Heavy Metals Exposure and Alzheimer’s Disease and Related Dementias

Metal Toxicity Links to Alzheimer’s Disease and Neuroinflammation

(2019) Tee Jong Huat et al.   JOURNAL OF MOLECULAR BIOLOGY

Randomized Trial of Verubecestat for Prodromal Alzheimer’s Disease

(2019) Michael F. Egan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Perinatal Lead (Pb) Exposure and Cortical Neuron-Specific DNA Methylation in Male Mice

(2019) John F. Dou et al.   Genes

Improving and Expanding Estimates of the Global Burden of Disease Due to Environmental Health Risk Factors

(2019) Rachel M. Shaffer et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Toxic metal(loid)-based pollutants and their possible role in autism spectrum disorder

(2018) Geir Bjørklund et al.   ENVIRONMENTAL RESEARCH

Altered microRNA, mRNA, and Protein Expression of Neurodegeneration-Related Biomarkers and Their Transcriptional and Epigenetic Modifiers in a Human Tau Transgenic Mouse Model in Response to Developmental Lead Exposure

(2018) Anwar M. Masoud et al.   JOURNAL OF ALZHEIMERS DISEASE

Circulatory Levels of Toxic Metals (Aluminum, Cadmium, Mercury, Lead) in Patients with Alzheimer’s Disease: A Quantitative Meta-Analysis and Systematic Review

(2018) Lin Xu et al.   JOURNAL OF ALZHEIMERS DISEASE

SLC39A14 deficiency alters manganese homeostasis and excretion resulting in brain manganese accumulation and motor deficits in mice

(2018) Supak Jenkitkasemwong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Importance of tau in cognitive decline as revealed by developmental exposure to lead

(2018) K. Wright et al.   TOXICOLOGY LETTERS

Functional analysis of SLC39A8 mutations and their implications for manganese deficiency and mitochondrial disorders

(2018) Eun-Kyung Choi et al.   Scientific Reports

Cadmium-induced apoptosis in neuronal cells is mediated by Fas/FasL-mediated mitochondrial apoptotic signaling pathway

(2018) Yan Yuan et al.   Scientific Reports

Associations between blood cadmium levels and cognitive function in a cross-sectional study of US adults aged 60 years or older

(2018) Hongyu Li et al.   BMJ Open

Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study

(2018) Weiye Wang et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Ferroportin disease mutations influence manganese accumulation and cytotoxicity

(2018) Eun-Kyung Choi et al.   FASEB JOURNAL

Infant Exposure to Lead (Pb) and Epigenetic Modifications in the Aging Primate Brain: Implications for Alzheimer's Disease

(2018) Syed Waseem Bihaqi et al.   JOURNAL OF ALZHEIMERS DISEASE

High Manganese, A Risk for Alzheimer's Disease: High Manganese Induces Amyloid-β Related Cognitive Impairment

(2018) Yawei Tong et al.   JOURNAL OF ALZHEIMERS DISEASE

Manganese causes neurotoxic iron accumulation via translational repression of Amyloid Precursor Protein (APP) and H-Ferritin

(2018) Vivek Venkataramani et al.   JOURNAL OF NEUROCHEMISTRY

Calculation of the disease burden associated with environmental chemical exposures: application of toxicological information in health economic estimation

(2017) Philippe Grandjean et al.   Environmental Health

Associations of cumulative Pb exposure and longitudinal changes in Mini-Mental Status Exam scores, global cognition and domains of cognition: The VA Normative Aging Study

(2017) Zishaan Farooqui et al.   ENVIRONMENTAL RESEARCH

Cadmium and Alzheimer’s disease mortality in U.S. adults: Updated evidence with a urinary biomarker and extended follow-up time

(2017) Qing Peng et al.   ENVIRONMENTAL RESEARCH

Mammalian Metallothionein-3: New Functional and Structural Insights

(2017) Milan Vašák et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Deficiency in the manganese efflux transporter SLC30A10 induces severe hypothyroidism in mice

(2017) Steven Hutchens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Celastrol Attenuates Cadmium-Induced Neuronal Apoptosis via Inhibiting Ca2+ -CaMKII-Dependent Akt/mTOR Pathway

(2017) Ruijie Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hepatic metal ion transporter ZIP8 regulates manganese homeostasis and manganese-dependent enzyme activity

(2017) Wen Lin et al.   JOURNAL OF CLINICAL INVESTIGATION

Metal Transporter Zip14 ( Slc39a14 ) Deletion in Mice Increases Manganese Deposition and Produces Neurotoxic Signatures and Diminished Motor Activity

(2017) Tolunay Beker Aydemir et al.   JOURNAL OF NEUROSCIENCE

Cadmium Exposure Impairs Cognition and Olfactory Memory in Male C57BL/6 Mice

(2017) Hao Wang et al.   TOXICOLOGICAL SCIENCES

Association of Serum Manganese Levels with  Alzheimer’s Disease and Mild Cognitive Impairment:  A Systematic Review and Meta‐Analysis

(2017) Ke Du et al.   Nutrients

Biometal Dyshomeostasis and Toxic Metal Accumulations in the Development of Alzheimer’s Disease

(2017) Yong Li et al.   Frontiers in Molecular Neuroscience

Manganese transporter Slc39a14 deficiency revealed its key role in maintaining manganese homeostasis in mice

(2017) Yongjuan Xin et al.   Cell Discovery

Elevated Blood Lead Levels in Children Associated With the Flint Drinking Water Crisis: A Spatial Analysis of Risk and Public Health Response

(2016) Mona Hanna-Attisha et al.   AMERICAN JOURNAL OF PUBLIC HEALTH

Blood cadmium levels and Alzheimer’s disease mortality risk in older US adults

(2016) Jin-young Min et al.   Environmental Health

Early-Life Exposure to Lead (Pb) Alters the Expression of microRNA that Target Proteins Associated with Alzheimer’s Disease

(2016) Anwar M. Masoud et al.   JOURNAL OF ALZHEIMERS DISEASE

Direct Comparison of Manganese Detoxification/Efflux Proteins and Molecular Characterization of ZnT10 Protein as a Manganese Transporter

(2016) Yukina Nishito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A SLC39A8 variant causes manganese deficiency, and glycosylation and mitochondrial disorders

(2016) Lisa G. Riley et al.   JOURNAL OF INHERITED METABOLIC DISEASE

International variability in diet and requirements of manganese: Causes and consequences

(2016) Jean H. Freeland-Graves et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Characterization of Mn(II) ion binding to the amyloid-β peptide in Alzheimer⿿s disease

(2016) Cecilia Wallin et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Developmental exposure to lead (Pb) alters the expression of the human tau gene and its products in a transgenic animal model

(2016) M. Dash et al.   NEUROTOXICOLOGY

Mechanisms of divalent metal toxicity in affective disorders

(2016) Archita Venugopal Menon et al.   TOXICOLOGY

Perinatal exposure to lead (Pb) promotes Tau phosphorylation in the rat brain in a GSK-3β and CDK5 dependent manner: Relevance to neurological disorders

(2016) Magdalena Gąssowska et al.   TOXICOLOGY

Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism–dystonia

(2016) Karin Tuschl et al.   Nature Communications

A Case Study of Environmental Injustice: The Failure in Flint

(2016) Carla Campbell et al.   International Journal of Environmental Research and Public Health

The Global Burden of Lead Toxicity Attributable to Informal Used Lead-Acid Battery Sites

(2016) Bret Ericson et al.   Annals of Global Health

“Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies”

(2016) Tanara V. Peres et al.   BMC Pharmacology & Toxicology

Neuroimaging identifies increased manganese deposition in infants receiving parenteral nutrition

(2015) Judy L Aschner et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

SLC39A8 Deficiency: A Disorder of Manganese Transport and Glycosylation

(2015) Julien H. Park et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Autosomal-Recessive Intellectual Disability with Cerebellar Atrophy Syndrome Caused by Mutation of the Manganese and Zinc Transporter Gene SLC39A8

(2015) Kym M. Boycott et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Cadmium-induced cell death of basal forebrain cholinergic neurons mediated by muscarinic M1 receptor blockade, increase in GSK-3β enzyme, β-amyloid and tau protein levels

(2015) Javier del Pino et al.   ARCHIVES OF TOXICOLOGY

Distribution of manganese and other biometals in flatiron mice

(2015) Young Ah Seo et al.   BIOMETALS

Baseline blood levels of manganese, lead, cadmium, copper, and zinc in residents of Beijing suburb

(2015) Long-Lian Zhang et al.   ENVIRONMENTAL RESEARCH

Ferroportin deficiency impairs manganese metabolism in flatiron mice

(2015) Young Ah Seo et al.   FASEB JOURNAL

Variance components of short-term biomarkers of manganese exposure in an inception cohort of welding trainees

(2015) Marissa G. Baker et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Manganese transport disorder: NovelSLC30A10mutations and early phenotypes

(2015) Marialuisa Quadri et al.   MOVEMENT DISORDERS

Environmental exposure to manganese in air: Associations with cognitive functions

(2015) Rosemarie M. Bowler et al.   NEUROTOXICOLOGY

Comparison of Metal Levels between Postmortem Brain and Ventricular Fluid in Alzheimer’s Disease and Nondemented Elderly Controls

(2015) Steven T. Szabo et al.   TOXICOLOGICAL SCIENCES

Manganese-Induced Parkinsonism and Parkinson’s Disease: Shared and Distinguishable Features

(2015) Gunnar Kwakye et al.   International Journal of Environmental Research and Public Health

Clinical Features of Alzheimer Disease With and Without Lewy Bodies

(2015) Eun Joo Chung et al.   JAMA Neurology

Manganese-induced neurotoxicity: from C. elegans to humans

(2015) Pan Chen et al.   Toxicology Research

Heavy metals toxicity: effect of cadmium ions on amyloid beta protein 1–42. Possible implications for Alzheimer’s disease

(2014) Gabriella Notarachille et al.   BIOMETALS

Alzheimer’s Disease and Environmental Exposure to Lead: The Epidemiologic Evidence and Potential Role of Epigenetics

(2014) Kelly M. Bakulski et al.   Current Alzheimer Research

Sex- and age-differences in blood manganese levels in the U.S. general population: national health and nutrition examination survey 2011–2012

(2014) Youssef Oulhote et al.   Environmental Health

Manganese Encephalopathy among Ephedron Abusers-Case Reports

(2014) Justyna Janocha-Litwin et al.   JOURNAL OF NEUROIMAGING

SLC30A10 Is a Cell Surface-Localized Manganese Efflux Transporter, and Parkinsonism-Causing Mutations Block Its Intracellular Trafficking and Efflux Activity

(2014) D. Leyva-Illades et al.   JOURNAL OF NEUROSCIENCE

Neurobehavioural effects of developmental toxicity

(2014) Philippe Grandjean et al.   LANCET NEUROLOGY

Classifying neurocognitive disorders: the DSM-5 approach

(2014) Perminder S. Sachdev et al.   Nature Reviews Neurology

Considerations on manganese (Mn) treatments for in vitro studies

(2014) Aaron B. Bowman et al.   NEUROTOXICOLOGY

Infantile postnatal exposure to lead (Pb) enhances tau expression in the cerebral cortex of aged mice: Relevance to AD

(2014) Syed Waseem Bihaqi et al.   NEUROTOXICOLOGY

Determining Prenatal, Early Childhood and Cumulative Long-Term Lead Exposure Using Micro-Spatial Deciduous Dentine Levels

(2014) Manish Arora et al.   PLoS One

Exposure to As-, Cd-, and Pb-Mixture Induces Aβ, Amyloidogenic APP Processing and Cognitive Impairments via Oxidative Stress-Dependent Neuroinflammation in Young Rats

(2014) Anushruti Ashok et al.   TOXICOLOGICAL SCIENCES

Noninvasive biomarkers of manganese exposure and neuropsychological effects in environmentally exposed adults in Brazil

(2014) Gustavo F. de Sousa Viana et al.   TOXICOLOGY LETTERS

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

Mild cognitive impairment in Parkinson's disease

(2013) A. J. Yarnall et al.   AGE AND AGEING

Associations between cadmium exposure and neurocognitive test scores in a cross-sectional study of US adults

(2013) Timothy Ciesielski et al.   Environmental Health

Manganese neurotoxicity and the role of reactive oxygen species

(2013) Ebany J. Martinez-Finley et al.   FREE RADICAL BIOLOGY AND MEDICINE

The effects of early life Pb exposure on the expression of IL1-β, TNF-α and Aβ in cerebral cortex of mouse pups

(2013) Ning Li et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Enhanced taupathy and AD-like pathology in aged primate brains decades after infantile exposure to lead (Pb)

(2013) Syed Waseem Bihaqi et al.   NEUROTOXICOLOGY

Iron depletion increases manganese uptake and potentiates apoptosis through ER stress

(2013) Young Ah Seo et al.   NEUROTOXICOLOGY

Oxidative Stress and the Pathogenesis of Alzheimer's Disease

(2013) Yan Zhao et al.   Oxidative Medicine and Cellular Longevity

Cadmium and Its Neurotoxic Effects

(2013) Bo Wang et al.   Oxidative Medicine and Cellular Longevity

Chronic manganese exposure impairs visuospatial associative learning in non-human primates

(2013) J.S. Schneider et al.   TOXICOLOGY LETTERS

Manganese neurotoxicity: new perspectives from behavioral, neuroimaging, and neuropathological studies in humans and non-human primates

(2013) Tomás R. Guilarte   Frontiers in Aging Neuroscience

ATP13A2 (PARK9) protein levels are reduced in brain tissue of cases with Lewy bodies

(2013) Karen E Murphy et al.   Acta Neuropathologica Communications

Mutations in SLC30A10 Cause Parkinsonism and Dystonia with Hypermanganesemia, Polycythemia, and Chronic Liver Disease

(2012) Marialuisa Quadri et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Syndrome of Hepatic Cirrhosis, Dystonia, Polycythemia, and Hypermanganesemia Caused by Mutations in SLC30A10 , a Manganese Transporter in Man

(2012) Karin Tuschl et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Physiologic implications of metal-ion transport by ZIP14 and ZIP8

(2012) Supak Jenkitkasemwong et al.   BIOMETALS

Ball and chain: The global burden of lead poisoning

(2012) Vinodinee Dissanayake et al.   CLINICAL TOXICOLOGY

Environmental Cadmium and Lead Exposures and Hearing Loss in U.S. Adults: The National Health and Nutrition Examination Survey, 1999 to 2004

(2012) Yoon-Hyeong Choi et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Impact of Manganese on and Transfer across Blood-Brain and Blood-Cerebrospinal Fluid Barrierin Vitro

(2012) Julia Bornhorst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate Profile and Metal-ion Selectivity of Human Divalent Metal-ion Transporter-1

(2012) Anthony C. Illing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of mitochondrial homeostasis and dynamics in Alzheimer's disease

(2012) J. Eva Selfridge et al.   NEUROBIOLOGY OF DISEASE

Increased β-amyloid deposition in Tg-SWDI transgenic mouse brain following in vivo lead exposure

(2012) Huiying Gu et al.   TOXICOLOGY LETTERS

The effect of lead exposure on brain iron homeostasis and the expression of DMT1/FP1 in the brain in developing and aged rats

(2012) Gaochun Zhu et al.   TOXICOLOGY LETTERS

The effect of cadmium on Aβ levels in APP/PS1 transgenic mice

(2012) XIAOLING LI et al.   Experimental and Therapeutic Medicine

National estimates of the prevalence of Alzheimer’s disease in the United States

(2011) Ron Brookmeyer et al.   Alzheimers & Dementia

The iron transporter ferroportin can also function as a manganese exporter

(2011) Michael S. Madejczyk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Regulation of Intracellular Manganese Homeostasis by Kufor-Rakeb Syndrome-associated ATP13A2 Protein

(2011) Jieqiong Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elemental bio-imaging of trace elements in teeth using laser ablation-inductively coupled plasma-mass spectrometry

(2011) Dominic Hare et al.   JOURNAL OF DENTISTRY

Cerebrospinal fluid/plasma quotients of essential and non-essential metals in patients with Alzheimer’s disease

(2011) Lars Gerhardsson et al.   JOURNAL OF NEURAL TRANSMISSION

Trace Element Levels and Cognitive Function in Rural Elderly Chinese

(2011) S. Gao et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Environmental Neurotoxicants and Developing Brain

(2011) Amir Miodovnik   MOUNT SINAI JOURNAL OF MEDICINE

Cerebrospinal fluid Tau/α-synuclein ratio in Parkinson's disease and degenerative dementias

(2011) Lucilla Parnetti et al.   MOVEMENT DISORDERS

In vivo visualization of olfactory pathophysiology induced by intranasal cadmium instillation in mice

(2011) Lindsey A. Czarnecki et al.   NEUROTOXICOLOGY

Calcium Signaling Is Involved in Cadmium-Induced Neuronal Apoptosis via Induction of Reactive Oxygen Species and Activation of MAPK/mTOR Network

(2011) Baoshan Xu et al.   PLoS One

Neurotoxic Effects and Biomarkers of Lead Exposure: A Review

(2011) T. Sanders et al.   REVIEWS ON ENVIRONMENTAL HEALTH

Cadmium stress: an oxidative challenge

(2010) Ann Cuypers et al.   BIOMETALS

N-acetylcysteine prevents memory deficits, the decrease in acetylcholinesterase activity and oxidative stress in rats exposed to cadmium

(2010) Jamile F. Gonçalves et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Association of Cumulative Lead Exposure with Parkinson’s Disease

(2010) Marc G. Weisskopf et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Manganese and Parkinson’s Disease: A Critical Review and New Findings

(2010) Tomás R. Guilarte   ENVIRONMENTAL HEALTH PERSPECTIVES

Elevated manganese and cognitive performance in school-aged children and their mothers

(2010) José A. Menezes-Filho et al.   ENVIRONMENTAL RESEARCH

Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death

(2010) Long Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Heavy metals (lead, cadmium and mercury) in maternal, cord blood and placenta of healthy women

(2010) Iman Al-Saleh et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

Synergistic Interactions between A , Tau, and  -Synuclein: Acceleration of Neuropathology and Cognitive Decline

(2010) L. K. Clinton et al.   JOURNAL OF NEUROSCIENCE

Manganese Induces Tau Hyperphosphorylation through the Activation of ERK MAPK Pathway in PC12 Cells

(2010) Tongjian Cai et al.   TOXICOLOGICAL SCIENCES

Oxidative stress in Alzheimer disease

(2010) Alejandro Gella et al.   Cell Adhesion & Migration

The role of zinc transporters in cadmium and manganese transport in mammalian cells

(2009) Seiichiro Himeno et al.   BIOCHIMIE

Biological half-life of cadmium in the urine of inhabitants after cessation of cadmium exposure

(2009) Yasushi Suwazono et al.   BIOMARKERS

Cadmium, Environmental Exposure, and Health Outcomes

(2009) Soisungwan Satarug et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Cognitive impairment in an adult Mexican population non-occupationally exposed to manganese

(2009) Rodolfo Solís-Vivanco et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer’s disease

(2009) Magali Dumont et al.   FASEB JOURNAL

Ferroportin is a manganese-responsive protein that decreases manganese cytotoxicity and accumulation

(2009) Zhaobao Yin et al.   JOURNAL OF NEUROCHEMISTRY

A review of human carcinogens—Part C: metals, arsenic, dusts, and fibres

(2009) Kurt Straif et al.   LANCET ONCOLOGY

Manganese and its Role in Parkinson’s Disease: From Transport to Neuropathology

(2009) Michael Aschner et al.   NEUROMOLECULAR MEDICINE

Increased β-amyloid levels in the choroid plexus following lead exposure and the involvement of low-density lipoprotein receptor protein-1

(2009) Mamta Behl et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A Closer Look at α-Secretase

(2008) Rolf Postina   Current Alzheimer Research

Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5

(2008) Long Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Harmful Effects of Cadmium on Olfactory System in Mice

(2008) Jean-Robert Bondier et al.   INHALATION TOXICOLOGY

Increased APLP1 expression and neurodegeneration in the frontal cortex of manganese-exposed non-human primates

(2008) Tomás R. Guilarte et al.   JOURNAL OF NEUROCHEMISTRY

Global approach to reducing lead exposure and poisoning

(2008) P MEYER et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH