Journal
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Volume 28, Issue -, Pages 132-137Publisher
WILEY-BLACKWELL
DOI: 10.1111/jgh.12034
Keywords
HBV; immune tolerance; intrinsic immunity
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Funding
- Natural Science Foundation of China [91029303, 30911120480, 81273220, 31200651, 31021061]
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Systemic immune tolerance induced by chronic hepatitis B virus (HBV) infection is a significant question, but the mechanism of which remains unclear. In this mini-review, we summarize the impaired innate and adaptive immune responses involved in immune tolerance in chronic HBV infection. Furthermore, we delineate a novel dual functional small RNA to inhibit HBV replication and stimulate innate immunity against HBV, which proposed a promising immunotherapeutic intervention to interrupt HBV-induced immunotolerance. A mouse model of HBV persistence was established and used to observe the immune tolerant to HBV vaccination, the cell-intrinsic immune tolerance of which might be reversed by chemically synthesized dual functional small RNA (3p-hepatitis B Virus X gene [HBx]-small interfering RNA) in vitro experiments and by biologically constructed dual functional vector (single-stranded RNA-HBx-short hairpin RNA) in vivo experiment using HBV-carrier mice.
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