Endosomal-Lysosomal Processing of Neurodegeneration-Associated Proteins in Astrocytes
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Endosomal-Lysosomal Processing of Neurodegeneration-Associated Proteins in Astrocytes
Authors
Keywords
-
Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 14, Pages 5149
Publisher
MDPI AG
Online
2020-07-22
DOI
10.3390/ijms21145149
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease
- (2020) Sandra Franco-Iborra et al. Autophagy
- Lysosome and Inflammatory Defects in GBA1 ‐Mutant Astrocytes Are Normalized by LRRK2 Inhibition
- (2020) Anwesha Sanyal et al. MOVEMENT DISORDERS
- Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose
- (2019) Anna-Carin Hoffmann et al. Scientific Reports
- Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity
- (2019) Maria S. Ioannou et al. CELL
- Trafficking and proteolytic processing of amyloid precursor protein and secretases in Alzheimer's disease development: An up-to-date review
- (2019) Melike Yuksel et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Lipid Metabolism Crosstalk in the Brain: Glia and Neurons
- (2019) Casey N. Barber et al. Frontiers in Cellular Neuroscience
- Extracellular Monomeric Tau Is Internalized by Astrocytes
- (2019) Juan Ramón Perea et al. Frontiers in Neuroscience
- Propagation of Protein Aggregation in Neurodegenerative Diseases
- (2019) Jaime Vaquer-Alicea et al. Annual Review of Biochemistry
- An endosomal LAPF is required for macrophage endocytosis and elimination of bacteria
- (2019) Tianliang Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Glucocerebrosidase and its relevance to Parkinson disease
- (2019) Jenny Do et al. Molecular Neurodegeneration
- The CLN3 gene and protein: What we know
- (2019) Myriam Mirza et al. Molecular Genetics & Genomic Medicine
- Mitochondria–Lysosome Crosstalk: From Physiology to Neurodegeneration
- (2019) Cláudia M. Deus et al. TRENDS IN MOLECULAR MEDICINE
- Autophagy Induction as a Therapeutic Strategy for Neurodegenerative Diseases
- (2019) Alvin Djajadikerta et al. JOURNAL OF MOLECULAR BIOLOGY
- A characterization of Gaucher iPS-derived astrocytes: Potential implications for Parkinson's disease
- (2019) Elma Aflaki et al. NEUROBIOLOGY OF DISEASE
- Apolipoprotein E, Receptors, and Modulation of Alzheimer’s Disease
- (2018) Na Zhao et al. BIOLOGICAL PSYCHIATRY
- Aging-related tau astrogliopathy (ARTAG): not only tau phosphorylation in astrocytes
- (2018) Isidro Ferrer et al. BRAIN PATHOLOGY
- Histone deacetylase–mediated regulation of endolysosomal pH
- (2018) Hari Prasad et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Aspirin induces Lysosomal biogenesis and attenuates Amyloid plaque pathology in a mouse model of Alzheimer's disease via PPARα
- (2018) Sujyoti Chandra et al. JOURNAL OF NEUROSCIENCE
- Extracellular α-synuclein levels are regulated by neuronal activity
- (2018) Kaoru Yamada et al. Molecular Neurodegeneration
- Internalization, axonal transport and release of fibrillar forms of alpha-synuclein
- (2018) Gregor Bieri et al. NEUROBIOLOGY OF DISEASE
- APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types
- (2018) Yuan-Ta Lin et al. NEURON
- Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH
- (2018) Hari Prasad et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures
- (2018) André M. Miranda et al. Nature Communications
- Endocytosis and Transcytosis of Amyloid-β Peptides by Astrocytes: A Possible Mechanism for Amyloid-β Clearance in Alzheimer’s Disease
- (2018) Marta Domínguez-Prieto et al. JOURNAL OF ALZHEIMERS DISEASE
- TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading
- (2018) Heidi Martini-Stoica et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Lysosome biogenesis in health and disease
- (2018) Lakshya Bajaj et al. JOURNAL OF NEUROCHEMISTRY
- Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs)
- (2018) Jennifer N. Rauch et al. Scientific Reports
- Compromised astrocyte function and survival negatively impact neurons in infantile neuronal ceroid lipofuscinosis
- (2018) Jenny Lange et al. Acta Neuropathologica Communications
- Mutant huntingtin reduction in astrocytes slows disease progression in the bachd conditional huntington’s disease mouse model
- (2018) Tara E Wood et al. HUMAN MOLECULAR GENETICS
- The Endolysosomal System and Proteostasis: From Development to Degeneration
- (2018) Bettina Winckler et al. JOURNAL OF NEUROSCIENCE
- Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer’s disease
- (2018) Xunde Xian et al. eLife
- Amyloid precursor protein and endosomal–lysosomal dysfunction in Alzheimer’s disease: inseparable partners in a multifactorial disease
- (2017) Ralph A. Nixon FASEB JOURNAL
- Effects of cholesterol transport inhibitor U18666A on APP metabolism in rat primary astrocytes
- (2017) Hongyan Yang et al. GLIA
- Reactive Astrocytes: Production, Function, and Therapeutic Potential
- (2017) Shane A. Liddelow et al. IMMUNITY
- Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes
- (2017) Gabriel Gustafsson et al. Journal of Neuroinflammation
- Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease
- (2017) Yumiko V. Taguchi et al. JOURNAL OF NEUROSCIENCE
- Live-Cell Imaging Reveals Tau Isoforms Imbalance Disrupts Traffic of APP Vesicles in Human Neurons
- (2017) Christy Oi Ying Hung JOURNAL OF NEUROSCIENCE
- Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes
- (2017) Jinar Rostami et al. JOURNAL OF NEUROSCIENCE
- Mutant Huntingtin Inhibits αB-Crystallin Expression and Impairs Exosome Secretion from Astrocytes
- (2017) Yan Hong et al. JOURNAL OF NEUROSCIENCE
- Mutant Huntingtin Is Secreted via a Late Endosomal/Lysosomal Unconventional Secretory Pathway
- (2017) Katarina Trajkovic et al. JOURNAL OF NEUROSCIENCE
- Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition
- (2017) Chia-Chen Liu et al. JOURNAL OF NEUROSCIENCE
- Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage
- (2017) Veronica Lindström et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Absence of CX3CR1 impairs the internalization of Tau by microglia
- (2017) Marta Bolós et al. Molecular Neurodegeneration
- Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes
- (2017) Na Zhao et al. NEURON
- The Complicated Relationship between Gaucher Disease and Parkinsonism: Insights from a Rare Disease
- (2017) Elma Aflaki et al. NEURON
- Cell Biology of Astrocyte-Synapse Interactions
- (2017) Nicola J. Allen et al. NEURON
- Recent progress in autophagic lysosome reformation
- (2017) Yang Chen et al. TRAFFIC
- Protein misfolding in neurodegenerative diseases: implications and strategies
- (2017) Patrick Sweeney et al. Translational Neurodegeneration
- Glial cells are functionally impaired in juvenile neuronal ceroid lipofuscinosis and detrimental to neurons
- (2017) Lotta Parviainen et al. Acta Neuropathologica Communications
- Astrocytes in mouse models of tauopathies acquire early deficits and lose neurosupportive functions
- (2017) Marta Sidoryk-Wegrzynowicz et al. Acta Neuropathologica Communications
- Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients
- (2016) Shuko Takeda et al. ANNALS OF NEUROLOGY
- Tau and tauopathies
- (2016) Thomas Arendt et al. BRAIN RESEARCH BULLETIN
- Tunneling nanotubes spread fibrillar α‐synuclein by intercellular trafficking of lysosomes
- (2016) Saïda Abounit et al. EMBO JOURNAL
- Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer’s disease
- (2016) Edward J. Goetzl et al. FASEB JOURNAL
- Frequency of nuclear mutant huntingtin inclusion formation in neurons and glia is cell-type-specific
- (2016) Anne H.P. Jansen et al. GLIA
- Impaired Autophagy in APOE4 Astrocytes
- (2016) Shira Simonovitch et al. JOURNAL OF ALZHEIMERS DISEASE
- Compartment-Dependent Degradation of Mutant Huntingtin Accounts for Its Preferential Accumulation in Neuronal Processes
- (2016) T. Zhao et al. JOURNAL OF NEUROSCIENCE
- Mutant Huntingtin Impairs BDNF Release from Astrocytes by Disrupting Conversion of Rab3a-GTP into Rab3a-GDP
- (2016) Y. Hong et al. JOURNAL OF NEUROSCIENCE
- Alpha-synuclein structure, functions, and interactions
- (2016) FatemehNouri Emamzadeh Journal of Research in Medical Sciences
- Trehalose rescues glial cell dysfunction in striatal cultures from HD R6/1 mice at early postnatal development
- (2016) Juan Perucho et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons
- (2016) Sofia Söllvander et al. Molecular Neurodegeneration
- The Biology of Huntingtin
- (2016) Frédéric Saudou et al. NEURON
- Loss of Bin1 Promotes the Propagation of Tau Pathology
- (2016) Sara Calafate et al. Cell Reports
- Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration
- (2015) Lucy Liu et al. CELL
- The role of TRPMLs in endolysosomal trafficking and function
- (2015) Kartik Venkatachalam et al. CELL CALCIUM
- Expression of familial Alzheimer disease presenilin 1 gene attenuates vesicle traffic and reduces peptide secretion in cultured astrocytes devoid of pathologic tissue environment
- (2015) Matjaž Stenovec et al. GLIA
- New Insights on Astrocyte Ion Channels: Critical for Homeostasis and Neuron-Glia Signaling
- (2015) M. L. Olsen et al. JOURNAL OF NEUROSCIENCE
- Huntington’s disease cerebrospinal fluid seeds aggregation of mutant huntingtin
- (2015) Z Tan et al. MOLECULAR PSYCHIATRY
- Huntingtin functions as a scaffold for selective macroautophagy
- (2015) Yan-Ning Rui et al. NATURE CELL BIOLOGY
- Depletion of microglia and inhibition of exosome synthesis halt tau propagation
- (2015) Hirohide Asai et al. NATURE NEUROSCIENCE
- The Effect of Aβ1-42 Oligomers on APP Processing and Aβ1-40 Generation in Cultured U-373 Astrocytes
- (2015) Dimitar Ourdev et al. Neurodegenerative Diseases
- Calcium signaling in membrane repair
- (2015) Xiping Cheng et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- The Blood–Brain Barrier
- (2015) Richard Daneman et al. Cold Spring Harbor Perspectives in Biology
- Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain
- (2015) Shuko Takeda et al. Nature Communications
- Neuroinflammation in Parkinson’s disease and its potential as therapeutic target
- (2015) Qinqin Wang et al. Translational Neurodegeneration
- Hyperphosphorylation of Intrinsically Disordered Tau Protein Induces an Amyloidogenic Shift in Its Conformational Ensemble
- (2015) Shaolong Zhu et al. PLoS One
- Astrocytosis in infantile neuronal ceroid lipofuscinosis: friend or foe?
- (2014) Charles Shyng et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Neuronal activity regulates extracellular tau in vivo
- (2014) Kaoru Yamada et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Enhancing Astrocytic Lysosome Biogenesis Facilitates A Clearance and Attenuates Amyloid Plaque Pathogenesis
- (2014) Q. Xiao et al. JOURNAL OF NEUROSCIENCE
- DNA Damage and Its Links to Neurodegeneration
- (2014) Ram Madabhushi et al. NEURON
- The role of the cytoskeleton and molecular motors in endosomal dynamics
- (2014) Elizabeth Granger et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Mitochondria and Quality Control Defects in a Mouse Model of Gaucher Disease—Links to Parkinson’s Disease
- (2013) Laura D. Osellame et al. Cell Metabolism
- Microtubule-based transport - basic mechanisms, traffic rules and role in neurological pathogenesis
- (2013) M. A. M. Franker et al. JOURNAL OF CELL SCIENCE
- LPS or ethanol triggers clathrin- and rafts/caveolae-dependent endocytosis of TLR4 in cortical astrocytes
- (2013) Maya Pascual-Lucas et al. JOURNAL OF NEUROCHEMISTRY
- Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
- (2013) Jean-Charles Lambert et al. NATURE GENETICS
- Activity-Induced Convergence of APP and BACE-1 in Acidic Microdomains via an Endocytosis-Dependent Pathway
- (2013) Utpal Das et al. NEURON
- ApoE influences amyloid- (A ) clearance despite minimal apoE/A association in physiological conditions
- (2013) P. B. Verghese et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds
- (2013) B. B. Holmes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts
- (2013) Nady Braidy et al. Translational Neurodegeneration
- Expression of mutant N-terminal huntingtin fragment (htt552-100Q) in astrocytes suppresses the secretion of BDNF
- (2012) Linhui Wang et al. BRAIN RESEARCH
- Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia
- (2012) Lisa Fellner et al. GLIA
- Proteomic Analysis of Wild-type and Mutant Huntingtin-associated Proteins in Mouse Brains Identifies Unique Interactions and Involvement in Protein Synthesis
- (2012) Brady P. Culver et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Low-density Lipoprotein Receptor Represents an Apolipoprotein E-independent Pathway of Aβ Uptake and Degradation by Astrocytes
- (2012) Jacob M. Basak et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- IFN-γ-induced increase in the mobility of MHC class II compartments in astrocytes depends on intermediate filaments
- (2012) Nina Vardjan et al. Journal of Neuroinflammation
- Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder
- (2012) C. Di Malta et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington’s disease patient cells
- (2012) Tarja A Juopperi et al. Molecular Brain
- Toll-Like Receptor 4 Promotes α-Synuclein Clearance and Survival of Nigral Dopaminergic Neurons
- (2011) Nadia Stefanova et al. AMERICAN JOURNAL OF PATHOLOGY
- Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation
- (2011) Mireille Bélanger et al. Cell Metabolism
- Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance
- (2011) Diego L. Medina et al. DEVELOPMENTAL CELL
- The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis
- (2011) Jie Zhao et al. Journal of Neuroinflammation
- The Role of Attenuated Astrocyte Activation in Infantile Neuronal Ceroid Lipofuscinosis
- (2011) S. L. Macauley et al. JOURNAL OF NEUROSCIENCE
- Assessment of α-Synuclein Secretion in Mouse and Human Brain Parenchyma
- (2011) Evangelia Emmanouilidou et al. PLoS One
- Human apoE Isoforms Differentially Regulate Brain Amyloid- Peptide Clearance
- (2011) J. M. Castellano et al. Science Translational Medicine
- Lipoprotein Lipase Is a Novel Amyloid β (Aβ)-binding Protein That Promotes Glycosaminoglycan-dependent Cellular Uptake of Aβ in Astrocytes
- (2010) Kazuchika Nishitsuji et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies
- (2010) He-Jin Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes
- (2010) Juliane P. Caviston et al. MOLECULAR BIOLOGY OF THE CELL
- Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease
- (2009) E. Sidransky et al. NEW ENGLAND JOURNAL OF MEDICINE
- apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain
- (2008) Rashid Deane et al. JOURNAL OF CLINICAL INVESTIGATION
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started