Celastrol Attenuates Cadmium-Induced Neuronal Apoptosis via Inhibiting Ca2+ -CaMKII-Dependent Akt/mTOR Pathway

Melatonin prevents abnormal mitochondrial dynamics resulting from the neurotoxicity of cadmium by blocking calcium-dependent translocation of Drp1 to the mitochondria

(2016) Shangcheng Xu et al.   JOURNAL OF PINEAL RESEARCH

Celastrol induces cell cycle arrest by MicroRNA-21-mTOR-mediated inhibition p27 protein degradation in gastric cancer

(2015) Min Sha et al.   Cancer Cell International

Treatment of Obesity with Celastrol

(2015) Junli Liu et al.   CELL

Rapamycin prevents cadmium-induced neuronal cell death via targeting both mTORC1 and mTORC2 pathways

(2015) Chong Xu et al.   NEUROPHARMACOLOGY

Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells: an in vitro and in vivo study

(2015) H-Y Li et al.   Cell Death & Disease

mTOR in aging, metabolism, and cancer

(2013) Marion Cornu et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Celastrol prevents cadmium-induced neuronal cell death via targeting JNK and PTEN-Akt/mTOR network

(2013) Sujuan Chen et al.   JOURNAL OF NEUROCHEMISTRY

Cadmium and Its Neurotoxic Effects

(2013) Bo Wang et al.   Oxidative Medicine and Cellular Longevity

Mitochondria in traumatic brain injury and mitochondrial-targeted multipotential therapeutic strategies

(2012) Gang Cheng et al.   BRITISH JOURNAL OF PHARMACOLOGY

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways

(2011) Radhamani Kannaiyan et al.   APOPTOSIS

NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action

(2011) Vincent Jaquet et al.   BRITISH JOURNAL OF PHARMACOLOGY

CaMKII is involved in cadmium activation of MAPK and mTOR pathways leading to neuronal cell death

(2011) Sujuan Chen et al.   JOURNAL OF NEUROCHEMISTRY

Calcium Signaling Is Involved in Cadmium-Induced Neuronal Apoptosis via Induction of Reactive Oxygen Species and Activation of MAPK/mTOR Network

(2011) Baoshan Xu et al.   PLoS One

Redox Regulation of the Intrinsic Pathway in Neuronal Apoptosis

(2010) James L. Franklin   ANTIOXIDANTS & REDOX SIGNALING

Celastrol: Molecular targets of Thunder God Vine

(2010) Antero Salminen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Celastrol Suppresses Angiogenesis-Mediated Tumor Growth through Inhibition of AKT/Mammalian Target of Rapamycin Pathway

(2010) X. Pang et al.   CANCER RESEARCH

Calcium, cellular aging, and selective neuronal vulnerability in Parkinson's disease

(2010) D. James Surmeier et al.   CELL CALCIUM

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Rapamycin Inhibits Cytoskeleton Reorganization and Cell Motility by Suppressing RhoA Expression and Activity

(2010) Lei Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitory Phosphorylation of GSK-3 by CaMKII Couples Depolarization to Neuronal Survival

(2010) Bin Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells

(2010) Long Chen et al.   LABORATORY INVESTIGATION

Mammalian Mitochondrial Complex I: Biogenesis, Regulation, and Reactive Oxygen Species Generation

(2009) Werner J.H. Koopman et al.   ANTIOXIDANTS & REDOX SIGNALING

Cadmium-induced Cytosolic Ca2+ Elevation and Subsequent Apoptosis in Renal Tubular Cells

(2009) Jeng-Hsien Yeh et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Characteristics and possible functions of mitochondrial Ca2+ transport mechanisms

(2009) Thomas E. Gunter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia

(2009) Kuniyasu Niizuma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The role of endoplasmic reticulum in cadmium-induced mesangial cell apoptosis

(2009) Sheng-Hao Wang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Calcium signaling in neurodegeneration

(2009) Philippe Marambaud et al.   Molecular Neurodegeneration

Cadmium Induces Intracellular Ca2+- and H2O2-Dependent Apoptosis through JNK- and p53-Mediated Pathways in Skin Epidermal Cell line

(2009) Young-Ok Son et al.   TOXICOLOGICAL SCIENCES

Cd-induced apoptosis was mediated by the release of Ca2+ from intracellular Ca storage

(2009) Zhuoyi Xie et al.   TOXICOLOGY LETTERS

Cadmium-induced autophagy and apoptosis are mediated by a calcium signaling pathway

(2008) S. H. Wang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis

(2008) Long Chen et al.   JOURNAL OF NEUROCHEMISTRY

Oxidative and Inflammatory Pathways in Parkinson’s Disease

(2008) Rebecca L. Miller et al.   NEUROCHEMICAL RESEARCH

Multiple Roles of Calcium Ions in the Regulation of Neurotransmitter Release

(2008) Erwin Neher et al.   NEURON

Role of mTOR in physiology and pathology of the nervous system

(2007) Lukasz Swiech et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Vascular endothelial growth factor (VEGF) signaling regulates hippocampal neurons by elevation of intracellular calcium and activation of calcium/calmodulin protein kinase II and mammalian target of rapamycin

(2007) Byung Woo Kim et al.   CELLULAR SIGNALLING

Inhibition of cadmium-induced oxidative injury in rat primary astrocytes by the addition of antioxidants and the reduction of intracellular calcium

(2007) Chung-Shi Yang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY