Advances with RNAi-Based Therapy for Hepatitis B Virus Infection

Epidermal growth factor receptor is a host-entry cofactor triggering hepatitis B virus internalization

(2019) Masashi Iwamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent advances in the development of HBV capsid assembly modulators

(2019) Bhavitavya Nijampatnam et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

A global scientific strategy to cure hepatitis B

(2019) Peter A Revill et al.   Lancet Gastroenterology & Hepatology

RNA Interference Therapy with ARC‐520 Results in Prolonged HBsAg Response in Patients with Chronic Hepatitis B Infection

(2019) Man‐Fung Yuen et al.   HEPATOLOGY

The machinery for endocytosis of epidermal growth factor receptor coordinates the transport of incoming hepatitis B virus to the endosomal network

(2019) Masashi Iwamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metazoan MicroRNAs

(2018) David P. Bartel   CELL

Hepatitis B virus sensitivity to interferon-α in hepatocytes is more associated with cellular interferon response than with viral genotype

(2018) Fang Shen et al.   HEPATOLOGY

Gene Therapy in Lipoprotein Lipase Deficiency: Case Report on the First Patient Treated with Alipogene Tiparvovec Under Daily Practice Conditions

(2018) Ursula Kassner et al.   HUMAN GENE THERAPY

Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates

(2018) Donald J. Foster et al.   MOLECULAR THERAPY

Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo

(2018) Matthew R Hassler et al.   NUCLEIC ACIDS RESEARCH

Flap endonuclease 1 is involved in cccDNA formation in the hepatitis B virus

(2018) Kouichi Kitamura et al.   PLoS Pathogens

Influence of Pre-existing Anti-capsid Neutralizing and Binding Antibodies on AAV Vector Transduction

(2018) Zachary Fitzpatrick et al.   Molecular Therapy-Methods & Clinical Development

Regulation of microRNA biogenesis and its crosstalk with other cellular pathways

(2018) Thomas Treiber et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chronic hepatitis B genotype E in African migrants: response to nucleos(t)ide treatment in real clinical practice

(2018) José Ángel Cuenca-Gómez et al.   BMC INFECTIOUS DISEASES

Serum HBV RNA: a New Potential Biomarker for Chronic Hepatitis B Virus Infection

(2018) Shi Liu et al.   HEPATOLOGY

Serum hepatitis B core-related antigen (HBcrAg) correlates with covalently closed circular DNA transcriptional activity in chronic hepatitis B patients

(2018) Barbara Testoni et al.   JOURNAL OF HEPATOLOGY

Immunomodulatory Function of HBeAg Related to Short-Sighted Evolution, Transmissibility, and Clinical Manifestation of Hepatitis B Virus

(2018) Anna Kramvis et al.   Frontiers in Microbiology

Identification of liver-specific enhancer–promoter activity in the 3′ untranslated region of the wild-type AAV2 genome

(2017) Grant J Logan et al.   NATURE GENETICS

Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates

(2017) Jayaprakash K. Nair et al.   NUCLEIC ACIDS RESEARCH

RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg

(2017) Christine I. Wooddell et al.   Science Translational Medicine

Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques

(2017) Benjamin J. Burwitz et al.   Nature Communications

Sustained Inhibition of HBV Replication In Vivo after Systemic Injection of AAVs Encoding Artificial Antiviral Primary MicroRNAs

(2017) Mohube Betty Maepa et al.   Molecular Therapy-Nucleic Acids

Enhanced antiviral and antifibrotic effects of short hairpin RNAs targeting HBV and TGF-β in HBV-persistent mice

(2017) Lei Ye et al.   Scientific Reports

Adeno-Associated Virus Overexpression of Angiotensin-Converting Enzyme-2 Reverses Diabetic Retinopathy in Type 1 Diabetes in Mice

(2016) James M. Dominguez et al.   AMERICAN JOURNAL OF PATHOLOGY

Blocking sense‐strand activity improves potency, safety and specificity of anti‐hepatitis B virus short hairpin RNA

(2016) Thomas Michler et al.   EMBO Molecular Medicine

Progress With Developing Use of Gene Editing To Cure Chronic Infection With Hepatitis B Virus

(2016) Abdullah Ely et al.   MOLECULAR THERAPY

Development of Patient-specific AAV Vectors After Neutralizing Antibody Selection for Enhanced Muscle Gene Transfer

(2016) Chengwen Li et al.   MOLECULAR THERAPY

Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor

(2016) Adrien Decorsière et al.   NATURE

Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV Replication

(2016) Christopher M. Murphy et al.   Cell Reports

AAV ancestral reconstruction library enables selection of broadly infectious viral variants

(2015) J Santiago-Ortiz et al.   GENE THERAPY

HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B

(2015) Michael Nassal   GUT

Inhibition of replication of hepatitis B virus in transgenic mice following administration of hepatotropic lipoplexes containing guanidinopropyl-modified siRNAs

(2015) Musa D. Marimani et al.   JOURNAL OF CONTROLLED RELEASE

Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas

(2015) Jean-Charles Nault et al.   NATURE GENETICS

Towards a molecular understanding of microRNA-mediated gene silencing

(2015) Stefanie Jonas et al.   NATURE REVIEWS GENETICS

Adeno-Associated Virus Vector Mediated Delivery of the HBV Genome Induces Chronic Hepatitis B Virus Infection and Liver Fibrosis in Mice

(2015) Lei Ye et al.   PLoS One

Alleviation of off-target effects from vector-encoded shRNAs via codelivered RNA decoys

(2015) Stefan Mockenhaupt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Silico Reconstruction of the Viral Evolutionary Lineage Yields a Potent Gene Therapy Vector

(2015) Eric Zinn et al.   Cell Reports

The Chimpanzee Model for Hepatitis B Virus Infection

(2015) S. F. Wieland   Cold Spring Harbor Perspectives in Medicine

Sustained inhibition of hepatitis B virus replication in vivo using RNAi-activating lentiviruses

(2014) D Ivacik et al.   GENE THERAPY

Hepatitis B virus infection enhances susceptibility toward adeno-associated viral vector transductionin vitroandin vivo

(2014) Marianna Hösel et al.   HEPATOLOGY

Genotypes and Genetic Variability of Hepatitis B Virus

(2014) Anna Kramvis   INTERVIROLOGY

Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

(2014) Jayaprakash K. Nair et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Non-viral vectors for gene-based therapy

(2014) Hao Yin et al.   NATURE REVIEWS GENETICS

Regulation of microRNA biogenesis

(2014) Minju Ha et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses

(2014) Christian Königer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of hepatitis B virus replication in cultured cells and in vivo using 2′-O-guanidinopropyl modified siRNAs

(2013) Musa D. Marimani et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hepatitis B and D Viruses Exploit Sodium Taurocholate Co-transporting Polypeptide for Species-Specific Entry into Hepatocytes

(2013) Yi Ni et al.   GASTROENTEROLOGY

Hepatocyte-targeted RNAi Therapeutics for the Treatment of Chronic Hepatitis B Virus Infection

(2013) Christine I Wooddell et al.   MOLECULAR THERAPY

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

(2013) Meritxell Huch et al.   NATURE

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

Selection and evaluation of clinically relevant AAV variants in a xenograft liver model

(2013) Leszek Lisowski et al.   NATURE

Overcoming Preexisting Humoral Immunity to AAV Using Capsid Decoys

(2013) F. Mingozzi et al.   Science Translational Medicine

A conformational heparan sulfate binding site essential to infectivity overlaps with the conserved hepatitis B virus A-determinant

(2012) Camille Sureau et al.   HEPATOLOGY

The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus

(2012) Tassilo Volz et al.   JOURNAL OF HEPATOLOGY

Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

(2012) Huan Yan et al.   eLife

Adeno-Associated Virus Antibody Profiles in Newborns, Children, and Adolescents

(2011) Roberto Calcedo et al.   Clinical and Vaccine Immunology

tRNALys3 promoter cassettes that efficiently express RNAi-activating antihepatitis B virus short hairpin RNAs

(2010) Victoria Dyer et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RNA Interference inhibits Hepatitis B Virus of different genotypes in Vitro and in Vivo

(2010) Ya-Li Zhang et al.   BMC MICROBIOLOGY

Quantitative assessment of the antiviral potencies of 21 shRNA vectors targeting conserved, including structured, hepatitis B virus sites

(2010) Dianxing Sun et al.   JOURNAL OF HEPATOLOGY

Hepatitis B virus genotype and basal core promoter/precore mutations are associated with hepatitis B-related acute-on-chronic liver failure without pre-existing liver cirrhosis

(2010) X. Ren et al.   JOURNAL OF VIRAL HEPATITIS

The Size of the Viral Inoculum Contributes to the Outcome of Hepatitis B Virus Infection

(2009) S. Asabe et al.   JOURNAL OF VIROLOGY

A Genetic Variant of Hepatitis B Virus Divergent from Known Human and Ape Genotypes Isolated from a Japanese Patient and Provisionally Assigned to New Genotype J

(2009) K. Tatematsu et al.   JOURNAL OF VIROLOGY

Controlling HBV Replicationin Vivoby Intravenous Administration of Triggered PEGylated siRNA-Nanoparticles

(2009) Sergio Carmona et al.   MOLECULAR PHARMACEUTICS

Efficient silencing of gene expression with modular trimeric Pol II expression cassettes comprising microRNA shuttles

(2009) A. Ely et al.   NUCLEIC ACIDS RESEARCH

Expressed Anti-HBV Primary MicroRNA Shuttles Inhibit Viral Replication Efficiently In Vitro and In Vivo

(2008) Abdullah Ely et al.   MOLECULAR THERAPY

Comparative Study of Anti-hepatitis B Virus RNA Interference by Double-stranded Adeno-associated Virus Serotypes 7, 8, and 9

(2008) Chun-Chi Chen et al.   MOLECULAR THERAPY

Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein

(2008) Joerg Petersen et al.   NATURE BIOTECHNOLOGY