Article
Cardiac & Cardiovascular Systems
Carolin Lerchenmueller, Ana Vujic, Sonja Mittag, Annie Wang, Charles P. Rabolli, Chiara Hess, Fynn Betge, Ashraf Y. Rangrez, Malay Chaklader, Christelle Guillermier, Frank Gyngard, Jason D. Roh, Haobo Li, Matthew L. Steinhauser, Norbert Frey, Beverly Rothermel, Christoph Dieterich, Anthony Rosenzweig, Richard T. Lee
Summary: Exercise can stimulate cardiomyogenesis in aged hearts, and pathways associated with circadian rhythm may play a role in physiologically stimulated cardiomyogenesis.
Article
Multidisciplinary Sciences
Yaarit Adamovich, Vaishnavi Dandavate, Saar Ezagouri, Gal Manella, Ziv Zwighaft, Jonathan Sobel, Yael Kuperman, Marina Golik, Asher Auerbach, Maxim Itkin, Sergey Malitsky, Gad Asher
Summary: The study showed that circadian clocks and clock proteins influence mouse exercise capacity, with effects on liver glycogen levels and muscle lipid utilization playing a key role. Training at different times of the day also showed varying effects on exercise performance.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Logan A. Pendergrast, Leonidas S. Lundell, Amy M. Ehrlich, Stephen P. Ashcroft, Milena Schoenke, Astrid L. Basse, Anna Krook, Jonas T. Treebak, Lucile Dollet, Juleen R. Zierath
Summary: This study aimed to investigate the effects of exercise timing on adipose tissue metabolism. The findings showed that exercise during the early active phase could increase the level of serum nonesterified fatty acids and promote thermogenesis and mitochondrial proliferation in adipose tissue. Additionally, the study found that a 10-hour fast could induce a similar lipolytic response to active phase exercise but did not replicate the transcriptomic changes, suggesting that gene expression alterations are not driven by feeding status.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Endocrinology & Metabolism
Nuria Casanova-Vallve, Drew Duglan, Megan E. Vaughan, Marie Pariollaud, Michal K. Handzlik, Weiwei Fan, Ruth T. Yu, Christopher Liddle, Michael Downes, Julien Delezie, Rebecca Mello, Alanna B. Chan, Pal O. Westermark, Christian M. Metallo, Ronald M. Evans, Katja A. Lamia
Summary: This study found that chronic nighttime physical activity can significantly alter the daily rhythms of murine muscle gene expression and support the fluctuations in daily exercise performance.
MOLECULAR METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Milena Schonke, Zhixiong Ying, Artemiy Kovynev, Wietse In Het Panhuis, Anne Binnendijk, Sabine van Der Poel, Amanda C. M. Pronk, Trea C. M. Streefland, Menno Hoekstra, Sander Kooijman, Patrick C. N. Rensen
Summary: The timing of exercise training plays a critical role in reducing fat mass and early-stage atherosclerotic lesions, as well as affecting the composition of gut microbiota.
Review
Biochemistry & Molecular Biology
Sandra Haupt, Max L. Eckstein, Alina Wolf, Rebecca T. Zimmer, Nadine B. Wachsmuth, Othmar Moser
Summary: The circadian rhythmicity of endogenous metabolic and hormonal processes is crucial for overall health. Adjusting the timing of diet and exercise can help reset disrupted circadian pacemakers and potentially prevent metabolic diseases. However, these lifestyle interventions cannot address the underlying issue of the misalignment between our biological and social time.
Article
Biochemistry & Molecular Biology
Laura Niiranen, Ville Stenback, Mikko Tulppo, Karl-Heinz Herzig, Kari A. Makela
Summary: Exercise has been proven to improve cognitive function, and studies on both humans and animals have shown this. Laboratory mice are often used as a model to study the effects of exercise, and running wheels provide a voluntary and stress-free form of exercise for mice. This study aimed to analyze the relationship between the cognitive state of a mouse and its wheel-running behavior. The results showed that high-runner mice exhibited enhanced learning capabilities and ate more compared to the other groups. Interestingly, individual mice had different reactions when introduced to running wheels, suggesting the importance of considering individual differences in voluntary endurance exercise studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Daniel Alveal-Mellado, Lidia Castillo-Mariqueo, Lydia Gimenez-Llort
Summary: The study showed that mice with exercise training exhibited higher levels of horizontal exploration in the open field test. There were sex-dependent differences in voluntary wheel running activity, with high-NIBI males running less than high-NIBI females. This may be influenced by NPS-like symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Jan Spaas, Richie P. Goulding, Charly Keytsman, Lena Fonteyn, Jack van Horssen, Richard T. Jaspers, Bert O. Eijnde, Rob C. I. Wust
Summary: Patients with multiple sclerosis (MS) have lower exercise tolerance due to reduced skeletal muscle oxidative phenotype. However, skeletal muscle mitochondria seem resistant to the effects of exercise training, suggesting that other physiological systems may be driving the improvements in exercise capacity following exercise training in MS.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Endocrinology & Metabolism
Ross Fitzpatrick, Gareth Davison, Jason J. Wilson, Gerard McMahon, Conor McClean
Summary: Exercise has numerous benefits for individuals with type 1 diabetes, but barriers such as post-exercise hypoglycaemia or hyperglycaemia exist. The timing of exercise may be crucial in preventing these blood glucose fluctuations.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biology
Heiko T. Jansen, Brandon Evans Hutzenbiler, Hannah R. Hapner, Madeline L. McPhee, Anthony M. Carnahan, Joanna L. Kelley, Michael W. Saxton, Charles T. Robbins
Summary: Feeding glucose to hibernating bears partially restores metabolic parameters to active season levels, with some indicators remaining incomplete due to the suppression of circulating free fatty acids. The study provides a controlled model to examine the relationship between nutrient availability and metabolism on the hibernation phenotype in bears.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Marlene Cervantes, Robert G. Lewis, Maria Agnese Della-Fazia, Emiliana Borrelli, Paolo Sassone-Corsi
Summary: The circadian clock and metabolism are closely linked, relying on interactions between organ systems for proper timing. Substance use disrupts communication between organs and alters rhythmic activities. This study finds that alterations in dopamine signaling in the brain can affect circadian metabolism in peripheral organs. Drugs like cocaine that increase dopamine levels disrupt circadian metabolic profiles in the liver, especially when dopamine D2 receptors are lost.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Nutrition & Dietetics
Pablo Vidal, Lisa A. Baer, Elisa Felix-Soriano, Felix T. Yang, Daniel A. Branch, Kedryn K. Baskin, Kristin Stanford
Summary: The prevalence of metabolic diseases is increasing, with diet being a major contributing factor. Exercise is effective in combating metabolic diseases. This study found that a high-fat diet impairs metabolic function, while a high-phosphate diet does not significantly affect glucose metabolism. Exercise can reverse the detrimental effects of a high-fat diet and restore metabolic function.
Article
Multidisciplinary Sciences
Byunghun So, Li Li Ji, Saba Imdad, Chounghun Kang
Summary: This study aimed to investigate the effect of voluntary wheel running (VWR) on the metabolic changes in the livers of high-fat diet (HFD)-induced NAFLD mice. LC-MS/MS was used to determine whether the tested intervention affected the protein expression profiles of the mouse livers. The results showed that VWR counteracted the adverse effects of HFD on the livers of the mice and affected the expression of proteins involved in ketogenesis, lipid metabolism, and the metabolism of drugs and xenobiotics.
Article
Biology
Musharraf Yusifova, Aykhan Yusifov, Sydney M. Polson, William D. Todd, Emily E. Schmitt, Danielle R. Bruns
Summary: Circadian misalignment caused by age, jet lag, and shift work leads to maladaptive health outcomes, including cardiovascular diseases. The understanding of the cardiac circadian clock is limited, hindering the development of therapies to restore it. Exercise has been suggested to reset the circadian clock in peripheral tissues, but it does not alleviate the pathological cardiac remodeling caused by the deletion of core circadian gene Bmal1. However, the deletion of Bmal1 affects systemic circadian output, indicating its critical role in regulating both cardiac and systemic circadian rhythm and function.
JOURNAL OF BIOLOGICAL RHYTHMS
(2023)
Article
Genetics & Heredity
Paul W. Hook, Sarah A. McClymont, Gabrielle H. Cannon, William D. Law, A. Jennifer Morton, Loyal A. Goff, Andrew S. McCallion
AMERICAN JOURNAL OF HUMAN GENETICS
(2018)
Article
Agriculture, Dairy & Animal Science
Sebastian D. McBride, A. Jennifer Morton
APPLIED ANIMAL BEHAVIOUR SCIENCE
(2018)
Article
Biotechnology & Applied Microbiology
Edith L. Pfister, Natalie DiNardo, Erica Mondo, Florie Borel, Faith Conroy, Cara Fraser, Gwladys Gernoux, Xin Han, Danjing Hu, Emily Johnson, Lori Kennington, PengPeng Liu, Suzanne J. Reid, Ellen Sapp, Petr Vodicka, Tim Kuchel, A. Jennifer Morton, David Howland, Richard Moser, Miguel Sena-Esteves, Guangping Gao, Christian Mueller, Marian DiFiglia, Neil Aronin
HUMAN GENE THERAPY
(2018)
Article
Biochemical Research Methods
Huw Garland, Nigel I. Wood, Elizabeth A. Skillings, Peter J. Detloff, A. Jennifer Morton, Robyn A. Grant
JOURNAL OF NEUROSCIENCE METHODS
(2018)
Article
Neurosciences
Koliane Ouk, Juliet Aungier, Marc Cuesta, A. Jennifer Morton
Article
Multidisciplinary Sciences
Aris A. Polyzos, Nigel I. Wood, Paul Williams, Peter Wipf, A. Jennifer Morton, Cynthia T. McMurray
Article
Biochemistry & Molecular Biology
Anne Ast, Alexander Buntru, Franziska Schindler, Regine Hasenkopf, Aline Schulz, Lydia Brusendorf, Konrad Klockmeier, Gerlinde Grelle, Benjamin McMahon, Hannah Niederlechner, Isabelle Jansen, Lisa Diez, Juliane Edel, Annett Boeddrich, Sophie A. Franklin, Barbara Baldo, Sigrid Schnoegl, Severine Kunz, Bettina Purfuerst, Annette Gaertner, Harm H. Kampinga, A. Jennifer Morton, Asa Petersen, Janine Kirstein, Gillian P. Bates, Erich E. Wanker
Article
Multidisciplinary Sciences
A. J. Morton, E. A. Skillings, N. I. Wood, Z. Zheng
SCIENTIFIC REPORTS
(2019)
Article
Biochemical Research Methods
Ugne Simanaviciute, Jewel Ahmed, Richard E. Brown, Natalie Connor-Robson, Tracy D. Farr, Emre Fertan, Nikki Gambles, Huw Garland, A. Jennifer Morton, Jochen F. Staiger, Elizabeth A. Skillings, Rebecca C. Trueman, Richard Wade-Martins, Nigel I. Wood, Aimee A. Wong, Robyn A. Grant
JOURNAL OF NEUROSCIENCE METHODS
(2020)
Article
Endocrinology & Metabolism
A. Jennifer Morton, Benita Middleton, Skye Rudiger, C. Simon Bawden, Timothy R. Kuchel, Debra J. Skene
JOURNAL OF PINEAL RESEARCH
(2020)
Article
Clinical Neurology
Szilvia Vas, Jackie M. Casey, Will T. Schneider, Lajos Kalmar, A. Jennifer Morton
Article
Multidisciplinary Sciences
A. U. Nicol, A. J. Morton
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
William T. Schneider, Szilvia Vas, Alister U. Nicol, A. Jennifer Morton
Summary: Research showed that in sheep with HD, transitions into wake were more sudden and accompanied by less reduction in slow wave power compared to normal sheep, indicating impaired readiness for waking. These abnormal dynamics of sleep transitions may potentially serve as an early biomarker for HD and could be applied to studying transition dynamics in other sleep disorders as well.
Article
Ophthalmology
Moritz Lindner, Michael J. Gilhooley, Teele Palumaa, A. Jennifer Morton, Steven Hughes, Mark W. Hankins
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2020)
Article
Neurosciences
Koliane Ouk, Juliet Aungier, Michelle Ware, A. Jennifer Morton