Plasma membrane gp96 enhances invasion and metastatic potential of liver cancer via regulation of uPAR

α7 Helix Region of αI Domain Is Crucial for Integrin Binding to Endoplasmic Reticulum Chaperone gp96

(2013) Feng Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt signaling and hepatocarcinogenesis: Molecular targets for the development of innovative anticancer drugs

(2013) Floriane Pez et al.   JOURNAL OF HEPATOLOGY

Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2

(2013) Pallav D Patel et al.   Nature Chemical Biology

Increased Expression of Gp96 by HBx-Induced NF-κB Activation Feedback Enhances Hepatitis B Virus Production

(2013) Hongxia Fan et al.   PLoS One

Role of Urokinase Receptor in Tumor Progression and Development

(2013) Hyangsoon Noh et al.   Theranostics

Proinflammatory Homeobox Gene, ISX, Regulates Tumor Growth and Survival in Hepatocellular Carcinoma

(2012) S.-H. Hsu et al.   CANCER RESEARCH

Listeria monocytogenesTriggers the Cell Surface Expression of Gp96 Protein and Interacts with Its N Terminus to Support Cellular Infection

(2012) Mariana Martins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracerebral infusion of the bispecific targeted toxin DTATEGF in a mouse xenograft model of a human metastatic non-small cell lung cancer

(2012) Jun Huang et al.   JOURNAL OF NEURO-ONCOLOGY

Hepatitis B Virus mRNA-Mediated miR-122 Inhibition Upregulates PTTG1-Binding Protein, Which Promotes Hepatocellular Carcinoma Tumor Growth and Cell Invasion

(2012) C. Li et al.   JOURNAL OF VIROLOGY

Inflammation- and stress-related signaling pathways in hepatocarcinogenesis

(2012) Hayato Nakagawa   WORLD JOURNAL OF GASTROENTEROLOGY

GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum

(2011) Michal Marzec et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Signaling Pathway and Molecular-Targeted Therapy for Hepatocellular Carcinoma

(2011) Masatoshi Kudo   DIGESTIVE DISEASES

Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G1-modulated P53 activity

(2011) Saifeng Wang et al.   HEPATOLOGY

Urokinase induces stromal cell-derived factor-1 expression in human hepatocellular carcinoma cells

(2011) Wen-Hsiu Hsu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A strategy to produce monoclonal antibodies against gp96 by prime-boost regimen using endogenous protein and E. coli heterologously-expressed fragment

(2011) Yu-dan Zhang et al.   JOURNAL OF CENTRAL SOUTH UNIVERSITY OF TECHNOLOGY

gp96 expression in neutrophils is critical for the onset of Escherichia coli K1 (RS218) meningitis

(2011) Rahul Mittal et al.   Nature Communications

Toll-like receptor 4-mediated c-Jun N-terminal kinase activation induces gp96 cell surface expression via AIMP1 phosphorylation

(2010) Gyuyoup Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RNAi-mediated downregulation of uPAR synergizes with targeting of HER2 through the ERK pathway in breast cancer cells

(2010) Changfei Li et al.   INTERNATIONAL JOURNAL OF CANCER

gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis

(2009) M. Staron et al.   BLOOD

The urokinase receptor: Focused cell surface proteolysis, cell adhesion and signaling

(2009) Francesco Blasi et al.   FEBS LETTERS

Cell-surface Processing of the Metalloprotease Pro-ADAMTS9 Is Influenced by the Chaperone GRP94/gp96

(2009) Bon-Hun Koo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heat-shock proteins in infection-mediated inflammation-induced tumorigenesis

(2009) Mark G Goldstein et al.   Journal of Hematology & Oncology

Regulation of cell signalling by uPAR

(2009) Harvey W. Smith et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A phase 2, randomized, double-blind, placebo-controlled trial of clinical activity and safety of subcutaneous Å6 in women with asymptomatic CA125 progression after first-line chemotherapy of epithelial ovarian cancer

(2008) Sharad A. Ghamande et al.   GYNECOLOGIC ONCOLOGY

A hybrid protein comprising ATF domain of pro-UK and VAS, an angiogenesis inhibitor, is a potent candidate for targeted cancer therapy

(2008) Qiming Sun et al.   INTERNATIONAL JOURNAL OF CANCER

Clathrin and LRP-1-Independent Constitutive Endocytosis and Recycling of uPAR

(2008) Katia Cortese et al.   PLoS One