Recent Progress on Functional Genomics Research of Enterovirus 71

Honeysuckle-encoded microRNA2911 inhibits Enterovirus 71 replication via targeting VP1 gene

(2018) Xihan Li et al.   ANTIVIRAL RESEARCH

Amino Acid Variation at VP1-145 of Enterovirus 71 Determines Attachment Receptor Usage and Neurovirulence in Human Scavenger Receptor B2 Transgenic Mice

(2018) Kyousuke Kobayashi et al.   JOURNAL OF VIROLOGY

VP1 Amino Acid Residue 145 of Enterovirus 71 Is a Key Residue for Its Receptor Attachment and Resistance to Neutralizing Antibody during Cynomolgus Monkey Infection

(2018) Ken Fujii et al.   JOURNAL OF VIROLOGY

Mutations in VP1 and 5′-UTR affect enterovirus 71 virulence

(2018) Ching-Kun Chang et al.   Scientific Reports

Picornavirus 2A protease regulates stress granule formation to facilitate viral translation

(2018) Xiaodan Yang et al.   PLoS Pathogens

Promyelocytic Leukemia Restricts Enterovirus 71 Replication by Inhibiting Autophagy

(2018) Deyan Chen et al.   Frontiers in Immunology

Enterovirus 71 antagonizes the inhibition of the host intrinsic antiviral factor A3G

(2018) Zhaolong Li et al.   NUCLEIC ACIDS RESEARCH

A VP1 mutation acquired during an enterovirus 71 disseminated infection confers heparan sulfate binding ability and modulates ex vivo tropism

(2018) Eirini D. Tseligka et al.   PLoS Pathogens

Human Virus-Derived Small RNAs Can Confer Antiviral Immunity in Mammals

(2017) Yang Qiu et al.   IMMUNITY

Enterovirus 3A Facilitates Viral Replication by Promoting Phosphatidylinositol 4-Kinase IIIβ–ACBD3 Interaction

(2017) Xia Xiao et al.   JOURNAL OF VIROLOGY

VP1 residues around the five-fold axis of enterovirus A71 mediate heparan sulfate interaction

(2017) Chee Wah Tan et al.   VIROLOGY

Berberine inhibits enterovirus 71 replication by downregulating the MEK/ERK signaling pathway and autophagy

(2017) Huiqiang Wang et al.   Virology Journal

The Golgi protein ACBD3 facilitates Enterovirus 71 replication by interacting with 3A

(2017) Xiaobo Lei et al.   Scientific Reports

Enterovirus 71 protease 2Apro and 3Cpro differentially inhibit the cellular endoplasmic reticulum-associated degradation (ERAD) pathway via distinct mechanisms, and enterovirus 71 hijacks ERAD component p97 to promote its replication

(2017) Tao Wang et al.   PLoS Pathogens

EV71 3D Protein Binds with NLRP3 and Enhances the Assembly of Inflammasome Complex

(2017) Wenbiao Wang et al.   PLoS Pathogens

miR-127-5p negatively regulates enterovirus 71 replication by directly targeting SCARB2

(2017) Chunhong Feng et al.   FEBS Open Bio

Crystal structure of 2C helicase from enterovirus 71

(2017) Hongxin Guan et al.   Science Advances

Inhibition of enterovirus VP4 myristoylation is a potential antiviral strategy for hand, foot and mouth disease

(2016) Yong Wah Tan et al.   ANTIVIRAL RESEARCH

MOV10 interacts with Enterovirus 71 genomic 5′UTR and modulates viral replication

(2016) Huanru Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT1 inhibits EV71 genome replication and RNA translation by interfering with the viral polymerase and 5′UTR RNA

(2016) Yang Han et al.   JOURNAL OF CELL SCIENCE

Enterovirus 71 2B Induces Cell Apoptosis by Directly Inducing the Conformational Activation of the Proapoptotic Protein Bax

(2016) Haolong Cong et al.   JOURNAL OF VIROLOGY

A Single Mutation in the VP1 of Enterovirus 71 Is Responsible for Increased Virulence and Neurotropism in Adult Interferon-Deficient Mice

(2016) Elizabeth A. Caine et al.   JOURNAL OF VIROLOGY

2C Proteins of Enteroviruses Suppress IKKβ Phosphorylation by Recruiting Protein Phosphatase 1

(2016) Qian Li et al.   JOURNAL OF VIROLOGY

Enterovirus 71 3C Promotes Apoptosis through Cleavage of PinX1, a Telomere Binding Protein

(2016) Jing Li et al.   JOURNAL OF VIROLOGY

Additive Promotion of Viral Internal Ribosome Entry Site-Mediated Translation by Far Upstream Element-Binding Protein 1 and an Enterovirus 71-Induced Cleavage Product

(2016) Chuan-Tien Hung et al.   PLoS Pathogens

Clinical Characteristics and Functional Motor Outcomes of Enterovirus 71 Neurological Disease in Children

(2016) Hooi-Ling Teoh et al.   JAMA Neurology

Cooperative effect of the VP1 amino acids 98E, 145A and 169F in the productive infection of mouse cell lines by enterovirus 71 (BS strain)

(2016) Carla Bianca Luena Victorio et al.   Emerging Microbes & Infections

TIA-1 and TIAR interact with 5′-UTR of enterovirus 71 genome and facilitate viral replication

(2015) Xiaohui Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of Positively Charged Residues in Enterovirus 71 Capsid Protein VP1 Essential for Production of Infectious Particles

(2015) Shilin Yuan et al.   JOURNAL OF VIROLOGY

Enterovirus 71 Proteins 2A and 3D Antagonize the Antiviral Activity of Gamma Interferon via Signaling Attenuation

(2015) Li-Chiu Wang et al.   JOURNAL OF VIROLOGY

Enterovirus 71 2C Protein Inhibits NF-κB Activation by Binding to RelA(p65)

(2015) Haiwei Du et al.   Scientific Reports

A Broadly Cross-protective Vaccine Presenting the Neighboring Epitopes within the VP1 GH Loop and VP2 EF Loop of Enterovirus 71

(2015) Longfa Xu et al.   Scientific Reports

Reciprocal Regulation between Enterovirus 71 and the NLRP3 Inflammasome

(2015) Hongbin Wang et al.   Cell Reports

Human Enterovirus Nonstructural Protein 2CATPase Functions as Both an RNA Helicase and ATP-Independent RNA Chaperone

(2015) Hongjie Xia et al.   PLoS Pathogens

Enterovirus 71 Virion-Associated Galectin-1 Facilitates Viral Replication and Stability

(2015) Pei-Huan Lee et al.   PLoS One

HuR and Ago2 Bind the Internal Ribosome Entry Site of Enterovirus 71 and Promote Virus Translation and Replication

(2015) Jing-Yi Lin et al.   PLoS One

Enterovirus 71 3C Inhibits Cytokine Expression through Cleavage of the TAK1/TAB1/TAB2/TAB3 Complex

(2014) X. Lei et al.   JOURNAL OF VIROLOGY

Downregulation of MicroRNA miR-526a by Enterovirus Inhibits RIG-I-Dependent Innate Immune Response

(2014) C. Xu et al.   JOURNAL OF VIROLOGY

Cell Surface Vimentin Is an Attachment Receptor for Enterovirus 71

(2014) N. Du et al.   JOURNAL OF VIROLOGY

PolyC-Binding Protein 1 Interacts with 5′-Untranslated Region of Enterovirus 71 RNA in Membrane-Associated Complex to Facilitate Viral Replication

(2014) Zhen Luo et al.   PLoS One

mRNA Decay Factor AUF1 Binds the Internal Ribosomal Entry Site of Enterovirus 71 and Inhibits Virus Replication

(2014) Jing-Yi Lin et al.   PLoS One

The identification and characterization of nucleic acid chaperone activity of human enterovirus 71 nonstructural protein 3AB

(2014) Fenfen Tang et al.   VIROLOGY

Oral immunization with recombinant enterovirus 71 VP1 formulated with chitosan protects mice against lethal challenge

(2014) Fushun Zhang et al.   Virology Journal

A Novel Universal Neutralizing Monoclonal Antibody against Enterovirus 71 That Targets the Highly Conserved “Knob” Region of VP3 Protein

(2014) Tanja K. Kiener et al.   PLoS Neglected Tropical Diseases

MicroRNA-23b Inhibits Enterovirus 71 Replication through Downregulation of EV71 VPl Protein

(2013) Bai-ping Wen et al.   INTERVIROLOGY

VP2 Dominated CD4+ T Cell Responses against Enterovirus 71 and Cross-Reactivity against Coxsackievirus A16 and Polioviruses in a Healthy Population

(2013) S. Tan et al.   JOURNAL OF IMMUNOLOGY

MDA5 Plays a Crucial Role in Enterovirus 71 RNA-Mediated IRF3 Activation

(2013) Rei-Lin Kuo et al.   PLoS One

Enterovirus 71 VP1 Activates Calmodulin-Dependent Protein Kinase II and Results in the Rearrangement of Vimentin in Human Astrocyte Cells

(2013) Cong Haolong et al.   PLoS One

Enterovirus 71 Protease 2Apro Targets MAVS to Inhibit Anti-Viral Type I Interferon Responses

(2013) Bei Wang et al.   PLoS Pathogens

Enterovirus 71 Binding to PSGL-1 on Leukocytes: VP1-145 Acts as a Molecular Switch to Control Receptor Interaction

(2013) Yorihiro Nishimura et al.   PLoS Pathogens

Molecular Determinants of Enterovirus 71 Viral Entry

(2012) Pan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cleavage of Interferon Regulatory Factor 7 by Enterovirus 71 3C Suppresses Cellular Responses

(2012) Xiaobo Lei et al.   JOURNAL OF VIROLOGY

Enterovirus 71 Disrupts Interferon Signaling by Reducing the Level of Interferon Receptor 1

(2012) J. Lu et al.   JOURNAL OF VIROLOGY

Characterization of Full-Length Enterovirus 71 Strains from Severe and Mild Disease Patients in Northeastern China

(2012) Xiaomei Wang et al.   PLoS One

COPI Is Required for Enterovirus 71 Replication

(2012) Jianmin Wang et al.   PLoS One

Immunization with recombinant enterovirus 71 viral capsid protein 1 fragment stimulated antibody responses in hamsters

(2012) Wei-Choong Ch’ng et al.   Virology Journal

Characterization and specificity of the linear epitope of the enterovirus 71 VP2 protein

(2012) Tanja K Kiener et al.   Virology Journal

Biochemical characterization of enterovirus 71 3D RNA polymerase

(2011) Hongbing Jiang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

DIDS blocks a chloride-dependent current that is mediated by the 2B protein of enterovirus 71

(2011) Shiqi Xie et al.   CELL RESEARCH

The virology and developments toward control of human enterovirus 71

(2011) Lina Yi et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Sumoylation-promoted Enterovirus 71 3C Degradation Correlates with a Reduction in Viral Replication and Cell Apoptosis

(2011) Shu-Chuan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enterovirus 71 2C Protein Inhibits TNF- -Mediated Activation of NF- B by Suppressing I B Kinase   Phosphorylation

(2011) Z. Zheng et al.   JOURNAL OF IMMUNOLOGY

Crystal Structure of Human Enterovirus 71 3C Protease

(2011) Sheng Cui et al.   JOURNAL OF MOLECULAR BIOLOGY

Cleavage of the Adaptor Protein TRIF by Enterovirus 71 3C Inhibits Antiviral Responses Mediated by Toll-Like Receptor 3

(2011) X. Lei et al.   JOURNAL OF VIROLOGY

Annexin II Binds to Capsid Protein VP1 of Enterovirus 71 and Enhances Viral Infectivity

(2011) S.-L. Yang et al.   JOURNAL OF VIROLOGY

Far upstream element binding protein 1 binds the internal ribosomal entry site of enterovirus 71 and enhances viral translation and viral growth

(2011) P.-N. Huang et al.   NUCLEIC ACIDS RESEARCH

A Single Nucleotide in Stem Loop II of 5′-Untranslated Region Contributes to Virulence of Enterovirus 71 in Mice

(2011) Ming-Te Yeh et al.   PLoS One

Mutations in VP2 and VP1 capsid proteins increase infectivity and mouse lethality of enterovirus 71 by virus binding and RNA accumulation enhancement

(2011) Sheng-Wen Huang et al.   VIROLOGY

Developments towards antiviral therapies against enterovirus 71

(2010) Kan X. Wu et al.   DRUG DISCOVERY TODAY

The 3C Protein of Enterovirus 71 Inhibits Retinoid Acid-Inducible Gene I-Mediated Interferon Regulatory Factor 3 Activation and Type I Interferon Responses

(2010) X. Lei et al.   JOURNAL OF VIROLOGY

Virology, epidemiology, pathogenesis, and control of enterovirus 71

(2010) Tom Solomon et al.   LANCET INFECTIOUS DISEASES

Neural pathogenesis of enterovirus 71 infection

(2010) Kuo-Feng Weng et al.   MICROBES AND INFECTION

Analysis of recombination and natural selection in human enterovirus 71

(2010) Xiaoming Chen et al.   VIROLOGY

Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China

(2010) Yang Wu et al.   Protein & Cell

hnRNP A1 Interacts with the 5' Untranslated Regions of Enterovirus 71 and Sindbis Virus RNA and Is Required for Viral Replication

(2009) J.-Y. Lin et al.   JOURNAL OF VIROLOGY

Introduction of a strong temperature-sensitive phenotype into enterovirus 71 by altering an amino acid of virus 3D polymerase

(2009) Yen-Hua Kung et al.   VIROLOGY

Enterovirus 71 3C Protease Cleaves a Novel Target CstF-64 and Inhibits Cellular Polyadenylation

(2009) Kuo-Feng Weng et al.   PLoS Pathogens

Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents

(2008) Chih-Jung Kuo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Heterogeneous nuclear ribonuclear protein K interacts with the enterovirus 71 5' untranslated region and participates in virus replication

(2008) J.-Y. Lin et al.   JOURNAL OF GENERAL VIROLOGY

Enterovirus 71 infection: a new threat to global public health?

(2008) Jane Qiu   LANCET NEUROLOGY

Far upstream element binding protein 2 interacts with enterovirus 71 internal ribosomal entry site and negatively regulates viral translation

(2008) Jing-Yi Lin et al.   NUCLEIC ACIDS RESEARCH

Identification of Human CD4+ T-Cell Epitopes on the VP1 Capsid Protein of Enterovirus 71

(2008) Damian Guang Wei Foo et al.   VIRAL IMMUNOLOGY

Relevance of RNA structure for the activity of picornavirus IRES elements

(2008) Olga Fernández-Miragall et al.   VIRUS RESEARCH

A mammalian cell-based reverse two-hybrid system for functional analysis of 3C viral protease of human enterovirus 71

(2007) Jin-Ching Lee et al.   ANALYTICAL BIOCHEMISTRY

Appearance of intratypic recombination of enterovirus 71 in Taiwan from 2002 to 2005

(2007) Shih-Chen Huang et al.   VIRUS RESEARCH