Nicotine promotes brain metastasis by polarizing microglia and suppressing innate immune function

Microglia are effector cells of CD47-SIRPα antiphagocytic axis disruption against glioblastoma

(2019) Gregor Hutter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of XIST in Breast Cancer Activates MSN-c-Met and Reprograms Microglia via Exosomal miRNA to Promote Brain Metastasis

(2018) Fei Xing et al.   CANCER RESEARCH

When Immune Cells Turn Bad—Tumor-Associated Microglia/Macrophages in Glioma

(2018) Saskia Roesch et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Parthenolide Inhibits STAT3 Signaling by Covalently Targeting Janus Kinases

(2018) Man Liu et al.   MOLECULES

A nomogram for predicting survival in patients with breast cancer brain metastasis

(2018) Zhou Huang et al.   Oncology Letters

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(2018) Florian Janker et al.   Oncotarget

Parthenolide inhibits tumor-promoting effects of nicotine in lung cancer by inducing P53 - dependent apoptosis and inhibiting VEGF expression

(2018) Wamidh H. Talib et al.   BIOMEDICINE & PHARMACOTHERAPY

Deciphering mechanisms of brain metastasis in melanoma - the gist of the matter

(2018) Torben Redmer   Molecular Cancer

Pro-inflammatory effects of e-cigarette vapour condensate on human alveolar macrophages

(2018) Aaron Scott et al.   THORAX

CCL20 triggered by chemotherapy hinders the therapeutic efficacy of breast cancer

(2018) Weilong Chen et al.   PLOS BIOLOGY

Clinical factors associated with mortality within three months after radiosurgery of asymptomatic brain metastases from non-small cell lung cancer

(2018) Bina Kakusa et al.   JOURNAL OF NEURO-ONCOLOGY

Regulation of Sox2 and stemness by nicotine and electronic-cigarettes in non-small cell lung cancer

(2018) Courtney M Schaal et al.   Molecular Cancer

Nicotine promotes cervical carcinoma cell line HeLa migration and invasion by activating PI3k/Akt/NF-κB pathway in vitro

(2017) Chengze Wang et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

The roles of microglia macrophages in tumor progression of brain cancer and metastatic disease

(2017) Shih-Ying Wu   Frontiers in Bioscience-Landmark

Melatonin protects mice against stress-induced inflammation through enhancement of M2 macrophage polarization

(2017) Woo-Jin Yi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Fingolimod Protects Against Ischemic White Matter Damage by Modulating Microglia Toward M2 Polarization via STAT3 Pathway

(2017) Chuan Qin et al.   STROKE

Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging

(2017) Michael F. Cuccarese et al.   Nature Communications

Nicotine-enhanced stemness and epithelial-mesenchymal transition of human umbilical cord mesenchymal stem cells promote tumor formation and growth in nude mice

(2017) Tao Li et al.   Oncotarget

Parthenolide suppresses non-small cell lung cancer GLC-82 cells growth via B-Raf/MAPK/Erk pathway

(2017) Minting Lin et al.   Oncotarget

The Effects of smoking status and smoking history on patients with brain metastases from lung cancer

(2017) Rachel F. Shenker et al.   Cancer Medicine

Alpha5 Nicotinic Acetylcholine Receptor Contributes to Nicotine-Induced Lung Cancer Development and Progression

(2017) Hai-Ji Sun et al.   Frontiers in Pharmacology

Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy

(2017) Michael A. Cannarile et al.   Journal for ImmunoTherapy of Cancer

Tumor-associated macrophage-derived CCL20 enhances the growth and metastasis of pancreatic cancer

(2016) Bingyan Liu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT

(2016) Srinivas Malladi et al.   CELL

α4β2 Nicotinic Acetylcholine Receptors

(2016) Simone Mazzaferro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Production of CCL20 from lung cancer cells induces the cell migration and proliferation through PI3K pathway

(2016) Beibei Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Astrocytic and microglial nicotinic acetylcholine receptors: an overlooked issue in Alzheimer’s disease

(2016) Saeed Sadigh-Eteghad et al.   JOURNAL OF NEURAL TRANSMISSION

Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer

(2016) Qing Chen et al.   NATURE

AKT-induced PKM2 phosphorylation signals for IGF-1-stimulated cancer cell growth

(2016) Young Soo Park et al.   Oncotarget

Stimulation of α7 nicotinic acetylcholine receptor regulates glutamate transporter GLAST via basic fibroblast growth factor production in cultured cortical microglia

(2015) Norimitsu Morioka et al.   BRAIN RESEARCH

The Biology of Brain Metastasis

(2015) Isaiah J. Fidler   CANCER JOURNAL

Tobacco smoke induces production of chemokine CCL20 to promote lung cancer

(2015) Gui-Zhen Wang et al.   CANCER LETTERS

Paracrine CCL20 loop induces epithelial-mesenchymal transition in breast epithelial cells

(2015) S. Marsigliante et al.   MOLECULAR CARCINOGENESIS

CD47 blockade triggers T cell–mediated destruction of immunogenic tumors

(2015) Xiaojuan Liu et al.   NATURE MEDICINE

Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study

(2015) Nicholas Butowski et al.   NEURO-ONCOLOGY

Nicotine enhances hepatocyte growth factor-mediated lung cancer cell migration by activating the α7 nicotine acetylcholine receptor and phosphoinositide kinase-3-dependent pathway

(2015) REMI YONEYAMA et al.   Oncology Letters

Loss of CX3CR1 increases accumulation of inflammatory monocytes and promotes gliomagenesis

(2015) Xi Feng et al.   Oncotarget

CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T-cell Checkpoint Immunotherapy in Pancreatic Cancer Models

(2014) Y. Zhu et al.   CANCER RESEARCH

Dimethylaminoparthenolide, A Water Soluble Parthenolide, Suppresses Lung Tumorigenesis Through Down-Regulating the STAT3 Signaling Pathway

(2014) Jung Song et al.   CURRENT CANCER DRUG TARGETS

Nicotine-Mediated Cell Proliferation and Tumor Progression in Smoking-Related Cancers

(2014) Courtney Schaal et al.   MOLECULAR CANCER RESEARCH

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

(2014) Marco Prinz et al.   NATURE REVIEWS NEUROSCIENCE

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

CCR6, the Sole Receptor for the Chemokine CCL20, Promotes Spontaneous Intestinal Tumorigenesis

(2014) Bisweswar Nandi et al.   PLoS One

Parthenolide inhibits pro-inflammatory cytokine production and exhibits protective effects on progression of collagen-induced arthritis in a rat model

(2014) Q Liu et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Microglia and Macrophages in Malignant Gliomas: Recent Discoveries and Implications for Promising Therapies

(2013) Anna Carolina Carvalho da Fonseca et al.   Clinical & Developmental Immunology

The Controversial Role of Microglia in Malignant Gliomas

(2013) Jun Wei et al.   Clinical & Developmental Immunology

Survival of patients with non-small-cell lung cancer after a diagnosis of brain metastases

(2013) A. Ali et al.   Current Oncology

Signal regulatory protein α is associated with tumor-polarized macrophages phenotype switch and plays a pivotal role in tumor progression

(2013) Yu-fei Pan et al.   HEPATOLOGY

Applicability of a Blood–Brain Barrier Specific Artificial Membrane Permeability Assay at the Early Stage of Natural Product-Based CNS Drug Discovery

(2013) Árpád Könczöl et al.   JOURNAL OF NATURAL PRODUCTS

Systematic review with meta-analysis of the epidemiological evidence in the 1900s relating smoking to lung cancer

(2012) Peter N Lee et al.   BMC CANCER

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Parthenolide attenuates LPS-induced fever, circulating cytokines and markers of brain inflammation in rats

(2011) Christoph Rummel et al.   CYTOKINE

PI3K/Akt and MAPK/ERK1/2 signaling pathways are involved in IGF-1-induced VEGF-C upregulation in breast cancer

(2011) Chenfang Zhu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Parthenolide inhibits STAT3 signaling and attenuates angiotensin II-induced left ventricular hypertrophy via modulation of fibroblast activity

(2011) Réka Skoumal et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Parthenolide sensitizes hepatocellular carcinoma cells to trail by inducing the expression of death receptors through inhibition of STAT3 activation

(2010) Daniela Carlisi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis

(2009) Daisuke Kamei et al.   BIOCHEMICAL JOURNAL

WNT/TCF Signaling through LEF1 and HOXB9 Mediates Lung Adenocarcinoma Metastasis

(2009) Don X. Nguyen et al.   CELL

A New Prognostic Index and Comparison to Three Other Indices for Patients With Brain Metastases: An Analysis of 1,960 Patients in the RTOG Database

(2007) Paul W. Sperduto et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS