Platelet immunoreceptor tyrosine-based activation motif (ITAM) and hemITAM signaling and vascular integrity in inflammation and development

C-type lectin like receptor 2 (CLEC-2) signals independently of lipid raft microdomains in platelets

(2015) Bhanu Kanth Manne et al.   BIOCHEMICAL PHARMACOLOGY

Impact of the PI3-kinase/Akt pathway on ITAM and hemITAM receptors: Haemostasis, platelet activation and antithrombotic therapy

(2015) Alyssa J. Moroi et al.   BIOCHEMICAL PHARMACOLOGY

Platelet GPVI repairs its own damage

(2015) J. Rayes et al.   BLOOD

Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development

(2015) K. L. Lowe et al.   BLOOD

Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complex-mediated inflammation in mice

(2015) A. Gros et al.   BLOOD

Targeting Bruton's tyrosine kinase with ibrutinib in B-cell malignancies

(2015) Y Wang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The expression of mouse CLEC-2 on leucocyte subsets varies according to their anatomical location and inflammatory state

(2015) Kate L. Lowe et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Distinct Pathways Regulate Syk Protein Activation Downstream of Immune Tyrosine Activation Motif (ITAM) and hemITAM Receptors in Platelets

(2015) Bhanu Kanth Manne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RASA3 is a critical inhibitor of RAP1-dependent platelet activation

(2015) Lucia Stefanini et al.   JOURNAL OF CLINICAL INVESTIGATION

Blocking neutrophil diapedesis prevents hemorrhage during thrombocytopenia

(2015) Carina Hillgruber et al.   JOURNAL OF EXPERIMENTAL MEDICINE

P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation

(2014) D. Pan et al.   BLOOD

Emerging roles for platelets as immune and inflammatory cells

(2014) C. N. Morrell et al.   BLOOD

CLEC-2 is required for development and maintenance of lymph nodes

(2014) C. Benezech et al.   BLOOD

Platelet Immunoreceptor Tyrosine-Based Activation Motif (ITAM) Signaling and Vascular Integrity

(2014) Yacine Boulaftali et al.   CIRCULATION RESEARCH

Development of the mammalian lymphatic vasculature

(2014) Ying Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Lymphatic function is required prenatally for lung inflation at birth

(2014) Zoltán Jakus et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A novel conditional platelet depletion mouse model reveals the importance of platelets in protection againstStaphylococcus aureusbacteremia

(2014) L. M. Wuescher et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Leukocyte extravasation and vascular permeability are each controlled in vivo by different tyrosine residues of VE-cadherin

(2014) Florian Wessel et al.   NATURE IMMUNOLOGY

Ibrutinib versus Ofatumumab in Previously Treated Chronic Lymphoid Leukemia

(2014) John C. Byrd et al.   NEW ENGLAND JOURNAL OF MEDICINE

High Precision Platelet Releasate Definition by Quantitative Reversed Protein Profiling—Brief Report

(2013) Patrick Wijten et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network

(2013) T. J. Stalker et al.   BLOOD

Platelet ITAM signaling

(2013) Wolfgang Bergmeier et al.   CURRENT OPINION IN HEMATOLOGY

Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life

(2013) Paul R. Hess et al.   JOURNAL OF CLINICAL INVESTIGATION

Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2

(2013) Brett H. Herzog et al.   NATURE

Lymphatic endothelial progenitors bud from the cardinal vein and intersomitic vessels in mammalian embryos

(2012) Y. Yang et al.   BLOOD

Platelets can enhance vascular permeability

(2012) N. Cloutier et al.   BLOOD

Podoplanin: emerging functions in development, the immune system, and cancer

(2012) Jillian L. Astarita et al.   Frontiers in Immunology

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development

(2011) B. A. Finney et al.   BLOOD

CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses

(2011) Diego Mourão-Sá et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

P2 receptors and platelet function

(2011) Béatrice Hechler et al.   Purinergic Signalling

Platelet Recruitment to the Inflamed Glomerulus Occurs via an αIIbβ3/GPVI-Dependent Pathway

(2010) Sapna Devi et al.   AMERICAN JOURNAL OF PATHOLOGY

Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation

(2010) P. Uhrin et al.   BLOOD

von Willebrand factor promotes leukocyte extravasation

(2010) B. Petri et al.   BLOOD

CLEC-2 activates Syk through dimerization

(2010) C. E. Hughes et al.   BLOOD

Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling

(2010) C. C. Bertozzi et al.   BLOOD

Platelets Play an Essential Role in Separating the Blood and Lymphatic Vasculatures During Embryonic Angiogenesis

(2010) Laura Carramolino et al.   CIRCULATION RESEARCH

Essentialin VivoRoles of the C-type Lectin Receptor CLEC-2

(2010) Katsue Suzuki-Inoue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CLEC-2 is not required for platelet aggregation at arteriolar shear

(2010) C. E. HUGHES et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Breaching multiple barriers: leukocyte motility through venular walls and the interstitium

(2010) Sussan Nourshargh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Platelets Control Leukocyte Recruitment in a Murine Model of Cutaneous Arthus Reaction

(2009) Toshihide Hara et al.   AMERICAN JOURNAL OF PATHOLOGY

Venular Basement Membranes Ubiquitously Express Matrix Protein Low-Expression Regions

(2009) Mathieu-Benoît Voisin et al.   AMERICAN JOURNAL OF PATHOLOGY

Monocytes and Neutrophils Exhibit Both Distinct and Common Mechanisms in Penetrating the Vascular Basement Membrane In Vivo

(2009) Mathieu-Benoît Voisin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations

(2009) B. Dumont et al.   BLOOD

CalDAG-GEFI is at the nexus of calcium-dependent platelet activation

(2009) L. Stefanini et al.   BLOOD

Platelets: Guardians of Tumor Vasculature

(2009) B. Ho-Tin-Noe et al.   CANCER RESEARCH

Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation

(2009) M. T. HARPER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Novel molecules in calcium signaling in platelets

(2009) W. BERGMEIER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Petechial bleeding after sunburn in a patient with mild thrombocytopenia

(2008) Carla Carbo et al.   AMERICAN JOURNAL OF HEMATOLOGY

G-Protein–Coupled Receptors as Signaling Targets for Antiplatelet Therapy

(2008) Susan S. Smyth et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inflammation induces hemorrhage in thrombocytopenia

(2008) T. Goerge et al.   BLOOD

Platelet Granule Secretion Continuously Prevents Intratumor Hemorrhage

(2008) B. Ho-Tin-Noe et al.   CANCER RESEARCH

Phospholipase C 2 is necessary for separation of blood and lymphatic vasculature in mice

(2008) H. Ichise et al.   DEVELOPMENT

Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice

(2008) Jianxin Fu et al.   JOURNAL OF CLINICAL INVESTIGATION

Compromised ITAM-based platelet receptor function in a patient with immune thrombocytopenic purpura

(2008) E. E. GARDINER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS