   Frontiers in Microbiology

MicroRNA‑145 inhibits migration and induces apoptosis in human non‑small cell lung cancer cells through regulation of the EGFR/PI3K/AKT signaling pathway

(2018) Bin Li et al.   ONCOLOGY REPORTS

Host MicroRNA hsa-miR-494-3p Promotes EV71 Replication by Directly Targeting PTEN

(2018) Qing Zhao et al.   Frontiers in Cellular and Infection Microbiology

Cantharidin Inhibits Anti-Apoptotic Bcl-2 Family Proteins and Induces Apoptosis in Human Osteosarcoma Cell Lines MG-63 and MNNG/HOS via Mitochondria-Dependent Pathway

(2018) Shoumin Feng et al.   MEDICAL SCIENCE MONITOR

Transcriptomic analysis of cells in response to EV71 infection and 2Apro as a trigger for apoptosis via TXNIP gene

(2018) Chenguang Yao et al.   Genes & Genomics

Recent Progress on Functional Genomics Research of Enterovirus 71

(2018) Huiqiang Wang et al.   VIROLOGICA SINICA

BH3-only protein BIM: An emerging target in chemotherapy

(2017) Shatrunajay Shukla et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Enterovirus 71 induces apoptosis by directly modulating the conformational activation of pro-apoptotic protein Bax

(2017) Xiaodong Han et al.   JOURNAL OF GENERAL VIROLOGY

Intracellular zinc flux causes reactive oxygen species mediated mitochondrial dysfunction leading to cell death in Leishmania donovani

(2017) Anjali Kumari et al.   PLoS One

Impact of genetic changes, pathogenicity and antigenicity on Enterovirus- A71 vaccine development

(2017) Pinn Tsin Isabel Yee et al.   VIROLOGY

Virus Infection and Death Receptor-Mediated Apoptosis

(2017) Xingchen Zhou et al.   Viruses-Basel

Picornaviruses and Apoptosis: Subversion of Cell Death

(2017) Sarah N. Croft et al.   mBio

MiR-16-5p mediates a positive feedback loop in EV71-induced apoptosis and suppresses virus replication

(2017) Caishang Zheng et al.   Scientific Reports

Structures and Corresponding Functions of Five Types of Picornaviral 2A Proteins

(2017) Xiaoyao Yang et al.   Frontiers in Microbiology

Intein-mediated backbone cyclization of VP1 protein enhanced protection of CVB3-induced viral myocarditis

(2017) Xingmei Qi et al.   Scientific Reports

Influenza virus infection induces translocation of apoptosis-inducing factor (AIF) in A549 cells: role of AIF in apoptosis and viral propagation

(2016) Xinyan Qu et al.   ARCHIVES OF VIROLOGY

The CREB3-Herp signalling module limits the cytosolic calcium concentration increase and apoptosis induced by poliovirus

(2016) Carmen Mirabelli et al.   JOURNAL OF GENERAL VIROLOGY

A Cluster of Paralytic Poliomyelitis Cases Due to Transmission of Slightly Diverged Sabin 2 Vaccine Poliovirus

(2016) Ekaterina A. Korotkova et al.   JOURNAL OF VIROLOGY

Susceptibility of human tonsillar epithelial cells to enterovirus 71 with normal cytokine response

(2016) Guang-Cheng Xie et al.   VIROLOGY

Innate Immunity Evasion by Enteroviruses: Insights into Virus-Host Interaction

(2016) Xiaobo Lei et al.   Viruses-Basel

Roles of the Picornaviral 3C Proteinase in the Viral Life Cycle and Host Cells

(2016) Di Sun et al.   Viruses-Basel

RASSF4 promotes EV71 replication to accelerate the inhibition of the phosphorylation of AKT

(2015) Fengfeng Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cleavage of DAP5 by coxsackievirus B3 2A protease facilitates viral replication and enhances apoptosis by altering translation of IRES-containing genes

(2015) P J Hanson et al.   CELL DEATH AND DIFFERENTIATION

miR-146a and miR-370 coordinate enterovirus 71-induced cell apoptosis through targeting SOS1 and GADD45β

(2015) Ya-Ling Chang et al.   CELLULAR MICROBIOLOGY

Inhibition of Histone Deacetylase Activity Aggravates Coxsackievirus B3-Induced Myocarditis by Promoting Viral Replication and Myocardial Apoptosis

(2015) Lei Zhou et al.   JOURNAL OF VIROLOGY

Host MicroRNA miR-197 Plays a Negative Regulatory Role in the Enterovirus 71 Infectious Cycle by Targeting the RAN Protein

(2015) Wen-Fang Tang et al.   JOURNAL OF VIROLOGY

Enterovirus 71 induces apoptosis of SH-SY5Y human neuroblastoma cells through stimulation of endogenous microRNA let-7b expression

(2015) XILING DU et al.   Molecular Medicine Reports

Regulation of host responses and viral replication by the mitogen-activated protein kinases in intestinal epithelial cells infected with Enterovirus 71

(2015) Chunyang Wang et al.   VIRUS RESEARCH

Death waits for no man – Does it wait for a virus? How enteroviruses induce and control cell death

(2014) Katharine G. Harris et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Coxsackievirus B3 induces crosstalk between autophagy and apoptosis to benefit its release after replicating in autophagosomes through a mechanism involving caspase cleavage of autophagy-related proteins

(2014) Le Xin et al.   INFECTION GENETICS AND EVOLUTION

dsRNA-Activation of TLR3 and RLR Signaling: Gene Induction-Dependent and Independent Effects

(2014) Saurabh Chattopadhyay et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Enterovirus 2Apro Targets MDA5 and MAVS in Infected Cells

(2014) Q. Feng et al.   JOURNAL OF VIROLOGY

Picornavirus Morphogenesis

(2014) P. Jiang et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activation of PI3K/Akt pathway limits JNK-mediated apoptosis during EV71 infection

(2014) Hua Zhang et al.   VIRUS RESEARCH

Reduced IRE1α mediates apoptotic cell death by disrupting calcium homeostasis via the InsP3 receptor

(2014) S M Son et al.   Cell Death & Disease

Differential gene expressions of the MAPK signaling pathway in enterovirus 71-infected rhabdomyosarcoma cells

(2013) Weifeng Shi et al.   Brazilian Journal of Infectious Diseases

Both PI3K- and mTOR-Signaling Pathways Take Part in CVB3-Induced Apoptosis of HeLa Cells

(2013) Xin Li et al.   DNA AND CELL BIOLOGY

Calcium flux and calpain-mediated activation of the apoptosis-inducing factor contribute to enterovirus 71-induced apoptosis

(2013) J.-R. Lu et al.   JOURNAL OF GENERAL VIROLOGY

The Interplays between Autophagy and Apoptosis Induced by Enterovirus 71

(2013) Xueyan Xi et al.   PLoS One

Coxsackievirus B3-induced calpain activation facilitates the progeny virus replication via a likely mechanism related with both autophagy enhancement and apoptosis inhibition in the early phase of infection: An in vitro study in H9c2 cells

(2013) Minghui Li et al.   VIRUS RESEARCH

The nuclear protein Sam68 is redistributed to the cytoplasm and is involved in PI3K/Akt activation during EV71 infection

(2013) Hua Zhang et al.   VIRUS RESEARCH

Enterovirus 71 Protease 2Apro Targets MAVS to Inhibit Anti-Viral Type I Interferon Responses

(2013) Bei Wang et al.   PLoS Pathogens

dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8

(2012) Y Estornes et al.   CELL DEATH AND DIFFERENTIATION

TRAIL induces autophagic protein cleavage through caspase activation in melanoma cell lines under arginine deprivation

(2012) Min You et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration

(2012) Rhonda M. Perciavalle et al.   NATURE CELL BIOLOGY

Small-molecule activation of the TRAIL receptor DR5 in human cancer cells

(2012) Gelin Wang et al.   Nature Chemical Biology

Viroporins: structure and biological functions

(2012) José Luis Nieva et al.   NATURE REVIEWS MICROBIOLOGY

Autophagy hijacked through viroporin-activated calcium/calmodulin-dependent kinase kinase-  signaling is required for rotavirus replication

(2012) S. E. Crawford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The crosstalk between autophagy and apoptosis: where does this lead?

(2012) Claire Gordy et al.   Protein & Cell

MEK1–ERKs signal cascade is required for the replication of Enterovirus 71 (EV71)

(2011) Bo Wang et al.   ANTIVIRAL RESEARCH

Following Cytochrome c Release, Autophagy Is Inhibited during Chemotherapy-Induced Apoptosis by Caspase 8-Mediated Cleavage of Beclin 1

(2011) H. Li et al.   CANCER RESEARCH

Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy

(2011) Flavie Strappazzon et al.   EMBO JOURNAL

Cleavage of the Adaptor Protein TRIF by Enterovirus 71 3C Inhibits Antiviral Responses Mediated by Toll-Like Receptor 3

(2011) X. Lei et al.   JOURNAL OF VIROLOGY

Picornavirus Subversion of the Autophagy Pathway

(2011) Kathryn A. Klein et al.   Viruses-Basel

The Coxsackievirus B 3Cpro Protease Cleaves MAVS and TRIF to Attenuate Host Type I Interferon and Apoptotic Signaling

(2011) Amitava Mukherjee et al.   PLoS Pathogens

The in vitro cleavage of the hAtg proteins by cell death proteases

(2010) Joanna M. Norman et al.   Autophagy

The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1

(2010) X. Lu et al.   JOURNAL OF GENERAL VIROLOGY

The 3C Protein of Enterovirus 71 Inhibits Retinoid Acid-Inducible Gene I-Mediated Interferon Regulatory Factor 3 Activation and Type I Interferon Responses

(2010) X. Lei et al.   JOURNAL OF VIROLOGY

Calcium Flux between the Endoplasmic Reticulum and Mitochondrion Contributes to Poliovirus-Induced Apoptosis

(2010) C. Brisac et al.   JOURNAL OF VIROLOGY

Rotavirus Nonstructural Protein 1 Suppresses Virus-Induced Cellular Apoptosis To Facilitate Viral Growth by Activating the Cell Survival Pathways during Early Stages of Infection

(2010) P. Bagchi et al.   JOURNAL OF VIROLOGY

Coxsackievirus Infection Induces Autophagy-Like Vesicles and Megaphagosomes in Pancreatic Acinar Cells In Vivo

(2010) C. C. Kemball et al.   JOURNAL OF VIROLOGY

Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain

(2010) Troy T. Rohn et al.   NEUROBIOLOGY OF DISEASE

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

(2010) E Wirawan et al.   Cell Death & Disease

Co-ordinated Role of TLR3, RIG-I and MDA5 in the Innate Response to Rhinovirus in Bronchial Epithelium

(2010) Louise Slater et al.   PLoS Pathogens

Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis

(2010) Yushan Zhu et al.   Protein & Cell

Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL

(2009) S Luo et al.   CELL DEATH AND DIFFERENTIATION

Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon–independent apoptosis in human melanoma cells

(2009) Robert Besch et al.   JOURNAL OF CLINICAL INVESTIGATION

Apoptosis in animal models of virus-induced disease

(2009) Penny Clarke et al.   NATURE REVIEWS MICROBIOLOGY

DAB2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosis

(2009) D. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The viral RNA recognition sensor RIG-I is degraded during encephalomyocarditis virus (EMCV) infection

(2009) Laura Papon et al.   VIROLOGY

RIG-I is cleaved during picornavirus infection

(2009) Paola M. Barral et al.   VIROLOGY

Caspase-mediated cleavage of ATG6/Beclin-1 links apoptosis to autophagy in HeLa cells

(2008) Dong-Hyung Cho et al.   CANCER LETTERS

Innate immunity to virus infection

(2008) Osamu Takeuchi et al.   IMMUNOLOGICAL REVIEWS

Early Phosphatidylinositol 3-Kinase/Akt Pathway Activation Limits Poliovirus-Induced JNK-Mediated Cell Death

(2008) A. Autret et al.   JOURNAL OF VIROLOGY

Coxsackievirus B4 Uses Autophagy for Replication after Calpain Activation in Rat Primary Neurons

(2008) S. Y. Yoon et al.   JOURNAL OF VIROLOGY

Functional Analysis of Picornavirus 2B Proteins: Effects on Calcium Homeostasis and Intracellular Protein Trafficking

(2008) A. S. de Jong et al.   JOURNAL OF VIROLOGY

Autophagosome Supports Coxsackievirus B3 Replication in Host Cells

(2008) J. Wong et al.   JOURNAL OF VIROLOGY