Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation

(2019) Suresh Kumar et al.   DEVELOPMENTAL CELL

Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal

(2019) Jingyue Jia et al.   DEVELOPMENTAL CELL

The complex relationship between TFEB transcription factor phosphorylation and subcellular localization

(2018) Rosa Puertollano et al.   EMBO JOURNAL

Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins

(2018) Suresh Kumar et al.   JOURNAL OF CELL BIOLOGY

Galectins Control mTOR in Response to Endomembrane Damage

(2018) Jingyue Jia et al.   MOLECULAR CELL

TFEB-driven endocytosis coordinates MTORC1 signaling and autophagy

(2018) Israel C. Nnah et al.   Autophagy

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes

(2017) Monther Abu-Remaileh et al.   SCIENCE

Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

(2017) Brian M. Castellano et al.   SCIENCE

Phagocytosis Enhances Lysosomal and Bactericidal Properties by Activating the Transcription Factor TFEB

(2016) Matthew A. Gray et al.   CURRENT BIOLOGY

TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis

(2016) Santosh Chauhan et al.   DEVELOPMENTAL CELL

Atg8 family LC3/GABARAP proteins are crucial for autophagosome–lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation

(2016) Thanh Ngoc Nguyen et al.   JOURNAL OF CELL BIOLOGY

TFEB at a glance

(2016) Gennaro Napolitano et al.   JOURNAL OF CELL SCIENCE

Development of liquid chromatography-tandem mass spectrometry methods for the quantitation of Anisakis simplex proteins in fish

(2016) Christiane Kruse Fæste et al.   JOURNAL OF CHROMATOGRAPHY A

MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5

(2015) Catherine L. Nezich et al.   JOURNAL OF CELL BIOLOGY

IRGM Governs the Core Autophagy Machinery to Conduct Antimicrobial Defense

(2015) Santosh Chauhan et al.   MOLECULAR CELL

Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation

(2015) Rui Huang et al.   MOLECULAR CELL

Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

(2015) Rushika M. Perera et al.   NATURE

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Human Immunodeficiency Virus Type 1 Nef Inhibits Autophagy through Transcription Factor EB Sequestration

(2015) Grant R. Campbell et al.   PLoS Pathogens

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

(2012) Eisuke Itakura et al.   CELL

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

(2012) Liron Bar-Peled et al.   CELL

Mycobacterium Tuberculosis Activates the DNA-Dependent Cytosolic Surveillance Pathway within Macrophages

(2012) Paolo S. Manzanillo et al.   Cell Host & Microbe

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

(2011) Ken Inoki et al.   Annual Review of Pharmacology and Toxicology

Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance

(2011) Diego L. Medina et al.   DEVELOPMENTAL CELL

Novel Protein Substrates of the Phospho-Form Modification System in Neisseria gonorrhoeae and Their Connection toO-Linked Protein Glycosylation

(2011) Jan Haug Anonsen et al.   INFECTION AND IMMUNITY

A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease

(2011) Patrick Brest et al.   NATURE GENETICS

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

IRGM Is a Common Target of RNA Viruses that Subvert the Autophagy Network

(2011) Isabel Pombo Grégoire et al.   PLoS Pathogens

LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis

(2010) Hilla Weidberg et al.   EMBO JOURNAL

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria

(2010) Sudha B. Singh et al.   NATURE CELL BIOLOGY

On the level: IRGM gene function is all about expression

(2009) Alan Huett et al.   Autophagy

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Crohn's disease adherent-invasiveEscherichia colicolonize and induce strong gut inflammation in transgenic mice expressing human CEACAM

(2009) Frédéric A. Carvalho et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE

Death and Resurrection of the Human IRGM Gene

(2009) Cemalettin Bekpen et al.   PLoS Genetics

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease

(2008) Steven A McCarroll et al.   NATURE GENETICS