Article
Immunology
Pekka Hurme, Miisa Komulainen, Marleena Tulkki, Annamari Leino, Beate Ruckert, Riitta Turunen, Tytti Vuorinen, Mubeccel Akdis, Cezmi A. Akdis, Tuomas Jartti
Summary: The cytokine profiles of Rhinovirus (RV) and respiratory syncytial virus (RSV)-induced first wheezing episode differ, with higher cytokine expression and longer hospitalization time in the RSV group. In the RV group, increased expression of I-309 (CCL1) and TARC is associated with fewer relapses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pediatrics
Yunlian Zhou, Lin Tong, Mengyao Li, Yingshuo Wang, Lanxin Li, Dehua Yang, Yuanyuan Zhang, Zhimin Chen
Summary: The study found that RSV bronchiolitis may increase the incidence of recurrent wheezing and asthma in children, with patients who develop asthma having higher birth weight and older age of onset.
FRONTIERS IN PEDIATRICS
(2021)
Review
Pediatrics
Ming-Yue Jiang, Yu-Ping Duan, Xun-Liang Tong, Qiang-Ru Huang, Meng-Meng Jia, Wei-Zhong Yang, Lu-Zhao Feng
Summary: Cough and shortness of breath are common manifestations of respiratory syncytial virus (RSV) infection, especially more severe in infants. More attention should be given to infants in areas with low human development index (HDI) levels. The current study confirms the association between RSV infection and wheezing or recurrent wheezing illness.
WORLD JOURNAL OF PEDIATRICS
(2023)
Article
Immunology
Jonathan M. Mansbach, Ruth J. Geller, Kohei Hasegawa, Pedro A. Piedra, Vasanthi Avadhanula, James E. Gern, Yury A. Bochkov, Janice A. Espinola, Ashley F. Sullivan, Carlos A. Camargo
Summary: This study found that infants with respiratory syncytial virus (RSV) at hospitalization followed by a new rhinovirus (RV) infection had the highest risk of recurrent wheezing among severe bronchiolitis cases.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Joseph P. McGinley, Gu Lung Lin, Deniz Oner, Tanya Golubchik, Daniel O'Connor, Matthew D. Snape, Olivier Gruselle, Annefleur C. Langedijk, Joanne Wildenbeest, Peter Openshaw, Harish Nair, Jeroen Aerssens, Louis Bont, Federico Martinon-Torres, Simon B. Drysdale, Andrew J. Pollard
Summary: The study evaluated the association between the severity of RSV disease and host age, viral load, and RSV subtypes. Younger infants were more likely to have severe RSV disease, while older infants, higher viral load, and RSV-A were associated with fever. RSV-A and RSV-B caused similar disease severity.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Endocrinology & Metabolism
Dandan Mu, Xianchun Mao, Lizhen Wang
Summary: RSV-induced bronchiolitis can cause severe histological changes and inflammation, which are associated with a decrease in Treg cells and related cytokines, and an increase in Th17 cells and related cytokines. Azithromycin can effectively attenuate these symptoms by restoring the levels of Treg cells, Th17 cells, and their related cytokines.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Virology
Xin Long, Jun Xie, Luo Ren, Guangyuan Yu, Enmei Liu, Yu Deng, Xiaoru Long
Summary: IL-17A has a significant role in respiratory syncytial virus (RSV) infection and is associated with respiratory system diseases in children and mice. CD3(+)CD4(+)T cells are its major cellular sources, and the IL-6/IL-21-IL-23R-ROR gamma t signaling pathway might participate in its regulation.
Article
Medicine, General & Internal
Shimon Amar, Yonat Shemer Avni, Norm O'Rourke, Tal Michael
Summary: The study examines the incidence rates of infectious diseases after a successful COVID-19 vaccination campaign and the lifting of social restrictions in Israel. The results suggest that the rates of respiratory and gastrointestinal infections have increased, indicating that similar trends could occur in other countries.
Article
Immunology
Zaid Haddadin, Stockton Beveridge, Kailee Fernandez, Danielle A. Rankin, Varvara Probst, Andrew J. Spieker, Tiffanie M. Markus, Laura S. Stewart, William Schaffner, Mary Lou Lindegren, Natasha Halasa
Summary: Respiratory syncytial virus (RSV) is the leading cause of acute respiratory infections (ARIs) in hospitalized children. RSV-positive children were more likely to be hospitalized, require intensive care unit admission, and receive oxygen compared with children positive for other viruses. Higher viral load, White race, younger age, and higher severity score were independently associated with hospitalization in RSV-positive children.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Pediatrics
Xiaoyan Zhang, Xiang Zhang, Hui Xu, Xiaolei Tang, Shunying Zhao, Haiming Yang
Summary: Infants with higher levels of serum bilirubin at birth have a lower risk of developing recurrent wheezing after severe RSV bronchiolitis.
PEDIATRIC PULMONOLOGY
(2023)
Article
Microbiology
Kim Chiok, Swechha M. Pokharel, Indira Mohanty, Lindsay Grace Miller, Shou-Jiang Gao, Arthur L. Haas, Kim C. Tran, Michael N. Teng, Santanu Bose
Summary: Understanding the interaction between RSV and the host is crucial for developing effective interventions. This study identifies the RSV nonstructural protein NS2 as the key component in activating autophagy by modulating the ISGylation of Beclin1.
Article
Biochemistry & Molecular Biology
Jae Woo Lee, Mi Na Kim, Eun Gyul Kim, Ji Su Leem, Seung Min Baek, Min Jung Kim, Kyung Won Kim, Myung Hyun Sohn
Summary: Viral respiratory infections can cause lung diseases with inflammation. CHI3L1 protein may be involved in regulating inflammatory responses through the MAPK pathways in airway epithelial cells following viral infections.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Microbiology
Kim Chiok, Swechha M. Pokharel, Indira Mohanty, Lindsay Grace Miller, Shou-Jiang Gao, Arthur L. Haas, Kim C. Tran, Michael N. Teng, Santanu Bose
Summary: Paramyxoviruses like RSV are a leading cause of viral pneumonia in infants. This study identified the viral protein NS2 as mediating autophagy induction by RSV, providing a potential target for interventions against RSV.
Review
Pediatrics
Rosa-Maria Ukkonen, Marjo Renko, Ilari Kuitunen
Summary: This systematic review and meta-analysis aimed to analyze the efficacy of azithromycin in the treatment of acute bronchiolitis and wheezing. The findings suggest that azithromycin may reduce hospitalization duration, but it does not reduce the need for intensive care unit treatment or prevent wheezing recurrence.
PEDIATRIC RESEARCH
(2023)
Article
Medicine, General & Internal
Jocelyn Moyes, Stefano Tempia, Sibongile Walaza, Meredith L. McMorrow, Florette Treurnicht, Nicole Wolter, Anne von Gottberg, Kathleen Kahn, Adam L. Cohen, Halima Dawood, Ebrahim Variava, Cheryl Cohen
Summary: Based on a study in South African children, the burden of RSV-associated illness was estimated, with newborns and infants being the most affected group. Implementing maternal vaccination and monoclonal antibody products for this group can help reduce the disease burden.
Letter
Allergy
Kathleen A. Lee-Sarwar, Rachel S. Kelly, Jessica Lasky-Su, Robert S. Zeiger, George T. O'Connor, Megan T. Sandel, Leonard B. Bacharier, Avraham Beigelman, Sheryl L. Rifas-Shiman, Vincent J. Carey, Benjamin J. Harshfield, Nancy Laranjo, Diane R. Gold, Scott T. Weiss, Augusto A. Litonjua
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2020)
Letter
Allergy
Watcharoot Kanchongkittiphon, Nora Kabil, Leonard B. Bacharier, Maleewan Kitcharoensakkul
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2020)
Article
Allergy
Kristie R. Ross, Ritika Gupta, Mark D. DeBoer, Joe Zein, Brenda R. Phillips, David T. Mauger, Chun Li, Ross E. Myers, Wanda Phipatanakul, Anne M. Fitzpatrick, Ngoc P. Ly, Leonard B. Bacharier, Daniel J. Jackson, Juan C. Celedon, Allyson Larkin, Elliot Israel, Bruce Levy, John Fahy, Mario Castro, Eugene R. Bleecker, Deborah Meyers, Wendy C. Moore, Sally E. Wenzel, Nizar N. Jarjour, Serpil C. Erzurum, W. Gerald Teague, Benjamin Gaston
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Article
Allergy
Anne M. Fitzpatrick, Stanley J. Szefler, David T. Mauger, Brenda R. Phillips, Loren C. Denlinger, Wendy C. Moore, Ronald L. Sorkness, Sally E. Wenzel, Peter J. Gergen, Eugene R. Bleecker, Mario Castro, Serpil C. Erzurum, John Fahy, Benjamin M. Gaston, Elliot Israel, Bruce D. Levy, Deborah A. Meyers, W. Gerald Teague, Leonard B. Bacharier, Ngoc P. Ly, Wanda Phipatanakul, Kristie R. Ross, Joe Zein, Nizar N. Jarjour
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Chris McKennan, Katherine Naughton, Catherine Stanhope, Meyer Kattan, George T. O'Connor, Megan T. Sandel, Cynthia M. Visness, Robert A. Wood, Leonard B. Bacharier, Avraham Beigelman, Stephanie Lovinsky-Desir, Alkis Togias, James E. Gern, Dan Nicolae, Carole Ober
Summary: The study found that race-associated DNA methylation patterns at birth and age 7 are nearly identical, indicating that blood DNA methylation levels are primarily driven by genetic factors and less sensitive to environmental exposures. Up to 51% of self-reported race-associated CpGs had race-dependent DNA methylation levels mediated through local genotype, with genetic factors explaining the majority of variation in DNA methylation levels at environmentally-associated CpGs.
Article
Allergy
Mengdi Lu, Augusto A. Litonjua, George T. O'Connor, Robert S. Zeiger, Leonard Bacharier, Michael Schatz, Vincent J. Carey, Scott T. Weiss, Hooman Mirzakhani
Summary: Childhood asthma development is affected by a complex interplay of maternal asthma and prenatal vitamin D status. This study suggests that adequate vitamin D intake throughout pregnancy can help reduce the risk of childhood asthma exacerbated by maternal asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Maleewan Kitcharoensakkul, Leonard B. Bacharier, Toni L. Schweiger, Brad Wilson, Charles W. Goss, Daphne Lew, Kenneth B. Schechtman, Mario Castro
Summary: Children who had severe RSV bronchiolitis in infancy are at increased risk of asthma and reduced lung function in later life. This study observed longitudinal changes in lung function and bronchial hyperreactivity from early to late childhood. Lung function decline in late childhood was associated with gender, asthma diagnosis, and allergic sensitization. Methacholine PC20 levels increased with age, while the frequency of abnormal bronchial hyperreactivity decreased.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Wanda Phipatanakul, David T. Mauger, Theresa W. Guilbert, Leonard B. Bacharier, Sandy Durrani, Daniel J. Jackson, Fernando D. Martinez, Anne M. Fitzpatrick, Amparito Cunningham, Susan Kunselman, Lisa M. Wheatley, Cindy Bauer, Carla M. Davis, Bob Geng, Kirsten M. Kloepfer, Craig Lapin, Andrew H. Liu, Jacqueline A. Pongracic, Stephen J. Teach, James Chmiel, Jonathan M. Gaffin, Matthew Greenhawt, Meera R. Gupta, Peggy S. Lai, Robert F. Lemanske, Wayne J. Morgan, William J. Sheehan, Jeffrey Stokes, Peter S. Thorne, Hans C. Oettgen, Elliot Israel
Summary: Asthma in children is largely influenced by allergen sensitization, and early intervention targeting IgE and IgE-mediated responses may help prevent and reduce the severity of asthma development.
CONTEMPORARY CLINICAL TRIALS
(2021)
Letter
Allergy
Anna Clara Rabha, Fatima Rodrigues Fernandes, Dirceu Sole, Leonard Benjamin Bacharier, Gustavo Falbo Wandalsen
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Critical Care Medicine
Helen K. Reddel, Leonard B. Bacharier, Eric D. Bateman, Christopher E. Brightling, Guy G. Brusselle, Roland Buhl, Alvaro A. Cruz, Liesbeth Duijts, Jeffrey M. Drazen, J. Mark FitzGerald, Louise J. Fleming, Hiromasa Inoue, Fanny W. Ko, Jerry A. Krishnan, Mark L. Levy, Jiangtao Lin, Kevin Mortimer, Paulo M. Pitrez, Aziz Sheikh, Arzu A. Yorgancioglu, Louis-Philippe Boulet
Summary: The article summarizes key recommendations from GINA 2021 and the recent changes, highlighting the importance of not relying solely on short-acting beta(2)-agonists for asthma treatment and provides targeted treatment suggestions based on severity and age.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Editorial Material
Allergy
Leonard B. Bacharier
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2022)
Article
Respiratory System
Helen K. Reddel, Leonard B. Bacharier, Eric D. Bateman, Christopher E. Brightling, Guy G. Brusselle, Roland Buhl, Alvaro A. Cruz, Liesbeth Duijts, Jeffrey M. Drazen, J. Mark FitzGerald, Louise J. Fleming, Hiromasa Inoue, Fanny W. Ko, Jerry A. Krishnan, Mark L. Levy, Jiangtao Lin, Kevin Mortimer, Paulo M. Pitrez, Aziz Sheikh, Arzu A. Yorgancioglu, Louis-Philippe Boulet
Summary: The Global Initiative for Asthma (GINA) Strategy Report provides clinicians with an evidence-based strategy for asthma management and prevention, emphasizing the importance of regular personalized assessment, treatment of modifiable risk factors, self-management education, and appropriate medication adjustment for optimizing asthma outcomes.
ARCHIVOS DE BRONCONEUMOLOGIA
(2022)
Article
Respiratory System
Helen K. Reddel, Leonard B. Bacharier, Eric D. Bateman, Christopher E. Brightling, Guy G. Brusselle, Roland Buhl, Alvaro A. Cruz, Liesbeth Duijts, Jeffrey M. Drazen, J. Mark FitzGerald, Louise J. Fleming, Hiromasa Inoue, Fanny W. Ko, Jerry A. Krishnan, Mark L. Levy, Jiangtao Lin, Kevin Mortimer, Paulo M. Pitrez, Aziz Sheikh, Arzu A. Yorgancioglu, Louis-Philippe Boulet
Summary: The GINA Strategy Report provides clinicians with an evidence-based strategy for asthma management and prevention, with specific recommendations and treatment options for different age groups and severity levels. Regular personalized assessment, treatment of modifiable risk factors, and appropriate medication adjustment and review remain essential for optimizing asthma outcomes.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Critical Care Medicine
Carole Ober, Chris G. McKennan, Kevin M. Magnaye, Matthew C. Altman, Charles Washington, Catherine Stanhope, Katherine A. Naughton, Mario G. Rosasco, Leonard B. Bacharier, Dean Billheimer, Diane R. Gold, Lisa Gress, Tina Hartert, Suzanne Havstad, Gurjit K. Khurana Hershey, Brian Hallmark, D. Kyle Hogarth, Daniel J. Jackson, Christine C. Johnson, Meyer Kattan, Robert F. Lemanske, Susan Lynch, Eneida A. Mendonca, Rachel L. Miller, Edward T. Naureckas, George T. O'Connor, Christine M. Seroogy, Ganesa Wegienka, Steven R. White, Robert A. Wood, Anne L. Wright, Edward M. Zoratti, Fernando D. Martinez, Dennis Ownby, Dan L. Nicolae, Albert M. Levin, James E. Gern
LANCET RESPIRATORY MEDICINE
(2020)
Article
Immunology
Maleewan Kitcharoensakkul, Leonard B. Bacharier, Huiqing Yin-Declue, Jonathan S. Boomer, Geneline Sajol, Marilyn K. Leung, Brad Wilson, Kenneth B. Schechtman, John P. Atkinson, Jonathan M. Green, Mario Castro
IMMUNITY INFLAMMATION AND DISEASE
(2020)