Mechanistic studies of anticancer aptamer AS1411 reveal a novel role for nucleolin in regulating Rac1 activation

Long-term outcomes of responders in a randomized, controlled phase II trial of aptamer AS1411 in AML.

(2017) D. Rizzieri et al.   JOURNAL OF CLINICAL ONCOLOGY

Interfering with the interaction between ErbB1, nucleolin and Ras as a potential treatment for glioblastoma

(2015) Yona Goldshmit et al.   Oncotarget

A nucleolin-DNMT1 regulatory axis in acute myeloid leukemogenesis

(2015) Na Shen et al.   Oncotarget

Methuosis

(2014) William A. Maltese et al.   AMERICAN JOURNAL OF PATHOLOGY

RETRACTED: Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule

(2014) Satish Srinivas Kitambi et al.   CELL

Grafting Aptamers onto Gold Nanostars Increases in Vitro Efficacy in a Wide Range of Cancer Cell Types

(2014) Duncan Hieu M. Dam et al.   MOLECULAR PHARMACEUTICS

C9orf72 nucleotide repeat structures initiate molecular cascades of disease

(2014) Aaron R. Haeusler et al.   NATURE

A phase II trial of AS1411 (a novel nucleolin-targeted DNA aptamer) in metastatic renal cell carcinoma

(2013) Jonathan E. Rosenberg et al.   INVESTIGATIONAL NEW DRUGS

In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation

(2013) Flavia Pichiorri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RAC1: An Emerging Therapeutic Option for Targeting Cancer Angiogenesis and Metastasis

(2013) H. K. Bid et al.   MOLECULAR CANCER THERAPEUTICS

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Roles for Actin Assembly in Endocytosis

(2012) Olivia L. Mooren et al.   Annual Review of Biochemistry

Hyperstimulation of macropinocytosis leads to lysosomal dysfunction during exposure to methamphetamine in SH-SY5Y cells

(2012) Akina Nara et al.   BRAIN RESEARCH

KRAS alleles: The LCS6 3′UTR variant and KRAS coding sequence mutations in the NCI-60 panel

(2012) Samrat T. Kundu et al.   CELL CYCLE

Synthesis and Evaluation of Indole-Based Chalcones as Inducers of Methuosis, a Novel Type of Nonapoptotic Cell Death

(2012) Michael W. Robinson et al.   JOURNAL OF MEDICINAL CHEMISTRY

RNA-binding protein nucleolin in disease

(2012) Kotb Abdelmohsen et al.   RNA Biology

Oncogenic Synergism between ErbB1, Nucleolin, and Mutant Ras

(2011) K. Farin et al.   CANCER RESEARCH

Macropinocytosis: an endocytic pathway for internalising large gulps

(2011) Jet Phey Lim et al.   IMMUNOLOGY AND CELL BIOLOGY

Endosomal Accumulation of the Activated Epidermal Growth Factor Receptor (EGFR) Induces Apoptosis

(2011) Jamie S. Rush et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced translation by Nucleolin via G-rich elements in coding and non-coding regions of target mRNAs

(2011) Kotb Abdelmohsen et al.   NUCLEIC ACIDS RESEARCH

Aptamer-Based Tumor-Targeted Drug Delivery for Photodynamic Therapy

(2010) Yen-An Shieh et al.   ACS Nano

Cetuximab (Erbitux)

(2010) W. Bou-Assaly et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

A New Paradigm for Aptamer Therapeutic AS1411 Action: Uptake by Macropinocytosis and Its Stimulation by a Nucleolin-Dependent Mechanism

(2010) E. M. Reyes-Reyes et al.   CANCER RESEARCH

Death pathways triggered by activated Ras in cancer cells

(2010) Jean et al.   Frontiers in Bioscience-Landmark

Induction of Nonapoptotic Cell Death by Activated Ras Requires Inverse Regulation of Rac1 and Arf6

(2010) Haymanti Bhanot et al.   MOLECULAR CANCER RESEARCH

Surface Expressed Nucleolin Is Constantly Induced in Tumor Cells to Mediate Calcium-Dependent Ligand Internalization

(2010) Ara G. Hovanessian et al.   PLoS One

Off-target effects of epidermal growth factor receptor antagonists mediate retinal ganglion cell disinhibited axon growth

(2009) Michael R. Douglas et al.   BRAIN

Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer

(2009) Paula J. Bates et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Nucleophosmin and Nucleolin Regulate K-Ras Plasma Membrane Interactions and MAPK Signal Transduction

(2009) Kerry L. Inder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nerve growth factor activation of the TrkA receptor induces cell death, by macropinocytosis, in medulloblastoma Daoy cells

(2009) Chunhui Li et al.   JOURNAL OF NEUROCHEMISTRY

Virus entry by macropinocytosis

(2009) Jason Mercer et al.   NATURE CELL BIOLOGY

Structure-Function Analysis of Nucleolin and ErbB Receptors Interactions

(2009) Keren Farin et al.   PLoS One

The Nucleolin Targeting Aptamer AS1411 Destabilizes Bcl-2 Messenger RNA in Human Breast Cancer Cells

(2008) S. Soundararajan et al.   CANCER RESEARCH

Cellular localization of the activated EGFR determines its effect on cell growth in MDA-MB-468 cells

(2008) Dustin C. Hyatt et al.   EXPERIMENTAL CELL RESEARCH

A Novel Small Molecule Regulator of Guanine Nucleotide Exchange Activity of the ADP-ribosylation Factor and Golgi Membrane Trafficking

(2008) Heling Pan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Active Ras Triggers Death in Glioblastoma Cells through Hyperstimulation of Macropinocytosis

(2008) J. H. Overmeyer et al.   MOLECULAR CANCER RESEARCH