Increased miltefosine tolerance in clinical isolates of Leishmania donovani is associated with reduced drug accumulation, increased infectivity and resistance to oxidative stress

Genomic Appraisal of the Multifactorial Basis forIn VitroAcquisition of Miltefosine Resistance in Leishmania donovani

(2016) P. Vacchina et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In vitro infectivity and differential gene expression of Leishmania infantum metacyclic promastigotes: negative selection with peanut agglutinin in culture versus isolation from the stomodeal valve of Phlebotomus perniciosus

(2016) Pedro J. Alcolea et al.   BMC GENOMICS

A mitochondrial HSP70 (HSPA9B) is linked to miltefosine resistance and stress response in Leishmania donovani

(2016) P. Vacchina et al.   Parasites & Vectors

Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes

(2016) Annelies Mondelaers et al.   PLoS One

Metabolic reconfiguration of the central glucose metabolism: a crucial strategy of Leishmania donovani for its survival during oxidative stress

(2015) Ayan K. Ghosh et al.   FASEB JOURNAL

Correction: Decline in Clinical Efficacy of Oral Miltefosine in Treatment of Post Kala-azar Dermal Leishmaniasis (PKDL) in India

(2015) V. Ramesh et al.   PLoS Neglected Tropical Diseases

Multi-analytical platform metabolomic approach to study miltefosine mechanism of action and resistance in Leishmania

(2014) Gisele A. B. Canuto et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Comparative transcript expression analysis of miltefosine-sensitive and miltefosine-resistant Leishmania donovani

(2014) Arpita Kulshrestha et al.   PARASITOLOGY RESEARCH

Infection with Leishmania major Induces a Cellular Stress Response in Macrophages

(2014) Alessandra A. Filardy et al.   PLoS One

Increasing Failure of Miltefosine in the Treatment of Kala-azar in Nepal and the Potential Role of Parasite Drug Resistance, Reinfection, or Noncompliance

(2013) Suman Rijal et al.   CLINICAL INFECTIOUS DISEASES

Miltefosine resistance in Leishmania donovani involves suppression of oxidative stress-induced programmed cell death

(2013) Jyotsna Mishra et al.   EXPERIMENTAL PARASITOLOGY

Miltefosine-unresponsiveLeishmania donovanihas a greater ability than miltefosine-responsiveL. donovanito resist reactive oxygen species

(2013) Mousumi Das et al.   FEBS Journal

Efficacy of Miltefosine in the Treatment of Visceral Leishmaniasis in India After a Decade of Use

(2012) S. Sundar et al.   CLINICAL INFECTIOUS DISEASES

Biomarkers of antimony resistance: need for expression analysis of multiple genes to distinguish resistance phenotype in clinical isolates of Leishmania donovani

(2012) Dhiraj Kumar et al.   PARASITOLOGY RESEARCH

Validation of a simple resazurin-based promastigote assay for the routine monitoring of miltefosine susceptibility in clinical isolates of Leishmania donovani

(2012) Arpita Kulshrestha et al.   PARASITOLOGY RESEARCH

Impact of Continuous Axenic Cultivation in Leishmania infantum Virulence

(2012) Diana Moreira et al.   PLoS Neglected Tropical Diseases

Drug Susceptibility in Leishmania Isolates Following Miltefosine Treatment in Cases of Visceral Leishmaniasis and Post Kala-Azar Dermal Leishmaniasis

(2012) Vasundhra Bhandari et al.   PLoS Neglected Tropical Diseases

Antimony-Resistant Clinical Isolates of Leishmania donovani Are Susceptible to Paromomycin and Sitamaquine

(2011) Arpita Kulshrestha et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations

(2011) Balaraman Kalyanaraman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Characterisation of antimony-resistant Leishmania donovani isolates: Biochemical and biophysical studies and interaction with host cells

(2011) Rupkatha Mukhopadhyay et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Overexpression of histone H2A modulates drug susceptibility in Leishmania parasites

(2010) Ruchi Singh et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Identification, characterization, and expression of a unique secretory lipase from the human pathogen Leishmania donovani

(2010) Alison M. Shakarian et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Enhanced Case Detection and Improved Diagnosis of PKDL in a Kala-azar-Endemic Area of Bangladesh

(2010) Dinesh Mondal et al.   PLoS Neglected Tropical Diseases

Development and validation of a quantitative assay for the measurement of miltefosine in human plasma by liquid chromatography–tandem mass spectrometry

(2008) Thomas P.C. Dorlo et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES