Article
Biochemistry & Molecular Biology
Perla Graciela Rodriguez-Gutierrez, Ana Gabriela Colima-Fausto, Paola Montserrat Zepeda-Olmos, Teresita De Jesus Hernandez-Flores, Juan Ramon Gonzalez-Garcia, Maria Teresa Magana-Torres
Summary: This study aimed to describe the biochemical-clinical characteristics of patients with primary hypertriglyceridemia in Mexico and investigate the variants in APOA5, GPIHBP1, LMF1, and LPL genes. The main findings include hypoalphalipoproteinemia, pancreatitis, and a median triglyceride value of 773.9 mg/dL in the patients. A total of 74 variants were found, of which 15 could be involved in the development of primary hypertriglyceridemia. A Mexican patient with hyperchylomicronemia syndrome due to GPIHBP1 deficiency was also reported.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Jose Rioja, Maria Jose Ariza, Maria Jose Benitez-Toledo, Javier Espildora-Hernandez, Inmaculada Coca-Prieto, Teresa Arrobas-Velilla, Ana Camacho, Gunilla Olivecrona, Miguel Angel Sanchez-Chaparro, Pedro Valdivielso
Summary: This study aimed to establish and validate cut-off points for the diagnosis of familial chylomicronemia syndrome (FCS) based on the ROC curve. The results showed that all FCS patients had post-heparin plasma lipoprotein lipase (LPL) activity below 25.1 mU/mL, with no overlap between FCS and multifactorial chylomicronemia syndrome (MCS) groups. Therefore, in addition to genetic testing, LPL activity in subjects with severe hypertriglyceridemia can serve as a reliable criterion for FCS diagnosis with a cut-off of 25.1 mU/mL.
JOURNAL OF CLINICAL LIPIDOLOGY
(2023)
Review
Endocrinology & Metabolism
Bhuvana Sunil, Christy Foster, Don P. Wilson, Ambika P. Ashraf
Summary: Landmark studies have shown that atherosclerosis begins in youth and more youth with lipid and lipoprotein disorders are being identified through screening. Existing lipid-lowering therapy for youth is safe but response may vary, indicating a need for new agents and approaches. Clinical trials on novel therapeutic agents for cholesterol and triglycerides are ongoing in youth, with a focus on altering lipid and lipoprotein metabolism.
THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Franklin Hanna Rodriguez, Jorge Mario Estrada, Henry Mauricio Arenas Quintero, Juan Patricio Nogueira, Gloria Liliana Porras-Hurtado
Summary: This study describes a screening program and its results for severe hypertriglyceridemia in Colombia. Among the 2415 patients screened, only one patient was diagnosed with familial chylomicronemia syndrome. The study suggests that more programs of this nature should be developed in the region, given the increasing importance of early detection of this metabolic disorder.
LIPIDS IN HEALTH AND DISEASE
(2023)
Review
Physiology
Lorand Kiss, Gabriella Fur, Sailaja Pisipati, Prasad Rajalingamgari, Nils Ewald, Vijay Singh, Zoltan Rakonczay
Summary: Hypertriglyceridemia (HTG) is a metabolic disorder characterized by high levels of triglycerides in the blood, and it increases the risk of acute pancreatitis (AP). This review discusses the pathophysiology of HTG-induced AP and the role of fatty acids in causing the consequences of HTG during AP. Experimental results suggest that reducing fatty acid production through lipase inhibitors may offer new therapeutic options for AP.
Review
Immunology
Shiyu Liu, Peter Szatmary, Jing-wen Lin, Qiqi Wang, Robert Sutton, Lu Chen, Tingting Liu, Wei Huang, Qing Xia
Summary: Acute pancreatitis is a common gastrointestinal disease characterized by acute onset of abdominal pain, often leading to organ failure and death. Monocytes, a type of cells in the innate immune system, are highlighted as key contributors and regulators of the inflammatory response and organ failure in acute pancreatitis, with a special focus on lipid modulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Vishnu Priya Pulipati, Ambika Amblee, Sara Elizabeth T. Yap, Hafeez Shaka, Bettina Tahsin, Leon Fogelfeld
Summary: The study retrospectively analyzed the response to continuous insulin infusion in adults with hypertriglyceridemia-associated acute pancreatitis, finding that 95% of patients achieved the defined TG goal, with half reaching it within 36 hours. Results indicated that absence of diabetes mellitus, lower BMI, and initial TG level were predictors of a faster response in serum triglycerides.
Article
Biochemistry & Molecular Biology
Xiaomin Hu, Liang Gong, Ruilin Zhou, Ziying Han, Li Ji, Yan Zhang, Shuyang Zhang, Dong Wu
Summary: HTGAP patients have higher rates of severe AP, organ failure, and longer hospital stays compared to non-HTGAP patients. Changes in gut microbiota are associated with disease severity and poor prognosis in HTGAP patients, suggesting a potential link between gut microbiota and hypertriglyceridemia-related acute pancreatitis.
Review
Pediatrics
John M. Grisham, Andrew H. Tran, Kate Ellery
Summary: Severe hypertriglyceridemia-induced acute pancreatitis (HTG-AP) is less common in pediatric patients compared to adults, but evidence suggests it can be associated with more severe course and complications. Treatment involves inpatient management, dietary modification, and long-term interventions. Evidence-based management guidelines for pediatric patients have not been well established.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pediatrics
Goolla Akhila, Ipsita Sahoo, Debashree Priyadarshini, Mrutunjay Dash
Summary: Hypertriglyceridemic pancreatitis is a rare but significant cause of pancreatitis in children, often associated with more severity and complications. In this case, a child with hypertriglyceridemic pancreatitis was successfully managed with intravenous insulin. Previous studies have shown the effectiveness of intravenous insulin in hypertriglyceridemic pancreatitis in adults, and there have been a few reports mentioning its use in children with diabetic ketoacidosis and hypertriglyceridemia. The authors found intravenous insulin to be highly effective in managing severe hypertriglyceridemic pancreatitis in this child.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Endocrinology & Metabolism
Walter Masson, Leandro Barbagelata, Milagros Fleitas, Nicole Herzkovich, Eliana Kerschner, Emiliano Rossi, Daniel Siniawski, Mar ia V. Ami, Juan P. Nogueira
Summary: This study presents the development and results of a screening program for FCS in Argentina. The program includes three stages: reviewing electronic records and identifying laboratory cases, categorizing suspected clinical cases and applying the FCS score, and performing genetic tests in probable cases. Although no patients were diagnosed with FCS, the importance of early detection of this metabolic disorder should not be overlooked, and more programs of this nature should be developed in our region.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2023)
Review
Medicine, General & Internal
Minhao Qiu, Xiaoying Zhou, Maddalena Zippi, Hemant Goyal, Zarrin Basharat, Mateusz Jagielski, Wandong Hong
Summary: This article provides an overview of the relationship between hypertriglyceridemia-associated acute pancreatitis (HTAP) and discusses various pathological mechanisms that may contribute to the development or exacerbation of HTAP.
ANNALS OF MEDICINE
(2023)
Review
Medicine, General & Internal
Manasvi Gupta, Besiana Liti, Christopher Barrett, Paul D. Thompson, Antonio B. Fernandez
Summary: Severe gestational hypertriglyceridemia can lead to acute pancreatitis, with a maternal mortality rate of approximately 20%. The recent recommendations from the National Lipid Association provide guidance on monitoring pregnant women at high risk for hyperlipidemia. It is suggested that high-risk women have their triglyceride levels checked once every trimester and follow appropriate treatment based on the results.
AMERICAN JOURNAL OF MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Lu Wang, Ting Xu, Ruifeng Wang, Xiaobing Wang, Dong Wu
Summary: In recent years, the number of acute pancreatitis cases caused by hypertriglyceridemia has been increasing, but the exact mechanism remains unclear, posing challenges for treatment and prevention. Animal models have become crucial for understanding and treating this disease, with researchers investigating different animal models and methods for studying hypertriglyceridemic acute pancreatitis.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Multidisciplinary Sciences
Lingling Tang, Lin Ma, Yuying Chen, Yuntao Hu, Xinyue Chen, Xiaohua Huang, Nian Liu
Summary: This study investigated the predictive value of radiomics based on T1-weighted contrast-enhanced MRI in forecasting the recurrence of acute pancreatitis. A radiomics model was constructed and compared with a clinical model, showing that the radiomics model had higher accuracy in predicting the recurrence of acute pancreatitis.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Dominik Spira, Nikolaus Buchmann, Marcus Doerr, Marcello R. P. Markus, Matthias Nauck, Sabine Schipf, Joachim Spranger, Ilja Demuth, Elisabeth Steinhagen-Thiessen, Henry Voelzke, Till Ittermann
Summary: The study found a consistent association between fT3 and almost all markers of insulin resistance, but this effect appears to diminish with age, indicating a potential age-related modification of the interaction between thyroid function and glucose metabolism. Further studies are needed to clarify causal relationships.
EUROPEAN THYROID JOURNAL
(2022)
Article
Gerontology
Hans-Werner Wahl, Johanna Drewelies, Sandra Duezel, Margie E. Lachman, Jacqui Smith, Peter Eibich, Elisabeth Steinhagen-Thiessen, Ilja Demuth, Ulman Lindenberger, Gert G. Wagner, Nilam Ram, Denis Gerstorf
Summary: Comparing two independent studies of older adults, it was found that there is no evidence to suggest that today's older adults have more positive views on aging than older adults did two decades ago. The subjective views on aging have not improved over time, and there is a possibility that individual age views have become increasingly decoupled from societal age views.
PSYCHOLOGY AND AGING
(2022)
Article
Clinical Neurology
Anne Fink, Achim Doerre, Ilja Demuth, Gabriele Doblhammer
Summary: This study assessed the impact of diabetes prevention strategies on the future number of dementia patients in Germany. The results showed that a relative reduction in death rates and dementia incidence in the non-diabetic population would increase the number of dementia cases to 3.38 million by 2040. However, a relative reduction in diabetes incidence and dementia incidence among diabetes patients would result in a decrease in dementia cases by 240,000.
Article
Medicine, General & Internal
Nikolaus Buchmann, Till Ittermann, Ilja Demuth, Marcello R. P. Markus, Henry Voelzke, Marcus Doerr, Nele Friedrich, Markus M. Lerch, Raul D. Santos, Sabine Schipf, Elisabeth Steinhagen-Thiessen
Summary: There is an inverse association between MetS and Lp(a), but this association is weaker in premenopausal women, possibly due to hormonal factors and menopausal alterations.
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2022)
Article
Geriatrics & Gerontology
Regina von Rennenberg, Thomas Liman, Christian H. Nolte, Alexander H. Nave, Jan F. Scheitz, Sandra Duezel, Vera Regitz-Zagrosek, Denis Gerstorf, Elisabeth Steinhagen-Thiessen, Ilja Demuth, Matthias Endres
Summary: There is evidence of an association between levels of high-sensitivity cardiac troponin T (hs-cTnT) and cognitive decline in older men, as measured by the Digit Symbol Substitution Test (DSST). This association remained significant even after adjusting for age, sex, education, and cardiovascular risk factors. However, there was no significant association between hs-cTnT and different cognitive domains at baseline.
Article
Psychology, Multidisciplinary
Denis Gerstorf, Nilam Ram, Johanna Drewelies, Sandra Duezel, Peter Eibich, Elisabeth Steinhagen-Thiessen, Stefan Liebig, Jan Goebel, Ilja Demuth, Arno Villringer, Gert G. Wagner, Ulman Lindenberger, Paolo Ghisletta
Summary: Increases in older adults' levels of cognitive performance over time have been documented in history, but there is little information about historical shifts in within-person cognitive decline and onset of decline. A study comparing data from two independent samples recruited in 1990 and 2010 found that although cognitive functioning has shifted to higher levels, there was no evidence of cohort differences in the amount or rate of decline and the onset of decline. This suggests that cognitive decline in old age proceeds similarly to two decades ago.
PSYCHOLOGICAL SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Kymberleigh A. Romano, Ina Nemet, Prasenjit Prasad Saha, Arash Haghikia, Xinmin S. Li, Maradumane L. Mohan, Beth Lovano, Laurie Castel, Marco Witkowski, Jennifer A. Buffa, Yu Sun, Lin Li, Christopher M. Menge, Ilja Demuth, Maximilian Koenig, Elisabeth Steinhagen-Thiessen, Joseph A. DiDonato, Arjun Deb, Fredrik Baeckhed, W. H. Wilson Tang, Sathyamangla Venkata Naga Prasad, Ulf Landmesser, David R. Van Wagoner, Stanley L. Hazen
Summary: A study found that the gut microbiota-dependent metabolite PAGln is associated with the presence and severity of heart failure both clinically and mechanistically. The circulating levels of PAGln are dose-dependently correlated with heart failure presence and indices of severity. It was also found that PAGln directly promotes heart failure-related phenotypes. Modulating the gut microbiome and PAGln production may be a potential therapeutic target for heart failure.
CIRCULATION-HEART FAILURE
(2023)
Article
Peripheral Vascular Disease
Engi Abdel-Hady Algharably, Linda Elizabeth Villagomez Fuentes, Sarah Toepfer, Maximilian Konig, Vera Regitz-Zagrosek, Lars Bertram, Juliane Bolbrinker, Ilja Demuth, Reinhold Kreutz
Summary: Genetic variants in the UMOD gene are associated with kidney function and hypertension, with possible sex-specific effects. This study found that a specific UMOD variant was linked to kidney function and physical function in older men, while also affecting hypertension prevalence in women.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Geriatrics & Gerontology
Sophie Potter, Sandra Duezel, Ilja Demuth, Denis Gerstorf, Johanna Drewelies
Summary: This study investigated the impact of the pandemic on health sensitivity among older adults in Germany, and found that older adults were more health sensitive when they perceived a greater risk of contracting COVID-19.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2023)
Article
Oncology
Verena Laura Banszerus, Maximilian Koenig, Ulf Landmesser, Valentin Max Vetter, Ilja Demuth
Summary: This study analyzed 779 participants who underwent diagnostic angiography and found that DNAmAA is associated with the presence of coronary artery disease, with this association being mainly driven by sex.
CLINICAL EPIGENETICS
(2023)
Article
Medicine, Research & Experimental
Valentin Max Vetter, Johanne Spieker, Yasmine Sommerer, Nikolaus Buchmann, Christian Humberto Kalies, Vera Regitz-Zagrosek, Lars Bertram, Ilja Demuth
Summary: Deterioration of vision, kidney function, and cardiovascular function are examples of diabetes-related complications. A biomarker based on reversible modifications of DNA can predict the development of complications in patients with diabetes over a seven-year period. This finding may help identify high-risk patients and improve targeted prevention.
COMMUNICATIONS MEDICINE
(2023)
Meeting Abstract
Geriatrics & Gerontology
Ilja Demuth, Valentin Vetter, Johanna Drewelies, Sandra Duezel, Dominik Spira, Elisabeth Steinhagen-Thiessen, Lars Bertram, Denis Gerstorf
INNOVATION IN AGING
(2022)
Meeting Abstract
Geriatrics & Gerontology
Johanna Drewelies, Sandra Duezel, Ilja Demuth, Elisabeth Steinhagen-Thiessen, Ulman Lindenberger, Jan Goebel, Gertraud Stadler, Denis Gerstorf
INNOVATION IN AGING
(2022)
Meeting Abstract
Geriatrics & Gerontology
Sandra Duezel, Johanna Drewelies, Ulman Lindenberger, Elisabeth Steinhagen-Thiessen, Ilja Demuth, Simone Kuhn
INNOVATION IN AGING
(2022)
Article
Psychology, Clinical
Frank Kroll, Stephanie Birgit Kossow, Ingrid Mundt, Anna Konrad, Alfred Pauls, Ilja Demuth, Klaus Michael Beier, Matthias Ziegler
Summary: Partnership quality is important for physical and psychological health. The Q-SEx-PaQ questionnaire, developed as part of the Berlin Aging Study, assesses the main dimensions of sexuality and partnership quality. This study analyzed data from younger and older participants and found satisfactory reliability and factorial validity of the Q-SEx-PaQ scores.
SEXUAL AND RELATIONSHIP THERAPY
(2022)
