The Contribution of Neutrophils to the Pathogenesis of RSV Bronchiolitis

RSV Infection Promotes Necroptosis and HMGB1 Release by Airway Epithelial Cells

(2020) Jennifer Simpson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Immune profiles provide insights into respiratory syncytial virus disease severity in young children

(2020) Santtu Heinonen et al.   Science Translational Medicine

HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling

(2020) Zhixuan Loh et al.   PLoS Pathogens

Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing

(2019) Veronika Butin-Israeli et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil Degranulation, Plasticity, and Cancer Metastasis

(2019) Faustino Mollinedo   TRENDS IN IMMUNOLOGY

Biological Roles of Neutrophil-Derived Granule Proteins and Cytokines

(2019) Marco Antonio Cassatella et al.   TRENDS IN IMMUNOLOGY

Simvastatin Improves Neutrophil Function and Clinical Outcomes in Pneumonia: a Pilot Randomised Controlled Trial

(2019) Elizabeth Sapey et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Baicalein triazole prevents respiratory tract infection by RSV through suppression of oxidative damage

(2019) Cuicui Zhang et al.   MICROBIAL PATHOGENESIS

Neutrophil recruitment and activation are differentially dependent on MyD88/TRIF and MAVS signaling during RSV infection

(2019) Freja C. M. Kirsebom et al.   Mucosal Immunology

Neutrophil Diversity in Health and Disease

(2019) Carlos Silvestre-Roig et al.   TRENDS IN IMMUNOLOGY

LAIR-1 Limits Neutrophilic Airway Inflammation

(2019) Kuldeep Kumawat et al.   Frontiers in Immunology

Cell intrinsic functions of neutrophils and their manipulation by pathogens

(2019) Lee-Ann H Allen et al.   CURRENT OPINION IN IMMUNOLOGY

Locally instructed CXCR4hi neutrophils trigger environment-driven allergic asthma through the release of neutrophil extracellular traps

(2019) Coraline Radermecker et al.   NATURE IMMUNOLOGY

Reduced Nasal Viral Load and IFN Responses in Infants with RSV Bronchiolitis and Respiratory Failure

(2018) Ryan S Thwaites et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Leukotriene B4-Mediated Neutrophil Recruitment Causes Pulmonary Capillaritis during Lethal Fungal Sepsis

(2018) Esther K.S. Lee et al.   Cell Host & Microbe

Neutrophil Extracellular Traps: The Biology of Chromatin Externalization

(2018) Gabriel Sollberger et al.   DEVELOPMENTAL CELL

Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions

(2018) Maximilien Evrard et al.   IMMUNITY

LAIR-1 limits neutrophil extracellular trap formation in viral bronchiolitis

(2018) Ruben J. Geerdink et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

S100A9 gene silencing inhibits the release of pro-inflammatory cytokines by blocking the IL-17 signalling pathway in mice with acute pancreatitis

(2018) Dong-Mei Wu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

An in vitro transepithelial migration assay to evaluate the role of neutrophils in Respiratory Syncytial Virus (RSV) induced epithelial damage

(2018) Yu Deng et al.   Scientific Reports

The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils

(2018) Akshay A. D’Cruz et al.   Science Signaling

Respiratory Syncytial Virus induces the classical ROS-dependent NETosis through PAD-4 and necroptosis pathways activation

(2018) Stéfanie P. Muraro et al.   Scientific Reports

Role of viral infections in the development and exacerbation of asthma in children

(2017) Tuomas Jartti et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Plasmacytoid dendritic cells protect from viral bronchiolitis and asthma through semaphorin 4a–mediated T reg expansion

(2017) Jason P. Lynch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Danirixin: A Reversible and Selective Antagonist of the CXC Chemokine Receptor 2

(2017) Jakob Busch-Petersen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Viral bronchiolitis

(2017) Todd A Florin et al.   LANCET

Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study

(2017) Ting Shi et al.   LANCET

An emerging role for neutrophil extracellular traps in noninfectious disease

(2017) Selina K Jorch et al.   NATURE MEDICINE

Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation

(2017) Marie Toussaint et al.   NATURE MEDICINE

Neutrophil Extracellular Traps in Respiratory Disease: guided anti-microbial traps or toxic webs?

(2017) B. Cortjens et al.   Paediatric Respiratory Reviews

Animal models of respiratory syncytial virus infection

(2017) Geraldine Taylor   VACCINE

HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins

(2016) Damien Bertheloot et al.   Cellular & Molecular Immunology

IL-8/IL-17 gene variations and the susceptibility to severe viral bronchiolitis

(2016) L. A. PINTO et al.   EPIDEMIOLOGY AND INFECTION

Human neutrophils in the saga of cellular heterogeneity: insights and open questions

(2016) Patrizia Scapini et al.   IMMUNOLOGICAL REVIEWS

Azithromycin therapy during respiratory syncytial virus bronchiolitis: Upper airway microbiome alterations and subsequent recurrent wheeze

(2016) Yanjiao Zhou et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cathelicidins Have Direct Antiviral Activity against Respiratory Syncytial Virus In Vitro and Protective Function In Vivo in Mice and Humans

(2016) Silke M. Currie et al.   JOURNAL OF IMMUNOLOGY

The role of neutrophils in inflammation resolution

(2016) Hefin R. Jones et al.   SEMINARS IN IMMUNOLOGY

Respiratory Syncytial Virus and Cellular Stress Responses: Impact on Replication and Physiopathology

(2016) Sandra Cervantes-Ortiz et al.   Viruses-Basel

Novel antigens for RSV vaccines

(2015) Barney S Graham et al.   CURRENT OPINION IN IMMUNOLOGY

Randomized trial to evaluate azithromycin's effects on serum and upper airway IL-8 levels and recurrent wheezing in infants with respiratory syncytial virus bronchiolitis

(2015) Avraham Beigelman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation

(2015) Md Ashik Ullah et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Neutrophils in respiratory syncytial virus infection: A target for asthma prevention

(2015) Ruben J. Geerdink et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Neutrophil extracellular traps cause airway obstruction during respiratory syncytial virus disease

(2015) Bart Cortjens et al.   JOURNAL OF PATHOLOGY

Neutrophil trails guide influenza-specific CD8+ T cells in the airways

(2015) K. Lim et al.   SCIENCE

Matrix Metalloproteinase-9 Mediates RSV Infection in Vitro and in Vivo

(2015) Michele Kong et al.   Viruses-Basel

Animal models of respiratory syncytial virus infection and disease

(2015) Randy E Sacco et al.   Current Opinion in Virology

RSV Vaccine-Enhanced Disease Is Orchestrated by the Combined Actions of Distinct CD4 T Cell Subsets

(2015) Cory J. Knudson et al.   PLoS Pathogens

Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury

(2015) Philipp Kruger et al.   PLoS Pathogens

Secretion of S100A8, S100A9, and S100A12 by Neutrophils Involves Reactive Oxygen Species and Potassium Efflux

(2015) Mélanie R. Tardif et al.   Journal of Immunology Research

Respiratory Syncytial Virus Fusion Protein Promotes TLR-4–Dependent Neutrophil Extracellular Trap Formation by Human Neutrophils

(2015) Giselle A. Funchal et al.   PLoS One

S100A8, S100A9 and S100A12 activate airway epithelial cells to produce MUC5AC via extracellular signal-regulated kinase and nuclear factor-κB pathways

(2014) Jin Hyun Kang et al.   IMMUNOLOGY

Activation of an Immunoregulatory and Antiviral Gene Expression Program in Poly(I:C)-Transfected Human Neutrophils

(2014) N. Tamassia et al.   JOURNAL OF IMMUNOLOGY

Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens

(2014) Nora Branzk et al.   NATURE IMMUNOLOGY

Respiratory Syncytial Virus Infection and Bronchiolitis

(2014) Giovanni Piedimonte et al.   PEDIATRICS IN REVIEW

Pulmonary matrix metalloproteinase-9 activity in mechanically ventilated children with respiratory syncytial virus

(2013) M. Y. F. Kong et al.   EUROPEAN RESPIRATORY JOURNAL

Toll-like receptor 7 gene deficiency and early-life Pneumovirus infection interact to predispose toward the development of asthma-like pathology in mice

(2013) Gerard E. Kaiko et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus

(2013) Jason S. Knight et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil-Mediated IFN Activation in the Bone Marrow Alters B Cell Development in Human and Murine Systemic Lupus Erythematosus

(2013) A. Palanichamy et al.   JOURNAL OF IMMUNOLOGY

Cxcl8 (IL-8) Mediates Neutrophil Recruitment and Behavior in the Zebrafish Inflammatory Response

(2013) S. de Oliveira et al.   JOURNAL OF IMMUNOLOGY

The Respiratory Syncytial Virus Fusion Protein and Neutrophils Mediate the Airway Mucin Response to Pathogenic Respiratory Syncytial Virus Infection

(2013) K. L. Stokes et al.   JOURNAL OF VIROLOGY

Hmgb1-IL-23-IL-17-IL-6-Stat3 Axis Promotes Tumor Growth in Murine Models of Melanoma

(2013) Qiu Tang et al.   MEDIATORS OF INFLAMMATION

Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo

(2013) Tim Lämmermann et al.   NATURE

The TLR4 antagonist Eritoran protects mice from lethal influenza infection

(2013) Kari Ann Shirey et al.   NATURE

Viral Etiologies of Infant Bronchiolitis, Croup and Upper Respiratory Illness During 4 Consecutive Years

(2013) E. Kathryn Miller et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

The Human Cathelicidin LL-37 Has Antiviral Activity against Respiratory Syncytial Virus

(2013) Silke M. Currie et al.   PLoS One

Local IL-17A Potentiates Early Neutrophil Recruitment to the Respiratory Tract during Severe RSV Infection

(2013) Arie Jan Stoppelenburg et al.   PLoS One

Phase II study of a neutrophil elastase inhibitor (AZD9668) in patients with bronchiectasis

(2013) Robert Stockley et al.   RESPIRATORY MEDICINE

TAK-242, a small-molecule inhibitor of Toll-like receptor 4 signalling, unveils similarities and differences in lipopolysaccharide- and lipidinduced inflammation and insulin resistance in muscle cells

(2012) Sophie E. Hussey et al.   BIOSCIENCE REPORTS

Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice

(2012) G. M. Thomas et al.   BLOOD

Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

(2012) Bryan G Yipp et al.   NATURE MEDICINE

Neutrophil heterogeneity in health and disease: a revitalized avenue in inflammation and immunity

(2012) M. Beyrau et al.   Open Biology

Matrix Metalloprotease 9 Mediates Neutrophil Migration into the Airways in Response to Influenza Virus-Induced Toll-Like Receptor Signaling

(2012) Linda M. Bradley et al.   PLoS Pathogens

IL-17–Induced Pulmonary Pathogenesis during Respiratory Viral Infection and Exacerbation of Allergic Disease

(2011) Sumanta Mukherjee et al.   AMERICAN JOURNAL OF PATHOLOGY

Animal models of human respiratory syncytial virus disease

(2011) Reinout A. Bem et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A therapeutic role for matrix metalloproteinase inhibitors in lung diseases?

(2011) R. E. Vandenbroucke et al.   EUROPEAN RESPIRATORY JOURNAL

Respiratory syncytial virus vaccine development

(2011) Julia L Hurwitz   Expert Review of Vaccines

Plasmacytoid Dendritic Cells Promote Host Defense against Acute Pneumovirus Infection via the TLR7-MyD88-Dependent Signaling Pathway

(2011) S. Davidson et al.   JOURNAL OF IMMUNOLOGY

Respiratory Syncytial Virus Binds and Undergoes Transcription in Neutrophils From the Blood and Airways of Infants With Severe Bronchiolitis

(2011) Clare P. Halfhide et al.   JOURNAL OF INFECTIOUS DISEASES

Characterization of the Interaction between Human Respiratory Syncytial Virus and the Cell Cycle in Continuous Cell Culture and Primary Human Airway Epithelial Cells

(2011) W. Wu et al.   JOURNAL OF VIROLOGY

Early Elevation of Matrix Metalloproteinase-8 and -9 in Pediatric ARDS Is Associated with an Increased Risk of Prolonged Mechanical Ventilation

(2011) Michele Y. F. Kong et al.   PLoS One

Neutrophil-Derived Cathelicidin Protects from Neointimal Hyperplasia

(2011) O. Soehnlein et al.   Science Translational Medicine

Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity

(2010) K. D. Metzler et al.   BLOOD

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophils Influence the Level of Antigen Presentation during the Immune Response to Protein Antigens in Adjuvants

(2010) C.-W. Yang et al.   JOURNAL OF IMMUNOLOGY

Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis

(2010) Harish Nair et al.   LANCET

CXCR2 mediates NADPH oxidase–independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation

(2010) Veronica Marcos et al.   NATURE MEDICINE

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity

(2010) Thomas B Clarke et al.   NATURE MEDICINE

Neutrophil-Derived CCL3 Is Essential for the Rapid Recruitment of Dendritic Cells to the Site of Leishmania major Inoculation in Resistant Mice

(2010) Mélanie Charmoy et al.   PLoS Pathogens

Respiratory Syncytial Virus Induces Oxidative Stress by Modulating Antioxidant Enzymes

(2009) Yashoda M. Hosakote et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Evidence for a cross-talk between human neutrophils and Th17 cells

(2009) M. Pelletier et al.   BLOOD

Interferon-gamma coordinates CCL3-mediated neutrophil recruitment in vivo

(2009) Cynthia A Bonville et al.   BMC IMMUNOLOGY

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

(2009) Caroline E. Sutton et al.   IMMUNITY

The severity-dependent relationship of infant bronchiolitis on the risk and morbidity of early childhood asthma

(2009) Kecia N. Carroll et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Plasmacytoid dendritic cells during infancy are inversely associated with childhood respiratory tract infections and wheezing

(2009) John W. Upham et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

(2009) Yanming Wang et al.   JOURNAL OF CELL BIOLOGY

A Systemic Neutrophil Response Precedes Robust CD8+ T-Cell Activation during Natural Respiratory Syncytial Virus Infection in Infants

(2009) M. V. Lukens et al.   JOURNAL OF VIROLOGY

Alarmins and antimicrobial immunity

(2009) D. Yang et al.   MEDICAL MYCOLOGY

Neutrophil TLR4 expression is reduced in the airways of infants with severe bronchiolitis

(2009) C P Halfhide et al.   THORAX

Alarmins link neutrophils and dendritic cells

(2009) De Yang et al.   TRENDS IN IMMUNOLOGY

Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans

(2009) Constantin F. Urban et al.   PLoS Pathogens

Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial

(2008) Josef S Smolen et al.   LANCET

Clarithromycin Targets Neutrophilic Airway Inflammation in Refractory Asthma

(2007) Jodie L. Simpson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE