Therapeutic applications of chelating drugs in iron metabolic disorders of the brain and retina

The Contribution of Iron to Protein Aggregation Disorders in the Central Nervous System

(2019) Karina Joppe et al.   Frontiers in Neuroscience

Retinal α-synuclein deposits in Parkinson’s disease patients and animal models

(2019) Lien Veys et al.   ACTA NEUROPATHOLOGICA

DMT1 Expression and Iron Levels at the Crossroads Between Aging and Neurodegeneration

(2019) Rosaria Ingrassia et al.   Frontiers in Neuroscience

Oxidative stress and neurodegeneration: the involvement of iron

(2018) Alessia Carocci et al.   BIOMETALS

Molecular basis of dopamine replacement therapy and its side effects in Parkinson’s disease

(2018) Hana You et al.   CELL AND TISSUE RESEARCH

Iron and Alzheimer’s Disease: An Update on Emerging Mechanisms

(2018) Darius J.R. Lane et al.   JOURNAL OF ALZHEIMERS DISEASE

Metals and Alzheimer’s Disease: How Far Have We Come in the Clinic?

(2018) Paul A. Adlard et al.   JOURNAL OF ALZHEIMERS DISEASE

Quantifying iron deposition within the substantia nigra of Parkinson's disease by quantitative susceptibility mapping

(2018) Hedi An et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Iron as a therapeutic target for Parkinson's disease

(2018) Caroline Moreau et al.   MOVEMENT DISORDERS

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Iron Overload Accelerates the Progression of Diabetic Retinopathy in Association with Increased Retinal Renin Expression

(2018) Kapil Chaudhary et al.   Scientific Reports

Striking while the iron is hot: Iron metabolism and Ferroptosis in neurodegeneration

(2018) Shashank Masaldan et al.   FREE RADICAL BIOLOGY AND MEDICINE

A review on iron chelators as potential therapeutic agents for the treatment of Alzheimer’s and Parkinson’s diseases

(2018) Yash Pal Singh et al.   MOLECULAR DIVERSITY

Ferroptosis and cell death mechanisms in Parkinson's disease

(2017) Stephanie J. Guiney et al.   NEUROCHEMISTRY INTERNATIONAL

A splice-site variant in FLVCR1 produces retinitis pigmentosa without posterior column ataxia

(2017) Imran H. Yusuf et al.   OPHTHALMIC GENETICS

Retinal biomarkers provide “insight” into cortical pharmacology and disease

(2017) Christine T.O. Nguyen et al.   PHARMACOLOGY & THERAPEUTICS

Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease

(2017) Fabio A. Zucca et al.   PROGRESS IN NEUROBIOLOGY

Prevalence and Natural History of Superficial Siderosis

(2017) Michael Pichler et al.   STROKE

α-Synuclein impairs ferritinophagy in the retinal pigment epithelium: Implications for retinal iron dyshomeostasis in Parkinson’s disease

(2017) Shounak Baksi et al.   Scientific Reports

Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress

(2017) Helmut Sies   Redox Biology

The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson’s disease

(2017) David I. Finkelstein et al.   Acta Neuropathologica Communications

Brain iron chelation by deferiprone in a phase 2 randomised double-blinded placebo controlled clinical trial in Parkinson’s disease

(2017) Antonio Martin-Bastida et al.   Scientific Reports

Effects of Neonatal Iron Feeding and Chronic Clioquinol Administration on the Parkinsonian Human A53T Transgenic Mouse

(2016) Jessica L. Billings et al.   ACS Chemical Neuroscience

Deferiprone-induced agranulocytosis: 20 years of clinical observations

(2016) Fernando Tricta et al.   AMERICAN JOURNAL OF HEMATOLOGY

β-Thalassemia

(2016) Raffaella Origa   GENETICS IN MEDICINE

Clinical Experience With Deferiprone Treatment for Friedreich Ataxia

(2016) Sandra Elincx-Benizri et al.   JOURNAL OF CHILD NEUROLOGY

Brain iron accumulation affects myelin-related molecular systems implicated in a rare neurogenetic disease family with neuropsychiatric features

(2016) M Heidari et al.   MOLECULAR PSYCHIATRY

Lithium suppression of tau induces brain iron accumulation and neurodegeneration

(2016) P Lei et al.   MOLECULAR PSYCHIATRY

Clioquinol Improves Cognitive, Motor Function, and Microanatomy of the Alpha-Synuclein hA53T Transgenic Mice

(2015) David I. Finkelstein et al.   ACS Chemical Neuroscience

Neurodegeneration with Brain Iron Accumulation: Genetic Diversity and Pathophysiological Mechanisms

(2015) Esther Meyer et al.   Annual Review of Genomics and Human Genetics

Ceruloplasmin activity and iron chelation treatment of patients with Parkinson’s disease

(2015) Guillaume Grolez et al.   BMC Neurology

Cortical superficial siderosis: detection and clinical significance in cerebral amyloid angiopathy and related conditions

(2015) Andreas Charidimou et al.   BRAIN

Ceruloplasmin functional changes in Parkinson’s disease-cerebrospinal fluid

(2015) Marco Barbariga et al.   Molecular Neurodegeneration

Is early-life iron exposure critical in neurodegeneration?

(2015) Dominic J. Hare et al.   Nature Reviews Neurology

7T T2∗-weighted magnetic resonance imaging reveals cortical phase differences between early- and late-onset Alzheimer's disease

(2015) Sanneke van Rooden et al.   NEUROBIOLOGY OF AGING

Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE

(2015) Scott Ayton et al.   Nature Communications

Functional and Structural Abnormalities in Deferoxamine Retinopathy: A Review of the Literature

(2015) Maura Di Nicola et al.   Biomed Research International

Deferiprone in Friedreich ataxia: A 6-Month randomized controlled trial

(2014) Massimo Pandolfo et al.   ANNALS OF NEUROLOGY

α-synuclein in the inner retina in parkinson disease

(2014) Ivan Bodis-Wollner et al.   ANNALS OF NEUROLOGY

Alzheimer's disease therapeutics targeted to the control of amyloid precursor protein translation: Maintenance of brain iron homeostasis

(2014) Sanghamitra Bandyopadhyay et al.   BIOCHEMICAL PHARMACOLOGY

Variability of the Transferrin Receptor 2 Gene in AMD

(2014) Daniel Wysokinski et al.   DISEASE MARKERS

Iron increases APP translation and amyloid-beta production in the retina

(2014) Lucie Y. Guo et al.   EXPERIMENTAL EYE RESEARCH

Is the Aluminum Hypothesis Dead?

(2014) Theodore I. Lidsky   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

Iron overload accelerates neuronal amyloid-β production and cognitive impairment in transgenic mice model of Alzheimer's disease

(2014) Javier Becerril-Ortega et al.   NEUROBIOLOGY OF AGING

An iron–dopamine index predicts risk of parkinsonian neurodegeneration in the substantia nigra pars compacta

(2014) Dominic J. Hare et al.   Chemical Science

Nigral Iron Elevation Is an Invariable Feature of Parkinson’s Disease and Is a Sufficient Cause of Neurodegeneration

(2014) Scott Ayton et al.   Biomed Research International

Association Between Serum Ferritin and Glaucoma in the South Korean Population

(2014) Shuai-Chun Lin et al.   JAMA Ophthalmology

A novel approach to rapidly prevent age-related cognitive decline

(2013) Paul A. Adlard et al.   AGING CELL

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

(2013) David Devos et al.   ANTIOXIDANTS & REDOX SIGNALING

Prevalence and mechanisms of cortical superficial siderosis in cerebral amyloid angiopathy

(2013) A. Charidimou et al.   NEUROLOGY

RETINA MEASUREMENTS FOR DIAGNOSIS OF PARKINSON DISEASE

(2013) Elena Garcia-Martin et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Retinal iron homeostasis in health and disease

(2013) Delu Song et al.   Frontiers in Aging Neuroscience

Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease

(2012) Scott Ayton et al.   ANNALS OF NEUROLOGY

Alterations in Brain Transition Metals in Huntington Disease

(2012) H. Diana Rosas et al.   ARCHIVES OF NEUROLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

(2012) Peng Lei et al.   NATURE MEDICINE

The retina as a window to the brain—from eye research to CNS disorders

(2012) Anat London et al.   Nature Reviews Neurology

The Neuronal Organization of the Retina

(2012) Richard H. Masland   NEURON

Iron Overload in Human Disease

(2012) Robert E. Fleming et al.   NEW ENGLAND JOURNAL OF MEDICINE

Free radicals and antioxidants: updating a personal view

(2012) Barry Halliwell   NUTRITION REVIEWS

Abnormal Fundus Autofluorescence Results of Patients in Long-term Treatment with Deferoxamine

(2012) Francesco Viola et al.   OPHTHALMOLOGY

Amyloid Precursor Protein Is Required for Normal Function of the Rod and Cone Pathways in the Mouse Retina

(2012) Tracy Ho et al.   PLoS One

Brain Iron Quantification in Mild Traumatic Brain Injury: A Magnetic Field Correlation Study

(2011) E. Raz et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Neurodegeneration with brain iron accumulation — Clinical syndromes and neuroimaging

(2011) Hyman M. Schipper   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Ophthalmic features of Friedreich ataxia

(2011) S Noval et al.   EYE

Zinc–desferrioxamine attenuates retinal degeneration in the rd10 mouse model of retinitis pigmentosa

(2011) Alexey Obolensky et al.   FREE RADICAL BIOLOGY AND MEDICINE

A pilot trial of deferiprone for neurodegeneration with brain iron accumulation

(2011) G. Abbruzzese et al.   HAEMATOLOGICA

Age-related Accumulation of Non-heme Ferric and Ferrous Iron in Mouse Ovarian Stroma Visualized by Sensitive Non-heme Iron Histochemistry

(2011) Yoshiya Asano   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

The Alzheimer’s therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity

(2011) Peter J. Crouch et al.   JOURNAL OF NEUROCHEMISTRY

Desferrioxamine treatment of aceruloplasminemia: Long-term follow-up

(2011) Ping-Lei Pan et al.   MOVEMENT DISORDERS

Posterior column ataxia with retinitis pigmentosa in a Japanese family with a novel mutation in FLVCR1

(2011) Hiroyuki Ishiura et al.   NEUROGENETICS

Iron-Chelating Therapy for Transfusional Iron Overload

(2011) Gary M. Brittenham   NEW ENGLAND JOURNAL OF MEDICINE

Pilot Safety Trial of Deferiprone in 10 Subjects With Superficial Siderosis

(2011) Michael Levy et al.   STROKE

Iron, Meat and Health

(2011) Catherine Geissler et al.   Nutrients

Mutations in FLVCR1 Cause Posterior Column Ataxia and Retinitis Pigmentosa

(2010) Anjali M. Rajadhyaksha et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

Combined Therapy with Idebenone and Deferiprone in Patients with Friedreich’s Ataxia

(2010) Daniel Velasco-Sánchez et al.   CEREBELLUM

Deferoxamine mesylate is toxic for retinal pigment epithelium cellsin vitro, and its toxicity is mediated by p38

(2010) Alexa Klettner et al.   Cutaneous and Ocular Toxicology

Oxidation and age-related macular degeneration: insights from molecular biology

(2010) Sam Khandhadia et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Molecular mechanisms of neurodegeneration in Alzheimer's disease

(2010) L. Crews et al.   HUMAN MOLECULAR GENETICS

Selective Translational Control of the Alzheimer Amyloid Precursor Protein Transcript by Iron Regulatory Protein-1

(2010) Hyun-Hee Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific Inhibition of NEIL-initiated Repair of Oxidized Base Damage in Human Genome by Copper and Iron

(2010) Muralidhar L. Hegde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain iron metabolism and its perturbation in neurological diseases

(2010) Robert R. Crichton et al.   JOURNAL OF NEURAL TRANSMISSION

Increased brain iron coincides with early plaque formation in a mouse model of Alzheimer's disease

(2010) Andreana C. Leskovjan et al.   NEUROIMAGE

Differential effects of age and history of hypertension on regional brain volumes and iron

(2010) Karen M. Rodrigue et al.   NEUROIMAGE

Prevalence of superficial siderosis in patients with cerebral amyloid angiopathy

(2010) J. Linn et al.   NEUROLOGY

Superficial siderosis - mechanism of disease: an alternative hypothesis

(2010) S. Nanda et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Primary Open-Angle Glaucoma

(2009) Young H. Kwon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases

(2008) Catherine M. Cahill et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism

(2008) T. Lambe et al.   BLOOD

Visual system involvement in patients with Friedreich's ataxia

(2008) Filippo Fortuna et al.   BRAIN

Diagnosis and treatment of Wilson disease: An update

(2008) Eve A. Roberts et al.   HEPATOLOGY

Body iron metabolism and pathophysiology of iron overload

(2008) Yutaka Kohgo et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

(2008) Lars Lannfelt et al.   LANCET NEUROLOGY

Iron localization in superficial siderosis of the central nervous system

(2008) Harry Kellermier et al.   NEUROPATHOLOGY

DEFEROXAMINE-RELATED OCULAR TOXICITY

(2008) JASRAJBIR S. BAATH et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Diabetic retinopathy and systemic vascular complications

(2007) Ning Cheung et al.   PROGRESS IN RETINAL AND EYE RESEARCH