PD-L1 upregulation by IFN-α/γ-mediated Stat1 suppresses anti-HBV T cell response

Immunological cure of HBV infection

(2019) Julia Lang et al.   Hepatology International

OX40 stimulation and PD-L1 blockade synergistically augment HBV-specific CD4 T cells in patients with HBeAg-negative infection

(2019) Felix Johannes Jacobi et al.   JOURNAL OF HEPATOLOGY

Anti-PD-1 Blockade with Nivolumab with and without Therapeutic Vaccination for Virally Suppressed Chronic Hepatitis B: A Pilot Study

(2019) Edward Gane et al.   JOURNAL OF HEPATOLOGY

Effects of pegylated interferon‐α based therapies on functional cure and the risk of hepatocellular carcinoma development in patients with chronic hepatitis B

(2019) Hong Ren et al.   JOURNAL OF VIRAL HEPATITIS

Hyper-Expression of PD-1 Is Associated with the Levels of Exhausted and Dysfunctional Phenotypes of Circulating CD161++TCR iVα7.2+ Mucosal-Associated Invariant T Cells in Chronic Hepatitis B Virus Infection

(2018) Yean K. Yong et al.   Frontiers in Immunology

Determinants of hepatic effector CD8 + T cell dynamics

(2017) Alexandre Pierre Benechet et al.   JOURNAL OF HEPATOLOGY

Type I Interferon in Chronic Virus Infection and Cancer

(2017) Laura M. Snell et al.   TRENDS IN IMMUNOLOGY

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2017) Angel Garcia-Diaz et al.   Cell Reports

The “adaptive responses” of low concentrations of HBCD in L02 cells and the underlying molecular mechanisms

(2016) Jing An et al.   CHEMOSPHERE

Hepatitis B Virus–Specific and Global T-Cell Dysfunction in Chronic Hepatitis B

(2016) Jang-June Park et al.   GASTROENTEROLOGY

Interferon-γ and Tumor Necrosis Factor-α Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis

(2016) Yuchen Xia et al.   GASTROENTEROLOGY

Interferon-γ facilitates hepatic antiviral T cell retention for the maintenance of liver-induced systemic tolerance

(2016) Zhutian Zeng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immune-modulators to combat hepatitis B virus infection: From IFN-α to novel investigational immunotherapeutic strategies

(2015) Nathalie Isorce et al.   ANTIVIRAL RESEARCH

Plasma membrane gp96 enhances invasion and metastatic potential of liver cancer via regulation of uPAR

(2015) Junwei Hou et al.   Molecular Oncology

Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection

(2015) Jonathan H Chen et al.   NATURE MEDICINE

Hepatic Immune Regulation and Its Involvement in Viral Hepatitis Infection

(2014) Percy A. Knolle et al.   GASTROENTEROLOGY

Restoration of HBV-specific CD8+ T cell function by PD-1 blockade in inactive carrier patients is linked to T cell differentiation

(2014) Bertram Bengsch et al.   JOURNAL OF HEPATOLOGY

The Programmed Death-1 Immune-Suppressive Pathway: Barrier to Antitumor Immunity

(2014) Suzanne Ostrand-Rosenberg et al.   JOURNAL OF IMMUNOLOGY

Enhancing Virus-Specific Immunity In Vivo by Combining Therapeutic Vaccination and PD-L1 Blockade in Chronic Hepadnaviral Infection

(2014) Jia Liu et al.   PLoS Pathogens

Reversal of hepatitis B virus-induced systemic immune tolerance by intrinsic innate immune stimulation

(2013) Qiuju Han et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Increased Expression of Gp96 by HBx-Induced NF-κB Activation Feedback Enhances Hepatitis B Virus Production

(2013) Hongxia Fan et al.   PLoS One

CD40 Activation Rescues Antiviral CD8+ T Cells from PD-1-Mediated Exhaustion

(2013) Masanori Isogawa et al.   PLoS Pathogens

Identification of an intrahepatic transcriptional signature associated with self-limiting infection in the woodchuck model of hepatitis B

(2012) Simon P. Fletcher et al.   HEPATOLOGY

Peginterferon-α does not improve early peripheral blood HBV-specific T-cell responses in HBeAg-negative chronic hepatitis

(2012) Amalia Penna et al.   JOURNAL OF HEPATOLOGY

Hepatitis B Virus mRNA-Mediated miR-122 Inhibition Upregulates PTTG1-Binding Protein, Which Promotes Hepatocellular Carcinoma Tumor Growth and Cell Invasion

(2012) C. Li et al.   JOURNAL OF VIROLOGY

Inhibition of Alpha Interferon (IFN- )-Induced MicroRNA-122 Negatively Affects the Anti-Hepatitis B Virus Efficiency of IFN- 

(2012) J. Hao et al.   JOURNAL OF VIROLOGY

TAT-mediated gp96 transduction to APCs enhances gp96-induced antiviral and antitumor T cell responses

(2012) Bao Zhao et al.   VACCINE

Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis-Prone CD8 T cells in persistent hepatitis B virus infection

(2011) Anna Schurich et al.   HEPATOLOGY

Immunotherapy for persistent viral infections and associated disease

(2011) Sjoerd H. van der Burg et al.   TRENDS IN IMMUNOLOGY

Heat shock protein gp96 enhances humoral and T cell responses, decreases Treg frequency and potentiates the anti-HBV activity in BALB/c and transgenic mice

(2011) Saifeng Wang et al.   VACCINE

Interferon-  and tumor necrosis factor-  induce an immunoinhibitory molecule, B7-H1, via nuclear factor- B activation in blasts in myelodysplastic syndromes

(2010) A. Kondo et al.   BLOOD

How chronic viral infections impact on antigen-specific T-cell responses

(2010) Helge Frebel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Antiviral Intrahepatic T-Cell Responses Can Be Restored by Blocking Programmed Death-1 Pathway in Chronic Hepatitis B

(2009) Paola Fisicaro et al.   GASTROENTEROLOGY

Chronically inflamed livers up-regulate expression of inhibitory B7 family members

(2009) Rachel Kassel et al.   HEPATOLOGY

Impact of hepatitis B virus X protein on the DNA damage response during hepatocarcinogenesis

(2009) Yasunobu Matsuda et al.   Medical Molecular Morphology

Expression of HBX, an oncoprotein of hepatitis B virus, blocks reoviral oncolysis of hepatocellular carcinoma cells

(2008) E-H Park et al.   CANCER GENE THERAPY

Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)

(2008) M. Marzec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA