Nano-Pulse Stimulation is a physical modality that can trigger immunogenic tumor cell death

Multiple nanosecond electric pulses increase the number but not the size of long-lived nanopores in the cell membrane

(2015) Andrei G. Pakhomov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cell membrane permeabilization by 12-ns electric pulses: Not a purely dielectric, but a charge-dependent phenomenon

(2015) Aude Silve et al.   BIOELECTROCHEMISTRY

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

(2015) Abhishek D. Garg et al.   Frontiers in Immunology

Nanoelectroablation of Murine Tumors Triggers a CD8-Dependent Inhibition of Secondary Tumor Growth

(2015) Richard Nuccitelli et al.   PLoS One

Dealing with damage: Plasma membrane repair mechanisms

(2014) Annette Draeger et al.   BIOCHIMIE

A protective effect after clearance of orthotopic rat hepatocellular carcinoma by nanosecond pulsed electric fields

(2014) Ru Chen et al.   EUROPEAN JOURNAL OF CANCER

Calcium influx affects intracellular transport and membrane repair following nanosecond pulsed electric field exposure

(2014) Gary Lee Thompson et al.   JOURNAL OF BIOMEDICAL OPTICS

Maturing Dendritic Cells Depend on RAGE for In Vivo Homing to Lymph Nodes

(2014) A. A. Manfredi et al.   JOURNAL OF IMMUNOLOGY

Physical modalities inducing immunogenic tumor cell death for cancer immunotherapy

(2014) Irena Adkins et al.   OncoImmunology

Consensus guidelines for the detection of immunogenic cell death

(2014) Oliver Kepp et al.   OncoImmunology

Trial Watch

(2014) Erika Vacchelli et al.   OncoImmunology

Nanosecond pulsed electric field stimulation of reactive oxygen species in human pancreatic cancer cells is Ca2+-dependent

(2013) Richard Nuccitelli et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sustained tumour eradication after induced caspase-3 activation and synchronous tumour apoptosis requires an intact host immune response

(2013) M H M Melis et al.   CELL DEATH AND DIFFERENTIATION

Molecular mechanisms of ATP secretion during immunogenic cell death

(2013) I Martins et al.   CELL DEATH AND DIFFERENTIATION

Oncolytic Virotherapy and Immunogenic Cancer Cell Death: Sharpening the Sword for Improved Cancer Treatment Strategies

(2013) Samuel T Workenhe et al.   MOLECULAR THERAPY

Two Modes of Cell Death Caused by Exposure to Nanosecond Pulsed Electric Field

(2013) Olga N. Pakhomova et al.   PLoS One

Trial watch

(2013) Erika Vacchelli et al.   OncoImmunology

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Oxidative effects of nanosecond pulsed electric field exposure in cells and cell-free media

(2012) Olga N. Pakhomova et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Nanoelectroablation therapy for murine basal cell carcinoma

(2012) Richard Nuccitelli et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nanoelectroablation of human pancreatic carcinoma in a murine xenograft model without recurrence

(2012) Richard Nuccitelli et al.   INTERNATIONAL JOURNAL OF CANCER

Non-thermal Nanoelectroablation of UV-induced Murine Melanomas Stimulates an Immune Response

(2012) Richard Nuccitelli et al.   Pigment Cell & Melanoma Research

Immunogenic Cell Death: Can It Be Exploited in PhotoDynamic Therapy for Cancer?

(2012) Elisa Panzarini et al.   Biomed Research International

The emergence of phox-ER stress induced immunogenic apoptosis

(2012) Abhishek D. Garg et al.   OncoImmunology

Nanosecond electric pulses cause mitochondrial membrane permeabilization in Jurkat cells

(2011) Tina Batista Napotnik et al.   BIOELECTROMAGNETICS

Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin

(2011) Abhishek D. Garg et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Human Tumor Cells Killed by Anthracyclines Induce a Tumor-Specific Immune Response

(2011) J. Fucikova et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Selective cytotoxicity of intense nanosecond-duration electric pulses in mammalian cells

(2010) Bennett L. Ibey et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death

(2009) Theocharis Panaretakis et al.   EMBO JOURNAL

A new pulsed electric field therapy for melanoma disrupts the tumor's blood supply and causes complete remission without recurrence

(2009) Richard Nuccitelli et al.   INTERNATIONAL JOURNAL OF CANCER

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE