Diabetes Causes Dysfunctional Dopamine Neurotransmission Favoring Nigrostriatal Degeneration in Mice

Diabetes, BMI, and Parkinson's

(2020) Tom Foltynie et al.   MOVEMENT DISORDERS

Calbindin-D28K Limits Dopamine Release in Ventral but Not Dorsal Striatum by Regulating Ca2+ Availability and Dopamine Transporter Function

(2019) Katherine R. Brimblecombe et al.   ACS Chemical Neuroscience

Mechanisms and regulation of dopamine release

(2019) Changliang Liu et al.   CURRENT OPINION IN NEUROBIOLOGY

Neuronal vulnerability in Parkinson disease: Should the focus be on axons and synaptic terminals?

(2019) Yvette C. Wong et al.   MOVEMENT DISORDERS

The Relevance of Insulin Action in the Dopaminergic System

(2019) Francesca Fiory et al.   Frontiers in Neuroscience

Body mass index, diabetes, and the risk of Parkinson's disease

(2019) Su‐Min Jeong et al.   MOVEMENT DISORDERS

Interaction of amyloidogenic proteins in pancreatic β cells from subjects with synucleinopathies

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Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites

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Determinants of dopaminergic neuron loss in Parkinson's disease

(2018) D.James Surmeier   FEBS Journal

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

Dopaminergic neurodegeneration in a rat model of long-term hyperglycemia: preferential degeneration of the nigrostriatal motor pathway

(2018) Justine Renaud et al.   NEUROBIOLOGY OF AGING

Diabetes and Parkinson disease

(2018) Rohit R. Das et al.   NEUROLOGY

Diabetes mellitus and Parkinson disease

(2018) Gennaro Pagano et al.   NEUROLOGY

Association between diabetes and subsequent Parkinson disease

(2018) Eduardo De Pablo-Fernandez et al.   NEUROLOGY

A High-fat, High-sugar ‘Western’ Diet Alters Dorsal Striatal Glutamate, Opioid, and Dopamine Transmission in Mice

(2018) Brandon M. Fritz et al.   NEUROSCIENCE

Mechanisms of α-Synuclein Induced Synaptopathy in Parkinson's Disease

(2018) Jessika C. Bridi et al.   Frontiers in Neuroscience

Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression and other pathophysiological consequences: An update on glucose toxicity

(2018) Biplab Giri et al.   BIOMEDICINE & PHARMACOTHERAPY

Diabetes mellitus to neurodegenerative disorders: Is oxidative stress fueling the flame?

(2018) Nandkishor K Mule et al.   CNS & Neurological Disorders-Drug Targets

Dopamine, oxidative stress and protein-quinone modifications in Parkinson's and other neurodegenerative diseases

(2018) Enrico Monzani et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inhibition of nigrostriatal dopamine release by striatal GABAA and GABAB receptors

(2018) Emanuel F. Lopes et al.   JOURNAL OF NEUROSCIENCE

Synaptic, Mitochondrial, and Lysosomal Dysfunction in Parkinson’s Disease

(2018) Maria Nguyen et al.   TRENDS IN NEUROSCIENCES

In vivo ROS production and use of oxidative stress-derived biomarkers to detect the onset of diseases such as Alzheimer’s disease, Parkinson’s disease, and diabetes

(2017) Aya Umeno et al.   FREE RADICAL RESEARCH

Effects of diet and insulin on dopamine transporter activity and expression in rat caudate-putamen, nucleus accumbens, and midbrain

(2017) Kymry T. Jones et al.   JOURNAL OF NEUROCHEMISTRY

Dissociation of Striatal Dopamine and Tyrosine Hydroxylase Expression from Aging-Related Motor Decline: Evidence from Calorie Restriction Intervention

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Increased risk of Parkinson disease with diabetes mellitus in a population-based study

(2017) Yu-Wan Yang et al.   MEDICINE

Human COMT over-expression confers a heightened susceptibility to dyskinesia in mice

(2017) Oscar Solís et al.   NEUROBIOLOGY OF DISEASE

Increase in the Incidence of Diabetes and Its Implications

(2017) Julie R. Ingelfinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Embryonic defence mechanisms against glucose-dependent oxidative stress require enhanced expression of Alx3 to prevent malformations during diabetic pregnancy

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Validation of optimal reference genes for quantitative real time PCR in muscle and adipose tissue for obesity and diabetes research

(2017) Lester J. Perez et al.   Scientific Reports

Membrane transporters as mediators of synaptic dopamine dynamics: implications for disease

(2016) Kelly M. Lohr et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Mitochondrial control of cell bioenergetics in Parkinson’s disease

(2016) Raquel Requejo-Aguilar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Converging roles of ion channels, calcium, metabolic stress, and activity pattern ofSubstantia nigradopaminergic neurons in health and Parkinson's disease

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Loss of Homeostasis in the Direct Pathway in a Mouse Model of Asymptomatic Parkinson's Disease

(2016) M. V. Escande et al.   JOURNAL OF NEUROSCIENCE

Glycation in Parkinson's disease and Alzheimer's disease

(2016) Hugo Vicente Miranda et al.   MOVEMENT DISORDERS

Synaptic failure and α-synuclein

(2016) Laura Calo et al.   MOVEMENT DISORDERS

Fluorescent false neurotransmitter reveals functionally silent dopamine vesicle clusters in the striatum

(2016) Daniela B Pereira et al.   NATURE NEUROSCIENCE

Insulin resistance and Parkinson’s disease: A new target for disease modification?

(2016) D. Athauda et al.   PROGRESS IN NEUROBIOLOGY

Retrograde Axonal Degeneration in Parkinson Disease

(2016) Patricia Tagliaferro et al.   Journal of Parkinsons Disease

Activation of DREAM (Downstream Regulatory Element Antagonistic Modulator), a Calcium-Binding Protein, Reduces L-DOPA-Induced Dyskinesias in Mice

(2015) Irene Ruiz-DeDiego et al.   BIOLOGICAL PSYCHIATRY

Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward

(2015) Melissa A. Stouffer et al.   Nature Communications

Diet-induced obesity accelerates the onset of terminal phenotypes in α-synuclein transgenic mice

(2014) Carola Rotermund et al.   JOURNAL OF NEUROCHEMISTRY

Protective and toxic roles of dopamine in Parkinson's disease

(2014) Juan Segura-Aguilar et al.   JOURNAL OF NEUROCHEMISTRY

System-based approaches to decode the molecular links in Parkinson's disease and diabetes

(2014) Jose A. Santiago et al.   NEUROBIOLOGY OF DISEASE

Diabetes and Risk of Parkinson's Disease: An Updated Meta-Analysis of Case-Control Studies

(2014) Lin Lu et al.   PLoS One

Defining Midbrain Dopaminergic Neuron Diversity by Single-Cell Gene Expression Profiling

(2014) Jean-Francois Poulin et al.   Cell Reports

Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease

(2013) Jeffrey H. Kordower et al.   BRAIN

Metabolic inflammation exacerbates dopaminergic neuronal degeneration in response to acute MPTP challenge in type 2 diabetes mice

(2013) Ling Wang et al.   EXPERIMENTAL NEUROLOGY

Dysregulation of glucose metabolism is an early event in sporadic Parkinson's disease

(2013) Laura Dunn et al.   NEUROBIOLOGY OF AGING

Monoamine transporters: Structure, regulation, and clinical implications

(2013) E. E. Benarroch   NEUROLOGY

Diabetes is associated with postural instability and gait difficulty in Parkinson disease

(2013) Vikas Kotagal et al.   PARKINSONISM & RELATED DISORDERS

Integrative Network Analysis Unveils Convergent Molecular Pathways in Parkinson's Disease and Diabetes

(2013) Jose A. Santiago et al.   PLoS One

Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model

(2013) S. Janezic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The use of animal models in diabetes research

(2012) Aileen JF King   BRITISH JOURNAL OF PHARMACOLOGY

Risk of Parkinson Disease Onset in Patients With Diabetes: A 9-year population-based cohort study with age and sex stratifications

(2012) Y. Sun et al.   DIABETES CARE

Dual Control of Dopamine Synthesis and Release by Presynaptic and Postsynaptic Dopamine D2 Receptors

(2012) A. Anzalone et al.   JOURNAL OF NEUROSCIENCE

Dementia is associated with Insulin Resistance in patients with Parkinson's Disease

(2012) Domenico Bosco et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Metabolic markers or conditions preceding Parkinson's disease: A case-control study

(2012) Rodolfo Savica et al.   MOVEMENT DISORDERS

Living on the edge with too many mouths to feed: Why dopamine neurons die

(2012) J. Paul Bolam et al.   MOVEMENT DISORDERS

L-DOPA-induced increase in TH-immunoreactive striatal neurons in parkinsonian mice: Insights into regulation and function

(2012) Isabel Espadas et al.   NEUROBIOLOGY OF DISEASE

Striatal Dopamine Release Is Triggered by Synchronized Activity in Cholinergic Interneurons

(2012) Sarah Threlfell et al.   NEURON

Dopamine Transporter Loss in 6-OHDA Parkinson’s Model Is Unmet by Parallel Reduction in Dopamine Uptake

(2012) Tanya Chotibut et al.   PLoS One

Diabetes and Risk of Parkinson's Disease: A systematic review and meta-analysis

(2011) E. Cereda et al.   DIABETES CARE

Diabetes and Risk of Parkinson's Disease

(2011) Q. Xu et al.   DIABETES CARE

Insulin resistance impairs nigrostriatal dopamine function

(2011) J.K. Morris et al.   EXPERIMENTAL NEUROLOGY

Projected numbers of people with movement disorders in the years 2030 and 2050

(2011) Jan-Philipp Bach et al.   MOVEMENT DISORDERS

Obesity, diabetes, and risk of Parkinson's disease

(2011) Natalia Palacios et al.   MOVEMENT DISORDERS

Dopamine D1 receptor deletion strongly reduces neurotoxic effects of methamphetamine

(2011) S. Ares-Santos et al.   NEUROBIOLOGY OF DISEASE

Forkhead Homeobox Type O Transcription Factors in the Responses to Oxidative Stress

(2010) Peter Storz   ANTIOXIDANTS & REDOX SIGNALING

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Synapsins Differentially Control Dopamine and Serotonin Release

(2010) B. M. Kile et al.   JOURNAL OF NEUROSCIENCE

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interplay between Cytosolic Dopamine, Calcium, and α-Synuclein Causes Selective Death of Substantia Nigra Neurons

(2009) Eugene V. Mosharov et al.   NEURON

Prospective Cohort Study of Type 2 Diabetes and the Risk of Parkinson's Disease

(2008) J. A. Driver et al.   DIABETES CARE

Unregulated Cytosolic Dopamine Causes Neurodegeneration Associated with Oxidative Stress in Mice

(2008) L. Chen et al.   JOURNAL OF NEUROSCIENCE

Altered vesicular dopamine storage in Parkinson's disease: a premature demise

(2008) W. Michael Caudle et al.   TRENDS IN NEUROSCIENCES