Review
Ophthalmology
Mohamed Belmouhand, Christina Eckmann-Hansen, Tomas Ilginis, Eva Birgitte Leinoe, Bo Kok Mortensen, Michael Larsen
Summary: Deferoxamine retinopathy is a pattern of outer retinal degeneration in iron-overloaded chronic anemia patients treated with deferoxamine. The cause of retinal degeneration seems to be insufficient iron chelation rather than deferoxamine itself. Adjusting chelation therapy may not improve visual function, suggesting a role of promoting slow retinal siderosis development.
Review
Nutrition & Dietetics
Janika Shah, Zi Yu Cheong, Bingyao Tan, Damon Wong, Xinyu Liu, Jacqueline Chua
Summary: This systematic review comprehensively summarizes the current understanding of the associations between dietary consumption, diabetic retinopathy (DR), and diabetic macular edema (DME). The review found that higher intakes of fruits, vegetables, dietary fibers, fish, a Mediterranean diet, oleic acid, and tea were protective against DR, while high intakes of diet soda, caloric intake, rice, and choline were associated with a higher risk of DR. There was no association between vitamin C, riboflavin, vitamin D, milk, and DR. A single study assessed dietary intake and DME, and found a risk of high sodium intake for DME progression.
Article
Nutrition & Dietetics
Anna Bryl, Malgorzata Mrugacz, Mariusz Falkowski, Katarzyna Zorena
Summary: Diabetes is a global social problem with increasing incidence. Controlling blood glucose, lipid profile, and blood pressure through healthy lifestyle, dietary changes, and physical activity can significantly reduce the risk of diabetes and diabetic retinopathy.
Review
Behavioral Sciences
Carina H. Fowler, Armen Bagdasarov, Nicolas L. Camacho, Aaron Reuben, Michael S. Gaffrey
Summary: Youth worldwide are regularly exposed to pollutants and chemicals that may interfere with healthy brain development. A systematic review of developmental MRI studies was conducted on known or suspected neurobiological impact of toxicants. The review included 46 studies and found substantial heterogeneity in measurements and age groups assessed. More research is needed on all toxicants reviewed, including larger samples, personal exposure monitoring, and diverse world regions.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Neurosciences
Xiaoting Huang, Yangsa Du, Danni Guo, Fangfang Xie, Chunyao Zhou
Summary: This study aimed to evaluate the coupling of structural connectivity (SC) and functional connectivity (FC) in the entire brain of healthy controls (HCs) and individuals with temporal lobe epilepsy (TLE). The results showed that TLE patients had lower SC-FC coupling strength in specific brain regions compared to HCs, indicating higher susceptibility to pathological disruption.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Medicine, General & Internal
Anna Bryl, Malgorzata Mrugacz, Mariusz Falkowski, Katarzyna Zorena
Summary: Diabetes mellitus is a significant social issue, and its retinal complications are major causes of blindness worldwide. Glucose level, hypertension, and hyperlipidemia have been found to be related to the development of diabetes complications. However, the exact mechanisms of this effect have not been fully explained.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Neurosciences
Yu Tang, Maohua Wang, Ting Zheng, Yan Xiao, Song Wang, Fugang Han, Guangxiang Chen
Summary: Neuroimaging studies have shown that postherpetic neuralgia (PHN) is closely associated with structural and functional abnormalities in the brain, particularly affecting regions like the thalamus and insula within the pain matrix. Disruption of multiple networks, including the default-mode network and limbic system, may contribute to the neurophysiological mechanisms underlying PHN.
Article
Clinical Neurology
Nadine Eijsker, Arjan Schroeder, Dirk J. A. Smit, Guido van Wingen, Damiaan Denys
Summary: Misophonia patients showed larger right amygdala volume and different functional connectivity patterns compared to healthy controls, suggesting dysfunction in emotional and attentional systems. This may be associated with heightened emotional reactivity, physical reflex-like reactions to triggers, and sensory enhancement of visual triggers in misophonia.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Environmental Sciences
Lufeng Hu, Qin Lan, Congrong Tang, Jianhui Yang, Xingjie Zhu, Feiyan Lin, Zheng Yu, Xianqin Wang, Congcong Wen, Xiuhua Zhang, Zhongqiu Lu
Summary: The study found that the metabolism of polyunsaturated fatty acids (PUFAs) was the key pathway in paraquat (PQ) poisoning. PQ caused cell death through the induction of ferroptosis. Inhibition of ferroptosis could be a novel strategy for the treatment of PQ poisoning.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Medicine, General & Internal
Jonathan J. Horsley, Rhys H. Thomas, FahmidaA. Chowdhury, Beate Diehl, Andrew W. Mcevoy, Anna Miserocchi, Jane de Tisi, Sjoerd B. Vos, Matthew C. Walker, Gavin P. Winston, John S. Duncan, Yujiang Wang, Peter N. Taylor
Summary: Our study investigated the use of structural connectivity abnormalities inferred from dMRI in combination with functional iEEG abnormalities to improve surgical outcomes in patients with epilepsy. Results showed that resection of maximal connectivity and iEEG abnormalities was significantly associated with seizure freedom, and the use of both modalities together correctly identified the surgical outcome for a majority of patients.
Article
Biochemistry & Molecular Biology
Manuela Loi, Stefano Bastianini, Giulia Candini, Nicola Rizzardi, Giorgio Medici, Valentina Papa, Laura Gennaccaro, Nicola Mottolese, Marianna Tassinari, Beatrice Uguagliati, Chiara Berteotti, Viviana Lo Martire, Giovanna Zoccoli, Giovanna Cenacchi, Stefania Trazzi, Christian Bergamini, Elisabetta Ciani
Summary: CDKL5 deficiency disorder (CDD) is a severe neurodevelopmental disease caused by mutations in the CDKL5 gene. Mouse models of CDD have helped understand the role of CDKL5 in brain development and function. This study reveals cardiac alterations in Cdkl5 +/- mice, including prolonged QT interval, increased heart rate, fibrosis, altered gap junction organization, mitochondrial dysfunction, and increased ROS production. These findings provide new insights into the function of CDKL5 in heart structure/function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Construction & Building Technology
Linfeng Mei, Qian Wang
Summary: This paper comprehensively reviews the previous research on structural optimization in the field of civil engineering, analyzing optimization objectives, trends, and processes while also identifying research limitations and proposing future directions. It provides critical insights into the achievements and challenges of current research, offering guidelines for future studies in structural optimization.
Review
Biochemistry & Molecular Biology
Michal B. Ponczek
Summary: Kininogens are multidomain glycoproteins with important roles in the intrinsic pathway of coagulation and the generation of the vasoactive peptide bradykinin. Despite previous failures to crystallize kininogen, new advancements in cryo-electron microscopy offer opportunities to study its structure at an atomic level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Environmental Sciences
Johnn Andersson, Kristina Hojckova, Bjorn A. Sanden
Summary: This paper reviews the understanding of the functional and structural scope of technological innovation systems (TIS) in the literature, highlighting the lack of clarity and consensus. It proposes a clear and shared underlying TIS model and provides guidance for empirical case studies related to boundary-setting.
ENVIRONMENTAL INNOVATION AND SOCIETAL TRANSITIONS
(2023)
Article
Clinical Neurology
Luqi Cheng, Yumin Yuan, Xie Tang, Yuan Zhou, Chunxia Luo, Daihong Liu, Yuanchao Zhang, Jiuquan Zhang
Summary: Using multimodal MRI, this study identified significant cortical thinning in multiple brain regions, including the right precentral gyrus, in ALS patients, along with alterations in white matter microstructure. The findings also indicated a tight coupling between cortical thickness and white matter integrity in the precentral gyrus cluster. Additionally, decreased self-inhibitory influence in the precentral gyrus cluster was observed in ALS patients, suggesting an imbalance in inhibitory and excitatory neurotransmitters in this region.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Ophthalmology
Maurizio Battaglia Parodi, Maria Vittoria Cicinel, Alessandro Marchese, Chiara Giuffre, Francesco Viola, Giovanni Staurenghi, Monica Varano, Francesco Bandello
Summary: Intravitreal aflibercept is effective in treating choroidal neovascularization secondary to angioid streaks, with improvements in visual acuity and central macular thickness at 48 weeks. Some patients may experience adverse events, warranting further observation and studies with different therapeutic regimens.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Pathology
Vladimir Bantseev, Joshua Horvath, Giulio Barteselli, Shrirang Ranade, Mauricio Maia, Daniela Bumbaca Yadav, Chris Schuetz, Amy Shelton, Helen S. Booler
Summary: The Port Delivery System with ranibizumab (PDS) is a drug delivery system designed to provide continuous intravitreal release of ranibizumab without introducing any new toxicology-related safety concerns. Toxicology program results showed that the PDS is biocompatible and safe for clinical development.
TOXICOLOGIC PATHOLOGY
(2021)
Article
Ophthalmology
Maria Vittoria Cicinelli, Maura Di Nicola, Carmen Rosaria Gigliotti, Marco Battista, Elisabetta Miserocchi, Antonella del Vecchio, Pietro Mortini, Francesco Bandello, Giulio Maria Modorati
Summary: This study investigated factors predictive of radiation-related complications in uveal melanoma patients undergoing gamma knife radiosurgery. The most common complications were radiation retinopathy, radiation papillopathy, and neovascular glaucoma. Factors like age and tumor location were associated with the occurrence of complications.
ACTA OPHTHALMOLOGICA
(2021)
Editorial Material
Ophthalmology
Carl W. Noble, Maura Di Nicola, Meghan E. Hermanson, Basil K. Williams
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Ophthalmology
Roberto dell'Omo, Mariaelena Filippelli, Gianni Virgili, Francesco Bandello, Giuseppe Querques, Paolo Lanzetta, Teresio Avitabile, Francesco Viola, Michele Reibaldi, Francesco Semeraro, Luciano Quaranta, Stanislao Rizzo, Edoardo Midena, Giuseppe Campagna, Ciro Costagliola
Summary: The number of eye surgical procedures in Italy significantly decreased during the lockdown due to the COVID-19 epidemic, with only 70% of recommended surgeries being performed. Elective surgeries decreased by 96.2%, urgent surgeries by 49.7%, and intravitreal injections by 48.5% during the lockdown period.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Basil K. Williams Jr, Maura Di Nicola
MEDICAL CLINICS OF NORTH AMERICA
(2021)
Article
Pharmacology & Pharmacy
Shrirang Ranade, Mark R. Wieland, Tammy Tam, Jennifer C. Rea, Judit Horvath, Aaron R. Hieb, Weitao Jia, Lori Grace, Giulio Barteselli, Jay M. Stewart
Summary: The Port Delivery System is an innovative intraocular drug delivery system that continuously releases ranibizumab for the treatment of eye diseases. It has stable and soluble properties, and controlled release is achieved through a release control element. In vitro studies confirmed its reproducibility and demonstrated that it can maintain a stable release rate for at least 6 months.
Editorial Material
Ophthalmology
M. Parravano, C. M. Eandi, M. Figus, M. Lupidi, F. Menchini, M. Nicolo', V Parisi, L. Toto, F. Viola, S. Vujosevic, G. Querques
Summary: Circadian rhythms, controlled by the internal clock, synchronize with external fluctuations. Melatonin, a hormone synthesized by the pineal gland, helps maintain daily rhythms. Disrupting circadian rhythms is linked to various diseases and accelerates retinal cell aging.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Paolo Milella, Chiara Mapelli, Marco Nassisi, Gaia Leone, Giada Ruggi, Antonio Scialdone, Giuseppe Casalino, Francesco Viola
Summary: This study reports the adaptive optics (AO) imaging results of Kyrieleis plaques (KP) in patients with Varicella Zoster virus (VZV)-associated posterior uveitis. AO imaging revealed segmental hyporeflectivity confined to the vessel wall without arterial wall disruption or extravascular involvement. The findings suggest that KP are localized within the inner arterial wall, possibly at the endothelial level.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Claudia Azzolini, Maura Di Nicola, Francesco Pozzo Giuffrida, Francesca Cappelli, Claudia Bellina, Francesco Viola, Paolo Chelazzi
Summary: The present study aimed to evaluate the diagnostic validity of retromode imaging in choroidal nevi using the cSLO Nidek Mirante. The results showed that retromode scanning laser ophthalmoscopy was able to detect choroidal nevi with a hypo-retro-reflective pattern, even in cases not visible on other imaging modalities. It also provided the most accurate delineation of lesion margins among the examined modalities. These findings demonstrate that RM-SLO is an innovative and non-invasive diagnostic tool for detecting and monitoring choroidal nevi.
Article
Ophthalmology
Matteo Airaldi, Alessandro Invernizzi, Vuong Nguyen, Stela Vujosevic, Federico Ricci, Pietro Monaco, Marco Nassisi, Daniel Barthelmes, Mark Gillies, Francesco Viola
Summary: This study compared the treatment outcomes of Vascular Endothelial Growth Factor (VEGF) inhibitors for Polypoidal Choroidal Vasculopathy (PCV) and type 1 Macular Neovascularization (MNV) in a Caucasian population. The results showed that PCV had slightly better visual acuity outcomes after 24 months of treatment compared to type 1 MNV, and received fewer anti-VEGF injections.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Glenn J. Jaffe, Bnana Cameron, David Kardatzke, Jane Ives, Giulio Barteselli, Shamika Gune
Summary: This study aimed to compare the rates of macular atrophy (MA) in eyes treated with different methods for neovascular age-related macular degeneration (nAMD). The results showed no evidence of worse MA with the Port Delivery System with ranibizumab (PDS) compared to monthly intravitreal ranibizumab injections.
OPHTHALMOLOGY RETINA
(2022)
Article
Ophthalmology
Maura Di Nicola, Basil K. Williams Jr, Jing Hua, Vladislav P. Bekerman, Arman Mashayekhi, Jerry A. Shields, Carol L. Shields
Summary: This study retrospectively analyzed 17 patients with retinal hemangioblastoma who underwent photodynamic therapy (PDT). The results showed that PDT is an effective treatment for both juxtapapillary and peripheral retinal hemangioblastomas, providing satisfactory tumor control, resolution of subretinal and intraretinal fluid, and stable or improved visual acuity.
OPHTHALMOLOGY RETINA
(2022)
Article
Ophthalmology
Maura Di Nicola, Basil K. Jr Jr Williams
Summary: Photodynamic therapy (PDT) is now commonly used for the treatment of retinal diseases and intraocular tumors, particularly in the diagnosis and treatment of certain conditions.
CURRENT OPHTHALMOLOGY REPORTS
(2021)