Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 60, Issue -, Pages 124-129Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2019.05.004
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Funding
- National Institutes of Health [R01 AI097312, R01 AI127793, R01 AI119965]
- Pinn Scholars Award of the University of Virginia
- U.S. Department of Veterans Affairs Merit Review Grant [I101BX002108]
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Neutrophils are a crucial first line of defense against infection, migrating rapidly into tissues where they deploy granule components and toxic oxidants for efficient phagocytosis and microbe killing. Subsequent apoptosis and clearance of dying neutrophils are essential for control of infection and resolution of the inflammatory response. A subset of microbial pathogens survive exposure to neutrophils by manipulating phagocytosis, phagosome-granule fusion, oxidant production, and lifespan. Elucidating how they accomplish this unusual feat provides new insights into normal neutrophil function. In this review, we highlight recent discoveries about the ways in which neutrophils use cell-intrinsic mechanisms to control infection, and how these defenses are subverted by pathogens.
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