Aptamers in Non-Small Cell Lung Cancer Treatment

Branched kissing loops for the construction of diverse RNA homooligomeric nanostructures

(2020) Di Liu et al.   Nature Chemistry

Bifunctional Aptamer–Doxorubicin Conjugate Crosses the Blood–Brain Barrier and Selectively Delivers Its Payload to Epithelial Cell Adhesion Molecule-Positive Tumor Cells

(2020) Joanna Macdonald et al.   Nucleic Acid Therapeutics

Comparison of next-generation sequencing and immunohistochemistry analysis for targeted therapy-related genomic status in lung cancer patients

(2020) Lin Nong et al.   Journal of Thoracic Disease

Next‐Generation Cancer‐Specific Hybrid Theranostic Nanomaterials: MAGE‐A3 NIR Persistent Luminescence Nanoparticles Conjugated to Afatinib for In Situ Suppression of Lung Adenocarcinoma Growth and Metastasis

(2020) Ming‐Hsien Chan et al.   Advanced Science

Targeted delivery of Rab26 siRNA with precisely tailored DNA prism for lung cancer therapy

(2019) Qian Liu et al.   CHEMBIOCHEM

Epithelial cell adhesion molecule (EpCAM) from pleural fluid cell lysates is a highly accurate diagnostic biomarker of adenocarcinomatous effusions

(2019) José M. Porcel et al.   RESPIROLOGY

Promise of G-Quadruplex Structure Binding Ligands as Epigenetic Modifiers with Anti-Cancer Effects

(2019) Antara Sengupta et al.   MOLECULES

The Roles of MicroRNA in Lung Cancer

(2019) Kuan-Li Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Beyond PD-L1 Markers for Lung Cancer Immunotherapy

(2019) Kamila Wojas-Krawczyk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AXL degradation in combination with EGFR-TKI can delay and overcome acquired resistance in human non-small cell lung cancer cells

(2019) Donghwa Kim et al.   Cell Death & Disease

ICOS costimulation at the tumor site in combination with CTLA-4 blockade therapy elicits strong tumor immunity

(2019) Mario Martínez Soldevilla et al.   MOLECULAR THERAPY

Codelivery of Genistein and miRNA-29b to A549 Cells Using Aptamer-Hybrid Nanoparticle Bioconjugates

(2019) Koita Sacko et al.   Nanomaterials

Efficient Epidermal Growth Factor Receptor Targeting Oligonucleotide as a Potential Molecule for Targeted Cancer Therapy

(2019) Tao Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Selective eradication of human non-small cell lung cancer cells using aptamer-decorated nanoparticles harboring a cytotoxic drug cargo

(2019) Shira Engelberg et al.   Cell Death & Disease

The Role of the CXCL12/CXCR4/ACKR3 Axis in Autoimmune Diseases

(2019) Eva M. García-Cuesta et al.   Frontiers in Endocrinology

Aptamers Chemistry: Chemical Modifications and Conjugation Strategies

(2019) Fadwa Odeh et al.   MOLECULES

Characterization of A Bifunctional Synthetic RNA Aptamer and A Truncated Form for Ability to Inhibit Growth of Non-Small Cell Lung Cancer

(2019) Hanlu Wang et al.   Scientific Reports

Oncogene addiction and tumor mutational burden in non‐small‐cell lung cancer: Clinical significance and limitations

(2019) Elisabeth Smolle et al.   Thoracic Cancer

A DNA Aptamer Targeting Galectin-1 as a Novel Immunotherapeutic Strategy for Lung Cancer

(2019) Yao-Tsung Tsai et al.   Molecular Therapy-Nucleic Acids

Lung Cancer Heterogeneity in Modulation of Th17/IL17A Responses

(2019) Dominique Armstrong et al.   Frontiers in Oncology

Chloroquine in combination with aptamer-modified nanocomplexes for tumor vessel normalization and efficient erlotinib/Survivin shRNA co-delivery to overcome drug resistance in EGFR-mutated non-small cell lung cancer

(2018) Tingting Lv et al.   Acta Biomaterialia

Blockade of the Complement C5a/C5aR1 Axis Impairs Lung Cancer Bone Metastasis by CXCL16-mediated Effects

(2018) Daniel Ajona et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Targeted co-delivery of epirubicin and NAS-24 aptamer to cancer cells using selenium nanoparticles for enhancing tumor response in vitro and in vivo

(2018) Seyed Hamid Jalalian et al.   CANCER LETTERS

Tumor biomarker testing in non-small-cell lung cancer: A decade of change

(2018) Paul A. VanderLaan et al.   LUNG CANCER

Evaluation of MUC1-Aptamer Functionalized Hybrid Nanoparticles for Targeted Delivery of miRNA-29b to Nonsmall Cell Lung Cancer

(2018) Maryna Perepelyuk et al.   MOLECULAR PHARMACEUTICS

Origins of biological function in DNA and RNA hairpin loop motifs from replica exchange molecular dynamics simulation

(2018) Jacob B. Swadling et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

TEMPORARY REMOVAL: MAFG is a potential therapeutic target to restore chemosensitivity in cisplatin-resistant cancer cells by increasing reactive oxygen species

(2018) Olga Vera-Puente et al.   Translational Research

MiR-29c reduces the cisplatin resistance of non-small cell lung cancer cells by negatively regulating the PI3K/Akt pathway

(2018) Dian-min Sun et al.   Scientific Reports

NF-kappaB: Two Sides of the Same Coin

(2018) Bruno Pires et al.   Genes

The Potential Biomarkers and Immunological Effects of Tumor-Derived Exosomes in Lung Cancer

(2018) Shamila D. Alipoor et al.   Frontiers in Immunology

Aptamer Therapeutics in Cancer: Current and Future

(2018) Yoshihiro Morita et al.   Cancers

Current Advances in Aptamers for Cancer Diagnosis and Therapy

(2018) Shin-ichiro Hori et al.   Cancers

Aptamer-miR-34c conjugate affects cell proliferation of non-small cell lung cancer cells

(2018) Valentina Russo et al.   Molecular Therapy-Nucleic Acids

Vimentin Diversity in Health and Disease

(2018) Frida Danielsson et al.   Cells

Three decades of nucleic acid aptamer technologies: Lessons learned, progress and opportunities on aptamer development

(2018) Tao Wang et al.   BIOTECHNOLOGY ADVANCES

Mipomersen and its use in familial hypercholesterolemia

(2018) Johnathon Seth Parham et al.   EXPERT OPINION ON PHARMACOTHERAPY

Aptamer-targeted delivery of Bcl-xL shRNA using alkyl modified PAMAM dendrimers into lung cancer cells

(2017) Sara Ayatollahi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

RhoA knockout fibroblasts lose tumor-inhibitory capacity in vitro and promote tumor growth in vivo

(2017) Twana Alkasalias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Combined PD-1/C5a Blockade Synergistically Protects against Lung Cancer Growth and Metastasis

(2017) Daniel Ajona et al.   Cancer Discovery

Increasing Tumor-Infiltrating T Cells through Inhibition of CXCL12 with NOX-A12 Synergizes with PD-1 Blockade

(2017) Dirk Zboralski et al.   Cancer Immunology Research

A CTLA-4 Antagonizing DNA Aptamer with Antitumor Effect

(2017) Bo-Tsang Huang et al.   Molecular Therapy-Nucleic Acids

Lung Cancer: Understanding Its Molecular Pathology and the 2015 WHO Classification

(2017) Kentaro Inamura   Frontiers in Oncology

Evaluation of somatostatin and nucleolin receptors for therapeutic delivery in non-small cell lung cancer stem cells applying the somatostatin-analog DOTATATE and the nucleolin-targeting aptamer AS1411

(2017) Sif Holmboe et al.   PLoS One

Midkine derived from cancer-associated fibroblasts promotes cisplatin-resistance via up-regulation of the expression of lncRNA ANRIL in tumour cells

(2017) Dongya Zhang et al.   Scientific Reports

CTLA-4 and PD-1 Pathways

(2016) Elizabeth I. Buchbinder et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Characteristics and Significance of the Pre-metastatic Niche

(2016) Yang Liu et al.   CANCER CELL

Aptamer-hybrid nanoparticle bioconjugate efficiently delivers miRNA-29b to non-small-cell lung cancer cells and inhibits growth by downregulating essential oncoproteins

(2016) Sunday Shoyele et al.   International Journal of Nanomedicine

AS1411 Aptamer-Decorated Biodegradable Polyethylene Glycol–Poly(lactic-co-glycolic acid) Nanopolymersomes for the Targeted Delivery of Gemcitabine to Non–Small Cell Lung Cancer In Vitro

(2016) Mona Alibolandi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

PD-L1 Expression in Lung Cancer

(2016) Hui Yu et al.   Journal of Thoracic Oncology

DNA–DNA kissing complexes as a new tool for the assembly of DNA nanostructures

(2016) Anna Barth et al.   NUCLEIC ACIDS RESEARCH

Aptamers: A promising chemical antibody for cancer therapy

(2016) Gang Zhou et al.   Oncotarget

Aptamer-miRNA-212 Conjugate Sensitizes NSCLC Cells to TRAIL

(2016) Margherita Iaboni et al.   Molecular Therapy-Nucleic Acids

A Novel PD-L1-targeting Antagonistic DNA Aptamer With Antitumor Effects

(2016) Wei-Yun Lai et al.   Molecular Therapy-Nucleic Acids

Inhibition of discoidin domain receptor 2-mediated lung cancer cells progression by gold nanoparticle-aptamer-assisted delivery of peptides containing transmembrane-juxtamembrane 1/2 domain

(2015) Daehwan Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cellular delivery of shRNA using aptamer-conjugated PLL-alkyl-PEI nanoparticles

(2015) Saeedeh Askarian et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

In vitro and in vivo evaluation of therapy targeting epithelial-cell adhesion-molecule aptamers for non-small cell lung cancer

(2015) Mona Alibolandi et al.   JOURNAL OF CONTROLLED RELEASE

Mechanistic studies of anticancer aptamer AS1411 reveal a novel role for nucleolin in regulating Rac1 activation

(2015) E. Merit Reyes-Reyes et al.   Molecular Oncology

A Highlight of Recent Advances in Aptamer Technology and Its Application

(2015) Hongguang Sun et al.   MOLECULES

Aptamer-Dendrimer Bioconjugates for Targeted Delivery of miR-34a Expressing Plasmid and Antitumor Effects in Non-Small Cell Lung Cancer Cells

(2015) Hongmei Wang et al.   PLoS One

PKCδ/midkine pathway drives hypoxia-induced proliferation and differentiation of human lung epithelial cells

(2014) Hanying Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Gemcitabine inhibits the micrometastasis of non-small cell lung cancer by targeting the EpCAM-positive circulating tumor cells via the HGF/cMET pathway

(2014) Z.J. LIAO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

CXC Chemokine Ligand 12 Promotes CCR7-Dependent Naive T Cell Trafficking to Lymph Nodes and Peyer's Patches

(2014) Z. Bai et al.   JOURNAL OF IMMUNOLOGY

Structure and function of pseudoknots involved in gene expression control

(2014) Alla Peselis et al.   Wiley Interdisciplinary Reviews-RNA

APC binds intermediate filaments and is required for their reorganization during cell migration

(2013) Yasuhisa Sakamoto et al.   JOURNAL OF CELL BIOLOGY

Whole Cell-SELEX Aptamers for Highly Specific Fluorescence Molecular Imaging of Carcinomas In Vivo

(2013) Hui Shi et al.   PLoS One

Novel MUC1 Aptamer Selectively Delivers Cytotoxic Agent to Cancer Cells In Vitro

(2012) Yan Hu et al.   PLoS One

Overexpression of Osteopontin, αvβ3 and Pim-1 Associated with Prognostically Important Clinicopathologic Variables in Non-Small Cell Lung Cancer

(2012) Yi Jin et al.   PLoS One

Significance of EpCAM and TROP2 expression in non-small cell lung cancer

(2012) Min Pak et al.   World Journal of Surgical Oncology

The Role of Osteopontin and Osteopontin Aptamer (OPN-R3) in Fibroblast Activity

(2011) Cedric Hunter et al.   JOURNAL OF SURGICAL RESEARCH

The role of CTLA-4 in immune regulation

(2007) Johan Verhagen et al.   IMMUNOLOGY LETTERS

RNA Aptamer-targeted Inhibition of NF-κB Suppresses Non-small Cell Lung Cancer Resistance to Doxorubicin

(2007) Jing Mi et al.   MOLECULAR THERAPY