Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity

LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer

(2018) Masoud F. Tavazoie et al.   CELL

Durable Complete Response After Discontinuation of Pembrolizumab in Patients With Metastatic Melanoma

(2018) Caroline Robert et al.   JOURNAL OF CLINICAL ONCOLOGY

Cholesterol negatively regulates IL-9–producing CD8+T cell differentiation and antitumor activity

(2018) Xingzhe Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PD-1/PD-L1 pathway: an adaptive immune resistance mechanism to immunogenic chemotherapy in colorectal cancer

(2018) Magalie Dosset et al.   OncoImmunology

IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade

(2017) Mark Ayers et al.   JOURNAL OF CLINICAL INVESTIGATION

A novel hemolytic complement-sufficient NSG mouse model supports studies of complement-mediated antitumor activity in vivo

(2017) Mohit K. Verma et al.   JOURNAL OF IMMUNOLOGICAL METHODS

5′-methylschweinfurthin G reduces chondrosarcoma tumor growth 

(2017) Jeff W. Stevens et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

(2017) Jedd D. Wolchok et al.   NEW ENGLAND JOURNAL OF MEDICINE

HMG-CoA reductase promotes protein prenylation and therefore is indispensible for T-cell survival

(2017) Sonja M Lacher et al.   Cell Death & Disease

Myeloid-specific genetic ablation of ATP-binding cassette transporter ABCA1 is protective against cancer

(2017) Maryam Zamanian-Daryoush et al.   Oncotarget

Mevalonate Metabolism in Immuno-Oncology

(2017) Georg Gruenbacher et al.   Frontiers in Immunology

PD-1/PD-L1 Blockade: Have We Found the Key to Unleash the Antitumor Immune Response?

(2017) Zijun Y. Xu-Monette et al.   Frontiers in Immunology

Cholesterol Metabolism in T Cells

(2017) Andreas Bietz et al.   Frontiers in Immunology

Beta blocker use correlates with better overall survival in metastatic melanoma patients and improves the efficacy of immunotherapies in mice

(2017) Kathleen M. Kokolus et al.   OncoImmunology

The oncolytic compound LTX-401 targets the Golgi apparatus

(2016) Heng Zhou et al.   CELL DEATH AND DIFFERENTIATION

Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy

(2016) Christina Pfirschke et al.   IMMUNITY

Atorvastatin promotes the expansion of myeloid-derived suppressor cells and attenuates murine colitis

(2016) Aihua Lei et al.   IMMUNOLOGY

Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism

(2016) Wei Yang et al.   NATURE

Management of Adverse Events Following Treatment With Anti-Programmed Death-1 Agents

(2016) Jeffrey S. Weber et al.   ONCOLOGIST

Targeting the MAPK and PI3K pathways in combination with PD1 blockade in melanoma

(2016) Marcel A. Deken et al.   OncoImmunology

Small molecule schweinfurthins selectively inhibit cancer cell proliferation and mTOR/AKT signaling by interfering with trans-Golgi-network trafficking

(2015) Xingfeng Bao et al.   CANCER BIOLOGY & THERAPY

Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents

(2015) Lorenzo Galluzzi et al.   CANCER CELL

3-Deoxyschweinfurthin B Lowers Cholesterol Levels by Decreasing Synthesis and Increasing Export in Cultured Cancer Cell Lines

(2015) Craig H. Kuder et al.   LIPIDS

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

(2015) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

T lymphocyte regulation by mevalonate metabolism

(2015) Martin Thurnher et al.   Science Signaling

Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF V600E melanoma

(2015) Siwen Hu-Lieskovan et al.   Science Translational Medicine

T lymphocyte regulation by mevalonate metabolism

(2015) Martin Thurnher et al.   Science Signaling

Synthesis and structure activity relationships of schweinfurthin indoles

(2014) John G. Kodet et al.   BIOORGANIC & MEDICINAL CHEMISTRY

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

Survival, Durable Tumor Remission, and Long-Term Safety in Patients With Advanced Melanoma Receiving Nivolumab

(2014) Suzanne L. Topalian et al.   JOURNAL OF CLINICAL ONCOLOGY

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Synthesis of Indole Analogues of the Natural Schweinfurthins

(2013) John G. Kodet et al.   JOURNAL OF ORGANIC CHEMISTRY

Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in Melanoma

(2013) Omid Hamid et al.   NEW ENGLAND JOURNAL OF MEDICINE

Zoledronic Acid Restores Doxorubicin Chemosensitivity and Immunogenic Cell Death in Multidrug-Resistant Human Cancer Cells

(2013) Chiara Riganti et al.   PLoS One

Inhibition of the mevalonate pathway to override chemoresistance and promote the immunogenic demise of cancer cells

(2013) Chiara Riganti et al.   OncoImmunology

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

A novel Ly6C/Ly6G-based strategy to analyze the mouse splenic myeloid compartment

(2011) Shawn Rose et al.   CYTOMETRY PART A

Pleiotropic Effects of a Schweinfurthin on Isoprenoid Homeostasis

(2011) Sarah A. Holstein et al.   LIPIDS

Structural analogues of schweinfurthin F: Probing the steric, electronic, and hydrophobic properties of the D-ring substructure

(2010) Natalie C. Ulrich et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Biologically active biotin derivatives of schweinfurthin F

(2010) Natalie C. Ulrich et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Schweinfurthin A Selectively Inhibits Proliferation and Rho Signaling in Glioma and Neurofibromatosis Type 1 Tumor Cells in a NF1-GRD-Dependent Manner

(2010) T. J. Turbyville et al.   MOLECULAR CANCER THERAPEUTICS

Synthesis and biological activity of a fluorescent schweinfurthin analogue

(2009) Craig H. Kuder et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Concise Synthesis of Pawhuskin A

(2008) Jeffrey D. Neighbors et al.   JOURNAL OF NATURAL PRODUCTS

Synthesis of the schweinfurthin hexahydroxanthene core through Shi epoxidation

(2007) Jeffrey D. Neighbors et al.   TETRAHEDRON LETTERS