Soluble uric acid induces myocardial damage through activating the NLRP3 inflammasome

Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

(2019) Yang Yang et al.   Cell Death & Disease

Uric acid: from a biological advantage to a potential danger. A focus on cardiovascular effects

(2019) Francesca Cortese et al.   VASCULAR PHARMACOLOGY

Gypenosides improve diabetic cardiomyopathy by inhibiting ROS-mediated NLRP3 inflammasome activation

(2018) Hailong Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

The NLRP3 inflammasome in acute myocardial infarction

(2017) Stefano Toldo et al.   Nature Reviews Cardiology

Soluble Uric Acid Activates the NLRP3 Inflammasome

(2017) Tarcio Teodoro Braga et al.   Scientific Reports

Crystal Formation in Inflammation

(2016) Bernardo S. Franklin et al.   Annual Review of Immunology

Mitochondria and the NLRP3 inflammasome: physiological and pathological relevance

(2016) Je-Wook Yu et al.   ARCHIVES OF PHARMACAL RESEARCH

TSPO: kaleidoscopic 18-kDa amid biochemical pharmacology, control and targeting of mitochondria

(2016) J. Gatliff et al.   BIOCHEMICAL JOURNAL

Effect of uric acid on mitochondrial function and oxidative stress in hepatocytes

(2016) Y. Yang et al.   GENETICS AND MOLECULAR RESEARCH

The treatment of hyperuricemia

(2016) Micaela Gliozzi et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

TIFA as a crucial mediator for NLRP3 inflammasome

(2016) Ting-Yang Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble uric acid primes TLR-induced proinflammatory cytokine production by human primary cells via inhibition of IL-1Ra

(2015) Tania O Crișan et al.   ANNALS OF THE RHEUMATIC DISEASES

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

(2015) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

Genipin suppresses NLRP3 inflammasome activation through uncoupling protein-2

(2015) Venugopal Rajanbabu et al.   CELLULAR IMMUNOLOGY

Soluble uric acid increases NALP3 inflammasome and interleukin-1β expression in human primary renal proximal tubule epithelial cells through the Toll-like receptor 4-mediated pathway

(2015) JING XIAO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Anti-inflammatory therapies for atherosclerosis

(2015) Magnus Bäck et al.   Nature Reviews Cardiology

Probenecid protects against cerebral ischemia/reperfusion injury by inhibiting lysosomal and inflammatory damage in rats

(2015) R. Wei et al.   NEUROSCIENCE

Genipin inhibits NLRP3 and NLRC4 inflammasome activation via autophagy suppression

(2015) Shui-Xing Yu et al.   Scientific Reports

TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control

(2014) Jemma Gatliff et al.   Autophagy

TXNIP mediates NLRP3 inflammasome activation in cardiac microvascular endothelial cells as a novel mechanism in myocardial ischemia/reperfusion injury

(2014) Yi Liu et al.   BASIC RESEARCH IN CARDIOLOGY

A key role of the mitochondrial citrate carrier (SLC25A1) in TNFα- and IFNγ-triggered inflammation

(2014) Vittoria Infantino et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

Uric Acid Metabolism in Pre-hypertension and the Metabolic Syndrome

(2014) Manfredi Rizzo et al.   Current Vascular Pharmacology

Cholesterol crystal-induced endothelial cell activation is complement-dependent and mediated by TNF

(2014) Stig Nymo et al.   IMMUNOBIOLOGY

Serum uric acid and cardiovascular risk: State of the art and perspectives

(2014) Goël Fenech et al.   JOINT BONE SPINE

The Lysosome Rupture-activated TAK1-JNK Pathway Regulates NLRP3 Inflammasome Activation

(2014) Masahiro Okada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol Crystals Induce Complement-Dependent Inflammasome Activation and Cytokine Release

(2014) E. O. Samstad et al.   JOURNAL OF IMMUNOLOGY

First Long-Term Behavioral Records from Cuvier’s Beaked Whales (Ziphius cavirostris) Reveal Record-Breaking Dives

(2014) Gregory S. Schorr et al.   PLoS One

Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death

(2013) Heriberto Lima Jr. et al.   CELL CYCLE

Chronic Hyperuricemia, Uric Acid Deposit and Cardiovascular Risk

(2013) Davide Grassi et al.   CURRENT PHARMACEUTICAL DESIGN

Sugar, Uric Acid, and the Etiology of Diabetes and Obesity

(2013) R. J. Johnson et al.   DIABETES

Changes in toll-like receptor (TLR)4–NFκB–IL1β signaling in male gout patients might be involved in the pathogenesis of primary gouty arthritis

(2013) Yu-Feng Qing et al.   RHEUMATOLOGY INTERNATIONAL

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Hyperuricaemia elevates circulating CCL2 levels and primes monocyte trafficking in subjects with inter-critical gout

(2012) R. Grainger et al.   RHEUMATOLOGY

Soluble uric acid increases intracellular calcium through an angiotensin II-dependent mechanism in immortalized human mesangial cells

(2011) Guilherme Albertoni et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The inflammasome: an integrated view

(2011) Olaf Gross et al.   IMMUNOLOGICAL REVIEWS

Gout

(2011) Tuhina Neogi   NEW ENGLAND JOURNAL OF MEDICINE

Pivotal Role of Toll-Like Receptors 2 and 4, Its Adaptor Molecule MyD88, and Inflammasome Complex in Experimental Tubule-Interstitial Nephritis

(2011) Matheus Correa-Costa et al.   PLoS One

Uric Acid: A Danger Signal From the RNA World That May Have a Role in the Epidemic of Obesity, Metabolic Syndrome, and Cardiorenal Disease: Evolutionary Considerations

(2011) Richard J. Johnson et al.   SEMINARS IN NEPHROLOGY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

The RAGE Axis

(2010) Shi Fang Yan et al.   CIRCULATION RESEARCH

High-Normal Serum Uric Acid Increases Risk of Early Progressive Renal Function Loss in Type 1 Diabetes: Results of a 6-year follow-up

(2010) L. H. Ficociello et al.   DIABETES CARE

Critical functions of priming and lysosomal damage for NLRP3 activation

(2010) Veit Hornung et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Uric acid transport and disease

(2010) Alexander So et al.   JOURNAL OF CLINICAL INVESTIGATION

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Pro-inflammatory and oxidative effects of noncrystalline uric acid in human mesangial cells: contribution to hyperuricemic glomerular damage

(2010) M. S. Convento et al.   UROLOGICAL RESEARCH

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Receptor for Advanced Glycation End Products (RAGE) Deficiency Attenuates the Development of Atherosclerosis in Diabetes

(2008) A. Soro-Paavonen et al.   DIABETES

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE