Genetic correlation, pleiotropy, and causal associations between substance use and psychiatric disorder

Determination of shared genetic etiology and possible causal relations between tobacco smoking and depression

(2020) Yinghao Yao et al.   PSYCHOLOGICAL MEDICINE

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

(2019) Mengzhen Liu et al.   NATURE GENETICS

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

(2019) Richard Karlsson Linnér et al.   NATURE GENETICS

Genome-wide association study identifies 30 loci associated with bipolar disorder

(2019) Eli A. Stahl et al.   NATURE GENETICS

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

(2019) Hunna J. Watson et al.   NATURE GENETICS

Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits

(2019) Andrew D. Grotzinger et al.   Nature Human Behaviour

Evidence for causal effects of lifetime smoking on risk for depression and schizophrenia: a Mendelian randomisation study

(2019) Robyn E. Wootton et al.   PSYCHOLOGICAL MEDICINE

Cannabis use, depression and self‐harm: phenotypic and genetic relationships

(2019) Karen Hodgson et al.   ADDICTION

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

(2019) Phil H. Lee et al.   CELL

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

(2018) Douglas M. Ruderfer et al.   CELL

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

(2018) Naomi R. Wray et al.   NATURE GENETICS

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

(2018) Marie Verbanck et al.   NATURE GENETICS

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

(2018) Antonio F. Pardiñas et al.   NATURE GENETICS

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

(2018) James J. Lee et al.   NATURE GENETICS

Mechanisms of clathrin-mediated endocytosis

(2018) Marko Kaksonen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The MR-Base platform supports systematic causal inference across the human phenome

(2018) Gibran Hemani et al.   eLife

Investigating possible causal effects of externalizing behaviors on tobacco initiation: A Mendelian randomization analysis

(2018) Meg E. Fluharty et al.   DRUG AND ALCOHOL DEPENDENCE

Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry

(2018) Loic Yengo et al.   HUMAN MOLECULAR GENETICS

GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia

(2018) Joëlle A. Pasman et al.   NATURE NEUROSCIENCE

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

(2018) Ditte Demontis et al.   NATURE GENETICS

Distinguishing genetic correlation from causation across 52 diseases and complex traits

(2018) Luke J. O’Connor et al.   NATURE GENETICS

Joint factorial structure of psychopathology and personality

(2018) Tom Rosenström et al.   PSYCHOLOGICAL MEDICINE

Biallelic mutations in human DCC cause developmental split-brain syndrome

(2017) Saumya S Jamuar et al.   NATURE GENETICS

Neural Cell Adhesion Molecules of the Immunoglobulin Superfamily Regulate Synapse Formation, Maintenance, and Function

(2017) Vladimir Sytnyk et al.   TRENDS IN NEUROSCIENCES

Functional mapping and annotation of genetic associations with FUMA

(2017) Kyoko Watanabe et al.   Nature Communications

Investigating causality in associations between smoking initiation and schizophrenia using Mendelian randomization

(2017) Suzanne H. Gage et al.   Scientific Reports

Association of Lifetime Mental Disorders and Subsequent Alcohol and Illicit Drug Use: Results From the National Comorbidity Survey–Adolescent Supplement

(2016) Kevin P. Conway et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders

(2016) Min-Tzu Lo et al.   NATURE GENETICS

Detection and interpretation of shared genetic influences on 42 human traits

(2016) Joseph K Pickrell et al.   NATURE GENETICS

Mortality in Women With Anorexia Nervosa

(2016) Jan Kask et al.   PSYCHOSOMATIC MEDICINE

Depression and cigarette smoking behavior: A critical review of population-based studies

(2016) Andrea H. Weinberger et al.   AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE

Cannabis Use and Risk of Psychiatric Disorders

(2016) Carlos Blanco et al.   JAMA Psychiatry

A general framework for estimating the relative pathogenicity of human genetic variants

(2014) Martin Kircher et al.   NATURE GENETICS

Advantages and pitfalls in the application of mixed-model association methods

(2014) Jian Yang et al.   NATURE GENETICS

B vitamin polymorphisms and behavior: Evidence of associations with neurodevelopment, depression, schizophrenia, bipolar disorder and cognitive decline

(2014) E. Siobhan Mitchell et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium

(2014) Amy E Taylor et al.   BMJ Open

Comorbidity of Severe Psychotic Disorders With Measures of Substance Use

(2014) Sarah M. Hartz et al.   JAMA Psychiatry

Pleiotropy in complex traits: challenges and strategies

(2013) Nadia Solovieff et al.   NATURE REVIEWS GENETICS

The many faces of pleiotropy

(2012) Annalise B. Paaby et al.   TRENDS IN GENETICS

The Structure of Genetic and Environmental Risk Factors for Syndromal and Subsyndromal Common DSM-IV Axis I and All Axis II Disorders

(2010) Kenneth S. Kendler et al.   AMERICAN JOURNAL OF PSYCHIATRY

Substance Use in Adolescence and Psychosis: Clarifying the Relationship

(2010) Emma Barkus et al.   Annual Review of Clinical Psychology

seqMINER: an integrated ChIP-seq data interpretation platform

(2010) Tao Ye et al.   NUCLEIC ACIDS RESEARCH

Prefrontal cortex AMPA receptor plasticity is crucial for cue-induced relapse to heroin-seeking

(2008) Michel C Van den Oever et al.   NATURE NEUROSCIENCE