Retrograde Axonal Degeneration in Parkinson Disease

Pathological Axonal Death through a MAPK Cascade that Triggers a Local Energy Deficit

(2015) Jing Yang et al.   CELL

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease

(2015) Ariadna Laguna et al.   NATURE NEUROSCIENCE

Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson's disease

(2015) Ulrika Nordström et al.   NEUROBIOLOGY OF DISEASE

An early axonopathy in a hLRRK2(R1441G) transgenic model of Parkinson disease

(2015) Patricia Tagliaferro et al.   NEUROBIOLOGY OF DISEASE

Early and Sustained Activation of Autophagy in Degenerating Axons after Spinal Cord Injury

(2014) Vinicius Toledo Ribas et al.   BRAIN PATHOLOGY

Axonal Transport: Cargo-Specific Mechanisms of Motility and Regulation

(2014) Sandra Maday et al.   NEURON

Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease

(2013) Jeffrey H. Kordower et al.   BRAIN

Sarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions

(2013) J. Gerdts et al.   JOURNAL OF NEUROSCIENCE

The current and projected economic burden of Parkinson's disease in the United States

(2013) Stacey L. Kowal et al.   MOVEMENT DISORDERS

Axonal transport deficits and neurodegenerative diseases

(2013) Stéphanie Millecamps et al.   NATURE REVIEWS NEUROSCIENCE

Transcription factor Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons

(2013) B. Kadkhodaei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Phr1 Ubiquitin Ligase Promotes Injury-Induced Axon Self-Destruction

(2013) Elisabetta Babetto et al.   Cell Reports

Animal Models of Parkinson's Disease: Vertebrate Genetics

(2013) Y. Lee et al.   Cold Spring Harbor Perspectives in Medicine

Alterations in axonal transport motor proteins in sporadic and experimental Parkinson’s disease

(2012) Yaping Chu et al.   BRAIN

WldS Prevents Axon Degeneration through Increased Mitochondrial Flux and Enhanced Mitochondrial Ca2+ Buffering

(2012) Michelle A. Avery et al.   CURRENT BIOLOGY

Living on the edge with too many mouths to feed: Why dopamine neurons die

(2012) J. Paul Bolam et al.   MOVEMENT DISORDERS

dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

(2012) J. M. Osterloh et al.   SCIENCE

Dopaminergic pathway reconstruction by Akt/Rheb-induced axon regeneration

(2011) Sang Ryong Kim et al.   ANNALS OF NEUROLOGY

Akt Suppresses Retrograde Degeneration of Dopaminergic Axons by Inhibition of Macroautophagy

(2011) H.-C. Cheng et al.   JOURNAL OF NEUROSCIENCE

AAV Transduction of Dopamine Neurons With Constitutively Active Rheb Protects From Neurodegeneration and Mediates Axon Regrowth

(2011) Sang Ryong Kim et al.   MOLECULAR THERAPY

Parkinson's disease and α-synuclein expression

(2011) Michael J. Devine et al.   MOVEMENT DISORDERS

Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons

(2011) M. Decressac et al.   NEUROBIOLOGY OF DISEASE

Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

(2011) David Ramonet et al.   PLoS One

Clinical progression in Parkinson disease and the neurobiology of axons

(2010) Hsiao-Chun Cheng et al.   ANNALS OF NEUROLOGY

Wallerian Degeneration, WldS, and Nmnat

(2010) Michael P. Coleman et al.   Annual Review of Neuroscience

The WldSmutation delays anterograde, but not retrograde, axonal degeneration of the dopaminergic nigro-striatal pathwayin vivo

(2010) Hsiao-Chun Cheng et al.   JOURNAL OF NEUROCHEMISTRY

Targeting NMNAT1 to Axons and Synapses Transforms Its Neuroprotective Potency In Vivo

(2010) E. Babetto et al.   JOURNAL OF NEUROSCIENCE

Genetic Animal Models of Parkinson's Disease

(2010) Ted M. Dawson et al.   NEURON

Mechanisms of acute axonal degeneration in the optic nerve in vivo

(2010) J. Knoferle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

WldSrequires Nmnat1 enzymatic activity and N16–VCP interactions to suppress Wallerian degeneration

(2009) Michelle A. Avery et al.   JOURNAL OF CELL BIOLOGY

Do polymorphisms in transcription factors LMX1A and LMX1B influence the risk for Parkinson’s disease?

(2009) Olle Bergman et al.   JOURNAL OF NEURAL TRANSMISSION

Non-Nuclear WldS Determines Its Neuroprotective Efficacy for Axons and Synapses In Vivo

(2009) B. Beirowski et al.   JOURNAL OF NEUROSCIENCE

Dynamic Changes in Presynaptic and Axonal Transport Proteins Combined with Striatal Neuroinflammation Precede Dopaminergic Neuronal Loss in a Rat Model of AAV  -Synucleinopathy

(2009) C. Y. Chung et al.   JOURNAL OF NEUROSCIENCE

Single Nigrostriatal Dopaminergic Neurons Form Widely Spread and Highly Dense Axonal Arborizations in the Neostriatum

(2009) W. Matsuda et al.   JOURNAL OF NEUROSCIENCE

Nurr1 Is Required for Maintenance of Maturing and Adult Midbrain Dopamine Neurons

(2009) B. Kadkhodaei et al.   JOURNAL OF NEUROSCIENCE

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

A dual leucine kinase–dependent axon self-destruction program promotes Wallerian degeneration

(2009) Bradley R Miller et al.   NATURE NEUROSCIENCE

Mutant LRRK2 R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease

(2009) Yanping Li et al.   NATURE NEUROSCIENCE

Association of transcription factor polymorphisms PITX3 and EN1 with Parkinson's disease

(2009) Dietrich Haubenberger et al.   NEUROBIOLOGY OF AGING

Characterisation of a novel NR4A2 mutation in Parkinson's disease brain

(2009) P.M.A. Sleiman et al.   NEUROSCIENCE LETTERS

The Wallerian degeneration slow ( Wlds ) gene does not attenuate disease in a mouse model of spinal muscular atrophy

(2008) Ferrill F. Rose et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration

(2008) Vincent Ries et al.   JOURNAL OF NEUROCHEMISTRY

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

(2008) Edward D. Plowey et al.   JOURNAL OF NEUROCHEMISTRY

Invited Article: Functional imaging in Parkinson disease

(2008) R. Nandhagopal et al.   NEUROLOGY

The neuroprotective factor Wlds fails to mitigate distal axonal and neuromuscular junction (NMJ) defects in mouse models of spinal muscular atrophy

(2008) Shingo Kariya et al.   NEUROSCIENCE LETTERS

Etiopathogenesis of Parkinson Disease: A New Beginning?

(2008) Weidong Le et al.   NEUROSCIENTIST

Progressive loss of dopaminergic neurons in the ventral midbrain of adult mice heterozygote for Engrailed1: A new genetic model for Parkinson's disease?

(2008) Gwenaëlle Le Pen et al.   PARKINSONISM & RELATED DISORDERS

Axonal  -synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease

(2007) S. Orimo et al.   BRAIN

The transcription factor PITX3 is associated with sporadic Parkinson's disease

(2007) Julia Fuchs et al.   NEUROBIOLOGY OF AGING