Manganese-induced neurotoxicity: from C. elegans to humans

Pathology of inherited manganese transporter deficiency

(2014) Mirna Lechpammer et al.   ANNALS OF NEUROLOGY

Interaction of Curcumin with Manganese May Compromise Metal and Neurotransmitter Homeostasis in the Hippocampus of Young Mice

(2014) Ariana Ern Schmitz et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Protective role of sodium para-amino salicylic acid against manganese-induced hippocampal neurons damage

(2014) Fang Wang et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes

(2014) Stephanie M.Y. Kong et al.   HUMAN MOLECULAR GENETICS

Is Parkinson's Disease a Vesicular Dopamine Storage Disorder? Evidence from a Study in Isolated Synaptic Vesicles of Human and Nonhuman Primate Striatum

(2014) C. Pifl et al.   JOURNAL OF NEUROSCIENCE

SLC30A10 Is a Cell Surface-Localized Manganese Efflux Transporter, and Parkinsonism-Causing Mutations Block Its Intracellular Trafficking and Efflux Activity

(2014) D. Leyva-Illades et al.   JOURNAL OF NEUROSCIENCE

Manganese disturbs metal and protein homeostasis in Caenorhabditis elegans

(2014) Suzanne Angeli et al.   Metallomics

Manganese-Induced Atypical Parkinsonism Is Associated with Altered Basal Ganglia Activity and Changes in Tissue Levels of Monoamines in the Rat

(2014) Safa Bouabid et al.   PLoS One

Dopamine-induced α-synuclein oligomers show self- and cross-propagation properties

(2014) Matthew S. Planchard et al.   PROTEIN SCIENCE

Manganese accumulation in bone following chronic exposure in rats: Steady-state concentration and half-life in bone

(2014) Stefanie L. O’Neal et al.   TOXICOLOGY LETTERS

Manganese efflux in Parkinsonism: Insights from newly characterized SLC30A10 mutations

(2013) Margaret R. DeWitt et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Blood Manganese Concentration is Elevated in Infants with Iron Deficiency

(2013) Sangkyu Park et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Nonoccupational Environmental Exposure to Manganese is Linked to Deficits in Peripheral and Central Olfactory Function

(2013) M. Guarneros et al.   CHEMICAL SENSES

Manganese-induced parkinsonism in methcathinone abusers: bio-markers of exposure and follow-up

(2013) K. Sikk et al.   EUROPEAN JOURNAL OF NEUROLOGY

Zn2+ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation

(2013) Taiji Tsunemi et al.   HUMAN MOLECULAR GENETICS

Two-year follow-up after chelating therapy in a patient with adult-onset parkinsonism and hypermanganesaemia due to SLC30A10 mutations

(2013) L. Di Toro Mammarella et al.   JOURNAL OF NEUROLOGY

The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans

(2013) Julia Bornhorst et al.   Metallomics

Analysis of vesicular monoamine transporter 2 polymorphisms in Parkinson’s disease

(2013) Laura Brighina et al.   NEUROBIOLOGY OF AGING

Manganese induces mitochondrial dynamics impairment and apoptotic cell death: A study in human Gli36 cells

(2013) Agustina Alaimo et al.   NEUROSCIENCE LETTERS

The Role of Autophagy Dysregulation in Manganese-Induced Dopaminergic Neurodegeneration

(2013) Jianbin Zhang et al.   NEUROTOXICITY RESEARCH

Decreased brain volumes in manganese-exposed welders

(2013) Yongmin Chang et al.   NEUROTOXICOLOGY

Early life versus lifelong oral manganese exposure differently impairs skilled forelimb performance in adult rats

(2013) Stephane A. Beaudin et al.   NEUROTOXICOLOGY AND TERATOLOGY

Evaluation of neurobehavioral and neuroinflammatory end-points in the post-exposure period in rats sub-acutely exposed to manganese

(2013) Santos Dinamene et al.   TOXICOLOGY

Manganese-induced oxidative DNA damage in neuronal SH-SY5Y cells: Attenuation of thymine base lesions by glutathione and N-acetylcysteine

(2013) Adrienne P. Stephenson et al.   TOXICOLOGY LETTERS

Mechanisms of lead and manganese neurotoxicity

(2013) April P. Neal et al.   Toxicology Research

Role of astrocytes in manganese mediated neurotoxicity

(2013) Marta Sidoryk-Wegrzynowicz et al.   BMC Pharmacology & Toxicology

Mutations in SLC30A10 Cause Parkinsonism and Dystonia with Hypermanganesemia, Polycythemia, and Chronic Liver Disease

(2012) Marialuisa Quadri et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Syndrome of Hepatic Cirrhosis, Dystonia, Polycythemia, and Hypermanganesemia Caused by Mutations in SLC30A10 , a Manganese Transporter in Man

(2012) Karin Tuschl et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Physiologic implications of metal-ion transport by ZIP14 and ZIP8

(2012) Supak Jenkitkasemwong et al.   BIOMETALS

Consequences of manganese administration for striatal dopamine and motor behavior in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-exposed C57BL/6 mice

(2012) C.A. Dodd et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Increased whole blood manganese concentrations observed in children with iron deficiency anaemia

(2012) Elisabeth Anne Smith et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Parkinson's disease and other neurodegenerative disorders among welders: A Danish cohort study

(2012) Line Kenborg et al.   MOVEMENT DISORDERS

Dystonia with brain manganese accumulation resulting fromSLC30A10mutations: A new treatable disorder

(2012) Maria Stamelou et al.   MOVEMENT DISORDERS

Genetic risk for Parkinson's disease correlates with alterations in neuronal manganese sensitivity between two human subjects

(2012) Asad A. Aboud et al.   NEUROTOXICOLOGY

Increased risk of parkinsonism associated with welding exposure

(2012) Brad A. Racette et al.   NEUROTOXICOLOGY

Microarray genomic profile of mitochondrial and oxidant response in manganese chloride treated PC12 cells

(2012) Equar Taka et al.   NEUROTOXICOLOGY

Manganese transport via the transferrin mechanism

(2012) Thomas E. Gunter et al.   NEUROTOXICOLOGY

In Vivo Manganese Exposure Modulates Erk, Akt and Darpp-32 in the Striatum of Developing Rats, and Impairs Their Motor Function

(2012) Fabiano M. Cordova et al.   PLoS One

Effect of intranasal manganese administration on neurotransmission and spatial learning in rats

(2012) Kamilla Blecharz-Klin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Manganese-induced toxicity in normal and human B lymphocyte cell lines containing a homozygous mutation in parkin

(2012) Jerome A. Roth et al.   TOXICOLOGY IN VITRO

Manganese exposure induces α-synuclein aggregation in the frontal cortex of non-human primates

(2012) Tatyana Verina et al.   TOXICOLOGY LETTERS

The iron transporter ferroportin can also function as a manganese exporter

(2011) Michael S. Madejczyk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Nrf2/HO-1 pathway activation by manganese is associated with reactive oxygen species and ubiquitin-proteasome pathway, not MAPKs signaling

(2011) Huangyuan Li et al.   JOURNAL OF APPLIED TOXICOLOGY

Blood manganese levels in patients with hepatic encephalopathy

(2011) Hugo Mendieta Zerón et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Role of manganese in neurodegenerative diseases

(2011) Aaron B. Bowman et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

The extrinsic and intrinsic apoptotic pathways are involved in manganese toxicity in rat astrocytoma C6 cells

(2011) Agustina Alaimo et al.   NEUROCHEMISTRY INTERNATIONAL

DMT1 polymorphism and risk of Parkinson’s disease

(2011) Qing He et al.   NEUROSCIENCE LETTERS

Prospective study on neurotoxic effects in manganese-exposed bridge construction welders

(2011) Rosemarie M. Bowler et al.   NEUROTOXICOLOGY

α-Synuclein overexpression enhances manganese-induced neurotoxicity through the NF-κB-mediated pathway

(2011) Krishnan Prabhakaran et al.   TOXICOLOGY MECHANISMS AND METHODS

Impaired in vivo dopamine release in parkin knockout mice

(2010) Genko Oyama et al.   BRAIN RESEARCH

Manganese and Parkinson’s Disease: A Critical Review and New Findings

(2010) Tomás R. Guilarte   ENVIRONMENTAL HEALTH PERSPECTIVES

Intellectual Impairment in School-Age Children Exposed to Manganese from Drinking Water

(2010) Maryse F. Bouchard et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Iron deficiency increases blood manganese level in the Korean general population according to KNHANES 2008

(2010) Yangho Kim et al.   NEUROTOXICOLOGY

Preweaning Mn exposure leads to prolonged astrocyte activation and lasting effects on the dopaminergic system in adult male rats

(2010) Cynthia H. Kern et al.   SYNAPSE

Changes in Dietary Iron Exacerbate Regional Brain Manganese Accumulation as Determined by Magnetic Resonance Imaging

(2010) Vanessa A. Fitsanakis et al.   TOXICOLOGICAL SCIENCES

A Possible Neuroprotective Action of a Vinylic Telluride against Mn-Induced Neurotoxicity

(2010) Daiana S. Ávila et al.   TOXICOLOGICAL SCIENCES

An analysis of the effects of Mn2+ on oxidative phosphorylation in liver, brain, and heart mitochondria using state 3 oxidation rate assays

(2010) Thomas E. Gunter et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Treatment strategies for Parkinson’s disease

(2010) Hong Yuan et al.   Neuroscience Bulletin

Extracellular Dopamine Potentiates Mn-Induced Oxidative Stress, Lifespan Reduction, and Dopaminergic Neurodegeneration in a BLI-3–Dependent Manner in Caenorhabditis elegans

(2010) Alexandre Benedetto et al.   PLoS Genetics

Uptake of Materials from the Nasal Cavity into the Blood and Brain

(2009) Mary Beth Genter et al.   Annals of the New York Academy of Sciences

Cognitive impairment in an adult Mexican population non-occupationally exposed to manganese

(2009) Rodolfo Solís-Vivanco et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Ethanol preference inC. elegans

(2009) J. Lee et al.   GENES BRAIN AND BEHAVIOR

Subacute intratracheal exposure of rats to manganese nanoparticles: Behavioral, electrophysiological, and general toxicological effects

(2009) Leila Sárközi et al.   INHALATION TOXICOLOGY

The Divalent Metal Transporter Homologues SMF-1/2 Mediate Dopamine Neuron Sensitivity in Caenorhabditis elegans Models of Manganism and Parkinson Disease

(2009) Raja Settivari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ferroportin is a manganese-responsive protein that decreases manganese cytotoxicity and accumulation

(2009) Zhaobao Yin et al.   JOURNAL OF NEUROCHEMISTRY

Parkinson's disease

(2009) Andrew J Lees et al.   LANCET

From Manganism to Manganese-Induced Parkinsonism: A Conceptual Model Based on the Evolution of Exposure

(2009) Roberto G. Lucchini et al.   NEUROMOLECULAR MEDICINE

A Chronic Iron-Deficient/High-Manganese Diet in Rodents Results in Increased Brain Oxidative Stress and Behavioral Deficits in the Morris Water Maze

(2009) Vanessa A. Fitsanakis et al.   NEUROTOXICITY RESEARCH

SMF-1, SMF-2 and SMF-3 DMT1 Orthologues Regulate and Are Regulated Differentially by Manganese Levels in C. elegans

(2009) Catherine Au et al.   PLoS One

Structure, mechanism and regulation of pyruvate carboxylase

(2008) Sarawut Jitrapakdee et al.   BIOCHEMICAL JOURNAL

Abnormal Motor Function and the Expression of Striatal Dopamine D2 Receptors in Manganese-Treated Mice

(2008) Jungmin Nam et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Mitochondrial-dependent manganese neurotoxicity in rat primary astrocyte cultures

(2008) Zhaoobao Yin et al.   BRAIN RESEARCH

Iron-enhanced paraquat-mediated dopaminergic cell death due to increased oxidative stress as a consequence of microglial activation

(2008) Jun Peng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effect of Chronic Low Level Manganese Exposure on Postural Balance: A Pilot Study of Residents in Southern Ohio

(2008) J Shawn. Standridge et al.   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Slc39a14 Gene Encodes ZIP14, A Metal/Bicarbonate Symporter: Similarities to the ZIP8 Transporter

(2008) K. Girijashanker et al.   MOLECULAR PHARMACOLOGY

Inhalation of divalent and trivalent manganese mixture induces a Parkinson's disease model: Immunocytochemical and behavioral evidences

(2008) J.L. Ordoñez-Librado et al.   NEUROSCIENCE

Postnatal manganese exposure alters dopamine transporter function in adult rats: Potential impact on nonassociative and associative processes

(2008) S.A. McDougall et al.   NEUROSCIENCE

Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease

(2008) J. Salazar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA