Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens

Env Exceptionalism: Why Are HIV-1 Env Glycoproteins Atypical Immunogens?

(2020) P.J. Klasse et al.   Cell Host & Microbe

Induction of Tier 1 HIV Neutralizing Antibodies by Envelope Trimers Incorporated into a Replication Competent Vesicular Stomatitis Virus Vector

(2019) C. Bresk et al.   Viruses-Basel

Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses

(2019) Masaru Kanekiyo et al.   NATURE IMMUNOLOGY

Developability Assessment of Physicochemical Properties and Stability Profiles of HIV-1 BG505 SOSIP.664 and BG505 SOSIP.v4.1-GT1.1 gp140 Envelope Glycoprotein Trimers as Candidate Vaccine Antigens

(2019) Neal Whitaker et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus

(2019) Jessica Marcandalli et al.   CELL

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

(2019) Kimberly M. Cirelli et al.   CELL

Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques

(2019) Amelia Escolano et al.   NATURE

Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization

(2019) Rui Kong et al.   CELL

Consistent elicitation of cross-clade HIV-neutralizing responses achieved in guinea pigs after fusion peptide priming by repetitive envelope trimer boosting

(2019) Cheng Cheng et al.   PLoS One

Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence

(2019) Kwinten Sliepen et al.   Nature Communications

Presentation of HIV-1 envelope glycoprotein trimers on diverse nanoparticle platforms

(2019) Philip J.M. Brouwer et al.   Current Opinion in HIV and AIDS

Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability

(2019) Viktoriya Dubrovskaya et al.   IMMUNITY

Presentation of HIV-1 Envelope Trimers on the Surface of Silica Nanoparticles

(2019) Stefanie Thalhauser et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle

(2019) Philip J. M. Brouwer et al.   Nature Communications

Critical design criteria for engineering a nanoparticulate HIV-1 vaccine

(2019) Stefanie Thalhauser et al.   JOURNAL OF CONTROLLED RELEASE

Neutralizing Antibody Induction by HIV-1 Envelope Glycoprotein SOSIP Trimers on Iron Oxide Nanoparticles May Be Impaired by Mannose Binding Lectin

(2019) Rajesh P. Ringe et al.   JOURNAL OF VIROLOGY

HIV-1 Vaccines Based on Antibody Identification, B Cell Ontogeny, and Epitope Structure

(2018) Peter D. Kwong et al.   IMMUNITY

Effects of Adjuvants on HIV-1 Envelope Glycoprotein SOSIP Trimers In Vitro

(2018) Gabriel Ozorowski et al.   JOURNAL OF VIROLOGY

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

(2018) Kai Xu et al.   NATURE MEDICINE

Co-evolution of HIV Envelope and Apex-Targeting Neutralizing Antibody Lineage Provides Benchmarks for Vaccine Design

(2018) Kimmo Rantalainen et al.   Cell Reports

Two-Component Ferritin Nanoparticles for Multimerization of Diverse Trimeric Antigens

(2018) Ivelin S. Georgiev et al.   ACS Infectious Diseases

Structural analysis of glycoproteins: building N-linked glycans with Coot

(2018) Paul Emsley et al.   Acta Crystallographica Section D-Structural Biology

Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization

(2018) Matteo Bianchi et al.   IMMUNITY

Development of a Pan-H1 Influenza Vaccine

(2018) Nicole Darricarrère et al.   JOURNAL OF VIROLOGY

Site-Specific Glycosylation of Virion-Derived HIV-1 Env Is Mimicked by a Soluble Trimeric Immunogen

(2018) Weston B. Struwe et al.   Cell Reports

Closing and opening holes in the glycan shield of HIV-1 envelope glycoprotein SOSIP trimers can redirect the neutralizing antibody response to the newly unmasked epitopes

(2018) Rajesh P. Ringe et al.   JOURNAL OF VIROLOGY

Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers

(2018) Talar Tokatlian et al.   SCIENCE

Enhancing Humoral Responses Against HIV Envelope Trimers via Nanoparticle Delivery with Stabilized Synthetic Liposomes

(2018) Talar Tokatlian et al.   Scientific Reports

HIV-1 vaccine design through minimizing envelope metastability

(2018) Linling He et al.   Science Advances

Particulate Array of Well-Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach

(2017) Paola Martinez-Murillo et al.   IMMUNITY

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches

(2017) Matthias Pauthner et al.   IMMUNITY

Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo

(2017) Max Medina-Ramírez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dense Array of Spikes on HIV-1 Virion Particles

(2017) Armando Stano et al.   JOURNAL OF VIROLOGY

Covalent Linkage of HIV-1 Trimers to Synthetic Liposomes Elicits Improved B Cell and Antibody Responses

(2017) Shridhar Bale et al.   JOURNAL OF VIROLOGY

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

MolProbity: More and better reference data for improved all-atom structure validation

(2017) Christopher J. Williams et al.   PROTEIN SCIENCE

Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding

(2017) Daniel W. Kulp et al.   Nature Communications

Global site-specific N-glycosylation analysis of HIV envelope glycoprotein

(2017) Liwei Cao et al.   Nature Communications

Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization

(2017) Alba Torrents de la Peña et al.   Cell Reports

HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies

(2016) Jon M. Steichen et al.   IMMUNITY

Computational design of self-assembling cyclic protein homo-oligomers

(2016) Jorge A. Fallas et al.   Nature Chemistry

Comparative Immunogenicity of HIV-1 gp140 Vaccine Delivered by Parenteral, and Mucosal Routes in Female Volunteers; MUCOVAC2, A Randomized Two Centre Study

(2016) Catherine A. Cosgrove et al.   PLoS One

Accurate design of megadalton-scale two-component icosahedral protein complexes

(2016) J. B. Bale et al.   SCIENCE

Antigen Receptor Nanoclusters: Small Units with Big Functions

(2016) Wanli Liu et al.   TRENDS IN IMMUNOLOGY

Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles

(2016) Linling He et al.   Nature Communications

High-Density Array of Well-Ordered HIV-1 Spikes on Synthetic Liposomal Nanoparticles Efficiently Activate B Cells

(2016) Jidnyasa Ingale et al.   Cell Reports

Composition and Antigenic Effects of Individual Glycan Sites of a Trimeric HIV-1 Envelope Glycoprotein

(2016) Anna-Janina Behrens et al.   Cell Reports

Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies

(2016) Laura E. McCoy et al.   Cell Reports

Sequential and Simultaneous Immunization of Rabbits with HIV-1 Envelope Glycoprotein SOSIP.664 Trimers from Clades A, B and C

(2016) P. J. Klasse et al.   PLoS Pathogens

Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes

(2015) Steven W. de Taeye et al.   CELL

Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans

(2015) Fernando Garces et al.   IMMUNITY

Structure-Guided Redesign Increases the Propensity of HIV Env To Generate Highly Stable Soluble Trimers

(2015) Javier Guenaga et al.   JOURNAL OF VIROLOGY

EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy

(2015) Benjamin A Barad et al.   NATURE METHODS

Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity

(2015) Kwinten Sliepen et al.   Retrovirology

Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen

(2015) J. G. Jardine et al.   SCIENCE

HIV-1 neutralizing antibodies induced by native-like envelope trimers

(2015) R. W. Sanders et al.   SCIENCE

Model Building and Refinement of a Natively Glycosylated HIV-1 Env Protein by High-Resolution Cryoelectron Microscopy

(2015) Jeong Hyun Lee et al.   STRUCTURE

Localized reconstruction of subunits from electron cryomicroscopy images of macromolecular complexes

(2015) Serban L. Ilca et al.   Nature Communications

Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike

(2015) Jeong Hyun Lee et al.   Nature Communications

Cleavage-Independent HIV-1 Env Trimers Engineered as Soluble Native Spike Mimetics for Vaccine Design

(2015) Shailendra Kumar Sharma et al.   Cell Reports

No receptor stands alone: IgG B-cell receptor intrinsic and extrinsic mechanisms contribute to antibody memory

(2014) Yinsheng Xu et al.   CELL RESEARCH

Polymeric penetration enhancers promote humoral immune responses to mucosal vaccines

(2014) Katja Klein et al.   JOURNAL OF CONTROLLED RELEASE

Accurate design of co-assembling multi-component protein nanomaterials

(2014) Neil P. King et al.   NATURE

Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits

(2014) Anila Yasmeen et al.   Retrovirology

Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies

(2013) Masaru Kanekiyo et al.   NATURE

Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

(2013) J. Jardine et al.   SCIENCE

A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies

(2013) Rogier W. Sanders et al.   PLoS Pathogens

Anti-HIV B Cell Lines as Candidate Vaccine Biosensors

(2012) T. Ota et al.   JOURNAL OF IMMUNOLOGY

Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes

(2010) Santiago F Gonzalez et al.   NATURE IMMUNOLOGY

Appion: An integrated, database-driven pipeline to facilitate EM image processing

(2009) Gabriel C. Lander et al.   JOURNAL OF STRUCTURAL BIOLOGY

Nanoparticles target distinct dendritic cell populations according to their size

(2008) Vania Manolova et al.   EUROPEAN JOURNAL OF IMMUNOLOGY