Zika Virus Infection Promotes Local Inflammation, Cell Adhesion Molecule Upregulation, and Leukocyte Recruitment at the Blood-Brain Barrier

Development of a human in vitro blood–brain tumor barrier model of diffuse intrinsic pontine glioma to better understand the chemoresistance

(2020) Clémence Deligne et al.   Fluids and Barriers of the CNS

Zika Virus: Origins, Pathological Action, and Treatment Strategies

(2019) Kirill Gorshkov et al.   Frontiers in Microbiology

Pathways Exploited by Flaviviruses to Counteract the Blood-Brain Barrier and Invade the Central Nervous System

(2019) Yasmin Mucunã Mustafá et al.   Frontiers in Microbiology

The Roles of prM-E Proteins in Historical and Epidemic Zika Virus-mediated Infection and Neurocytotoxicity

(2019) Ge Li et al.   Viruses-Basel

Plasma VCAM1 levels correlate with disease severity in Parkinson’s disease

(2019) Caroline Perner et al.   Journal of Neuroinflammation

Role and Molecular Mechanisms of Pericytes in Regulation of Leukocyte Diapedesis in Inflamed Tissues

(2019) Paulina Rudziak et al.   MEDIATORS OF INFLAMMATION

PECAM-1 Stabilizes Blood-Brain Barrier Integrity and Favors Paracellular T-Cell Diapedesis Across the Blood-Brain Barrier During Neuroinflammation

(2019) Isabella Wimmer et al.   Frontiers in Immunology

Model systems for studying the blood-brain barrier: Applications and challenges

(2019) Sadhana Jackson et al.   BIOMATERIALS

RAGE and CCR7 mediate the transmigration of Zika-infected monocytes through the blood-brain barrier

(2019) Gabriel Costa de Carvalho et al.   IMMUNOBIOLOGY

Selective Disruption of the Blood–Brain Barrier by Zika Virus

(2019) Ana Rachel Leda et al.   Frontiers in Microbiology

Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells

(2019) Nilda Vanesa Ayala-Nunez et al.   Nature Communications

High susceptibility, viral dynamics and persistence of South American Zika virus in New World monkey species

(2019) Neil Berry et al.   Scientific Reports

Analysis of the immunological biomarker profile during acute Zika virus infection reveals the overexpression of CXCL10, a chemokine linked to neuronal damage

(2018) Felipe Gomes Naveca et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Brain microvascular endothelial-astrocyte cell responses following Japanese encephalitis virus infection in an in vitro human blood-brain barrier model

(2018) Adjanie Patabendige et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Neuroimmune Axes of the Blood–Brain Barriers and Blood–Brain Interfaces: Bases for Physiological Regulation, Disease States, and Pharmacological Interventions

(2018) Michelle A. Erickson et al.   PHARMACOLOGICAL REVIEWS

The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: A case series

(2018) Ravi Mehta et al.   PLoS Neglected Tropical Diseases

Interleukin 6-Mediated Endothelial Barrier Disturbances Can Be Attenuated by Blockade of the IL6 Receptor Expressed in Brain Microvascular Endothelial Cells

(2018) Kinga G. Blecharz-Lang et al.   Translational Stroke Research

IP-10 Promotes Blood–Brain Barrier Damage by Inducing Tumor Necrosis Factor Alpha Production in Japanese Encephalitis

(2018) Ke Wang et al.   Frontiers in Immunology

Evolution of Two Major Zika Virus Lineages: Implications for Pathology, Immune Response, and Vaccine Development

(2018) Jacob T. Beaver et al.   Frontiers in Immunology

AXL promotes Zika virus infection in astrocytes by antagonizing type I interferon signalling

(2018) Jian Chen et al.   Nature Microbiology

The emergence of Zika virus and its new clinical syndromes

(2018) Theodore C. Pierson et al.   NATURE

Ocular Manifestations of Emerging Flaviviruses and the Blood-Retinal Barrier

(2018) Sneha Singh et al.   Viruses-Basel

Cell-adhesion molecules and their soluble forms: Promising predictors of “tumor progression” and relapse in leukemia

(2018) Ieda Cristina Cunha Ferreira e Fonseca et al.   TUMOR BIOLOGY

Zika virus induces strong inflammatory responses and impairs homeostasis and function of the human retinal pigment epithelium

(2018) Yannick Simonin et al.   EBioMedicine

High dengue virus load differentially modulates human microvascular endothelial barrier function during early infection

(2017) Hui Jen Soe et al.   JOURNAL OF GENERAL VIROLOGY

Zika virus infection of cellular components of the blood-retinal barriers: implications for viral associated congenital ocular disease

(2017) Tracoyia Roach et al.   Journal of Neuroinflammation

Animal Models of Zika Virus Infection, Pathogenesis, and Immunity

(2017) Thomas E. Morrison et al.   JOURNAL OF VIROLOGY

Zika Virus Persistently Infects and Is Basolaterally Released from Primary Human Brain Microvascular Endothelial Cells

(2017) Megan C. Mladinich et al.   mBio

Consequences of congenital Zika virus infection

(2017) Derek J Platt et al.   Current Opinion in Virology

Differential virulence between Asian and African lineages of Zika virus

(2017) Yannick Simonin et al.   PLoS Neglected Tropical Diseases

Zika Virus Infects, Activates, and Crosses Brain Microvascular Endothelial Cells, without Barrier Disruption

(2017) Michelle P. Papa et al.   Frontiers in Microbiology

Neurologic Complications Associated With the Zika Virus in Brazilian Adults

(2017) Ivan Rocha Ferreira da Silva et al.   JAMA Neurology

Zika virus targets blood monocytes

(2017) Kellie Ann Jurado et al.   Nature Microbiology

A Three-Dimensional Cell Culture System To Model RNA Virus Infections at the Blood-Brain Barrier

(2017) John C. Bramley et al.   mSphere

Osteopontin facilitates West Nile virus neuroinvasion via neutrophil “Trojan horse” transport

(2017) Amber M. Paul et al.   Scientific Reports

Mechanisms of restriction of viral neuroinvasion at the blood–brain barrier

(2016) Jonathan J Miner et al.   CURRENT OPINION IN IMMUNOLOGY

ALCAM (CD166) is involved in extravasation of monocytes rather than T cells across the blood–brain barrier

(2016) Ruth Lyck et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

In vitro models of the blood–brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use

(2016) Hans C Helms et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Encephalitic Arboviruses: Emergence, Clinical Presentation, and Neuropathogenesis

(2016) Hamid Salimi et al.   Neurotherapeutics

Stem Cell-Based Human Blood–Brain Barrier Models for Drug Discovery and Delivery

(2016) S. Aday et al.   TRENDS IN BIOTECHNOLOGY

Zika Virus Infection in Mice Causes Panuveitis with Shedding of Virus in Tears

(2016) Jonathan J. Miner et al.   Cell Reports

Zika Virus Strains Potentially Display Different Infectious Profiles in Human Neural Cells

(2016) Yannick Simonin et al.   EBioMedicine

In vitro discrimination of the role of LRP1 at the BBB cellular level: Focus on brain capillary endothelial cells and brain pericytes

(2015) Pietra Candela et al.   BRAIN RESEARCH

Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier

(2015) Michael Abadier et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

In Vitro Blood–Brain Barrier Models—An Overview of Established Models and New Microfluidic Approaches

(2015) Anette Wolff et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier

(2015) Helen M. Lazear et al.   Science Translational Medicine

Serum levels of soluble vascular cell adhesion molecules may correlate with the severity of dengue virus-1 infection in adults

(2015) Baolin Liao et al.   Emerging Microbes & Infections

Drak2 Contributes to West Nile Virus Entry into the Brain and Lethal Encephalitis

(2014) S. Wang et al.   JOURNAL OF IMMUNOLOGY

Expression of Neuronal CXCL10 Induced by Rabies Virus Infection Initiates Infiltration of Inflammatory Cells, Production of Chemokines and Cytokines, and Enhancement of Blood-Brain Barrier Permeability

(2014) Qingqing Chai et al.   JOURNAL OF VIROLOGY

A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells

(2014) Romeo Cecchelli et al.   PLoS One

West Nile Virus-Induced Cell Adhesion Molecules on Human Brain Microvascular Endothelial Cells Regulate Leukocyte Adhesion and Modulate Permeability of the In Vitro Blood-Brain Barrier Model

(2014) Kelsey Roe et al.   PLoS One

Viral Pathogen-Associated Molecular Patterns Regulate Blood-Brain Barrier Integrity via Competing Innate Cytokine Signals

(2014) B. P. Daniels et al.   mBio

Infection of Pericytes In Vitro by Japanese Encephalitis Virus Disrupts the Integrity of the Endothelial Barrier

(2013) C.-J. Chen et al.   JOURNAL OF VIROLOGY

Inflammatory cell trafficking across the blood-brain barrier: chemokine regulation and in vitro models

(2012) Yukio Takeshita et al.   IMMUNOLOGICAL REVIEWS

Differential Regulation of CD4+ T Cell Adhesion to Cerebral Microvascular Endothelium by the β-Chemokines CCL2 and CCL3

(2012) Kenneth Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Infection of human pericytes by HIV-1 disrupts the integrity of the blood-brain barrier

(2012) Shinsuke Nakagawa et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Infectious Agents and Neurodegeneration

(2012) Giovanna De Chiara et al.   MOLECULAR NEUROBIOLOGY

Capture, crawl, cross: the T cell code to breach the blood–brain barriers

(2012) Britta Engelhardt et al.   TRENDS IN IMMUNOLOGY

Improved Survival, Vascular Differentiation and Wound Healing Potential of Stem Cells Co-Cultured with Endothelial Cells

(2011) Dora C. S. Pedroso et al.   PLoS One

Dengue hemorrhagic fever-associated immunomediators induced via maturation of dengue virus nonstructural 4B protein in monocytes modulate endothelial cell adhesion molecules and human microvascular endothelial cells permeability

(2011) James F. Kelley et al.   VIROLOGY

Differential Roles for Endothelial ICAM-1, ICAM-2, and VCAM-1 in Shear-Resistant T Cell Arrest, Polarization, and Directed Crawling on Blood-Brain Barrier Endothelium

(2010) O. Steiner et al.   JOURNAL OF IMMUNOLOGY

A Paradoxical Role for Neutrophils in the Pathogenesis of West Nile Virus

(2010) Fengwei Bai et al.   JOURNAL OF INFECTIOUS DISEASES

A hitchhiker's guide to the nervous system: the complex journey of viruses and toxins

(2010) Sara Salinas et al.   NATURE REVIEWS MICROBIOLOGY

Review: Leucocyte-endothelial cell crosstalk at the blood-brain barrier: A prerequisite for successful immune cell entry to the brain

(2010) J. Greenwood et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Expression of Chemokines and Their Receptors by Human Brain Endothelium: Implications for Multiple Sclerosis

(2009) Eve A. Subileau et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The blood–brain barrier and immune function and dysfunction

(2009) William A. Banks et al.   NEUROBIOLOGY OF DISEASE

West Nile virus infection modulates human brain microvascular endothelial cells tight junction proteins and cell adhesion molecules: Transmigration across the in vitro blood-brain barrier

(2009) Saguna Verma et al.   VIROLOGY

The blood-brain barrier in the cerebrum is the initial site for the Japanese encephalitis virus entering the central nervous system

(2008) Tsan-Hsiun Liu et al.   JOURNAL OF NEUROVIROLOGY

ICAM-1 Participates in the Entry of West Nile Virus into the Central Nervous System

(2008) J. Dai et al.   JOURNAL OF VIROLOGY